{"title":"Halobacteria Formula Improvement of Skin Care-A Randomized, Double-Blind, Placebo-Controlled Clinical Study.","authors":"Leong-Perng Chan, Cheng Da-Long, Ya-Ping Tseng, Chia-Hua Liang","doi":"10.1111/jocd.16648","DOIUrl":"10.1111/jocd.16648","url":null,"abstract":"<p><strong>Background: </strong>Halobacteria trueperi, an extremophilic microorganism thriving in high-salt environments, produces extracellular polysaccharides with potential anti-inflammatory and anti-aging properties. However, its clinical efficacy in skin improvement remains unclear. This study focuses on H. trueperi TCI66207, isolated from the Pacific Ocean at a depth of 662 m near Hualien, and its potential to enhance skin parameters, aiming to develop a novel functional formulation for pharmaceutical and cosmetic use.</p><p><strong>Aims: </strong>This sudy aims to evaluate the clinical efficacy of H. trueperi TCI66207 on various skin parameters and its potential for developing new functional cosmetic formulations.</p><p><strong>Patients/methods: </strong>A total of 40 subjects were recruited and randomly divided into two groups: the test group applied a serum containing H. trueperi TCI66207, while the placebo group used a basic serum. Subjects were instructed to apply the serum twice daily for 4 weeks. Skin parameters, including moisture, brightness, elasticity, pigmentation (spots and UV spots), texture, wrinkles, pores, and collagen density, were assessed before and after the 4-week application period.</p><p><strong>Results: </strong>After 4 weeks of using the H. trueperi TCI66207 serum, significant improvements were observed in all measured skin parameters compared to baseline, with notable enhancements in moisture, brightness, elasticity, texture, and collagen density, along with reductions in wrinkles, spots, and pore size.</p><p><strong>Conclusions: </strong>Halobacteria trueperi TCI66207 serum demonstrates a clear ability to improve skin conditions and delay signs of aging, making it a promising candidate for the development of new cosmetic formulations with potent anti-aging and skin-rejuvenating properties.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16648"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Akintilo, Jeremy B Green, Joely Kaufman, Bahar Ghane-Motlagh, David L Freytag, Konstantin Frank, Michael Alfertshofer, Sebastian Cotofana
{"title":"When to change needles during neuromodulator injections-An electron-microscopy investigation into needle tip deformation.","authors":"Lisa Akintilo, Jeremy B Green, Joely Kaufman, Bahar Ghane-Motlagh, David L Freytag, Konstantin Frank, Michael Alfertshofer, Sebastian Cotofana","doi":"10.1111/jocd.16506","DOIUrl":"10.1111/jocd.16506","url":null,"abstract":"<p><strong>Background: </strong>Neuromodulator injections are minimally invasive procedures performed across the globe. Despite their ubiquity, there is a dearth of information on whether and how needle tips used for neuromodulator procedures are deformed after repeated injections.</p><p><strong>Objective: </strong>We investigated the magnitude of needle tip deformation following sequential injection passes (3×, 5×, and 10×) during facial neuromodulator injections with three commonly used needle sizes (30G, 31G, and 32G).</p><p><strong>Methods: </strong>Neuromodulator was administered for four different aesthetic indications. Each collected needle was mounted and imaged in a Philips XL-30 Scanning electron microscope. Images were processed using ImageJ photo analysis software.</p><p><strong>Results: </strong>Forty-five needle tips were investigated. When comparing the facial regions of interest, a statistically significant difference in deformation percentage was found when injecting 10× (p = 0.044) with greatest damage after injecting the glabella (38.4%), followed by lateral canthus (27.9%), forehead (27.5%), and midface (23.1%). Independent of facial region targeted, the mean percentage of needle deformation at 3× was 14.8%, at 5× 19.6%, and at 10× 29.2% with p < 0.001. Smaller needle size corresponded to smaller percentage of damage.</p><p><strong>Conclusion: </strong>Exchanging needles after more than five injection passes will minimize needle deformation and likely increase injection precision.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16506"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Energy-Based Device Management of Nodular Reaction Following Poly-D, L-Lactic Acid Injection for Tear Trough Rejuvenation.","authors":"Suk Bae Seo, Jovian Wan, Kyu-Ho Yi","doi":"10.1111/jocd.16575","DOIUrl":"10.1111/jocd.16575","url":null,"abstract":"<p><strong>Background: </strong>Poly-D,L-lactic acid (PDLLA) is used for tear trough rejuvenation but can cause complications like nodular reactions. This report describes using a radiofrequency device to manage these nodules.</p><p><strong>Case presentation: </strong>A 42-year-old woman developed firm, non-inflammatory nodules 3 weeks after receiving PDLLA (Juvelook) injections in the tear trough area. The nodules were firm and not associated with erythema or tenderness.</p><p><strong>Intervention: </strong>The monopolar radiofrequency device was used directly on the nodules with 150 shots at an energy level 115 J, 28.75 J/cm². The treatment resulted in complete resolution of the nodules within 24 hours.</p><p><strong>Results: </strong>The radiofrequency treatment effectively resolved the nodular reaction without recurrence, highlighting the device's compatibility with the unique structure of Juvelook's PDLLA.</p><p><strong>Conclusion: </strong>Radiofrequency therapy is effective for managing nodular reactions following PDLLA injections. Further research is needed to optimise protocols and improve the safety of biostimulator treatments in cosmetic procedures.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16575"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anissa Zaouak, Amal Chamli, Houda Hammami, Samy Fenniche
{"title":"Earlobe Loss After Herpes Zoster Infection: An Uncommon Complication.","authors":"Anissa Zaouak, Amal Chamli, Houda Hammami, Samy Fenniche","doi":"10.1111/jocd.16642","DOIUrl":"10.1111/jocd.16642","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16642"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rehabilitation of a 13-Year History of Habitual Tic-Induced Nail Dystrophy.","authors":"Liang Chen, Zheyuan Li, Tianyi Liu","doi":"10.1111/jocd.16641","DOIUrl":"10.1111/jocd.16641","url":null,"abstract":"<p><strong>Background: </strong>Habitual tic nail dystrophy is a prevalent condition among adults; however, it has received limited scholarly attention.</p><p><strong>Aims: </strong>This study aims to report the case of habitual tic nail dystrophy with a duration of 13 years.</p><p><strong>Methods: </strong>The patient was advised to modify his lifestyle habits and was followed up regularly over the course of 1 year to assess changes in the appearance of his nails.</p><p><strong>Results: </strong>The appearance of the nails normalized during the 1-year follow-up period.</p><p><strong>Conclusions: </strong>The appearance of nails in patients with habitual tic nail dystrophy can be significantly improved through lifestyle modifications and by minimizing the stimulation of the nail matrix.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16641"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana El Hawa, William Abou Shahla, Callie Fares, Dana Saade
{"title":"Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections.","authors":"Mariana El Hawa, William Abou Shahla, Callie Fares, Dana Saade","doi":"10.1111/jocd.16624","DOIUrl":"10.1111/jocd.16624","url":null,"abstract":"<p><strong>Background: </strong>The demand for aesthetic procedures aimed at restoring and preserving a youthful appearance is growing. While numerous non-surgical facial rejuvenation techniques are available, there is a need for a comprehensive review of clinic-based procedures targeting non-facial body parts.</p><p><strong>Aims: </strong>This review aims to describe and evaluate clinic-based techniques for rejuvenating the neck, chest, and hands, focusing on various types of fillers and other non-invasive procedures.</p><p><strong>Methods: </strong>In this first part of this review, we conducted an extensive literature review on PubMed, reporting the effectiveness of different fillers, detailing their preparation, required volume per area, injection methods, durability, and any associated side effects. We also discuss the use of mesotherapy, microneedling, chemical peeling, and Profhilo in these specific body areas.</p><p><strong>Conclusion: </strong>The review synthesizes the latest data on the effectiveness and safety of these procedures, highlighting the advancements in filler technology and the growing popularity of non-invasive techniques for body rejuvenation. This article serves as a valuable resource for practitioners and patients interested in non-surgical body rejuvenation, providing insights into the best practices.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16624"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minjia Yuan, Lili Hu, Cuicui Zhu, Qi Li, Hang Tie, Haihua Ruan, Tao Wu, Hongyang Zhang, Liang Xu
{"title":"Comparison and Assessment of Anti-Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine-Encapsulated EGCG.","authors":"Minjia Yuan, Lili Hu, Cuicui Zhu, Qi Li, Hang Tie, Haihua Ruan, Tao Wu, Hongyang Zhang, Liang Xu","doi":"10.1111/jocd.16628","DOIUrl":"10.1111/jocd.16628","url":null,"abstract":"<p><strong>Aim: </strong>To compare and evaluate the differences between EGCG and phosphatidylcholine-encapsulated EGCG in terms of their anti-inflammatory and antioxidant capacities.</p><p><strong>Methods: </strong>In this study, transdermal absorption experiments were conducted to compare the absorption capacity of EGCG and phosphatidylcholine-encapsulated EGCG. Subsequently, the disparity in anti-inflammatory and antioxidant efficacy between EGCG and phosphatidylcholine-encapsulated EGCG were evaluated through cytotoxicity experiments, as well as the determination of cellular inflammatory factors and the measurement of ROS content under different treatment conditions.</p><p><strong>Results: </strong>The concentration of EGCG, encapsulated in phosphatidylcholine, in porcine skin is 40.76 ± 1.29 μg/cm<sup>2</sup>, which is significantly higher than the concentration of EGCG alone (31.62 ± 2.01 μg/cm<sup>2</sup>). Also, the ability of phosphatidylcholine-encapsulated EGCG to suppress inflammatory factors such as tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) was notably superior to that of EGCG alone. Both phosphatidylcholine-encapsulated EGCG and EGCG showed excellent ROS scavenging ability in terms of antioxidant capacity.</p><p><strong>Conclusion: </strong>The percutaneous absorption and anti-inflammatory impact of EGCG encapsulated within phosphatidylcholine were substantially enhanced when compared to EGCG by itself. Additionally, both formulations exhibited enhanced ROS scavenging capacities, albeit the variance between them was not pronounced. These insights furnish a vital theoretical underpinning for the utilization of phosphatidylcholine-encapsulated EGCG in cosmetic applications, specifically for fostering products with anti-inflammatory and antioxidant benefits.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":"e16628"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of Pathogenesis and Trends in the Treatment of Melasma in Last Two Decades.","authors":"Rashmi Sarkar, Aanchal Bansal, Michael Gold","doi":"10.1111/jocd.16758","DOIUrl":"10.1111/jocd.16758","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":"e16758"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring Complementary and Alternative Medicine Use for the Management of Acne Vulgaris Among University Students: Forms, Trends, and Information Sources.","authors":"Sari Taha, Manal Taha, Sa'ed H Zyoud","doi":"10.1111/jocd.16775","DOIUrl":"https://doi.org/10.1111/jocd.16775","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a common skin disease that has physical and psychological impacts. Patients diagnosed with acne often use complementary and alternative medicine, despite the insufficient evidence.</p><p><strong>Aims: </strong>This cross-sectional study sought to identify the types, trends in and reasons for utilizing complementary and alternative medicine for acne among university students.</p><p><strong>Patients/methods: </strong>The study was conducted among health sciences students from March to June, 2023, using clinical examination and a questionnaire. All participants were assessed for a diagnosis of acne.</p><p><strong>Results: </strong>The final sample size consisted of 367 participants, of whom 68.9% were females and 31.1% were males. The study revealed a high prevalence of acne (74.4%). Among those with acne, 59.7% reported using complementary and alternative medicine, with the biological forms being most frequent at 90.2%. The reasons commonly stated for using complementary and alternative medicine were lack of severity (48.5%) and the potential for internet-based self-treatment (33.1%). The main sources of information were the internet (44.8%) and social media (41.1%). Age, gender, and the occurrence of acne on the chin were associated with complementary and alternative medicine use (p < 0.05).</p><p><strong>Conclusions: </strong>The use of complementary and alternative medicine for treating acne is widespread, with a tendency toward biological forms. Healthcare practitioners should be familiar with the patterns of complementary and alternative medicine use for the treatment of acne to better meet patient needs and concerns. Policymaking can leverage the role of online resources in addressing the use of unconventional treatment modalities.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":"e16775"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comprehensive Study on Adverse Reactions of Benzoyl Peroxide (BPO) in Dermatological Aesthetics Utilizing the FAERS Database.","authors":"Siyuan Zhou, Su Yan, Shaopeng Ming","doi":"10.1111/jocd.16787","DOIUrl":"10.1111/jocd.16787","url":null,"abstract":"<p><strong>Background: </strong>Benzoyl peroxide (BPO) is widely used in dermatological aesthetics for treating acne and other skin conditions. However, its potential adverse reactions remain a concern.</p><p><strong>Aims: </strong>This study aimed to investigate the application of BPO in dermatological aesthetics, analyze its associated adverse reactions, and provide insights into patient safety.</p><p><strong>Methods: </strong>The study analyzed adverse reaction reports related to BPO in the Food and Drug Administration's Adverse Event Reporting System database from 2004 to 2024. Demographic characteristics, types of adverse reactions, and specific issues related to the novel drug EPSOLAY (5% microencapsulated BPO) were examined.</p><p><strong>Results: </strong>The findings reveal that BPO users are predominantly female (74.18%), with a significant proportion falling within the 18-44 age group (37.45%). The most common adverse reactions involve skin and subcutaneous tissue disorders (36.34%), including skin swelling, pain, and burning sensations. Reports on EPSOLAY indicate adverse reactions such as erythema, pruritus, and skin exfoliation, but no tumor-related reports have been recorded.</p><p><strong>Conclusions: </strong>BPO usage in dermatological aesthetics is associated with various adverse reactions, primarily affecting the skin. The introduction of EPSOLAY has not altered the adverse reaction profile significantly. However, the risk of BPO decomposing into the carcinogen benzene under certain conditions necessitates enhanced patient education, improved production processes, and continuous post-marketing surveillance to ensure drug safety.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":"e16787"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}