金属剂增强玻璃离聚体水泥的抗菌性能：系统综述和荟萃分析：金属金属剂对生物膜的改变。

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-07 DOI:10.1016/j.jdent.2025.105892

Marcelle Danelon , Gabriel Pereira Nunes , Torsten Sterzenbach , Christian Hannig

{"title":"金属剂增强玻璃离聚体水泥的抗菌性能：系统综述和荟萃分析：金属金属剂对生物膜的改变。","authors":"Marcelle Danelon , Gabriel Pereira Nunes , Torsten Sterzenbach , Christian Hannig","doi":"10.1016/j.jdent.2025.105892","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review and meta-analysis (SRM) aimed to assess the impact of incorporating metallic agents into glass ionomer cement (GIC) and resin-modified glass ionomer cement (RMGIC) on their microbiological properties and antibacterial activity.</div></div><div><h3>Data sources</h3><div>Following PRISMA guidelines, the SRM included studies published up to August 21, 2024.</div></div><div><h3>Study selection</h3><div>The eligibility criteria included clinical trials, <em>in situ</em>, and <em>in vitro</em> studies. The data were analyzed using RevMan software, and bias risk was assessed with the Joanna Briggs Institute’s Checklist for <em>in vitro</em> studies and the ROBINS-I tool for clinical trials.</div></div><div><h3>Results</h3><div>Out of 2,393 screened records, 32 studies were included. Results showed that metallic agents like silver, zinc oxide, titanium dioxide, and copper enhanced the antimicrobial properties of GIC and RMGIC. Most studies reported superior antimicrobial effects compared to controls, with only two studies showing neutral effects. Meta-analysis revealed that GIC with 5 % TiO₂ or 2 % ZnO nanoparticles significantly reduced <em>S. mutans</em> viability, while silver zeolite at 1 % and 5 % concentrations showed strong effects. Similarly, adding silver or ZnO to RMGIC improved its activity against <em>S. mutans</em> and <em>L. acidophilus</em>. The studies showed a low risk of bias.</div></div><div><h3>Conclusions</h3><div>Metallic agents enhance the antimicrobial efficacy of GIC/RMGIC, offering a promising solution for biofilm control in dental restorations. However, further research is needed to optimize their clinical application, particularly through in vivo studies, and to assess their impact on mechanical, esthetic, and cytotoxic properties.</div></div><div><h3>Clinical relevance</h3><div>Incorporating metallic agents into GIC and RMGIC enhances their antibacterial properties, improving biofilm control in dental restorations. This modification may reduce the risk of secondary caries and prolong restoration longevity.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105892"},"PeriodicalIF":4.8000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancing antimicrobial properties of glass ionomer cement through metallic agent reinforcement: A systematic review and meta-analysis\",\"authors\":\"Marcelle Danelon , Gabriel Pereira Nunes , Torsten Sterzenbach , Christian Hannig\",\"doi\":\"10.1016/j.jdent.2025.105892\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>This systematic review and meta-analysis (SRM) aimed to assess the impact of incorporating metallic agents into glass ionomer cement (GIC) and resin-modified glass ionomer cement (RMGIC) on their microbiological properties and antibacterial activity.</div></div><div><h3>Data sources</h3><div>Following PRISMA guidelines, the SRM included studies published up to August 21, 2024.</div></div><div><h3>Study selection</h3><div>The eligibility criteria included clinical trials, <em>in situ</em>, and <em>in vitro</em> studies. The data were analyzed using RevMan software, and bias risk was assessed with the Joanna Briggs Institute’s Checklist for <em>in vitro</em> studies and the ROBINS-I tool for clinical trials.</div></div><div><h3>Results</h3><div>Out of 2,393 screened records, 32 studies were included. Results showed that metallic agents like silver, zinc oxide, titanium dioxide, and copper enhanced the antimicrobial properties of GIC and RMGIC. Most studies reported superior antimicrobial effects compared to controls, with only two studies showing neutral effects. Meta-analysis revealed that GIC with 5 % TiO₂ or 2 % ZnO nanoparticles significantly reduced <em>S. mutans</em> viability, while silver zeolite at 1 % and 5 % concentrations showed strong effects. Similarly, adding silver or ZnO to RMGIC improved its activity against <em>S. mutans</em> and <em>L. acidophilus</em>. The studies showed a low risk of bias.</div></div><div><h3>Conclusions</h3><div>Metallic agents enhance the antimicrobial efficacy of GIC/RMGIC, offering a promising solution for biofilm control in dental restorations. However, further research is needed to optimize their clinical application, particularly through in vivo studies, and to assess their impact on mechanical, esthetic, and cytotoxic properties.</div></div><div><h3>Clinical relevance</h3><div>Incorporating metallic agents into GIC and RMGIC enhances their antibacterial properties, improving biofilm control in dental restorations. This modification may reduce the risk of secondary caries and prolong restoration longevity.</div></div>\",\"PeriodicalId\":15585,\"journal\":{\"name\":\"Journal of dentistry\",\"volume\":\"160 \",\"pages\":\"Article 105892\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of dentistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0300571225003367\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of dentistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300571225003367","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

目的：本系统综述和荟萃分析（SRM）旨在评估金属剂掺入玻璃离聚体水泥（GIC）和树脂改性玻璃离聚体水泥（RMGIC）对其微生物学特性和抗菌活性的影响。数据来源：遵循PRISMA指南，SRM纳入了截至2024年8月21日发表的研究。研究选择：入选标准包括临床试验、原位研究和体外研究。使用RevMan软件对数据进行分析，并使用体外研究Joanna Briggs Institute’s Checklist和临床试验ROBINS-I工具评估偏倚风险。结果：在2393份筛选记录中，纳入了32项研究。结果表明，银、氧化锌、二氧化钛和铜等金属助剂增强了GIC和RMGIC的抗菌性能。与对照组相比，大多数研究报告了优越的抗菌效果，只有两项研究显示中性效果。荟萃分析显示，添加5% tio2或2% ZnO纳米粒子的GIC显著降低了S. mutans的活力，而添加1%和5%浓度的银沸石对S. mutans的活力有较强的影响。同样，在RMGIC中添加银或氧化锌可以提高其对变形链球菌和嗜酸乳杆菌的活性。这些研究显示偏倚风险较低。结论：金属制剂可增强GIC/RMGIC的抗菌效果，为修复体生物膜控制提供了一种有前景的解决方案。然而，需要进一步的研究来优化它们的临床应用，特别是通过体内研究，并评估它们对机械、美学和细胞毒性的影响。临床意义：将金属制剂加入到GIC和RMGIC中，可以增强其抗菌性能，改善口腔修复中生物膜的控制。这种改良可以降低继发性龋齿的风险，延长修复寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Enhancing antimicrobial properties of glass ionomer cement through metallic agent reinforcement: A systematic review and meta-analysis

Objectives

This systematic review and meta-analysis (SRM) aimed to assess the impact of incorporating metallic agents into glass ionomer cement (GIC) and resin-modified glass ionomer cement (RMGIC) on their microbiological properties and antibacterial activity.

Data sources

Following PRISMA guidelines, the SRM included studies published up to August 21, 2024.

Study selection

The eligibility criteria included clinical trials, in situ, and in vitro studies. The data were analyzed using RevMan software, and bias risk was assessed with the Joanna Briggs Institute’s Checklist for in vitro studies and the ROBINS-I tool for clinical trials.

Results

Out of 2,393 screened records, 32 studies were included. Results showed that metallic agents like silver, zinc oxide, titanium dioxide, and copper enhanced the antimicrobial properties of GIC and RMGIC. Most studies reported superior antimicrobial effects compared to controls, with only two studies showing neutral effects. Meta-analysis revealed that GIC with 5 % TiO₂ or 2 % ZnO nanoparticles significantly reduced S. mutans viability, while silver zeolite at 1 % and 5 % concentrations showed strong effects. Similarly, adding silver or ZnO to RMGIC improved its activity against S. mutans and L. acidophilus. The studies showed a low risk of bias.

Conclusions

Metallic agents enhance the antimicrobial efficacy of GIC/RMGIC, offering a promising solution for biofilm control in dental restorations. However, further research is needed to optimize their clinical application, particularly through in vivo studies, and to assess their impact on mechanical, esthetic, and cytotoxic properties.

Clinical relevance

Incorporating metallic agents into GIC and RMGIC enhances their antibacterial properties, improving biofilm control in dental restorations. This modification may reduce the risk of secondary caries and prolong restoration longevity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.