Journal of Cosmetic Dermatology最新文献

{"title":"Periprocedural Skincare for Nonenergy and Nonablative Energy-Based Aesthetic Procedures in Patients With Skin of Color","authors":"Andrew F. Alexis,&nbsp;Anneke Andriessen,&nbsp;Renée A. Beach,&nbsp;Valeria Barreto Campos,&nbsp;Lisa R. Ginn,&nbsp;Rodrigo Gutiérrez Bravo,&nbsp;Levashni Naidoo,&nbsp;Monica Li","doi":"10.1111/jocd.16712","DOIUrl":"10.1111/jocd.16712","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anti-aging facial procedures with nonenergy and nonablative energy devices are increasingly popular among patients with skin of color (SOC). Algorithms have addressed the measures to reduce the side effects related to aesthetic procedures, but few focus on SOC patients and periprocedural integrating skincare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eight dermatologists from Brazil, Canada, South Africa, Mexico, and the USA participated in a meeting and an online follow-up to develop an algorithm for periprocedural skincare for nonenergy and nonablative energy-based facial aesthetic procedures in patients with SOC. A Delphi method was used to develop this algorithm and integrate information from the literature with panels' clinical experience and opinion, resulting in the current algorithm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The algorithm has five sections, starting with a medical history and skin examination, followed by pretreatment measures beginning 2–4 weeks before the procedure, then measures on the day of the procedure, aftercare 1–7 days after the procedure, and follow-up care 1–4 weeks after the procedure and ongoing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This algorithm provides guidelines for treatment optimization of non-energy, non-ablative energy-based devices for SOC patients. It also provides physicians with skincare recommendations pre-, peri-, and post-aesthetic procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Molecular Mechanisms of Rosacea: Insights From Transcriptomics and In Vitro Experiments","authors":"Luzhu Chen,&nbsp;Juan Wang","doi":"10.1111/jocd.16753","DOIUrl":"10.1111/jocd.16753","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rosacea is a prevalent inflammatory skin condition, but its molecular mechanisms and treatment responses remain poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to investigate the molecular mechanisms underlying rosacea and explore drug response through transcriptomic analysis and in vitro experiments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>We performed high-throughput RNA sequencing to analyze gene expression patterns in rosacea patients. In vitro experiments, including RT-qPCR, Western blot, ELISA, scratch, and Transwell assays, were used to evaluate gene and protein expression and cell behavior in HaCaT cells under simulated rosacea conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Transcriptomic analysis revealed significantly elevated expression of inflammatory-related genes in rosacea patients. In vitro, HaCaT cells exhibited enhanced proliferation and migration abilities, accompanied by increased expression of pro-inflammatory genes and proteins. Specifically, Toll-like receptor 2 (TLR2) and S100A9 proteins were upregulated, potentially promoting these processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study elucidates the molecular mechanisms of rosacea, highlighting the role of inflammatory pathways and altered cell behavior in the disease. TLR2 and S100A9 may contribute to disease progression, offering potential targets for future therapeutic strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series With Cysteamine–Isobionicamide Complex: Clues for Skin-Rejuvenating Activity","authors":"Lesley Clark-Loeser,&nbsp;Riccardo Sfriso,&nbsp;Laure Dirlewanger,&nbsp;Behrooz Kasraee","doi":"10.1111/jocd.16743","DOIUrl":"10.1111/jocd.16743","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin aging is inevitable. Wrinkles, skin texture abnormalities, senile hyperpigmentation, loss of skin tone, dryness, atrophy, and telangiectasias represent some of the hallmarks of aged skin. Skin rejuvenation can be addressed by topical therapies, such as topical retinoids and antioxidants or physical modalities with energy-based devices, all providing acceptable outcomes. In this case series, we aimed to test the rejuvenating potential of the combination of cysteamine (a naturally occurring antioxidant) and isobionicamide (a derivative of the anti-aging molecule niacinamide) applied topically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Healthy male and female patients (<i>N</i> = 7) aged between 25 and 70 years and having Fitzpatrick skin types I–VI were recruited. Topical application of a cysteamine-isobionicamide formula was done once daily. Treatment lasted for 16 weeks. Clinical high-resolution photos were acquired using LifeViz 3D at recruitment and after 16 weeks. Blinded dermatological examinations and scoring were performed. Self-assessment and quality of life (QoL) questionnaires were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Clinical photos showed improvement in skin luminosity, increased evenness of skin tone, and reduction of fine wrinkles as well as hyperpigmentation. Patients as well as clinical investigators blinded to the chronology of photos observed the improvements in skin texture, luminosity, and radiance, the brightening of the dark spots, as well as the reduction of both number and volume of wrinkles after 16 weeks of daily application. Furthermore, a significant improvement in patients' quality of life was recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case series represents the first evidence that topical application of cysteamine isobionic-amide complex could be considered as a safe and effective option in the reversal of skin photoaging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Role of a Hybrid Filler of Hyaluronic Acid and Calcium Hydroxyapatite in the Management of Post-Acne Scars Using 2D and OCT Digital Morphometry","authors":"Ilaria Proietti,&nbsp;Emanuele Amore,&nbsp;Camilla Chello,&nbsp;Federica Trovato,&nbsp;Francesca Paola Sasso,&nbsp;Giovanni Pellacani,&nbsp;Stefania Guida,&nbsp;Concetta Potenza","doi":"10.1111/jocd.16768","DOIUrl":"10.1111/jocd.16768","url":null,"abstract":"&lt;p&gt;Acne scars are a frequent consequence of severe acne, characterized by depressions (atrophic) or raised areas on the skin (hypertrophic or keloid). These scars represent the abnormal outcome of wound healing, resulting in altered collagen production. Treatment options depend on the type and severity of the scars and may involve topical treatments, chemical peels, laser therapy, dermal fillers, and the use of botulinum toxin [&lt;span&gt;1&lt;/span&gt;]. The choice of a proper treatment may reduce and even resolve the cutaneous disorder, leading to a refinement in skin texture and appearance, improving patients' confidence and dermatology quality life index (DLQI). Early treatments are essential to reduce long-term scarring [&lt;span&gt;2, 3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;We present the case of a 30-year-old woman with Fitzpatrick skin phototype II, who came to our Department to manage post-acne scars. She was treated with oral isotretinoin with partial response and already tried peeling, such as salicylic and glycolic ones, and pulsed light, without benefits. At clinical observation, the patient presented depressions and erythematous lesions on the zygomatic areas bilaterally.&lt;/p&gt;&lt;p&gt;We decided to use a hybrid injectable, combining hyaluronic acid (HA) and calcium hydroxyapatite (CaHA), in a 1.25 mL prefilled syringe with lidocaine hydrochloride (3 mg/mL) with 27G 1/2″ thin-walled sterile injected in subcutaneous layer by 23G 40 mm cannula. A cannula, with its flexible and blunt tip, significantly reduces the chances of puncturing blood vessels, thereby lowering the risk of serious complications such as tissue necrosis or visual disturbances. Additionally, using a cannula can minimize pain, swelling, and bruising, leading to a safer and more satisfactory aesthetic result. We performed the procedure at T0 and a follow-up visit after 12 weeks (T1). At T0 and T1, we collected two-dimensional (2D) photos (VISIA) and optical coherence tomography (OCT) images.&lt;/p&gt;&lt;p&gt;In 2D photos, we found a smoother appearance of the skin, with reduced scar depth and improved texture from baseline. The VISIA analysis showed that pores (P), redness (R), and uniformity (U) of the skin on the left and right cheeks improved from T0 to T1 (Table 1; Figure 1B).&lt;/p&gt;&lt;p&gt;OCT analysis conducted on the left and right cheeks at T0 and T1 revealed an improvement in scar depth and increased dermal thickness. In addition, increased rarefaction of the dermis can be seen at T0, which regains firmness after hydroxyapatite administration. Collagen density increased after 12 weeks (Table 2; Figure 1C,D).&lt;/p&gt;&lt;p&gt;Additionally, a reduction of DLQI from 25 to 5 was registered, therefore revealing an improvement in the quality of life.&lt;/p&gt;&lt;p&gt;In the field of acne scar treatment, the decision-making process for choosing the appropriate injectable must be tailored to the specific needs of the patient's skin. For our patient, the goal was to reorganize the fibrillar collagen fibers in the papillary dermis into a linear and ordered","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric and Angular Measurements in Healthy Persian Females in Comparison to the Golden Ratio","authors":"Farideh Jokar,&nbsp;Maryam Hadibarhaghtalab,&nbsp;Hengameh Kasraei,&nbsp;S. Yasamin Parvar,&nbsp;Vahid Seifi,&nbsp;Zahra Vojdani Jahromi","doi":"10.1111/jocd.16777","DOIUrl":"10.1111/jocd.16777","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Anthropology is the scientific exploration of the human body morphology. The present study aims to establish the anthropometric norms among young Persian ethnic women and compare them with golden proportion, a mathematical formula in facial esthetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study was performed on Persian women between July 2020 and January 2021. Persian women were randomly selected based on the inclusion criteria of the study. Two standard photos were taken of each participant in profile and frontal angle, and then the anthropometric ratios were extracted and compared in different groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two hundred twenty-five Persian women aged 20–50 years with an average age of 32.4 ± 7.09 were included. The golden ratio in Fars ethnicity was 1.79 ± 0.24. Forehead height I significantly increased with age (<i>p</i> value = 0.03). Philtrum length also showed a significant age-related increase (<i>p</i> value = 0.001). Lower and upper lip heights increased with age (<i>p</i> value = 0.002). Our results revealed statistically significant differences in the mean labial fissure width among the three age groups (<i>p</i> value = 0.009). Lower vermilion height significantly decreased with increasing age (<i>p</i> value = 0.028). The mentolabial and nasal dorsum angles exhibited significant differences among the age groups (<i>p</i> value = 0.002). Furthermore, the jaw and chin angles were notably lower in the younger age groups (<i>p</i> value = 0.047 and 0.001, respectively). When comparing different ethnicities, the Turk ethnicity stood out as having a significantly higher chin angle.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In conclusion, the present study challenges the universality of the golden ratio, with Persian females demonstrating a closer adherence to a ratio of 1.75 and recommending a modified golden ratio for Middle Eastern. Our findings also highlight the importance of considering age-related changes in cosmetic interventions, particularly lip and forehead dimensions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Body Remodeling and Cellulite Appearance Improvement Treatments in the Thighs Using Symmed Radiofrequency Device","authors":"Alejandra Fernández Santos,&nbsp;Alejandra Iglesias Fernández,&nbsp;Lorena Suárez Fernández,&nbsp;Leticia Huergo Zapico,&nbsp;Susana Valero Freitag","doi":"10.1111/jocd.16796","DOIUrl":"10.1111/jocd.16796","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aging associated with the passage of time causes alterations in subcutaneous tissues and the overall appearance of the skin that generate aesthetic unconformities in people. Within the wide range of available techniques on the market, radiofrequency (RF) diathermy has emerged as one of the most used non-invasive methods to combat them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This clinical trial aims to determine and quantify the effectiveness and safety of the high-frequency RF-based device Symmed (Termosalud Inc., Gijón, Spain) in cellulite appearance improvement and thigh remodeling treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Eight sessions of Symmed were performed every 72/96 h in eight subjects' thighs. Safety and effectiveness of the device were evaluated before and after the treatments by digital photographs, body contours measurements, and ultrasound images of skin echogenicity and fat tissue thickness. Information regarding the satisfaction level of the participants was obtained throughout a customized questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the treatments, significant reductions of 3% in thighs circumferences (<i>p</i> &lt; 0.05) and 20% in subcutaneous fat layer thickness (<i>p</i> &lt; 0.01) were detected. Dermal echogenicity, used as an indicator of skin organization and collagen content, showed a significant 6% increase (<i>p</i> &lt; 0.05). Before and after photographs revealed a general improvement in skin appearance. The results were complemented by a high satisfaction level (100%) and the absence of adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Symmed RF therapy is a non-invasive, safe, effective, and well-tolerated procedure for the treatment of thighs cellulite appearance and body remodeling.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Study of PN HPT for Treating Postsurgical Atrophic and Depressed Scars","authors":"Antonino Araco,&nbsp;Francesco Araco,&nbsp;Mauro Raichi","doi":"10.1111/jocd.16764","DOIUrl":"10.1111/jocd.16764","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Postsurgical atrophic scars tend to respond poorly to treatments, especially non-energy-based ones. Hydrophilic PN HPT (Polynucleotides High Purification Technology) injected intradermally is a non-energy-based option with an immediate volume-enhancing effect that indirectly improves the fibroblast synthesis of collagen and extracellular matrix. The PN HPT ingredient has the further benefit of a dermal “priming” effect that enhances the efficacy of other scar treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Verify retrospectively, with advanced techniques, the efficacy of PN HPT monotherapy as postsurgical scar treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective data collection in 18- to 65-year-old women with moderate-to-severe atrophic scars after mammary surgery undergoing a five-session intradermal treatment course with 0.75% PN HPT gel formulation in single-use syringes starting 6 months after surgery. Primary retrospective efficacy parameter: changes in scar morphology and symptom severity after three and 6 months (modified Vancouver Scar Scale, mVSS). Secondary efficacy parameters: roughness score 6 months after baseline (Antera 3D CS tridimensional skin analysis system) and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales) after three and 6 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Total mean mVSS highly significantly improved from 11.2 ± 1.92 at baseline to 7.0 ± 1.68 and 6.9 ± 1.55 after three and 6 months, respectively; the mean Antera 3D CS roughness score improved from 13.5 ± 4.14 to 10.0 ± 3.49 after 6 months. After three and 6 months, the GAIS subscores for investigators and cohort subjects were identical (3.0 ± 0.81 and 3.0 ± 0.72, respectively). The photographic documentation supported the previous results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In monotherapy, the intradermal PN HPT ingredient seems to quickly and safely relieve the burden of postsurgical atrophic scars. However, the lack of a formal parallel control group is a severe limitation. The objective quantitative measurements confirmed the long-lasting benefits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Rose Stem Cell-Derived Exosomes (RSCEs) in Skin Treatment: From Healing to Hyperpigmentation Management: Case Series and Review","authors":"Lidia Majewska,&nbsp;Karolina Dorosz,&nbsp;Jacek Kijowski","doi":"10.1111/jocd.16776","DOIUrl":"10.1111/jocd.16776","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To present and analyze eight clinical cases illustrating the use of rose stem cell-derived exosomes (RSCEs) in treating various dermatological conditions and to review current literature on plant-derived exosomes in medicine and dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>RSCEs possess low cytotoxicity, high biocompatibility, and effective cellular uptake, making them promising agents for dermatological therapies. A literature review included in the introduction and discussion covers the broader role of plant-derived exosomes, highlighting their therapeutic potential in skin treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A case-by-case analysis was conducted on eight patients with conditions including atopic dermatitis (AD), hyperpigmentation, scarring, wounds, melasma, and antiaging concerns. Each case provided insights into RSCEs' efficacy, with a focus on their antioxidant and anti-inflammatory properties, as well as specific learning points derived from clinical observations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cases demonstrated RSCEs' multifaceted therapeutic effects across different skin conditions, supporting their role in enhancing skin regeneration, wound healing, and reducing hyperpigmentation and scarring. The literature review underscored RSCEs' unique bioactivity, suggesting mechanisms for their observed effects, including anti-inflammatory and rejuvenating properties, which contributed to favorable clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RSCEs show potential as a valuable treatment in dermatology, as evidenced by the positive results across multiple skin conditions and their alignment with existing literature on plant-derived exosomes. This case series emphasizes the need for further randomized and controlled clinical trials to confirm these preliminary findings and expand RSCEs' clinical application in dermatology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Should We Use Hyaluronidase for Dissolving Hyaluronic Acid Fillers?","authors":"Gi-Woong Hong,&nbsp;Hyewon Hu,&nbsp;Jovian Wan,&nbsp;Kathleen Chang,&nbsp;Youngjin Park,&nbsp;Massimo Vitale,&nbsp;Giovanni Damiani,&nbsp;Kyu-Ho Yi","doi":"10.1111/jocd.16783","DOIUrl":"10.1111/jocd.16783","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyaluronic acid (HA) fillers are commonly used in esthetic medicine for facial contouring and rejuvenation. However, complications such as overcorrection, vascular occlusion, and irregular filler distribution necessitate the use of hyaluronidase to dissolve the fillers. This study aimed to evaluate the efficacy of hyaluronidase in degrading different types of HA fillers and provide clinical guidelines for its use based on filler type, dosage, and application techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A series of in vitro and in vivo experiments were conducted to assess the dissolution of biphasic and monophasic HA fillers using varying concentrations of hyaluronidase. The in vivo component used animal models to determine the duration of hyaluronidase activity in biological tissues, whereas the in vitro study examined the dissolution rates of HA fillers in response to different hyaluronidase concentrations and application methods. A control study using saline was also performed to compare the natural hydration process of the fillers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Hyaluronidase efficacy was found to vary based on the type of HA filler and the enzyme's concentration. Biphasic fillers dissolved more rapidly at lower concentrations of hyaluronidase compared to monophasic fillers, which required higher concentrations and longer exposure times for effective breakdown. The study also demonstrated that direct injection of hyaluronidase into the filler mass was more effective than surface application. Pharmacokinetic analysis revealed that hyaluronidase activity diminished within 30 min in biological tissues, highlighting the need for timely intervention in clinical scenarios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hyaluronidase is effective in dissolving HA fillers, with its efficacy dependent on the type of filler, concentration, and application technique. Biphasic fillers respond more quickly to hyaluronidase, whereas monophasic fillers require higher doses and multiple treatments. Clinical recommendations include using direct injection techniques, tailoring hyaluronidase dosage based on the filler type, and considering hypersensitivity reactions. Future research should focus on the long-term effects of hyaluronidase and refining clinical protocols for its use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Study on Adverse Reactions of Benzoyl Peroxide (BPO) in Dermatological Aesthetics Utilizing the FAERS Database","authors":"Siyuan Zhou,&nbsp;Su Yan,&nbsp;Shaopeng Ming","doi":"10.1111/jocd.16787","DOIUrl":"10.1111/jocd.16787","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Benzoyl peroxide (BPO) is widely used in dermatological aesthetics for treating acne and other skin conditions. However, its potential adverse reactions remain a concern.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to investigate the application of BPO in dermatological aesthetics, analyze its associated adverse reactions, and provide insights into patient safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study analyzed adverse reaction reports related to BPO in the Food and Drug Administration's Adverse Event Reporting System database from 2004 to 2024. Demographic characteristics, types of adverse reactions, and specific issues related to the novel drug EPSOLAY (5% microencapsulated BPO) were examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings reveal that BPO users are predominantly female (74.18%), with a significant proportion falling within the 18–44 age group (37.45%). The most common adverse reactions involve skin and subcutaneous tissue disorders (36.34%), including skin swelling, pain, and burning sensations. Reports on EPSOLAY indicate adverse reactions such as erythema, pruritus, and skin exfoliation, but no tumor-related reports have been recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BPO usage in dermatological aesthetics is associated with various adverse reactions, primarily affecting the skin. The introduction of EPSOLAY has not altered the adverse reaction profile significantly. However, the risk of BPO decomposing into the carcinogen benzene under certain conditions necessitates enhanced patient education, improved production processes, and continuous post-marketing surveillance to ensure drug safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}