Journal of Cosmetic Dermatology最新文献

{"title":"A Multi-Center Clinical Trial to Evaluate the Efficacy of the Next Generation TriHex Technology Antiaging Regimen","authors":"Michael Gold,&nbsp;Charles Boyd,&nbsp;Deanne Mraz,&nbsp;Tiffany Robison,&nbsp;Faiza Shafiq,&nbsp;Alan D. Widgerow","doi":"10.1111/jocd.70192","DOIUrl":"https://doi.org/10.1111/jocd.70192","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alastin Restorative Skin Complex Serum with TriHex Technology (Alastin Skincare Inc., Carlsbad, CA) has undergone reformulation to add Octapeptide-45 and magnolol for improving facial skin hydration, elasticity, plumping, and overall skin quality. Detailed science on TriHex Technology 2.0 and magnolol has been recently published. This open-label study was conducted to validate the science and demonstrate product efficacy and tolerability in individuals with moderate to severe facial skin aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multi-center clinical study was conducted from February to August 2024. A total of 44 eligible participants (43 female, 1 male), ages 35–69 years, and Fitzpatrick skin Types I–VI were enrolled in and completed the study following 12 weeks of Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology (RSC 2.0) use twice daily, along with an Alastin Skincare Inc. supportive regimen (cleanser, moisturizer, sunscreen used as needed). A 1-week run-in phase using the supportive regimen only was conducted, and eligibility was reassessed at baseline. Follow-up visits were performed at Weeks 4, 8, and 12, where facial skin quality parameters were evaluated clinically and subject assessments and satisfaction questionnaires, biopsy collection, photography, and hydration and elasticity measurements were completed. Participants also maintained a study diary over the 12-week treatment period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant improvements for all clinically evaluated facial skin parameters were achieved at Week 12. Histology revealed increased stimulation of new adipocytes, epidermal keratinocyte HA (CD44), and new dermal collagen and elastin fibers post treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology has been demonstrated to be safe and effective for improving overall facial skin quality, achieving notable improvements in volume, plumping, hydration, and extracellular matrix (ECM) collagen and elastin stimulation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Evaluation of Androgenetic Alopecia: Demographic Characteristics, Psychosocial Impact, and the Role of Social Media in Treatment Choices","authors":"Arzu Ferhatosmanoğlu,&nbsp;Zeynep Karaca Ural,&nbsp;Leyla Baykal Selçuk,&nbsp;İbrahim Etem Arıca,&nbsp;Deniz Aksu Arıca","doi":"10.1111/jocd.70167","DOIUrl":"https://doi.org/10.1111/jocd.70167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Androgenetic alopecia (AGA) has a significant psychosocial impact on both genders. This study investigated AGA severity, psychosocial burden, sociodemographic factors, and the influence of social media on treatment-seeking behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 390 patients diagnosed with AGA at a university hospital in Turkey between January 2023 and 2024 were included. Data on disease severity, psychological impact, treatment awareness, and social media engagement were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean AGA onset age was 23.9 years in men and 29.46 years in women. Severe AGA was observed in 38.5% of men and 41% of women, with men experiencing significantly higher emotional and functional distress (<i>p</i> = 0.05, <i>p</i> = 0.003). Early-onset AGA (before age 20) was associated with increased psychological distress, including higher emotion, function, and stigma scores, along with lower self-confidence (<i>p</i> = 0.007, <i>p</i> &lt; 0.001, <i>p</i> = 0.037, <i>p</i> &lt; 0.001). Social media was used by 69.3% of participants for hair loss information, mainly on Google, Instagram, and TikTok, but had no significant impact on treatment choices (<i>p</i> = 0.971) or psychological distress (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AGA significantly affects psychological well-being, particularly in men with severe hair loss and individuals with early-onset AGA. While social media is a primary information source, it does not influence treatment decisions or psychological distress. These findings highlight the need for evidence-based digital health communication to counter misinformation. Future research should examine the long-term psychological effects of AGA and further explore the role of social media in patient education and treatment behaviors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment","authors":"Sofia Iglesia,&nbsp;Lily I. Jiang,&nbsp;Tatiana Kononov,&nbsp;Alisar S. Zahr","doi":"10.1111/jocd.70196","DOIUrl":"https://doi.org/10.1111/jocd.70196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Facial skin aging is a cumulative result of both intrinsic and extrinsic stressors. Chemical peels are commonly performed noninvasive skin rejuvenation procedures targeting these stressors. Innovation in chemical peels has remained limited, creating an opportunity for the industry to evolve with next-generation technology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>A novel topical antioxidant biostimulating treatment (ABT) was developed that utilizes a typical chemoexfoliation base as a vehicle to deliver a unique blend of antioxidant biostimulating acidic phytocompounds (ABAP). It was hypothesized that controlled delivery of ABAP could occur through a typical AHA/BHA chemical peel vehicle. These ABAPs, such as asiatic, ursolic, madecassic, and oleanolic acids, are known for skin rejuvenation in the papillary dermis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>The ABT was tested in both ex vivo and in vivo settings to elucidate its mechanism of action and determine its efficacy and safety on 32 female subjects aged 38–60 years with Fitzpatrick skin types I–V.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The ABT upregulated elastin and collagen after superficial wounding of the skin by over 25% when compared to untreated or vehicle controls. Clinical evaluation by an expert grader demonstrated that the ABT significantly improved fine lines, wrinkles, tactile laxity, and overall appearance after three ABT sessions. Clinical photography demonstrated an improvement in fine lines, wrinkles, skin smoothness, laxity, radiance, and overall appearance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The ABT developed with ABAP technology was efficacious in improving facial skin aging for skin rejuvenation and safe for all skin tones.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne","authors":"Rongli Yang,&nbsp;Yiyang Bai,&nbsp;Chang Liu,&nbsp;Jintian Luo,&nbsp;Yajie Yang,&nbsp;Shaoli Cheng,&nbsp;Muyan Zou,&nbsp;Xin Mu","doi":"10.1111/jocd.70198","DOIUrl":"https://doi.org/10.1111/jocd.70198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to explore the clinical efficacy and safety of botulinum toxin A combined with hyaluronic acid in improving facial pore enlargement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A retrospective study was conducted on 40 acne patients with enlarged pores. Botulinum toxin A and non-cross-linked hyaluronic acid compound were injected into the patient's face using mesotherapy with nine 32-gauge microneedles. VISIA was used to record the conditions of facial pores, texture, and porphyrins. The physician's assessment of the improvement score and the patient satisfaction evaluation are used to evaluate the treatment effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>One month after treatment, the combination of botulinum toxin and non-cross-linked hyaluronic acid compound significantly improved facial pore enlargement. Although the effects decreased, the conditions of facial pores, texture, and porphyrins 4 months after treatment still had a significant difference from those at baseline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of botulinum toxin A and non-cross-linked hyaluronic acid compound is safe and effective in treating enlarged pores, indicating its promotional value.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Studies on the Application of Concentrated Growth Factors for Enhancing the Recovery From Flap Ischemia–Reperfusion Injuries","authors":"BoQiao Zhou,&nbsp;XianYan Luo","doi":"10.1111/jocd.70203","DOIUrl":"https://doi.org/10.1111/jocd.70203","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the therapeutic potential of locally injecting concentrated growth factor (CGF) into flaps for treating flap ischemia–reperfusion injury (FIRI) following reconstructive surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nineteen patients with FIRI were enrolled in this study. After clinical identification of ischemia–reperfusion (IR) injury, CGF was prepared from each patient's autologous blood and locally injected into the affected flap tissue. Flap viability was assessed using clinical indicators such as color, texture, and capillary refill. Patients were followed for 6 months postoperatively to assess long-term outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seven days after CGF injection, 18 of 19 patients demonstrated complete flap survival. In one case, total necrosis occurred due to hematoma formation and insufficient dressing compression, but healing was achieved through dressing changes. Overall, patients showed improvements in flap color (from dark to ruddy), texture (softened), and skin tension (decreased), with visible wrinkle formation. Long-term follow-up confirmed satisfactory appearance and functional outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Local injection of CGF effectively enhances flap survival by promoting recovery from IR injury. This strategy may offer a promising adjunctive therapy in reconstructive procedures to improve tissue viability and healing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Rosacea Treatment: Combination of a Low Crosslinked Injectable Hyaluronic Acid Filler With Standard Therapeutical Interventions—An International Real World Case Series","authors":"Ilaria Proietti,&nbsp;Sadiye Kus,&nbsp;Emanuele Amore,&nbsp;Francesca Svara,&nbsp;Chiara Battilotti,&nbsp;Concetta Potenza,&nbsp;Patricia Ogilvie","doi":"10.1111/jocd.70199","DOIUrl":"https://doi.org/10.1111/jocd.70199","url":null,"abstract":"&lt;p&gt;Rosacea is a chronic inflammatory skin disease that primarily affects the central area of the face, causing erythema, telangiectasia, swelling, and often small papules resembling acne. It has a multifactorial etiology with genetic factors, environmental triggers, and abnormalities in blood vessels and the immune system playing a pivotal role. The milder form, known as erythematous rosacea, commonly manifests with erythema, transient redness, individual telangiectasias, alongside hypersensitivity symptoms and cosmetic intolerance [&lt;span&gt;1&lt;/span&gt;]. The burden of disease of rosacea and it's implication on patient's quality of life is a frequently underestimated aspect of this common skin disease [&lt;span&gt;2&lt;/span&gt;]. Primary treatments commonly include topical therapies and oral antibiotics, alongside the avoidance of triggering factors [&lt;span&gt;3&lt;/span&gt;]. Nonetheless, these therapies frequently fail to sustain a lasting response. In recent years, innovative techniques have emerged with the aim of achieving long-term cosmetic improvements. In this context, laser and light sources, such as the long-pulsed neodymium-doped yttrium aluminum garnet laser (Nd:YAG), intense pulsed light (IPL), potassium titanyl phosphate (KTP) laser, and pulsed dye laser (PDL) therapy, have been proposed due to their effectiveness in treating telangiectasia and erythematous lesions [&lt;span&gt;4&lt;/span&gt;]. Moreover, evidence suggests Hyaluronic acid (HA) as a potential strategy in the treatment of inflammatory skin conditions, including rosacea, either alone or in combination with other interventions [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Case 1: A 52-year-old woman, Fitzpatrick scale II, who presented in March 2023 with erythematous rosacea previously treated with doxycycline and topical ivermectin, yielding temporary benefit. Upon clinical evaluation, erythema and localized telangiectasia were observed in the malar and nasal regions associated with episodic burning sensation and cosmetic intolerance. The patient underwent a Nd:YAG session at 6 joules followed by an IPL session at 14 joules 1 month later, in April 2023. Finally, in June 2023, micro-injections of Vycross HA filler (VYC-12) were performed in the reticular dermis of the malar and nasolabial regions, totaling 1 mL per side. After 4 months from HA injection, improvement in skin quality and reduction of erythema were observed. Standardized photographs were obtained at baseline and at the four-month follow-up visit using the VectraH1camera system (CanfieldScientific Inc., Fairfield, New Jersey) (Figure 1).&lt;/p&gt;&lt;p&gt;Case 2: A 38-year-old patient with Fitzpatrick scale II presented in June 2024 with moderate erythema, dryness, and sensitivity present for 4 years. While waiting for winter to introduce vascular laser treatment, the patient underwent one session of VYC-12 L (1 cc per cheek), with microdroplets injected into the dermis to enhance skin hydration and prime the skin. Alongside, she was prescribed topical ivermectin and a tea tree o","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing Methodological Concerns in PRP Treatment for Lichen Planopilaris: A Response to Willaert et al.","authors":"Abbas Dehghani,&nbsp;Zahra Lotfi,&nbsp;Azadeh Goodarzi","doi":"10.1111/jocd.70180","DOIUrl":"https://doi.org/10.1111/jocd.70180","url":null,"abstract":"<p>We appreciate the opportunity to respond to the correspondence by Willaert et al., titled “Methodological considerations in PRP treatment for lichen planopilaris: addressing potential bias,” regarding our study on the efficacy of platelet-rich plasma (PRP) in lichen planopilaris (LPP). We value their insights and acknowledge the importance of minimizing bias in clinical research.</p><p>While we recognize that the absence of double-blinding may introduce a degree of performance bias, we would like to clarify several key points.</p><p>First, implementing a fully double-blinded design in interventional studies involving PRP poses practical challenges. The procedure involves visible and perceptible differences between groups, making it difficult to effectively blind participants without the use of a placebo injection (e.g., saline). However, ethical concerns arise when administering an unnecessary scalp injection, which could potentially cause discomfort or introduce confounding variables.</p><p>Second, to mitigate bias, we incorporated objective assessments, including trichoscopic evaluations and photographic documentation, alongside patient-reported outcomes such as the LPP Activity Index. The improvements observed in these objective measures reinforce the validity of our findings and suggest that the observed efficacy of PRP is not solely attributable to patient expectations.</p><p>Third, our control group received clobetasol, a well-established treatment for LPP, rather than placebo. If performance bias had substantially influenced the results, we would expect a markedly exaggerated difference between groups. However, the data demonstrated a consistent and measurable benefit of PRP as an adjunct to clobetasol, highlighting its clinical relevance.</p><p>In conclusion, while performance bias is a recognized limitation in trials involving interventional procedures, we believe our study's design, inclusion of objective measures, and use of an active control group provide a robust assessment of PRP's efficacy. We appreciate the discussion on methodological refinements and look forward to future advancements in PRP research.</p><p>The authors have nothing to report.</p><p>The authors declare no conflicts of interest.</p><p>Methodological considerations in PRP treatment for lichen planopilaris: Addressing potential bias https://doi.org/10.1111/jocd.70157</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Correlations Between UV Exposure and Search Trends for Mites and Rosacea in Shanghai","authors":"Sitong Li,&nbsp;Jiacheng Lin,&nbsp;Jiaqi Li,&nbsp;Xiaohui Mo,&nbsp;Qiang Ju","doi":"10.1111/jocd.70184","DOIUrl":"https://doi.org/10.1111/jocd.70184","url":null,"abstract":"&lt;p&gt;Online search data, such as Google Trends and Baidu Index, offer valuable insights into skin conditions, including seasonal trends in itch and the links with air pollution [&lt;span&gt;1, 2&lt;/span&gt;]. Mites, microscopic arthropods in the subclass Acari, are associated with various skin diseases, with demodex mites linked to rosacea [&lt;span&gt;3&lt;/span&gt;]. Given the influence of UV radiation on skin conditions, this study examines the relationship between Baidu search queries for mites, rosacea, and UV radiation levels in Shanghai, China. By analyzing the correlations between these search trends and UV exposure, we aim to uncover seasonal patterns and explore how UV radiation influences public interest in these skin concerns.&lt;/p&gt;&lt;p&gt;We extracted Baidu Index data on mites and rosacea from https://index.baidu.com/v2/index.html, and erythemal UV dose (UVD) data, as a measure of UV radiation levels, from the Tropospheric Emission Monitoring Internet Service (TEMIS) at https://www.temis.nl/uvradiation/UVdose.php. The dataset spans from January 1, 2015, to December 31, 2019.&lt;/p&gt;&lt;p&gt;Seasonal decomposition analysis with a 365-day cycle reveals strong seasonal patterns in both mite searches and UVD data. Rosacea searches trends exhibit weaker seasonality, consistent with previously reported rosacea consultation pattern [&lt;span&gt;4&lt;/span&gt;]. The steady annual increase in rosacea-related searches reflects growing public awareness and concern (Figure 1).&lt;/p&gt;&lt;p&gt;This study used Pearson correlation analysis to assess the linear relationship between two variables; however, this method does not reveal causal relationships. Therefore, the Granger causality test was applied to explore causal relationships in the time series data. Pearson correlation analysis of seasonal components revealed a strong positive correlation between UVD and mite search queries (&lt;i&gt;r&lt;/i&gt; = 0.787, &lt;i&gt;p&lt;/i&gt; &lt; 0.05), indicating that both may be influenced by similar seasonal factors. A moderate positive correlation was observed between UVD and rosacea searches (&lt;i&gt;r&lt;/i&gt; = 0.295, &lt;i&gt;p&lt;/i&gt; &lt; 0.05), suggesting an association between UV exposure and rosacea. However, the correlation between mite and rosacea queries was very weak (&lt;i&gt;r&lt;/i&gt; = 0.052, &lt;i&gt;p&lt;/i&gt; &lt; 0.05), likely due to distinct influencing factors, nonlinear relationships, or potential lag effects.&lt;/p&gt;&lt;p&gt;Granger causality tests showed that diff_UVD significantly Granger-causes diff_mite (&lt;i&gt;F&lt;/i&gt; [28, 3480] = 2.5609, &lt;i&gt;p&lt;/i&gt; = 1.246 × 10&lt;sup&gt;−5&lt;/sup&gt;), indicating that UV exposure changes predict fluctuations in public interest in mites. Additionally, diff_mite significantly Granger-causes rosacea (&lt;i&gt;F&lt;/i&gt; [14, 3564] = 5.2993, &lt;i&gt;p&lt;/i&gt; = 4.358 × 10&lt;sup&gt;−10&lt;/sup&gt;), demonstrating a strong temporal association between interest in mites and subsequent interest in rosacea. Although diff_UVD also Granger-causes rosacea (&lt;i&gt;F&lt;/i&gt; [30, 3468] = 1.487, &lt;i&gt;p&lt;/i&gt; = 0.04291), the &lt;i&gt;p&lt;/i&gt;-value is close to 0.05, suggesting a weaker predictive relationship,","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Rotational Radiofrequency-Based Technology Leads to Adipose Tissue Reduction and Contouring Effect in the Thighs, Abdomen, and Flanks”","authors":"","doi":"10.1111/jocd.70190","DOIUrl":"https://doi.org/10.1111/jocd.70190","url":null,"abstract":"<p>Santos AF, Fernández AI, Fernández LS, Zapico LH, Freitag SV. Rotational Radiofrequency-Based Technology Leads to Adipose Tissue Reduction and Contouring Effect in the Thighs, Abdomen, and Flanks. <i>Journal of Cosmetic Dermatology</i>. 2024; 23: 3263–3271. http://doi.org/10.1111/jocd.16431.</p><p>In the “Results” section of the “Abstract” of the reference article, the text “Abdomen/flanks and thighs subcutaneous fat layer thickness was significantly reduced by 8% and 6%, respectively” was incorrect. This has been corrected as follows: “Abdomen/flanks and thighs subcutaneous fat layer thickness was significantly reduced by 6% and 8%, respectively.”</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate","authors":"Koo Chul Kwon,&nbsp;Mi Jung Kim,&nbsp;Sang A. Yoon","doi":"10.1111/jocd.70195","DOIUrl":"https://doi.org/10.1111/jocd.70195","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>_L-glutamine and linoleic acid (LA) can suppress inflammatory cytokine expression; however, studies on their simultaneous application are limited due to polarity differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the effect of glutamine linoleate vesicles (QLAsomes) on skin sensitization by assessing their impact on sensitization-related protein expression, bacterial growth, and clinical efficacy in relieving skin itchiness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>After synthesizing and analyzing QLAsomes, their inhibitory effects on capsaicin-induced cytokine expression and <i>Staphylococcus aureus</i> growth were evaluated. In a double-blind clinical trial, 24 participants (ages 22–63) with sensitized skin applied 10 wt% QLAsome cream on one side and a vehicle or no cream on the other twice daily for 2 weeks. Itchiness in the elbow area was assessed using a visual analog scale and expert evaluation. Skin barrier changes were measured using transepidermal water loss (TEWL), skin erythema, and stratum corneum (SC) hydration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>QLAsomes, formed by _L-glutamine and LA through hydrogen bonding, were spherical vesicles (164.6 ± 3.1 nm). Based on the inhibitory effects of _L-glutamine and LA on inflammation-related factors, QLAsomes inhibited the capsaicin-induced expression of these factors more effectively than the individual components. IL-4 inhibition was improved by over 26%. Matrix metalloproteinase-1, which degrades collagen, showed 32% and 23% improvements compared to _L-glutamine and LA, respectively. In a clinical evaluation, 10 wt% QLAsome cream reduced itching by 45% compared to before application, which is a 67% improvement compared to placebo. Skin evaluations revealed improvements in erythema (12%), TEWL (15%), and SC hydration (19%), suggesting that QLAsomes enhance the skin barrier function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>QLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}