Anti-erosive effect of fluoride solutions associated with methacrylate polymer: A randomized crossover in situ study

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-30 DOI:10.1016/j.jdent.2025.105944

Taiana Paola Prado , Karine Carvalho Santos , Carlos Rocha Gomes Torres , Taís Scaramucci , Idalina Vieira Aoki , Alessandra Buhler Borges

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引用次数: 0

Abstract

Objectives

To evaluate the anti-erosive effect of solutions containing fluoride and aminomethacrylate copolymer associations on enamel and dentin, using a randomized crossover in situ model.

Methods

Bovine enamel and dentin specimens were fixed in intraoral devices. Participants (n = 12) installed the devices and rinsed with seven experimental solutions in a randomized sequence, with 2-day washout between them: Ultrapure water-C; Sodium fluoride-F (225 ppmF-); Stannous Chloride-Sn (800 ppm Sn2+); Aminomethacrylate- AA (2 %); FSn; F+AA; FSn+AA. After treatments, they retained the device for acquired pellicle maturation (30 min). Specimens were then extraorally exposed to 0.03 % HCl, pH 2.3 (3 min). This cycling was repeated six times. Calcium released from the acid solutions was measured photometrically, and mineral loss (ML) was calculated. KOHsoluble fluoride (μg/cm2) and surface microhardness (KHNred) were also measured. Data were submitted to RM-ANOVA and Tukey tests (5 %).

Results

For mineral loss in enamel, the F+AA and FSn+AA solutions were statistically superior than F and FSn, respectively. In dentin, the F+AA solution showed the best performance (p < 0.001). The KHNred results for the enamel were: C = Sn < AA = F = FSn < F+AA = FSn+AA. The FSn groups exhibited higher concentration of fluoride adsorbed on both enamel and dentin surface (p < 0.05).

Conclusion

The addition of aminomethacrylate copolymer to fluoride solutions improved their efficacy in protecting the tooth against erosion in the presence of acquired pellicle, being a promising agent to be incorporated in mouthrinses.

Clinical significance

The investigation of the anti-erosive effect of polymers and fluoride provides subsidies for identifying the most promising associations, which open new perspectives for the development of formulations capable of preventing erosion progression to more advanced stages, which requires complex and costly restorative interventions.

查看原文本刊更多论文

与甲基丙烯酸酯聚合物相关的氟溶液的抗侵蚀作用：一项随机交叉原位研究。

目的：采用随机交叉原位模型，评估含氟和氨基甲基丙烯酸酯共聚物结合溶液对牙釉质和牙本质的抗侵蚀作用。方法：将牛牙釉质和牙本质标本固定在口腔内装置中。参与者（n=12）安装设备并按随机顺序用7种实验溶液冲洗，其间有2天的洗脱期：超纯水c；氟化钠- f (225 ppmF-)；氯化亚锡-锡（800 ppm Sn2+）；氨基甲基丙烯酸酯- AA (2%)；烟度;F + AA;烟度+ AA。处理后，他们保留装置以获得性膜成熟（30min）。然后将标本口外暴露于0.03% HCl, pH 2.3 （3min）。这样的循环重复了六次。用光度法测定酸溶液中钙的释放量，并计算矿物质损失（ML）。测定了水溶性氟（μg/cm2）和表面显微硬度（KHNred）。数据提交RM-ANOVA和Tukey检验（5%）。结果：对于牙釉质的矿物质流失，F+AA和FSn+AA溶液分别优于F和FSn溶液。结论：在牙本质中加入氨基甲基丙烯酸酯共聚物可以提高氟溶液在获得性膜存在下对牙齿的保护效果，是一种很有前途的漱口剂。临床意义：聚合物和氟化物的抗侵蚀作用的研究为确定最有希望的关联提供了补贴，这为开发能够防止侵蚀进展到更多的配方开辟了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.