A randomised, controlled, trial investigating the effect of tooth brushing with a sodium bicarbonate toothpaste for 12 weeks compared to a conventional fluoride toothpaste on gingivitis

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-06 DOI:10.1016/j.jdent.2025.105886

Nicola X. West , Jianhong Qiu , Alexander J. Pollard , Maria Davies , Gary Smith , Paola Gomez-Pereira , Joon Seong

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引用次数: 0

Abstract

Objectives

To determine the effect on gingival inflammation of toothbrushing with sodium bicarbonate toothpaste for 12 weeks compared to brushing with a conventional fluoride toothpaste.

Methods

An ethically-approved, single-centre, controlled, examiner-blind, randomized, two-treatment arm, parallel study in consenting healthy ≥18yr participants with ≥20 teeth diagnosed with localised gingivitis. Approximately 200 eligible participants brushed for 2weeks with a fluoride acclimatization toothpaste before randomization to brushing 2/daily with a sodium bicarbonate (test) or fluoride (control) toothpaste. No pre-prophylaxis was conducted prior to study start. Modified gingival index (MGI), bleeding index (BI) and Turesky plaque index (TPI), were measured at baseline, 3, 6 and 12weeks. Participants completed a diary for compliance monitoring.

Results

190 participants were randomised, 188 completed the study. The test group demonstrated a statistically significant reduction in number of bleeding sites from baseline to 12-weeks (p = 0.0032), 6-weeks (p = 0.0031) and 3-weeks (p = 0.0091), and compared to control group from baseline to 12-weeks (p = 0.0013). The test group showed significantly (all p < 0.0001) decreased mean MGI score from baseline to 3-weeks, 6-weeks, and 12-weeks compared to control group; significantly decreased mean overall TPI score from baseline to 3-weeks (p = 0.0012), 6-weeks (p = 0.0058), and 12-weeks (p < 0.0001) compared to control; and significantly reduced mean interproximal TPI scores compared to control group from baseline to 3-weeks (p = 0.0022), 6-weeks (p = 0.0099) and 12-weeks (p < 0.0001).

Conclusions

Twice daily toothbrushing with a sodium bicarbonate toothpaste significantly improved oral health reducing localised gingivitis compared to brushing with a conventional fluoride toothpaste, measured by BI, MGI and TPI over 12 weeks.

Clinical Significance

Localised, gingivitis can be resolved or prevented with excellent home-use oral hygiene measures, but this is rarely achieved with mechanical brushing alone. Twice daily toothbrushing with sodium bicarbonate toothpaste demonstrated added value in reducing localised gingivitis and improving oral health compared to brushing with a conventional fluoride toothpaste.

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一项随机对照试验调查了用碳酸氢钠牙膏刷牙12周与用传统含氟牙膏刷牙对牙龈炎的影响。

目的：比较用碳酸氢钠牙膏和常规含氟牙膏刷牙12周对牙龈炎症的影响。方法：一项经伦理批准的、单中心、对照、检查者盲、随机、双治疗组、平行研究，参与者年龄≥18岁，牙齿≥20颗，诊断为局部性牙龈炎。大约200名符合条件的参与者使用氟化物适应牙膏刷牙2周，然后随机分配使用碳酸氢钠（测试）或氟化物（对照）牙膏刷牙2次/天。在研究开始前未进行预预防。分别在基线、3周、6周和12周测量改良牙龈指数（MGI）、出血指数（BI）和Turesky斑块指数（TPI）。参与者完成了一份日记，以监测遵守情况。结果：190名参与者被随机分配，188人完成了研究。与对照组相比，试验组从基线到12周（p=0.0032）、6周（p=0.0031）和3周（p=0.0091）出血部位数量减少具有统计学意义（p=0.0013）。结论：在12周的BI、MGI和TPI测量中，与使用常规含氟牙膏刷牙相比，使用碳酸氢钠牙膏每天刷牙两次可显著改善口腔健康，减少局部牙龈炎。临床意义：局部牙龈炎可以通过良好的家庭口腔卫生措施来解决或预防，但仅靠机械刷牙很少能做到这一点。与传统的含氟牙膏相比，每天用碳酸氢钠牙膏刷牙两次，在减少局部牙龈炎和改善口腔健康方面具有附加价值。

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.