Journal of Cosmetic Dermatology最新文献

{"title":"Hyaluronic High Definition Fill Technique.","authors":"Luciana M Lourenço, David Di Sessa, Ana Carolina Franco Tebet, Maria Gabriela Ortiz de Noronha, Helena Lourenço de Medeiros, Rosa Sigrist","doi":"10.1111/jocd.16692","DOIUrl":"https://doi.org/10.1111/jocd.16692","url":null,"abstract":"<p><strong>Introduction: </strong>Achieving a defined abdomen through traditional surgical methods like liposuction and abdominoplasty involves risks and significant downtime. Hyaluronic acid (HA) body filling has emerged as a minimally invasive alternative, offering immediate results with reduced recovery periods.</p><p><strong>Patients and methods: </strong>The high-definition abdomen through HA technique (HHD) was implemented on young men with BMI < 24.9, excluding those with obesity or excessive skin laxity. HA gel with large particle sizes (800-1800 μm) and high G prime was chosen based on subcutaneous thickness. Injections were guided by ultrasound into the lamellar fat layer between Camper's fascia and Scarpa's fascia, targeting abdominal metameres for enhancement. Participants completed the Global Aesthetic Improvement Scale.</p><p><strong>Results: </strong>The technique produced satisfactory outcomes, enhancing abdominal metamere definition. Mild post-procedural hematomas and transient discomfort were noted. At 10 months, 71.4% of patients reported \"much improved,\" and 28.6% reported \"improved,\" per the GAIS questionnaire.</p><p><strong>Discussion: </strong>Customizing HA characteristics and employing ultrasound guidance ensured safe and precise injections, minimizing vascular risks. Limitations such as HA's temporary nature and exclusions for surgical candidates were acknowledged.</p><p><strong>Conclusion: </strong>HHD using large particle HA proved effective in achieving aesthetic abdominal enhancements with minimal risks and downtime. This technique not only provided immediate results but also contributed to enhanced patient satisfaction and self-esteem. Further research is needed to explore broader applications and refine outcomes across diverse patient groups.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16692"},"PeriodicalIF":2.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Mechanisms of Huayu Quban Capsule in Treating Acne Vulgaris Are Uncovered Through Network Pharmacology and Molecular Docking.","authors":"Lei Zhang, Yu Huang, Wei Zhu","doi":"10.1111/jocd.16632","DOIUrl":"https://doi.org/10.1111/jocd.16632","url":null,"abstract":"<p><strong>Purpose: </strong>To uncover how the Huayu Quban (HYQB) capsule treats acne vulgaris (AV) through the use of network pharmacology and molecular docking technology.</p><p><strong>Methods: </strong>The traditional Chinese medicine system pharmacology database (TCMSP) was used to identify the components and potential targets of HYQB capsule. Targets related to AV were identified by screening the GeneCards, Disease Gene Network (DisGeNET) and Online Mendelian Inheritance in Man (OMIM) databases. The protein-protein interaction (PPI) network between targets of active ingredients and AV targets was built using the STRING database. Cytoscape3.7.2 software was used to create the visualization network for the 'herb-component-target' and identify the key targets. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were utilized for functional enrichment analysis of the primary targets. Subsequently, molecular docking technology was employed to confirm the interaction between key components and core targets.</p><p><strong>Results: </strong>The technique discovered 50 different active substances and 270 associated therapeutic targets in the HYQB capsule as well as predicting 70 targets for treating acne vulgaris. Cytoscape hubba plug-in identified 19 key target genes, with the top 5 being TNF, IL1B, CCL2, SIRT1, IFNG, and IL10. Analysis of KEGG pathways revealed significant enrichment of immune-related pathways, including TNF and IL-17 signaling pathways, among the target genes. The HYQB capsule also involves lipid and atherosclerosis, Th17 cell differentiation, and the AGE-RAGE signaling pathway in diabetic complication signaling pathways. Molecular docking results showed that quercetin, luteolin, kaempferol, and wogonin, the core components of HYQB, had good binding ability with the first 4 core targets.</p><p><strong>Conclusions: </strong>The HYQB capsule may have a synergistic effect on inhibiting sebaceous adipogenesis and sebum cell differentiation and play an effect on AV through anti-inflammatory and antioxidant effects of different signaling pathways.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic Ingredients in Dermatology: A Call for Research.","authors":"Nupur Singh, Angela N Brown, Michael H Gold","doi":"10.1111/jocd.16673","DOIUrl":"https://doi.org/10.1111/jocd.16673","url":null,"abstract":"<p><strong>Background: </strong>With the ever-changing cosmetic landscape, Ayurvedic skincare, rooted in the holistic medical system of Ayurveda from India, has gained popularity in Western countries due to its natural ingredients and multipurpose benefits. Originating from the earth's sources, such as plants and minerals, each ingredient like ashwagandha, turmeric, and neem among others are believed to address various cosmetic and medical issues.</p><p><strong>Aims and methods: </strong>Despite centuries of anecdotal evidence, modern clinical trials validating these claims are limited. This paper looked to investigate current literature regarding Ayurvedic skincare and promote its continued research.</p><p><strong>Results: </strong>Existing in vitro studies have demonstrated significant potential, indicating the need for further large-scale testing. The rise of Ayurvedic ingredients is partially driven by the increasing cost of healthcare and the belief in the superiority of natural self-medication. However, healthcare providers must educate patients on the potential dangers of relying solely on natural products. Products like concentrated lemon juice or homemade sunscreens lack scientific validation and have been implicated in various cosmetic and medical issues, highlighting the need to prevent misinformation and improve education from trusted sources.</p><p><strong>Conclusions: </strong>This paper explores the current literature that establishes promising prospects for Ayurvedic skincare, emphasizing the need for quality control and clinical trials, and highlights how Ayurvedic medicine, as it modernizes, holds the potential to become a major player in cosmetic dermatology.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16673"},"PeriodicalIF":2.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TFC-1326 Compound Reduces Clinical Signs of Skin Aging. Evidence From In Vitro Human Adipose and Skin Models and Pilot Clinical Trial.","authors":"Géraldine Deliencourt-Godefroy, Jocelyne Legoedec, Marion Bourdens, Noémie Juin, Linh-Trang Nguyen, Marie-Christine Branchet, Sylvie Boisnic, Mayoura Keophiphath","doi":"10.1111/jocd.16679","DOIUrl":"https://doi.org/10.1111/jocd.16679","url":null,"abstract":"<p><strong>Background: </strong>Anti-freeze Glycoproteins (AFGPs) were described to preserve biological materials and protect them from different stresses.</p><p><strong>Aims: </strong>The effects of a synthetic anti-freeze glycoprotein-based compound, TFC-1326, on human skin quality and its biological actions were studied.</p><p><strong>Methods: </strong>The effects of various concentrations of TFC-1326 on the biology of human preadipocytes, differentiated in the proinflammatory microenvironment, and on human fibroblasts grown in coculture with human mature adipocytes or monocultured in stress conditions were investigated in, in vitro studies. Additionally, the efficacy of a 1% TFC-1326 topical cream was evaluated in a clinical investigation on the skin biology and appearance of 20 women aged between 40 and 65 years throughout 84 days of application.</p><p><strong>Results: </strong>The in vitro studies revealed that TFC-1326 mitigated the deleterious effects of a proinflammatory cytokine cocktail produced by human macrophages, by restoring preadipocyte adipogenic capacity and by reducing their fibroinflammatory state. TFC-1326 also stimulated the proliferative capacity of dermal fibroblasts co-cultured with mature adipocytes as well as their production of hyaluronic acid and procollagen type I, while decreasing IL6 secretion and increasing fibroblast viability. Furthermore, daily 1% TFC-1326 topical cream application, measurably improved skin radiance and laxity, as well as skin density. Finally, significant reductions of the volume and depth of the crow's feet wrinkles were also observed.</p><p><strong>Conclusions: </strong>The compound TFC-1326 significantly improved the physiological appearance and cellular functions of aging skin.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16679"},"PeriodicalIF":2.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Pragmatic Two-Center Clinical Study to Evaluate the Clinical Outcome of Triple-Frequency Ultrasound in the Treatment of Mild-to-Severe Acne Vulgaris.","authors":"Irina G Chervinskaya, Nataliia V Gaidash, Ilja L Kruglikov","doi":"10.1111/jocd.16672","DOIUrl":"https://doi.org/10.1111/jocd.16672","url":null,"abstract":"<p><strong>Objectives: </strong>Earlier, quickly alternating dual-frequency ultrasound waves (LDM technology) were successfully applied for the treatment of different inflammatory skin conditions such as rosacea and acne. In this retrospective pragmatic two-center clinical study, we applied the triple-frequency LDM (TF-LDM) technology with frequencies of 1/3/10 and 3/10/19 MHz for the treatment of mild-to-severe acne skin to assess the effectivity and sustainability of the treatment outcomes.</p><p><strong>Methods: </strong>Twenty-two patients with mild-to-severe acne were included in this study: 11 patients were treated with TF-LDM (1/3/10 MHz), and other 11 patients-with TF-LDM (3/10/19 MHz). Assessment of the acne severity was done using the bilateral facial photographs. The photos were evaluated at baseline (T1), on the day of the last treatment (T2), and during the follow-up controls (T3). Assessment of the acne severity was provided in accordance with a modified Global Evaluation Acne (mGEA) scale by nine independent dermatologists who were blinded to treatment assignments.</p><p><strong>Results: </strong>The average improvement of the mGEA scoring between T1 and T2 across all patients was 73.69% ± 13.90% (p < 0.01), whereas the skin improvement between T1 and T3 was 90.14% ± 8.35% (p < 0.01). The state of the skin was also statistically significantly improved between T2 and T3 (53.26% ± 29.24%, p < 0.02). There was no difference in treatment outcomes between the patients treated with TF-LDM (1/3/10 MHz) and TF-LDM (3/10/19 MHz).</p><p><strong>Conclusions: </strong>TF-LDM is an effective method for the treatment of the mild-to-severe acne skin that provides a significant skin improvement and long-lasting treatment results. The method demonstrates no significant side effects, is pain-free, well tolerated, and highly accepted by patients.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections.","authors":"Mariana El Hawa, William Abou Shahla, Callie Fares, Dana Saade","doi":"10.1111/jocd.16624","DOIUrl":"https://doi.org/10.1111/jocd.16624","url":null,"abstract":"<p><strong>Background: </strong>The demand for aesthetic procedures aimed at restoring and preserving a youthful appearance is growing. While numerous non-surgical facial rejuvenation techniques are available, there is a need for a comprehensive review of clinic-based procedures targeting non-facial body parts.</p><p><strong>Aims: </strong>This review aims to describe and evaluate clinic-based techniques for rejuvenating the neck, chest, and hands, focusing on various types of fillers and other non-invasive procedures.</p><p><strong>Methods: </strong>In this first part of this review, we conducted an extensive literature review on PubMed, reporting the effectiveness of different fillers, detailing their preparation, required volume per area, injection methods, durability, and any associated side effects. We also discuss the use of mesotherapy, microneedling, chemical peeling, and Profhilo in these specific body areas.</p><p><strong>Conclusion: </strong>The review synthesizes the latest data on the effectiveness and safety of these procedures, highlighting the advancements in filler technology and the growing popularity of non-invasive techniques for body rejuvenation. This article serves as a valuable resource for practitioners and patients interested in non-surgical body rejuvenation, providing insights into the best practices.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonfacial Skin Rejuvenation of the Neck, Chest, and Hands. Part Two: Using Laser Techniques.","authors":"Callie Fares, William Abou Shahla, Mariana El Hawa, Dana Saade","doi":"10.1111/jocd.16671","DOIUrl":"https://doi.org/10.1111/jocd.16671","url":null,"abstract":"<p><strong>Background: </strong>Interest in aesthetic procedures that help maintain a youthful look is on the rise. While many nonsurgical techniques focus on facial rejuvenation, there is a need for a detailed review of treatments, specifically for nonfacial areas.</p><p><strong>Aim: </strong>This review explores various clinic-based methods for revitalizing the neck, chest, and hands, with a particular emphasis on different laser treatments.</p><p><strong>Methods: </strong>For this second part of the review, we conducted a comprehensive search on PubMed to evaluate the effectiveness of various laser treatments. The review covers treatment parameters such as wavelength, fluence, and pulse, along with outcomes, follow-up care, and potential side effects. A discussion on the role of sclerotherapy in treating these areas was also included.</p><p><strong>Conclusions: </strong>This article compiles recent findings on the safety and effectiveness of these treatments, showcasing progress in laser technologies and the growing trend of noninvasive body rejuvenation. It offers practical insights for both practitioners and patients looking for reliable options in nonsurgical body treatments.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfocused Ultrasound With Visualization Induces Remodeling of Collagen and Elastin Within the Skin.","authors":"Kay Marquardt, Christian Hartmann, Flora Wegener, Je-Young Park, Douglas Halbert, Stephen Hsu, Thomas Hengl","doi":"10.1111/jocd.16638","DOIUrl":"https://doi.org/10.1111/jocd.16638","url":null,"abstract":"<p><strong>Purpose: </strong>Microfocused ultrasound with real-time visualization (MFU-V) is often used for noninvasive skin lifting, by precisely targeting dermal and subcutaneous tissues to create thermal coagulation points (TCPs). These TCPs denature collagen and initiate a transient inflammatory response, ultimately attracting dermal fibroblasts and inducing efficient neocollagenesis and extracellular matrix (ECM) remodeling, yielding to MFU-V's desired skin-lifting effects. The current study investigates MFU-V's underlying mode of action based on the histological progression of TCPs in the skin, providing new insight into the technology's regenerative effect.</p><p><strong>Methods: </strong>Following standard triple-depth MFU-V treatment, in vivo skin samples were assessed using histology and immunohistochemistry to evaluate TCPs, heat shock protein (HSP47), and elastin expression in fibroblasts.</p><p><strong>Results: </strong>MFU-V treatment induced elongated, flame-like TCPs with denatured collagen at focal depths of 1.5, 3.0, and 4.5 mm within the skin-each corresponding to its respective transducer depth. Time-dependent progression of TCPs showed significantly increased scores of fibroblasts and mature collagen along with recruitment of HSP47-positive fibroblasts to TCP areas on Day 90. Collagen formation and later maturation were visualized. Newly synthesized elastin significantly increased in the TCP area on Day 90 compared to Day 14.</p><p><strong>Conclusion: </strong>This work provides histological evidence of stimulation and regeneration of newly synthesized elastin fibers after TCP induction. MFU-V-generated TCPs triggered the body's own healing cascade of collagen denaturation, transient inflammation, proliferation, and tissue remodeling, resulting in attraction of HSP47-positive fibroblasts to the TCP sites, and new collagen and elastin fiber regeneration by fibroblasts. Besides the well-described neocollagenesis, this study demonstrates that MFU-V treatment induces elastin neogenesis that may result not only in skin lifting but also in improved skin elasticity, providing an overall regenerative effect.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipocyte Apoptosis Following a Novel Method for Double Chin Reduction: A Pilot Human Histology Study.","authors":"David J Goldberg","doi":"10.1111/jocd.16643","DOIUrl":"https://doi.org/10.1111/jocd.16643","url":null,"abstract":"<p><strong>Background: </strong>Submental fullness is perceived as unattractive by both men and women. The noninvasive simultaneous delivery of HIFES and synchronized radiofrequency+ (Sync RF+) technologies aims to address the submental fullness by concurrently targeting the skin, adipose tissue, and weakened anterior belly of the digastric muscle, the three contributing layers to the double chin appearance.</p><p><strong>Aims: </strong>This study aims to investigate the histological changes to adipose tissue related to cell morphology, caspase-7, and Bcl-2 levels to detect adipocyte apoptosis following the HIFES and Sync RF+ treatment on human subjects.</p><p><strong>Methods: </strong>The active group (n = 6) received single 20-min treatment on the submental area, while the control group (n = 2) did not receive any treatment. Biopsies of subcutaneous fat tissue were obtained at baseline, and 24 h and 7 days posttreatment. The specimens were histologically and immunohistochemically analyzed for changes in morphology, caspase-7, and Bcl-2 levels.</p><p><strong>Results: </strong>Observed caspase-7 levels increased by 511% at 24-h posttreatment, and 101% at 7 days (p < 0.0001), while the Bcl-2 levels decreased by 89% at 24 h and 24% at 7 days posttreatment (p < 0.0001). The control group had no statistically significant relative changes in the activity of caspase-7. Posttreatment adipocytes were shrunken in size, and shapes lost their uniformity compared to baseline. Five of six subjects reported the treatment as being comfortable. No adverse events were observed during the study.</p><p><strong>Conclusions: </strong>The results of this human histology study indicate that noninvasive HIFES and Sync RF+ technologies have a favorable safety profile for submental fat reduction through the induction of adipocyte apoptosis.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT06282172.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity, Parallel Ultrasound Tightening of Facial Skin: Clinical and Pathologic Results.","authors":"Dong Hye Suh, Sang Jun Lee, Kye Yong Song, Hye-Jin Ahn, Min Kyung Shin","doi":"10.1111/jocd.16670","DOIUrl":"https://doi.org/10.1111/jocd.16670","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}