新型含功能单体底漆溶剂配方对提高牙本质黏附耐久性的影响

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-28 DOI:10.1016/j.jdent.2025.105945

Shanshan Feng, Shihui Yang, Shuwei Qiao, Zilu Tian, Qi Lin, Lingkang Lin, Xi He, Song Zhu

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引用次数: 0

摘要

目的研究醋酸乙酯（EAC）和乙醇（ET）混合配制的功能单体4-甲酰基苯基丙烯酸酯（FA）底漆在蚀刻和冲洗两种模式下对全键通用（ABU）和单键通用（SBU）粘合剂耐久性的影响。方法采用酰基氯反应合成sfa。以乙酸乙酯和乙醇为二元溶剂体系，溶剂比分别为7:3、6:4、5:5和4:6，制备FA引物。通过测量转化度（DC）和接触角，结合微拉伸结合强度（µTBS）和断裂模式，立即和10,000热循环确定乙酸乙酯与乙醇的最佳配比。观察基质金属蛋白酶（MMPs）活性和界面黏合剂浸润情况，并用扫描电镜观察纳米渗漏和树脂破布情况。结果EAC:ET-4:6混合溶剂处理后，即刻组和老化组的µTBS和脱矿牙本质表面接触角均有显著提高。通过共聚焦激光扫描显微镜（CLSM）和扫描电镜（SEM）进一步观察树脂破布在键合界面的浸润性能得到增强。杂化层中MMPs活性明显受到抑制，键合界面的纳米泄漏程度显著降低，从而提高了键合的稳定性和耐久性。结论适当比例的乙醇和乙酸乙酯溶剂的fa引物可简化操作程序，增强胶原纤维抗酶降解能力，改善杂化层的密封性，从而提高粘接强度。以乙酸乙酯-乙醇混合溶剂配制的FA引物旨在达到高强度、低渗漏和长期持久的粘合效果，具有双重功能优势：有效的胶原交联能力，增强粘合耐久性，降低继发性龋齿发生率，同时降低技术敏感性。这些发现为FA引物在临床实践中的应用提供了新的视角。

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The effect of novel solvent formula of primer containing functional monomer on improving the durability of dentin adhesion

Objective

The study was designed to investigate how varying ratios of a functional monomer, 4-formylphenyl acrylate (FA) primer, formulated with a blend of ethyl-acetate (EAC) and ethanol (ET), impact the adhesive durability of All Bond Universal (ABU) and Single Bond Universal (SBU) under both etching and rinsing modes.

Methods

FA was synthesized via the acyl chloride reaction. FA primer was prepared by mixing ethyl acetate and ethanol as a binary solvent system at solvent ratios of 7:3, 6:4, 5:5, and 4:6. The optimal ratio of ethyl acetate to ethanol was determined by measuring the degree of conversion (DC) and contact angle, combining the microtensile bond strength (µTBS) and fracture pattern immediately and 10,000 thermocycles. Matrix metalloproteinases (MMPs) activities and adhesive infiltration at the interface were observed, whereas scanning electron microscopy was used to further evaluate nanoleakage and resin rags.

Results

Application of the primer containing a mixed EAC:ET-4:6 solvent resulted in a significant enhancement in the µTBS of both immediate and aging groups, and the contact angle of the demineralized dentin surface. Confocal Laser Scanning Microscope (CLSM) and Scanning Electron Microscope (SEM) were further observed the infiltration properties of resin rags in the bonding interface were strengthened. The MMPs activities in the hybrid layer was clearly inhibited, and the degree of nanoleakage at the bonding interface reduced remarkably, thus, it improved the stability and durability of the bond.

Conclusion

FA primers containing appropriate ratios of ethanol and ethyl acetate solvents can simplify operation procedures, enhances collagen fiber resistance to enzymatic degradation, and improves hybrid layer sealing, thereby increasing bonding strength.

Clinical Significance

The FA primer formulated with an ethyl acetate-ethanol mixed solvent aim to achieve high-strength, low leakage, and long-term durable adhesive effects, demonstrating dual functional advantages: Effective collagen crosslinking capacity leading to enhanced bond durability and reduced secondary caries incidence, alongside decreased technique sensitivity. These findings provide novel perspectives for FA primer applications in clinical practice.

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.