Journal of Cosmetic Dermatology最新文献

{"title":"New Elastic Fiber Formation Can Be Induced by Intradermal Injection of Transparent Porcine-Derived Type I Atelocollagen in Mice","authors":"Seung Min Oh,&nbsp;Min Seong Kim,&nbsp;Geebum Kim,&nbsp;Myungjune Oh","doi":"10.1111/jocd.71166","DOIUrl":"https://doi.org/10.1111/jocd.71166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin aging is characterized by the loss of collagen and elastic fibers, leading to reduced elasticity and wrinkle formation. Although skin boosters are widely used for skin rejuvenation, direct evidence of elastic fiber regeneration remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the regenerative effects of transparent porcine-derived low-immunogenic Type I atelocollagen in naturally aged skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Transparent porcine-derived Type I atelocollagen was injected intradermally into the dorsal skin of young (4 months old) and naturally aged (15 months old) mice. Skin tissues were collected 2 and 4 weeks after treatment. Histological analyses (hematoxylin and eosin and Verhoeff staining) were performed to assess skin thickness and elastic fiber regeneration. Macrophage polarization was evaluated by immunohistochemistry, enzyme-linked immunosorbent assay, and quantitative real-time PCR. The expression of elastogenesis-related genes (Eln, Ebp, Fbn1, Fbln5, Lox, Loxl1, Mfap4, and Ltbp4) and skin elasticity in aged mice were also analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Transparent porcine-derived Type I atelocollagen significantly increased epidermal and dermal thickness and promoted robust elastic fiber regeneration. Newly formed elastic fibers extended into the upper dermis, restoring a dermal architecture resembling that of young skin. Transient activation of the M2 macrophage pathway was observed during tissue remodeling, with no histological evidence of persistent inflammation at 4 weeks after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transparent porcine-derived Type I atelocollagen enhanced skin thickness, promoted elastic fiber regeneration, and restored youthful dermal architecture while demonstrating favorable biocompatibility through transient M2 macrophage-mediated tissue remodeling. These findings support the potential of transparent porcine-derived atelocollagen as an effective skin booster for skin rejuvenation, warranting further investigation of its molecular mechanisms and long-term clinical efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Summary of Pruritus Management in Patients With Atopic Dermatitis: Implications for Nursing Practice","authors":"Yuzhen Shen,&nbsp;Qian Shen,&nbsp;Manni Chen,&nbsp;Rufang Liu","doi":"10.1111/jocd.71111","DOIUrl":"https://doi.org/10.1111/jocd.71111","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To synthesize the most current and relevant evidence regarding pruritus management in patients with atopic dermatitis (AD), and to identify implications for nursing assessment, education, monitoring, and follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>An extensive literature search was conducted across multiple databases, including the Cochrane Library, Embase, and PubMed in English, as well as Chinese databases such as WanFang Data and CNKI. The search encompassed publications from the inception of these databases up to December 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 26 publications were ultimately included in the analysis. These consisted of 14 randomized controlled trials, 3 systematic reviews, 2 cohort studies, 1 scoping review, 2 observational studies, 1 case report, 1 expert opinion, and 4 expert consensus documents. The findings were organized into physician-directed therapies, nursing-implemented or nursing-supported interventions, and nursing-specific practice implications; region-specific or traditional therapies were presented separately because of their limited international generalizability. Key implications for nursing practice were identified in the areas of symptom assessment, skin barrier care, patient education, treatment adherence, safety monitoring, and follow-up support. Nurses play an important supportive role in implementing physician-directed therapies and non-pharmacological interventions while also promoting adherence and long-term disease management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Evidence-based management of pruritus in atopic dermatitis requires integration of pharmacological and non-pharmacological strategies. Nursing practice contributes substantially through symptom assessment, patient education, skin care support, adherence promotion, safety monitoring, and follow-up, thereby helping improve pruritus control and quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Association Between Injury Etiology and Scar Outcomes: A Retrospective Clinical Study”","authors":"Meerab Akhtar Abbasi,&nbsp;Kumar Singh,&nbsp;Maheen Hamid","doi":"10.1111/jocd.71170","DOIUrl":"https://doi.org/10.1111/jocd.71170","url":null,"abstract":"&lt;p&gt;We read the article ‘Association between Injury Etiology and Scar Outcomes’, published by Huang et al., in Journal of Cosmetic Dermatology, with great interest. Scar is fibrous connective tissue which replaces non-injured tissue following injury [&lt;span&gt;1&lt;/span&gt;]. We commend the authors for this valuable study, which underscores the importance of injury etiology as an important determinant of scar outcomes and explores the role of injury etiology in early clinical risk stratification [&lt;span&gt;2&lt;/span&gt;]. Some methodological issues that could increase the generalizability of the results, however, remain unaddressed.&lt;/p&gt;&lt;p&gt;Although the authors considered many important variables like age, gender, scar stage, and injury etiology, we believe that some other patient-specific variables such as nutritional status and certain systemic factors that were not taken into account could have affected scar outcomes.&lt;/p&gt;&lt;p&gt;Recent literature also indicates that poor nutrition can cause healing to be impaired, as it can affect the functioning of cells (fibroblasts) that have a central role in the healing process and in the formation of scars [&lt;span&gt;3&lt;/span&gt;]. Furthermore, there is evidence from previous studies suggesting that some systemic factors such as the circulating cytokines, endocrine factors such as vitamin D status and the renin-angiotensin system, and lifestyle factors such as smoking, diet, psychological stress and exercise may be involved in scar formation and its progression [&lt;span&gt;4&lt;/span&gt;]. Thus, the exclusion of these factors may have led to confounding and therefore impacted the reported association between etiology and scar outcomes.&lt;/p&gt;&lt;p&gt;Moreover, although the post-injury intervention and the effect it had on scar outcome were evaluated in a descriptive manner within this cohort, these paths toward interventions were not included in the final architecture of the prognostic nomogram. Based on management algorithms for hypertrophic scars and keloids, the initial management should be based on the individual patient's risk profile and, ideally, adjusted to the dynamic situation to prevent abnormal fibroblastic proliferation. For instance, silicone gel sheeting treatment, pressure garments, or specific intralesional treatment of high-risk wounds can yield far greater preventative results when it is treated early, before the formation of abnormal scar tissue [&lt;span&gt;5&lt;/span&gt;]. The predictive model is based solely on baseline characteristics and does not take into account the fact that some patients had early preventive care and others had late therapeutic care; therefore, its clinical predictive accuracy is called into question. If heterogeneity of early prophylactic treatment were added to the multi-variable predictive model, then the model would have been of much greater clinical value and been able to provide true individual scar prevention.&lt;/p&gt;&lt;p&gt;To conclude, Huang et al. have contributed very well by assessing the etiology of the injury and ident","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Hyaluronic Acid and Collagen Injections for Perioral Rejuvenation: A Randomized Controlled Trial","authors":"Qing Liu,&nbsp;Chen Huang,&nbsp;Juan Zhang,&nbsp;Zhen Liang,&nbsp;Jiaxi Liu,&nbsp;Baoqiang Song","doi":"10.1111/jocd.71169","DOIUrl":"https://doi.org/10.1111/jocd.71169","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The perioral region, a critical facial aesthetic subunit, undergoes age-related changes addressed primarily through dermal fillers. Optimal rejuvenation requires tailored approaches integrating anatomical precision, filler physicochemical properties, and standardized aging assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To prospectively compare hyaluronic acid (HA)-collagen combination therapy against monotherapies for perioral rejuvenation using protocol-guided aging evaluations and personalized strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ninety female patients with perioral aging were randomized equally into three groups (Dec 2022–Dec 2023): Group A (HA alone), Group B (HA-collagen), and Group C (collagen alone). Treatments were customized using baseline Comprehensive Perioral Aging Scale (CPAS) scores. Outcomes were assessed via CPAS and Global Aesthetic Improvement Scale (GAIS) posttreatment, at 3 months, and 6 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Group B demonstrated statistically superior improvements in CPAS and GAIS versus monotherapy groups at all intervals (<i>p</i> &lt; 0.05). The combination regimen achieved optimal tissue support, lifting effects, and aesthetic outcomes, with sustained benefits at 6-month follow-up. Baseline characteristics showed no intergroup differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Protocol-guided HA-collagen synergy produces enhanced perioral rejuvenation compared to single-agent therapies, offering improved structural support and longevity of aesthetic corrections. This randomized trial validates personalized CPAS-based combination approaches for age-related perioral changes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Side Effects of Green Tea Extract on Facial Skin Aging: A Systematic Review","authors":"Taryn Lubbers,&nbsp;Cyrus W. Abrahamson,&nbsp;Paavali A. Hannikainen,&nbsp;Daniel Stuart,&nbsp;James C. Wang","doi":"10.1111/jocd.71125","DOIUrl":"https://doi.org/10.1111/jocd.71125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There has been an increasing demand for natural cosmeceuticals that can be used for their anti-aging effects. Green tea extract (GTE) is a powerful antioxidant making it a promising candidate for combating photodamage and skin aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To establish the effectiveness and side effects of using topical GTE on the face to improve skin appearance and photoaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This systematic review was conducted according to PRISMA guidelines. Studies were excluded if they did not utilize the epigallocatechin gallate (EGCG) component of GTE, did not focus on facial skin aging, were not controlled trials, used a green tea beverage exclusively, or if the full text was unavailable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four hundred eighty-one studies were identified, from which seven were extracted. Five studies measured skin elasticity which all found some degree of improvement after treatment with GTE. Four of the five studies looking at wrinkles reported a decrease in fine line wrinkles. The effect of GTE on skin irritability (erythema, inflammation, and dryness) was debated. Other notable effects include an improvement in skin tone, texture, radiance, scavenging ability, firmness and density.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GTE shows potential as an anti-aging compound for facial skin, but more studies are needed as the literature is varying and sparse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>PROSPERO: CRD42024610718</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Aging Potential of Callus Culture: Mechanisms, Efficacy and Future Trends","authors":"Amir Mohammad Sharafi,&nbsp;Ali Khajeei,&nbsp;Maryam Hasan Zadeh Navroodi,&nbsp;Soheila Mokari,&nbsp;Seydeh Halimeh Najafi,&nbsp;Mohaddeseh Argha,&nbsp;Faezeh Talaei Shahmirzadi,&nbsp;Parina Asgharian,&nbsp;Tooba Gholikhani","doi":"10.1111/jocd.71066","DOIUrl":"https://doi.org/10.1111/jocd.71066","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Callus culture technology revolutionizes skin antiaging research, offering a sustainable and efficient method for producing bioactive compounds with potent geroprotective properties. This plant tissue and cell culture technique enables the controlled biosynthesis of beneficial phytochemicals while mitigating the variability and contamination risks inherent in traditional plant sources. By manipulating phytohormonal pathways, researchers can increase the yield of secondary metabolites that possess therapeutic and cosmetic efficacy, aligning with ethical standards of environmental stewardship.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A thorough literature search was carried out to assess the anti-aging potential of callus culture using the search terms (callus culture OR plant stem cells) AND (anti-aging OR skin aging OR photoaging) AND (skin OR skincare) AND (bioactive compounds OR phytochemicals OR antioxidants). Additional searches included (mechanisms OR collagen OR anti-inflammatory OR wound healing) AND (cosmetic OR cosmeceutical OR skin rejuvenation). Relevant studies were also identified by screening the reference lists of the retrieved articles.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Numerous studies have demonstrated the efficacy of callus cultures derived from various plant species, such as &lt;i&gt;Malus domestica&lt;/i&gt; (apple), &lt;i&gt;Oryza sativa&lt;/i&gt; (rice), &lt;i&gt;Centella asiatica&lt;/i&gt;, and &lt;i&gt;Aster yomena&lt;/i&gt;, in generating phytochemicals rich in antioxidants and anti-inflammatory agents. These compounds promote skin health and combat oxidative stress. In vitro cultures have shown the ability to increase keratinocyte proliferation, stimulate collagen synthesis, inhibit elastase activity, and reduce the levels of inflammatory markers associated with skin aging. Furthermore, the callus culture extracts mitigate the adverse effects of oxidative stress and inflammation, major contributors to skin aging. This renders them invaluable sources of geroprotective agents suitable for cosmeceutical and pharmaceutical applications. The growing consumer demand for natural ingredients has led to a notable market shift toward the use of botanical preparations for anti-aging solutions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In conclusion, the integration of callus culture techniques offers a novel approach for the development of antiaging skincare products. By leveraging the inherent ability of plant cells to synthesize bioactive metabolites, researchers and cosmetic scientists can create effective and sus","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Sodium Hyaluronate Injection for Moderate-To-Severe Neck Wrinkles: A Multicenter, Single-Blind, Randomized, Parallel-Controlled Trial","authors":"Ji-Na Zheng,&nbsp;Jianming Yang,&nbsp;Kai Yang,&nbsp;Zhiyu Liu,&nbsp;Qian Yu,&nbsp;Xiaoke Liu,&nbsp;Xiuli Li,&nbsp;Shuqin Zhang,&nbsp;Man Hu,&nbsp;Hongyue Diao,&nbsp;Julien Cle'ment,&nbsp;Shiliang Wang,&nbsp;Yuxin Hou,&nbsp;Hengtao Li,&nbsp;Yuna Luo,&nbsp;Kun Chen,&nbsp;Jiajia Liu,&nbsp;Yougai Huang,&nbsp;Weiwei Li,&nbsp;Yan Liu,&nbsp;Yuling Shi,&nbsp;Jun Gu,&nbsp;Yu Gong","doi":"10.1111/jocd.71135","DOIUrl":"https://doi.org/10.1111/jocd.71135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyaluronic acid (HA) occupies the micro-environment of the dermal matrix, filling depressions and imparting a smooth appearance to the skin. HA fillers are widely used for wrinkle correction. Still, the efficacy and safety of ANN0032, a new HA-based injection, have not yet been assessed in clinical trials for moderate to severe neck wrinkles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of ANN0032, a novel HA-based injection, for the correction of moderate-to-severe horizontal neck wrinkles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this multicenter, randomized, single-blind, parallel-controlled trial, 156 subjects were randomized (1:1) to receive either ANN0032 treatment (<i>n</i> = 78) or an established HA filler Hearty (<i>n</i> = 78). The primary efficacy endpoint was the proportion of subjects achieving a ≥ 1-point improvement on the Allergan Transverse Neck Lines Scale (ATNLS) at Week 4 posttreatment, as assessed by blinded evaluators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At Week 4, ANN0032 demonstrated non-inferior improvement compared with Hearty, with 83.3% versus 71.8% of subjects achieving the primary endpoint (rate difference, 11.54%; 95% CI: −3.29% to 26.37%). Both groups showed comparable safety profiles with no serious adverse events reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ANN0032, a HA-based filler, demonstrated non-inferior efficacy and a favorable safety profile compared to an established HA filler, Hearty, in improving moderate-to-severe neck wrinkles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"","doi":"10.1111/jocd.71139","DOIUrl":"https://doi.org/10.1111/jocd.71139","url":null,"abstract":"<p>The cover image is based on the article <i>Toward Plane-Thickness-Aliquot Matching in Dual-Plane Biostimulator Injection</i> by Jui-Yu Lin and Chuan-Yuan Lin, https://doi.org/10.1111/jocd.71068.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction and Prevention of the Mephisto Sign: A Practical Clinical Maneuver for Botulinum Toxin Injections","authors":"Aslan Yurekli,&nbsp;Ismail Hakki Unal","doi":"10.1111/jocd.71136","DOIUrl":"https://doi.org/10.1111/jocd.71136","url":null,"abstract":"&lt;p&gt;Botulinum toxin is a widely preferred, safe, and effective treatment option in aesthetic dermatology for the correction of forehead, glabellar, and periorbital wrinkles [&lt;span&gt;1&lt;/span&gt;]. However, several complications may occur after injection, leading to patient dissatisfaction from an aesthetic perspective. One such complication is the Mephisto sign, which is characterized by a conspicuous elevation of the lateral eyebrows following botulinum toxin injections into the forehead [&lt;span&gt;2&lt;/span&gt;]. This phenomenon may result from suppression of the central or medial frontalis muscle by the toxin, leaving the lateral fibers relatively more active [&lt;span&gt;2, 3&lt;/span&gt;]. It may occur after central forehead treatment and may also be facilitated by unintended diffusion from glabellar injections into the medial frontalis region. The resulting appearance is frequently interpreted as a “surprised” or “malicious” expression, often prompting corrective injections.&lt;/p&gt;&lt;p&gt;In clinical practice, this complication is usually addressed preventively by applying a low dose of toxin bilaterally to the lateral frontalis region to balance muscle activity [&lt;span&gt;2&lt;/span&gt;]. Nevertheless, this approach is not always sufficient for all patients. Human facial musculature varies substantially between individuals: in some, the lateral fibers are markedly dominant, while in others they are less active compared to the medial portion. Differences in forehead height, baseline brow position, frontalis strength, and sex-related anatomy may further influence treatment outcomes. These variations may be particularly relevant in male patients, in whom lateral frontalis activity may be stronger or extend more superiorly. Such anatomical and functional variations may render standard injection protocols ineffective in certain cases. Therefore, a simple method that enables clinicians to evaluate the balance of frontalis muscle activity prior to injection would be of great importance in optimizing clinical outcomes.&lt;/p&gt;&lt;p&gt;To anticipate the development of the Mephisto sign, we propose a noninvasive clinical maneuver. During examination, the physician gently blocks the patient's medial frontalis with a finger while asking the patient to elevate the eyebrows. A marked rise in the lateral brows under these conditions may indicate a higher tendency toward the Mephisto sign after injection (Figure 1). Conversely, absent or minimal lateral brow elevation during the same maneuver may suggest a lower-risk pattern (Figure 2). This simple maneuver may serve as a practical adjunct to dynamic pre-injection assessment and may help the clinician determine whether the lateral fibers should be specifically targeted during the procedure.&lt;/p&gt;&lt;p&gt;This approach may offer several advantages: it may reduce the risk of post-injection complications, increase patient satisfaction, and minimize the need for corrective treatments. It is intended to complement, rather than replace, comprehensive pre-injection evaluatio","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Nintedanib for Refractory Generalized Keloids: A Prospective Exploratory Pilot Study","authors":"Chenmei Liu,&nbsp;Lian Zhang,&nbsp;Dan Sun,&nbsp;Aiqing Lin,&nbsp;Renliang He,&nbsp;Bin Yang","doi":"10.1111/jocd.71107","DOIUrl":"https://doi.org/10.1111/jocd.71107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Generalized keloids are severe, treatment-refractory, disfiguring dermatoses that substantially impair physical and psychosocial well-being and have limited effective systemic treatment options.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the short-term safety, tolerability, and exploratory clinical outcomes of oral nintedanib in patients with refractory generalized keloids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this single-center, open-label, assessor-blinded exploratory pilot study, 10 adults with refractory generalized keloids received oral nintedanib 150 mg once daily or 150 mg twice daily for 8 weeks. The primary exploratory endpoint was change in Vancouver scar scale (VSS) score from baseline to Week 8. Secondary endpoints included pruritus and pain visual analogue scale (VAS) scores, patient and observer scar assessment scale (POSAS), dermatology life quality index (DLQI), imaging and histological assessments, and safety outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All participants completed treatment and follow-up. Mean VSS scores decreased from 11.2 ± 1.3 to 8.2 ± 1.1 in the low-dose group and from 10.4 ± 1.8 to 8.2 ± 1.9 in the high-dose group. Pruritus severity and visible scar vascularity showed numerical improvements over 8 weeks, whereas POSAS and DLQI changed little. Histological assessment suggested reduced cellularity and more organized collagen architecture after treatment. No serious adverse events or treatment discontinuations occurred; the most common treatment-related adverse events were mild diarrhea and transient transaminase elevation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this small, uncontrolled exploratory pilot study, oral nintedanib was associated with early favorable changes in selected clinician-rated and symptom-based outcomes, whereas POSAS and DLQI showed limited short-term change. These findings are preliminary and hypothesis-generating and warrant confirmation in larger controlled studies with longer treatment and follow-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}