Journal of dentistry最新文献

{"title":"Untargeted-metabolomics reveals size-dependent metabolic disparities of apical periodontitis lesions","authors":"Mengchen Tang ,&nbsp;Yilin Zhang ,&nbsp;Huang Fang ,&nbsp;Zihan Li ,&nbsp;Lijia Huang ,&nbsp;Lisha Gu","doi":"10.1016/j.jdent.2025.106096","DOIUrl":"10.1016/j.jdent.2025.106096","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to investigate the variations in metabolic differences associated with the disease severity of apical periodontitis (AP) by comparing lesions of different sizes.</div></div><div><h3>Methods</h3><div>Twelve apical tissue samples were collected during apical microsurgery from patients without systemic diseases, comprising 6 large lesions (greater than 1000 mm³) and 6 small lesions (&lt;1000 mm³). Liquid chromatography-mass spectrometry was conducted to analyze the metabolic profiles of AP lesions with different sizes. Principal component analysis and orthogonal partial least squares discriminant analysis were utilized to characterize lesion size-dependent metabolic disparities. Subsequently, differentially expressed metabolites (DEMs) screening and enrichment analysis was employed to clarify metabolic pathways that correlate with AP lesion size heterogeneity.</div></div><div><h3>Results</h3><div>Among the 2431 detected metabolites, 21 DEMs were identified. Large lesions exhibited the upregulation of 11 metabolites (e.g., α-linolenic acid, eicosatetraenoic acid), which were predominantly enriched in “α-linolenic acid metabolism” and “unsaturated fatty acid biosynthesis”. Small lesions showed the upregulation of 10 metabolites (e.g., choline, 2′-deoxyinosine), which were enriched in pathways related to “purine metabolism”, “glycine, serine and threonine metabolism”, “glycerophospholipid metabolism” and “glutathione metabolism”.</div></div><div><h3>Conclusion</h3><div>There are distinct metabolic profiles characterize between different states of AP. Large lesions exhibited elevated levels of fatty acid derivatives, implicating enhanced unsaturated fatty acid biosynthesis. Conversely, small lesions showed upregulation of nitrogenous bases and amino acid derivatives, suggesting dysregulation in purine and glutathione-related pathways. The distinct metabolite profiles indicate their biomarker potential for disease severity and efficacy optimization.</div></div><div><h3>Clinical significance</h3><div>The differential-expressed metabolites and pathways observed between large and small lesions suggests their potential role as biomarkers for as targets for further mechanistic investigation.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106096"},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of low-concentration bleaching gels with hyaluronic acid and NF_TiO2 nanoparticles activated by violet LED: A randomized clinical trial","authors":"Priscila Borges Gobbo de Melo ,&nbsp;Marcos Roberto de Lima Benati ,&nbsp;Iago César Ribeiro Teles Matos ,&nbsp;Guilherme Silva dos Santos ,&nbsp;Matheus Kury ,&nbsp;Fernando Luís Esteban Florez ,&nbsp;Vanessa Cavalli","doi":"10.1016/j.jdent.2025.106095","DOIUrl":"10.1016/j.jdent.2025.106095","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the bleaching efficacy, tooth sensitivity (TS), pulpal oxygen saturation (SaO₂), and patient satisfaction following in-office bleaching using experimental gels containing hyaluronic acid (HA) or carbomer 940 (CAR), co-doped TiO₂ nanoparticles with nitrogen and fluoride (NP; NF_TiO₂), and 6 % hydrogen peroxide (HP), activated by violet LED.</div></div><div><h3>Methods</h3><div>Seventy-two participants were randomly assigned to three groups (<em>n</em> = 24): HP35 (commercial bleaching gel), HA-NP-HP6+LED, and CAR-NP-HP6+LED. Bleaching was performed in three weekly sessions (1 × 30 min; 1-week interval). TS (VAS) and SaO₂ were recorded before and after each session, with TS reassessed seven days post-treatment. Tooth color was evaluated at baseline, 14 days, and 6 months post-treatment. The parameters ΔEab, ΔE₀₀, ΔWI_D, and ΔSGU were calculated. Patient satisfaction was assessed using a subjective scale. Statistical analysis was performed using one-way ANOVA with Tukey post hoc and non-parametric tests (α = 0.05).</div></div><div><h3>Results</h3><div>The HP35 group showed significantly higher bleaching efficacy after 14 days. However, at the 6-month evaluation, the experimental gels exhibited similar performance. TS was significantly lower in the experimental groups (<em>p</em> &lt; 0.05), while SaO₂ levels remained stable across all groups. All participants (100 %) reported satisfaction with the outcomes.</div></div><div><h3>Conclusions</h3><div>Low-concentration bleaching gels containing 6 % hydrogen peroxide and NF_TiO₂ nanoparticles showed comparable efficacy to a 35 % hydrogen peroxide gel after 6 months, with less tooth sensitivity and no adverse effects on pulp oxygen saturation. Patient satisfaction was high across all groups, supporting the clinical viability of these safer experimental gels.</div></div><div><h3>Clinical Relevance</h3><div>Low-concentration gels enhanced with NF_TiO₂ nanoparticles and activated by violet LED may provide an effective and patient-centered bleaching option, maintaining long-term results while minimizing sensitivity.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106095"},"PeriodicalIF":5.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Validation of intraoral scanner as a tool for the epidemiological diagnosis of caries” [J Dent. 2025 Sep:160:105913. doi: 10.1016/j.jdent.2025.105913. Epub 2025 Jun 18]","authors":"Ândrea P Daneris ,&nbsp;Sarah Arangurem Karam ,&nbsp;Fausto Medeiros Mendes ,&nbsp;Maximiliano Sérgio Cenci ,&nbsp;Flávio Fernando Demarco ,&nbsp;Marcos Britto Correa","doi":"10.1016/j.jdent.2025.106067","DOIUrl":"10.1016/j.jdent.2025.106067","url":null,"abstract":"","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106067"},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in dentists’ thresholds for restorative treatment of active non-cavitated carious lesions: a multinational cross-sectional study","authors":"Ömer Hatipoğlu ,&nbsp;Nessrin Taha ,&nbsp;Mohmed Isaqali Karobari ,&nbsp;Thiyezen Abdullah Aldhelai ,&nbsp;Daoud M. Ayyad ,&nbsp;Ahmed A. Madfa ,&nbsp;Jose Martin-Cruces ,&nbsp;Rafael Fernández-Grisales ,&nbsp;Maira Kopbayeva ,&nbsp;Wen Yi Lim ,&nbsp;Suha Alfirjani ,&nbsp;Kacper Nijakowski ,&nbsp;Tanvi Deepak shah ,&nbsp;Eftychia Pappa ,&nbsp;Silvana Jukić Krmek ,&nbsp;Novaldy Wahjudianto ,&nbsp;Azhar Iqbal ,&nbsp;Imran Zainal Abidin ,&nbsp;Martha Gallegos Intriago ,&nbsp;Yasmine Elhamouly ,&nbsp;Fatma Pertek Hatipoğlu","doi":"10.1016/j.jdent.2025.106092","DOIUrl":"10.1016/j.jdent.2025.106092","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess patterns across 21 countries in dentists’ thresholds for initiating operative treatment of active non-cavitated carious lesions and to evaluate the influence of caries risk, clinician characteristics, and geographic variation on decision-making in accordance with current guidelines.</div></div><div><h3>Methods</h3><div>A cross-sectional, vignette-style web-based survey was conducted between June and October 2023 across 21 countries. A standardized questionnaire, comprising theoretical radiographic scenarios of occlusal and approximal active non-cavitated carious lesions at four progressive stages (E1,E2,EDJ,D1), was distributed to general dentists and specialists. Respondents selected the radiographic threshold at which they would initiate invasive treatment for patients with low and high caries risk. Guideline-concordant benchmarks were predefined as D1 for low-risk and EDJ/D1 for high-risk; any earlier choice was coded as overtreatment. Cumulative-link mixed models estimated determinants of thresholds; guideline concordance was summarized descriptively.</div></div><div><h3>Results</h3><div>A total of 3680 dentists provided 7360 valid responses. High caries risk significantly predicted earlier intervention (occlusal OR= 0.34; approximal OR= 0.38, p &lt; 0.001). Female dentists and restorative specialists were more conservative, while age showed no significant effect. Overall guideline adherence was low (22.7 % in low-risk and 32.7 % in high-risk scenarios). Substantial inter-country variation was observed; Bangladesh and Portugal showed highest adherence, while Kazakhstan and Colombia demonstrated overtreatment tendencies.</div></div><div><h3>Conclusions</h3><div>Despite global promotion of minimally invasive dentistry, overtreatment of enamel lesions remains widespread. Addressing systemic, educational, and policy-level barriers is essential to improve adherence to evidence-based, risk-informed caries management.</div></div><div><h3>Clinical significance</h3><div>This multinational study highlights substantial variability and premature intervention in caries management across countries. Identifying patterns of overtreatment and guideline discordance informs dental education and policy, emphasizing the urgent need to reinforce minimally invasive, risk-based strategies in clinical practice across participating countries.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106092"},"PeriodicalIF":5.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of enzymatic deproteinization and surface pre-reacted glass ionomer “SPRG” fillers in self-etch adhesives: Boosting anti-demineralization and ABRZ","authors":"Citra Kusumasari ,&nbsp;Ratna Meidyawati ,&nbsp;Iffi Aprillia ,&nbsp;A’an Mi’dad Arrizza ,&nbsp;Natasya Hillary ,&nbsp;Ahmed Abdou","doi":"10.1016/j.jdent.2025.106088","DOIUrl":"10.1016/j.jdent.2025.106088","url":null,"abstract":"<div><h3>Objectives</h3><div>to evaluate the effect of smear-layer deproteinization using papain gel and SPRG-adhesive on marginal-gap, anti-demineralization of enamel and dentin after chemical pH cycling and assess acid-base resistance zone (ABRZ) characteristics.</div></div><div><h3>Methods</h3><div>Cylindrical cavities were prepared cervically in thirty-two extracted premolars. Teeth were divided into two pretreatment groups (<em>n</em> = 16); deproteinization with papain enzyme gel (Papacarie Duo, Brazil) for 60 s, and no-deproteinization. Each group was subdivided by adhesive type (<em>n</em> = 8); SPRG-based (FL Bond II, Shofu, Japan), and Silica-based (Clearfil SE Bond 2, Kuraray Noritake Dental Inc., Japan). Cavities were restored with flowable composite, followed by a 4-day pH-cycling (6 h demineralization and 18 h remineralization). Specimens were immersed in Rhodamine B, sectioned perpendicularly and evaluated by confocal laser scanning microscopy for wall lesion depth (WLD), outer lesion depth (OLD), complete demineralization, and the marginal-gap length. ABRZ ultrastructure and thickness were assessed using scanning electron microscopy.</div></div><div><h3>Results</h3><div>For enamel, The silica-based adhesive exhibited a significantly higher WLD, OLD and complete demineralization compared to SPRG-based adhesive in both pretreatment conditions (<em>p</em> &lt; 0.05) while insignificant difference in the marginal-gap depth between groups (<em>p</em> &gt; 0.05). For Dentin, complete demineralization and marginal-gap were significantly higher for silica-based adhesive without deproteinization compared to SPRG-based adhesive with deproteinization (<em>p</em> &lt; 0.05). Deproteinization increased ABRZ thickness in both adhesives.</div></div><div><h3>Conclusions</h3><div>SPRG-based adhesive enhances resistance to demineralization during acidic challenge at the mid-/high-micron levels, While enzymatic smear layer deproteinization using papain gel increases the thickness of ABRZ at the micron level.</div></div><div><h3>Clinical significance</h3><div>A simple chairside protocol that combines papain-based smear-layer deproteinization with SPRG-based self-etch adhesive may enhance interfacial demineralization resistance. This synergy could reduce marginal gaps and demineralization at restoration borders, thereby lowering the risk of secondary caries and extending restoration longevity in practice.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106088"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of quantitative light-induced fluorescence technology in early caries detection and resin infiltration treatment","authors":"Yangyang Shi ,&nbsp;Xue Feng ,&nbsp;Mingyun Li ,&nbsp;Xiao Guo ,&nbsp;Haohao Wang ,&nbsp;Dongyue Dai ,&nbsp;Jinzhi He ,&nbsp;Lei Cheng","doi":"10.1016/j.jdent.2025.106086","DOIUrl":"10.1016/j.jdent.2025.106086","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study is to explore the specific application scenarios of quantitative light-induced fluorescence (QLF) in detecting early caries before and after treatment, so as to provide more evidence for the clinical application of QLF.</div></div><div><h3>Methods</h3><div>(1) The accuracy of QLF in detecting the lesion depth of early caries was evaluated by combining transverse microradiography (TMR) and spectrophotometer analysis (<em>n</em> = 6). (2) Resin infiltration therapy was used as a representative method for the treatment of early caries to evaluate the ability of QLF in assessing the therapeutic effect on early caries (<em>n</em> = 6). (3) <em>Re</em>-demineralization of early caries after treatment was performed to evaluate the detection capability of QLF for deeper lesions (<em>n</em> = 6).</div></div><div><h3>Results</h3><div>In the detection of early caries, when the demineralization depth was &lt;200 µm, both QLF and spectrophotometer analysis were accurate and correlated well with TMR results (<em>r</em>=-0.9938, <em>r</em>=0.9776, <em>p</em> &lt; 0.05). In addition, both QLF and spectrophotometer detection could effectively reflect the therapeutic effect on early caries after resin infiltration treatment. However, when the early caries treated with infiltrative resin were re-demineralized and the lesion depth &gt; 200 µm, the diagnostic accuracy of QLF for the re-demineralized early caries decreased significantly, which was not as precise as TMR and spectrophotometer analysis.</div></div><div><h3>Conclusion</h3><div>When the demineralization depth is &lt;200 µm, QLF can be used to detect early caries and evaluate the therapeutic effect on early caries. However, QLF is not suitable for detecting deep re-demineralized lesions exceeds 200 μm after resin infiltration treatment.</div></div><div><h3>Clinical significance</h3><div>Timely diagnosis and treatment of early caries are very important in clinic. Exploring the specific applicability of QLF in detecting early caries before and after treatment is helpful to provide more evidence for its clinical application, which is of great significance for the prevention and treatment of caries.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106086"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the diagnostic and treatment accuracy of Large Language Models (LLMs) in Peri-implant diseases: A clinical experimental study","authors":"Igor Amador Barbosa,&nbsp;Mauro Sergio Almeida Alves,&nbsp;Paloma Rayse Zagalo de Almeida,&nbsp;Patricia de Almeida Rodrigues,&nbsp;Roberta Pimentel de Oliveira,&nbsp;Silvio Augusto Fernades de Menezes,&nbsp;João Daniel Mendonça de Moura,&nbsp;Ricardo Roberto de Souza Fonseca","doi":"10.1016/j.jdent.2025.106091","DOIUrl":"10.1016/j.jdent.2025.106091","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluated the coherence, consistency, and diagnostic accuracy of eight AI-based chatbots in clinical scenarios related to dental implants.</div></div><div><h3>Methods</h3><div>A double-blind, clinical experimental study was carried out between February and March 2025, to evaluate eight AI-based chatbots using six fictional cases simulating peri‑implant mucositis and peri‑implantitis. Each chatbot answered five standardized clinical questions across three independent runs per case, generating 720 binary outputs. Blinded investigators scored each response against a gold standard. Statistical analyses included chi-square and Fisher’s exact and Cohen’s Kappa tests were used to assess intra-model consistency, stability and reliability for each AI chatbot.</div></div><div><h3>Results</h3><div>GPT-4o demonstrated the highest diagnostic accuracy (88.8 %), followed by Gemini (77.7 %), OpenAI o3-mini (72.2 %), OpenAI o3-mini-high (71.1 %), Claude (66.6 %), OpenAI o1 (60 %), DeepSeek (55.5 %), and Copilot (49.9 %). GPT-4o also showed the highest intra-model stability (κ = 0.82) and consistency, while Copilot and DeepSeek showed the lowest reliability. Significant differences were observed only in the reference citation criterion (p &lt; 0.001), with Gemini being the only AI chatbot to achieve 100 % compliance, but GPT-4o consistently outperformed the other AI chatbots across all evaluation domains.</div></div><div><h3>Conclusion</h3><div>GPT-4o demonstrated superior diagnostic accuracy and response consistency, reinforcing the influence of AI chatbot architecture and training on clinical reasoning performance. In contrast, Copilot showed lower reliability and higher variability, emphasizing the need for cautious, evidence-based adoption of AI tools in the diagnosis of peri‑implant diseases.</div></div><div><h3>Clinical relevance</h3><div>Understanding AI performance in peri‑implant diagnosis to support evidence-based decision-making using AI and its responsible clinical use.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106091"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing root caries with silver diamine fluoride, sodium fluoride and direct restorations: A cost-effectiveness analysis","authors":"Shijia Hu ,&nbsp;Catherine Hsu Ling Hong ,&nbsp;Xiaoli Gao ,&nbsp;Hwee-Lin Wee ,&nbsp;Yi Wang ,&nbsp;Bien Wen Pui Lai ,&nbsp;Shenna Yu-En Ho ,&nbsp;Patrick Finbarr Allen ,&nbsp;Sharon Hui Xuan Tan","doi":"10.1016/j.jdent.2025.106093","DOIUrl":"10.1016/j.jdent.2025.106093","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the cost-effectiveness of silver diamine fluoride (SDF) relative to sodium fluoride (NaF) and traditional resin-modified glass ionomer cements (RMGIC) restorations for the management of root caries in older adults aged 60 and above.</div></div><div><h3>Methods</h3><div>A Markov model design was chosen and two models were constructed: 1) Clinic-based model - with access to dental facility that allows for placement of traditional restorations, 2) Community-based model - without access to dental facility due to mobility, lack of executive function, or financial barriers. Modelling was done over a 10-year time horizon with a cycle length of one year. Data on transition probabilities and relative risks were obtained from published literature for the base case. Outcomes of interest were incremental cost per incremental caries-controlled year and incremental cost per incremental extraction-free year. Probabilistic sensitivity analyses were conducted to account for uncertainty in the base case.</div></div><div><h3>Results</h3><div>In the clinic-based model, both SDF and NaF were dominated by traditional RMGIC restorations, which had lower cost, and higher number of caries-controlled and extraction-free years, with a 90% probability of being cost-effective. In the community-based model, NaF was dominated by SDF, which incurred lower cost and resulted in a higher number of caries-controlled and extraction-free years, with almost 100% probability of being cost-effective.</div></div><div><h3>Conclusions</h3><div>Traditional RMGIC restoration was the most cost-effective option for managing root caries when full dental facility is available. In situations where treatment is provided in a community setting, SDF was more cost-effective than NaF.</div></div><div><h3>CLINICAL SIGNIFICANCE</h3><div>Based on limited clinical studies and within the Singapore oral health system, traditional RMGIC restoration was most cost-effective in clinical settings for managing root caries, while SDF was most cost-effective in community settings.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106093"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between dental caries and body mass index in socially vulnerable adolescents: a group-based trajectory analysis","authors":"Bárbara Mulatinho Lopo Gonçalves ,&nbsp;Luciana Armada ,&nbsp;Tonje Holte Stea ,&nbsp;Maria Augusta Bessa Rebelo ,&nbsp;Jefferson Calixto Carvalho ,&nbsp;Lucio Souza Gonçalves ,&nbsp;Mario Vianna Vettore","doi":"10.1016/j.jdent.2025.106087","DOIUrl":"10.1016/j.jdent.2025.106087","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine bidirectional associations between dental caries and body mass index (BMI) among adolescents living in vulnerable communities in Brazil.</div></div><div><h3>Methods</h3><div>In a cohort study involving adolescents (<em>n</em> = 323), BMI, number of decayed teeth and odontogenic infections (PUFA/pufa index) were recorded at three time points between 12 and 15 years of age. Trajectories of dental caries, odontogenic infections, and BMI were developed using group-based trajectory modelling. Associations between dental caries and odontogenic infections trajectories with changes in BMI z-scores, and between BMI trajectories and dental caries and odontogenic infections incidence were adjusted for sugar intake and socioeconomic conditions using multiple Poisson regression.</div></div><div><h3>Results</h3><div>Three distinct trajectories of dental caries (stable low, moderate increasing, and high increase), odontogenic infections (stable low, stable moderate, and stable high), and BMI z-scores (stable low, stable moderate, and stable high) were identified. Compared with the stable moderate BMI z-score trajectory, the stable low was associated with increased risk of dental caries incidence (IRR 1.48, 95%CI 1.05–2.09). The high increase dental caries trajectory (IRR 1.38, 95%CI 1.02–1.88) and high stable odontogenic infections trajectory (IRR 1.50, 95%CI 1.12–2.00) were associated with positive changes in BMI z-scores.</div></div><div><h3>Conclusions</h3><div>Adolescents living in deprived communities with persistently low BMI were at higher risk of dental caries. Those with increasing dental caries and consistently high levels of odontogenic infections were at higher risk of BMI z-scores increases. Effective individual and public health strategies to reduce dental caries and malnutrition in adolescents should be aligned.</div></div><div><h3>Clinical significance</h3><div>Dental caries and body mass index are interrelated in underprivileged adolescents.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106087"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between systemic exposure to antibiotics in early childhood and molar-incisor hypomineralization (MIH): A systematic review and meta-analysis","authors":"Éva Mlinkó ,&nbsp;Dalma Tábi ,&nbsp;Bianca Golzio Navarro Cavalcante ,&nbsp;Bence Szabó ,&nbsp;Péter Hegyi ,&nbsp;János Vág ,&nbsp;Enikő Vasziné Szabó ,&nbsp;Noémi Katinka Rózsa ,&nbsp;Gábor Varga","doi":"10.1016/j.jdent.2025.106094","DOIUrl":"10.1016/j.jdent.2025.106094","url":null,"abstract":"<div><h3>Objective</h3><div>Molar Incisor Hypomineralization (MIH) is a developmental enamel defect affecting one in six children worldwide. Although antibiotics have been suggested to influence dental development, their association with MIH remains unclear. This systematic review and meta-analysis evaluated the association between early childhood antibiotic exposure and the risk of developing MIH.</div></div><div><h3>Data Sources</h3><div>MEDLINE (via PubMed), Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to December 17, 2024.</div></div><div><h3>Study Selection</h3><div>Observational studies (cross-sectional, case-control) including children aged 6–14 years diagnosed with MIH using validated criteria were eligible. Exposure was defined as antibiotic use before age 4. Studies involving special populations or other enamel defects were excluded. Risk of bias was assessed using the QUIPS tool. A random-effects model calculated odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>From 3308 records, 41 studies met the criteria and 31 were included in the meta-analysis, with 22,141 participants aged 6–14. Antibiotic use before age 4 was significantly associated with MIH (OR:1.50, 95% CI 1.13 – 1.99, <em>p</em> = 0.0070). Amoxicillin (OR: 1.87; 95% CI: 0.83–4.21, <em>p</em> = 0.104) and penicillin (OR: 2.15; 95% CI: 0.73–6.34, <em>p</em> = 0.130) resulted in higher odds for the development of MIH.</div></div><div><h3>Conclusion</h3><div>Early antibiotic use before age 4 is associated with higher odds of developing MIH. However, given the low certainty of evidence, this finding should be interpreted with caution, as it remains unclear whether the link is direct or indirect, highlighting the need for further research to guide prevention strategies.</div></div><div><h3>Clinical Relevance</h3><div>MIH poses diagnostic and treatment challenges. Contributing factors must be identified judiciously. Prudent antibiotic use should be integrated into clinical practice to reduce potential risk and promote better long-term oral health in children.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106094"},"PeriodicalIF":5.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}