胺甲基丙烯酸酯共聚物与氟化物在牙膏中对牙齿侵蚀磨损的协同作用。

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-11 DOI:10.1016/j.jdent.2025.105904

Victor Cavallaro Bottesini , Daniele Mara da Silva Ávila , Carlos Rocha Gomes Torres , Taís Scaramucci , Alessandra Bühler Borges

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引用次数: 0

摘要

目的：评价含氨甲基丙烯酸酯共聚物（AMC）含氟牙膏配方对牙釉质初始侵蚀和牙齿侵蚀磨损的保护作用。材料与方法：将抛光后的牛牙釉质标本分为6组（n=13）：安慰剂牙膏（PL）、AMC牙膏（AMC 4%）、氟化钠牙膏（F, 1450 ppm F-）、AMC+NaF牙膏（AMC+F）、磨损阴性对照组（ANC -有磨损的超纯水）和侵蚀阴性对照组（ENC -无磨损的超纯水）。标本进行侵蚀/磨蚀循环，其中包括0.3%柠檬酸暴露（pH 2.69, 5分钟，4次/天），处理（2次/天：刷牙15秒，泥浆105秒），中间阶段（1小时）浸泡在人唾液中。在基线、第一次酸激后、第一次处理后和第二次酸激后评估Knoop显微硬度，从而计算处理的再硬化（%Re）和保护电位（%Prot）。循环5天后，使用轮廓术测量表面损失（SL）。氢氧化钾可溶性氟化物也被定量。数据分析采用单因素方差分析和Tukey检验（5%）。结果：AMC+F组的%Re和%Prot值明显高于其他各组(p结论：在牙膏配方中加入氨基甲基丙烯酸酯共聚物，可增强氟化钠对初始侵蚀和牙磨损的保护作用。临床意义：氨基甲基丙烯酸酯可减少牙釉质侵蚀，增强氟化物的保护作用，有望成为一种有效控制腐蚀牙磨损的药物。

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Synergistic effect of aminomethacrylate copolymer and fluoride in toothpastes against erosive tooth wear

Objective

To evaluate the protective potential of fluoride toothpaste formulations associated with aminomethacrylate copolymer (AMC) against enamel initial erosion and erosive tooth wear.

Material and Methods

Polished bovine enamel specimens were divided into six groups (n = 13): placebo toothpaste (PL), AMC toothpaste (AMC 4 %), sodium fluoride toothpaste (F, 1450 ppm F^-), AMC+NaF toothpaste (AMC+F), abrasion negative control (ANC - ultrapure water with abrasion), and erosion negative control- (ENC - ultrapure water without abrasion). Specimens underwent erosive/abrasive cycling, which included 0.3 % citric acid exposure (pH 2.69, 5 min, 4x/day), treatments (2x/day: brushing 15 s, and slurry 105 s), with immersion in human saliva in the intermediate periods (1 h). Knoop microhardness was assessed at baseline, after the first acid challenge, after the first treatment, and after the second acid challenge, allowing the calculation of rehardening ( %Re) and protective potential ( %Prot) of the treatments. After 5 days of cycling, surface loss (SL) was measured using profilometry. KOH-soluble fluoride was also quantified. Data were analyzed by one-way ANOVA and Tukey’s test (5 %).

Results

The AMC+F group showed significantly higher %Re and %Prot values compared to all other groups (p < 0.05). SL data (Mean ± SD) were: ENC (7.46±2.26)a, ANC (10.14±2.08)ab, PL (13.11±2.69)c, AMC (7.74±2.10)a, F (11.38±2.07)bc, AMC+F (7.52±2.59)a. KOH-soluble fluoride did not differ significantly in fluoride-containing groups (p = 0.001).

Conclusion

The addition of aminomethacrylate copolymer to a toothpaste formula enhanced the protective effect of sodium fluoride against initial erosion and erosive tooth wear.

Clinical Significance

Aminomethacrylate reduced enamel erosion and it enhanced fluoride’s protective effect, showing potential as an agent for effective control of erosive tooth wear.

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.