Journal of Cosmetic Dermatology最新文献

{"title":"Seasonal Correlations Between UV Exposure and Search Trends for Mites and Rosacea in Shanghai","authors":"Sitong Li, Jiacheng Lin, Jiaqi Li, Xiaohui Mo, Qiang Ju","doi":"10.1111/jocd.70184","DOIUrl":"https://doi.org/10.1111/jocd.70184","url":null,"abstract":"<p>Online search data, such as Google Trends and Baidu Index, offer valuable insights into skin conditions, including seasonal trends in itch and the links with air pollution [<span>1, 2</span>]. Mites, microscopic arthropods in the subclass Acari, are associated with various skin diseases, with demodex mites linked to rosacea [<span>3</span>]. Given the influence of UV radiation on skin conditions, this study examines the relationship between Baidu search queries for mites, rosacea, and UV radiation levels in Shanghai, China. By analyzing the correlations between these search trends and UV exposure, we aim to uncover seasonal patterns and explore how UV radiation influences public interest in these skin concerns.</p><p>We extracted Baidu Index data on mites and rosacea from https://index.baidu.com/v2/index.html, and erythemal UV dose (UVD) data, as a measure of UV radiation levels, from the Tropospheric Emission Monitoring Internet Service (TEMIS) at https://www.temis.nl/uvradiation/UVdose.php. The dataset spans from January 1, 2015, to December 31, 2019.</p><p>Seasonal decomposition analysis with a 365-day cycle reveals strong seasonal patterns in both mite searches and UVD data. Rosacea searches trends exhibit weaker seasonality, consistent with previously reported rosacea consultation pattern [<span>4</span>]. The steady annual increase in rosacea-related searches reflects growing public awareness and concern (Figure 1).</p><p>This study used Pearson correlation analysis to assess the linear relationship between two variables; however, this method does not reveal causal relationships. Therefore, the Granger causality test was applied to explore causal relationships in the time series data. Pearson correlation analysis of seasonal components revealed a strong positive correlation between UVD and mite search queries (<i>r</i> = 0.787, <i>p</i> < 0.05), indicating that both may be influenced by similar seasonal factors. A moderate positive correlation was observed between UVD and rosacea searches (<i>r</i> = 0.295, <i>p</i> < 0.05), suggesting an association between UV exposure and rosacea. However, the correlation between mite and rosacea queries was very weak (<i>r</i> = 0.052, <i>p</i> < 0.05), likely due to distinct influencing factors, nonlinear relationships, or potential lag effects.</p><p>Granger causality tests showed that diff_UVD significantly Granger-causes diff_mite (<i>F</i> [28, 3480] = 2.5609, <i>p</i> = 1.246 × 10<sup>−5</sup>), indicating that UV exposure changes predict fluctuations in public interest in mites. Additionally, diff_mite significantly Granger-causes rosacea (<i>F</i> [14, 3564] = 5.2993, <i>p</i> = 4.358 × 10<sup>−10</sup>), demonstrating a strong temporal association between interest in mites and subsequent interest in rosacea. Although diff_UVD also Granger-causes rosacea (<i>F</i> [30, 3468] = 1.487, <i>p</i> = 0.04291), the <i>p</i>-value is close to 0.05, suggesting a weaker predictive relationship,","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Rotational Radiofrequency-Based Technology Leads to Adipose Tissue Reduction and Contouring Effect in the Thighs, Abdomen, and Flanks”","authors":"","doi":"10.1111/jocd.70190","DOIUrl":"https://doi.org/10.1111/jocd.70190","url":null,"abstract":"<p>Santos AF, Fernández AI, Fernández LS, Zapico LH, Freitag SV. Rotational Radiofrequency-Based Technology Leads to Adipose Tissue Reduction and Contouring Effect in the Thighs, Abdomen, and Flanks. <i>Journal of Cosmetic Dermatology</i>. 2024; 23: 3263–3271. http://doi.org/10.1111/jocd.16431.</p><p>In the “Results” section of the “Abstract” of the reference article, the text “Abdomen/flanks and thighs subcutaneous fat layer thickness was significantly reduced by 8% and 6%, respectively” was incorrect. This has been corrected as follows: “Abdomen/flanks and thighs subcutaneous fat layer thickness was significantly reduced by 6% and 8%, respectively.”</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate","authors":"Koo Chul Kwon,&nbsp;Mi Jung Kim,&nbsp;Sang A. Yoon","doi":"10.1111/jocd.70195","DOIUrl":"https://doi.org/10.1111/jocd.70195","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>_L-glutamine and linoleic acid (LA) can suppress inflammatory cytokine expression; however, studies on their simultaneous application are limited due to polarity differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the effect of glutamine linoleate vesicles (QLAsomes) on skin sensitization by assessing their impact on sensitization-related protein expression, bacterial growth, and clinical efficacy in relieving skin itchiness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After synthesizing and analyzing QLAsomes, their inhibitory effects on capsaicin-induced cytokine expression and <i>Staphylococcus aureus</i> growth were evaluated. In a double-blind clinical trial, 24 participants (ages 22–63) with sensitized skin applied 10 wt% QLAsome cream on one side and a vehicle or no cream on the other twice daily for 2 weeks. Itchiness in the elbow area was assessed using a visual analog scale and expert evaluation. Skin barrier changes were measured using transepidermal water loss (TEWL), skin erythema, and stratum corneum (SC) hydration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>QLAsomes, formed by _L-glutamine and LA through hydrogen bonding, were spherical vesicles (164.6 ± 3.1 nm). Based on the inhibitory effects of _L-glutamine and LA on inflammation-related factors, QLAsomes inhibited the capsaicin-induced expression of these factors more effectively than the individual components. IL-4 inhibition was improved by over 26%. Matrix metalloproteinase-1, which degrades collagen, showed 32% and 23% improvements compared to _L-glutamine and LA, respectively. In a clinical evaluation, 10 wt% QLAsome cream reduced itching by 45% compared to before application, which is a 67% improvement compared to placebo. Skin evaluations revealed improvements in erythema (12%), TEWL (15%), and SC hydration (19%), suggesting that QLAsomes enhance the skin barrier function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>QLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comments on “Oral Tranexamic Acid Treats Papulopustular Rosacea by Improving the Skin Barrier”","authors":"Zining Xu,&nbsp;Biao Yu,&nbsp;Bingyang Xu,&nbsp;Shuhong Ye,&nbsp;Yuxin Qing,&nbsp;Bin Zhao,&nbsp;Sun Hong,&nbsp;Na Wu,&nbsp;Jiawen Wu","doi":"10.1111/jocd.70151","DOIUrl":"https://doi.org/10.1111/jocd.70151","url":null,"abstract":"<p>We appreciate the reviewer's attention to the figures in our article. Figure 1a–d were intended to provide representative clinical images of patients before and after treatment. We will work closely with the journal's editorial team to ensure that all figures are correctly included in the final published version to maintain the integrity of our study's findings.</p><p>In conclusion, we are grateful for the opportunity to address these important points and hope our responses provide clarity on the scope and implications of our study. We remain committed to advancing the understanding and treatment of rosacea through rigorous research.</p><p>Thank you for your consideration.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Delayed Complications of Hyaluronic Acid Fillers: Case Series From the Middle East","authors":"Yara Saad,&nbsp;Zeina Tannous","doi":"10.1111/jocd.70166","DOIUrl":"https://doi.org/10.1111/jocd.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyaluronic acid (HA) dermal fillers are primarily utilized for restoring volume loss and for the correction of wrinkles and folds. While HA injections are generally considered safe, undesirable and serious complications have been on the rise due to the increased frequency of these procedures. Late-onset complications involve filler migration, foreign body granuloma reactions, delayed hypersensitivity reactions, and infections, among others.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Objectives</h3>\u0000 \u0000 <p>Raising awareness about late complications associated with HA filler injections and highlighting proper management strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We hereby present three patients who experienced distinct forms of delayed reactions to HA fillers, provide a systematic approach to their evaluation, and outline effective treatment strategies to ensure optimal patient outcomes. Written informed consent was obtained from the patients for publication of the details of their medical cases and any accompanying images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Delayed complications to HA fillers include erythema, edema, inflammation, nodules, and infections. These late-onset reactions present weeks to months post-injection and may be influenced by immune responses, filler properties, and procedural factors. Ultrasound imaging is a valuable tool in diagnosing and managing these complications, guiding treatments such as hyaluronidase and corticosteroid injections. Preventive measures, including aseptic techniques, patient screening, and proper injector training, help in reducing risks and optimizing patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HA filler injections remain among the most popular cosmetic procedures, generally offering safe outcomes when performed by skilled professionals. Complications may still occur and require prompt recognition and management. This article highlights the importance of imaging in diagnosing non-ischemic complications and provides practical recommendations for managing delayed HA filler reactions. Ensuring patient safety relies on proper training, adherence to aseptic techniques, and careful patient and product selection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Moisturizing Effect of Dendrobium officinale, Sparassis crispa, and Their Compound Extracts","authors":"Hankun Ren,&nbsp;Peina Zha,&nbsp;Yueheng Liu,&nbsp;Weihong Zhang,&nbsp;Hong Meng,&nbsp;Taiju Di","doi":"10.1111/jocd.70189","DOIUrl":"https://doi.org/10.1111/jocd.70189","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Recently, natural plants have been widely developed and applied in moisturizing cosmetics. <i>Dendrobium officinale</i> Kimura et Migo (<i>D. officinale</i>) is known as one of the “Nine Immortals” of Chinese herbal medicine, whereas <i>Sparassis crispa</i> (Wulf.) Fr. (<i>S. crispa</i>) is known as the “king of mushrooms”; both of which have excellent biological activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To explore the effects of <i>D. officinale</i> polysaccharide (DOP) with different molecular weights and <i>S. crispa</i> on the expression of moisturizing-related genes and verify the moisturizing performance of their complex.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PCR was carried out to explore the aquaporin 3 (AQP3), hyaluronic acid synthetase1 (HAS1), HAS2, and HAS3 genes expression. Immunofluorescence (IF) analysis was used to test the protein level expression of hyaluronic acid (HA), AQP3, claudin-1, and filaggrin (FLG) influenced by moisturizing composition in a reconstructed epidermis skin model. The ability of samples to resist cell drying damage was evaluated by a cell drying damage model. Furthermore, this study validated the effect of the compositions during their application in cosmetics through tests of skin moisture content, crow's feet, and skin elasticity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that DOP with molecular weights of 100 k–500 kDa (Dalton) had higher effects on AQP3 gene expression compared to that with molecular weights of 10 k–100 kDa and 1 k–10 kDa. Additionally, the extract of <i>S. crispa</i> significantly promoted the expression of HAS1, HAS2, and HAS3 genes, which are genes encoding hyaluronic acid synthesis. In addition, the mRNA and protein expression levels of HA, AQP3, claudin-1, and FLG were significantly increased as a result of the moisturizing composition consisting of DOP (100 k–500 kDa) and <i>S. crispa</i>. The application of the moisturizing composition markedly increased the skin moisture content, improved eye wrinkles, and enhanced skin elasticity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In summary, our study proved that <i>D. officinale</i> and <i>S. crispa</i> had good moisturizing effects, and as natural plant humectants, they may have broad applications in future moisturizing cosmetics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study","authors":"David J. Goldberg","doi":"10.1111/jocd.70159","DOIUrl":"https://doi.org/10.1111/jocd.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Combining monopolar radiofrequency (RF) with targeted ultrasound (TUS), this study investigated whether these modalities promote facial rejuvenation through the production of hyaluronic acid (HA) in human skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven subjects (51–64 years, BMI 21.1–29.8 kg/m²) were enrolled and divided into three treatment groups in this single-center study; Group A (<i>n</i> = 3, simultaneous RF + TUS), Group B (<i>n</i> = 3, stand-alone RF), and control (<i>n</i> = 1, no treatment). Both treated groups underwent four (4) 60-min treatments on the face delivered 7–14 days apart. Punch biopsies (3 mm in diameter) were collected from the infra-auricular area at baseline and both follow-up visits and stained for HA by using hyaluronic acid binding protein. Digital photographs were taken to document changes in visual appearance. Finally, the subjects' comfort and satisfaction were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was a statistically significant (<i>p</i> &lt; 0.05) average increase at 1 month in the HA-stained area of +112 358.7 μm² in group A (RF + TUS) representing an increase of 48.65%. The treatment effect peaked at 3 months with an increase of +156 345.2 μm², corresponding to a 67.69% increase in the HA-stained area. In Group B, there was no significant difference in the average increase of the HA-stained area between 1 month (+14 830 μm²) and 3 months (+20 995 μm²) corresponding to a 6.76% and 9.56% increase, respectively. The control samples did not indicate any changes throughout the study. Digital photographs of the RF + TUS group showed both a decrease in rhytids and tighter skin. Therapies were comfortable with no adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, this study has shown that the combination treatment of RF + TUS has a more pronounced and sustained effect on facial rejuvenation compared to RF alone. The measurable increase in the production of HA with simultaneous use of RF + TUS peaked at a 3-month follow-up, suggesting the gradual advancement of the treatment effect and overall improvement in facial appearance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT05987917</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Completion of Isotretinoin Therapy in Acne Patients Reporting Mood Disturbance","authors":"Joshua Farrell,&nbsp;Thomas Jonathan Stewart,&nbsp;Robert Rosen","doi":"10.1111/jocd.70106","DOIUrl":"https://doi.org/10.1111/jocd.70106","url":null,"abstract":"&lt;p&gt;Isotretinoin is frequently discontinued in acne patients who report mood disturbance despite systematic reviews showing that it is not associated with an increased risk for depression and may even ameliorate depressive symptoms [&lt;span&gt;1, 2&lt;/span&gt;]. The viability of completing isotretinoin therapy in acne patients reporting mood disturbance has not been fully explored. In this study, we characterize our cases of acne vulgaris treated with isotretinoin where mood disturbance was reported early in the course, comparing cases that completed with those that did not complete treatment.&lt;/p&gt;&lt;p&gt;We searched the electronic medical records at a large dermatology clinic for adults with acne vulgaris who commenced isotretinoin reporting mood disturbance. It was their first course of isotretinoin prescribed in doses ranging from 0.2 to 0.7 mg/kg. All patients were reviewed within 3 months of initiation. Completing the treatment course was defined as receiving a minimum cumulative dose of 150 mg/kg (facial and truncal disease) and 120 mg/kg (facial disease only). Patients with a prior history of mood disorder and/or reporting suicidal ideation were excluded. A chi-squared test was used, and &lt;i&gt;p&lt;/i&gt; values of less than 0.05 were considered statistically significant.&lt;/p&gt;&lt;p&gt;Five hundred and thirty-two eligible cases were retrieved. One hundred and forty patients discontinued, whilst 392 continued the medication, with 128 remaining on their original dose and 264 on a lower dose. Two hundred and fifty-three patients completed the full course. There were no episodes of self-harm or suicide. Two hundred and ninety-two patients were female, and the mean age was 21 years. Patient age 25 years or older (&lt;i&gt;p&lt;/i&gt; = 0.002), significant therapeutic response in the first 3 months (&lt;i&gt;p&lt;/i&gt; = 0.007), family history of acne vulgaris (&lt;i&gt;p&lt;/i&gt; = 0.040), and formal psychiatric input (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) were associated with an increased likelihood of completing the medication course (Table 1). Other significant associations were age ≥ 25 years with abnormal blood test results (&lt;i&gt;p&lt;/i&gt; = 0.032) and female sex with other prescribed acne treatments (&lt;i&gt;p&lt;/i&gt; = 0.112).&lt;/p&gt;&lt;p&gt;Overall adherence to isotretinoin therapy in acne patients is around 80% [&lt;span&gt;1&lt;/span&gt;]. Patients and prescribers are more highly motivated to continue on a medication that is providing clinical benefit, irrespective of its adverse effects [&lt;span&gt;3&lt;/span&gt;]. Older patients perceive medication safety behaviors to be more important and more closely adhere to monitoring practices compared to younger patients [&lt;span&gt;4&lt;/span&gt;]. Older patients may also have exhausted a relatively higher number of alternative treatments prior to isotretinoin.&lt;/p&gt;&lt;p&gt;Acne vulgaris is associated with an increased risk of developing depression independent of dermatologic therapy. The probability of developing major depressive disorder is 18.5% in patients with acne compared to 12% in the general population [&lt;span&gt;5&lt;/span&gt;]. As such, ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pomegranate Flower Water Extract Negatively Regulates Melanogenesis by Suppressing MITF Expression and Its Target Enzymes","authors":"Peng Shu,&nbsp;Nannan Xu,&nbsp;Nuermaimaiti Abudukelimu,&nbsp;Parida Aiziti,&nbsp;Deng Zang,&nbsp;Jiangyu Zhao,&nbsp;Yuan Wang","doi":"10.1111/jocd.70163","DOIUrl":"https://doi.org/10.1111/jocd.70163","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long-term use, it is very important for searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti-inflammatory, antioxidant, and antidiabetic properties, but its potential skin-lightening effects have not been well explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We investigated the effect of pomegranate flower water extract (PFE) on skin lightening and elucidated its underlying mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The radical scavenging capacity was measured by ABTS and DPPH assays, and the mechanism of lightening was detected by Western blot.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PFE could obviously inhibit tyrosinase activity, which its inhibition IC₅₀ value was lower than the positive control, kojic acid. Meanwhile, the radical scavenging capacity was also better than vitamin C (VC). Then the synthesis ability of melanin was measured in B16F10 cells; we found that PFE, in its safe concentrations, could reduce the synthesis of melanin resulting from inhibiting TYR activities. The expression of the main melanogenesis enzymes TYR, TRP-1, and TRP-2 was sharply reduced. Interestingly, MITF, a transcription factor of TYR, was obviously decreased its expression when treated with PFE at 50, 100, and 150 μg/mL, which was even significantly lower than the downregulation by kojic acid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pomegranate flower extract possessed a strong antimelanogenesis effect, which resulted from inhibiting the expression of MITF and its downstream target enzymes involved in melanin synthesis. These findings provide a strong scientific basis for the use of PFE as a safe and effective skin-lightening ingredient in the cosmetic industry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta-Analysis Study","authors":"Aditya K. Gupta,&nbsp;Mary A. Bamimore,&nbsp;Paradi Mirmirani,&nbsp;Vincent Piguet,&nbsp;Mesbah Talukder","doi":"10.1111/jocd.70185","DOIUrl":"https://doi.org/10.1111/jocd.70185","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scant evidence exists for the relative efficacy of therapies for alopecia areata (AA)—including those approved by the Food and Drug Administration, namely, baricitinib, deuruxolitinib, and ritlecitinib.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We determined the relative efficacy and safety of monotherapy with janus kinase inhibitors (JAKIs), apremilast, and dupilumab.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following a systematic review, we conducted Bayesian network meta-analysis (NMAs) that produced Surface Under the Cumulative RAnking (SUCRA) values and point estimates for pairwise relative effects; we also performed sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, regimens with eight various JAKIs were compared, namely, ruxolitinib, ATI-501, baricitinib, brepocitinib, deuruxolitinib, ivarmacitinib, ritlecitinib, and tofacitinib. Our analyses ranked “deuruxolitinib 12 mg twice daily for 24 weeks,” the most efficacious insofar as “proportion of participants achieving SALT ≤ 20 at 24 weeks” (SALT₂₀) (SUCRA = 92.6%), and “proportion of participants achieving SALT ≤ 10 at 24 weeks” (SALT₁₀) (SUCRA = 97.7%). As per SALT₂₀, the highest-ranked regimen was more efficacious than “baricitinib 2 mg once daily for 24 weeks” (odds ratio [OR] = 5.37, 95% credible interval [CI] = 1.59, 13.70, <i>p &lt;</i> 0.05). Furthermore, the efficacy of the FDA-approved JAKIs exhibited a dose-dependent relationship; for instance, baricitinib 4 mg once daily for 24 weeks was more efficacious than “baricitinib 2 mg once daily for 24 weeks” in terms of SALT₂₀ (OR = 2.25, 95% CI = 1.56, 3.21, <i>p</i> &lt; 0.05). Results from our sensitivity analyses support that our base analyses were robust.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We produced high-quality evidence on the comparative effectiveness of monotherapies for AA with various regimens of 8 JAKIs, including the FDA-approved ones. Our findings can improve clinicians' decision-making and update guidelines for medical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}