Journal of Cosmetic Dermatology最新文献

{"title":"Evaluating the Efficacy of Acupotomy Subcision and Hyaluronic Acid Injections for Neck Wrinkles: A Randomized Trial","authors":"Taolue Ni,&nbsp;Fang Ren,&nbsp;Tianqi Zhang,&nbsp;Dong Hua,&nbsp;Gang Chen,&nbsp;Hao Chen","doi":"10.1111/jocd.70214","DOIUrl":"https://doi.org/10.1111/jocd.70214","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Horizontal neck wrinkles are a prevalent sign of aging, with emerging research highlighting the effectiveness of treatments such as acupotomy subcision (AS) and hyaluronic acid (HA) injections in rejuvenating aged skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aims to evaluate and compare the efficacy of three distinct treatment modalities for neck wrinkles: AS, HA injections, and a combination of both. The primary objective is to determine which treatment approach offers the most effective and satisfactory outcomes in terms of wrinkle reduction and skin rejuvenation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this randomized clinical trial, 30 female participants with neck Allergan Transverse Neck Lines Scale (ATNLS) scores ranging from 3 to 4 were randomly allocated into three treatment groups: AS, HA, and AS+HA. Each participant received treatment once a month for 3 months, followed by clinical assessments at 1 month and 6 months posttreatment. The assessments included ATNLS scores, Global Aesthetic Improvement Scores (GAIS), and analysis of skin elasticity and collagen levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All treatment groups demonstrated improvements in ATNLS scores and GAIS after the final treatment. Notably, the AS+HA group showed a significantly higher number of participants reporting beneficial results at the 6-month follow-up. This group also exhibited a statistically significant increase in skin elasticity and collagen levels compared to the other groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combined approach of HA and acupotomy subcision is effective in treating horizontal neck wrinkles, leading to significant improvements in skin elasticity and collagen levels. This study suggests that the synergistic effect of AS and HA may enhance the overall efficacy of treatments for reducing neck wrinkles, providing a promising option for patients seeking noninvasive neck rejuvenation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Generic Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream Compared With TRI-LUMA for the Treatment of Moderate-To-Severe Melasma in Chinese Patients: A Randomized, Single-Center, Placebo-Controlled Trial","authors":"Honghua Hu,&nbsp;Pengfei Zhou,&nbsp;Hongliang Yao,&nbsp;Chengyao Zhu,&nbsp;Bo Shen,&nbsp;Bo Feng,&nbsp;Xiangke Yu,&nbsp;Lunfei Liu","doi":"10.1111/jocd.70205","DOIUrl":"https://doi.org/10.1111/jocd.70205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Treatment with fluocinolone acetonide, hydroquinone, and tretinoin cream is the gold standard for melasma; however, the effects of this treatment in the Chinese population remain unclear. Due to the differences between Chinese and Caucasian subjects, further clinical trials in Chinese patients with melasma are needed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of fluocinolone acetonide, hydroquinone, and tretinoin creams in Chinese patients with moderate-to-severe melasma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We recruited 53 patients who received a generic formulation (triple combination cream, TCC), brand formulation (TRI-LUMA), or placebo once daily for 8 weeks. In weeks 4 and 8, efficacy was evaluated based on the Melasma Severity Scale and Melasma Area and Severity Index. In addition, safety was assessed based on the incidence and severity of treatment-emergent adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The generic TCC group achieved 52.2% efficacy compared to 57.1% in the TRI-LUMA group. There was no significant difference in the incidence of adverse effects between the TCC and TRI-LUMA groups (69.6% and 90.5%, respectively; <i>p</i> &gt; 0.05). The incidence of adverse events in the placebo group was 0%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Generic TCC was as effective as TRI-LUMA and had a similar safety profile in this study of Chinese subjects with moderate-to-severe melasma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iCare Technique of Dissolving Ellanse M Nodules Using Collagenase: A Case Series and Experimental Study","authors":"Larry Wu","doi":"10.1111/jocd.70201","DOIUrl":"https://doi.org/10.1111/jocd.70201","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ellanse is a polycaprolactone-based collagen stimulator that is rarely associated with the formation of palpable nodules. The current management of palpable nodules include triamcinolone injection, consumption of oral methotrexate, and surgical excision. The absence of an effective reversal agent that is safe has limited the popularity of Ellanse as a facial rejuvenation modality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This article presents a dual focus (1) a case series demonstrating the efficacy of the iCare technique in treating 10 nodules from Ellanse M treatment in three patients and (2) an experimental study investigating the in vitro and in vivo dissolution of Ellanse M aliquots. In the case series, nodules, which have persisted for an average of 2 years following initial Ellanse M treatment, are effectively managed with the iCare technique. The iCare technique of dissolution involves injecting a collagenase mixture that is five times the initial injected volume of Ellanse. The case series finding demonstrates the iCare technique as a viable solution in managing Ellanse-associated nodules. An allergy test is also conducted prior to injection of collagenase mixture to demonstrate the safety of collagenase mixture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Experimental Study</h3>\u0000 \u0000 <p>An experiment is conducted by mixing 0.1 mL Ellanse M aliquots with 0.5 mL collagenase mixture (Slide X). Controls are provided by adding 0.5 mL of lignocaine 2% and adrenaline 1:80 000 (Slide L), 0.5 mL hyaluronidase (Slide H), 0.5 mL of 40 mg/mL of triamcinolone (Slide T) separately to 0.1 mL Ellanse M aliquots.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ellanse M is converted from a gel into a solution by collagenase mixture (X) while it is not affected by lignocaine and adrenaline (L), hyaluronidase (H), or triamcinolone (T). The conversion of Ellanse gel into a solution occurs within 5 min of adding the mixture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The case series demonstrates the iCare technique's efficacy in addressing delayed onset nodules associated with Ellanse treatment. The experimental study demonstrates in vitro and in vivo dissolution of injected Ellanse aliquots. This article offers a promising solution to significant issues associated with Ellanse treatment—namely, the formation of nodules and the lack of an effective fast-acting reversal agent.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Prevalence of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis”","authors":"","doi":"10.1111/jocd.70207","DOIUrl":"https://doi.org/10.1111/jocd.70207","url":null,"abstract":"<p>\u0000 <span>Pérez-Buenfil, A</span>, <span>Morales-Sánchez, A</span>. <span>Prevalence of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis</span>. <i>J Cosmet Dermatol.</i> <span>2025</span> Apr; <span>24</span>(<span>4</span>):e70121. https://doi.org/10.1111/jocd.70121. PMID: 40200598; PMCID: PMC11979448.\u0000 </p><p>ORCID: https://orcid.org/0000-0002-9601-4516</p><p>First Name: Luis Angel</p><p>ORCID: https://orcid.org/0000-0002-1180-6750</p><p>First Name: Martha Alejandra</p><p>Last Name: Morales-Sánchez</p><p>The citation will be: <b>Pérez-Buenfil LA, Morales-Sánchez MA</b>. Prevalence of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis.</p><p>We apologize for this error, and these corrections were previously submitted through the Wiley system during the proof revision stage.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Electrotrichogenic Device Promotes Hair Growth in Men With Androgenetic Alopecia: A Pilot Study","authors":"Samuel Jellard,&nbsp;Stephanie Moore,&nbsp;Carlos Andrés Chacón-Martínez","doi":"10.1111/jocd.70202","DOIUrl":"https://doi.org/10.1111/jocd.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Androgenetic alopecia (AGA) is the most common cause of hair loss globally, affecting millions of people, particularly men. Current treatments include FDA-approved drugs and devices, but many patients experience side effects or suboptimal results. The niostem device is a new, wearable device that delivers low-level electrical stimulation to promote hair growth. This pilot study aims to evaluate the efficacy and safety of the niostem device in male AGA patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 21 male patients with AGA used the niostem device daily for 30 min over 6 months. Participants had not used any anti-hair loss products within the 6 months preceding the start of the study. Hair density, thickness, and terminal hair counts were assessed at baseline, 3 months, and 6 months using trichoscopic measurements. Patient-reported outcomes were recorded, and adverse events were monitored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The niostem device resulted in significant increases in hair count, with a 12% increase in total hair density at 3 months and a 19.3% increase at 6 months. Hair thickness also increased by 8.8% in 6 months. Terminal hair density improved significantly over time, with visible hair growth observed in the participants. No adverse events were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The niostem device demonstrated a significant increase in hair density and hair thickness in male AGA patients, with no adverse effects. Further large-scale studies are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Yan Bian,&nbsp;Chi Zhang,&nbsp;Shaohua Wang,&nbsp;Lili Zhang,&nbsp;Hong Cai","doi":"10.1111/jocd.70191","DOIUrl":"https://doi.org/10.1111/jocd.70191","url":null,"abstract":"<p>The cover image is based on the Article <i>A Rare Case of Delayed-Onset Hypersensitivity Reaction and Complete Secondary Treatment Failure Following Repeated Cosmetic Botulinum Toxin Type A Injections</i> by Yan Bian et al., https://doi.org/10.1111/jocd.70145.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Impact of Pediatric and Adolescent Hyperhidrosis: A Systematic Review and Call for Research","authors":"Sheila Sharifi,&nbsp;Mohammad Jafferany","doi":"10.1111/jocd.70213","DOIUrl":"https://doi.org/10.1111/jocd.70213","url":null,"abstract":"&lt;p&gt;Hyperhidrosis is characterized by excessive sweating of the axilla, palms, soles, and face, estimated to affect 3% of the United States population [&lt;span&gt;1&lt;/span&gt;]. The disease extends beyond physical impairment, significantly impacting daily functioning and psychosocial well-being. The onset of primary hyperhidrosis is thought to be during the adolescent years or earlier, although studies examining the psychological impacts of the disease in pediatric and adolescent populations remain limited [&lt;span&gt;1&lt;/span&gt;]. This systematic review is the first to synthesize and evaluate the literature on the psychosocial effects of primary hyperhidrosis in these populations.&lt;/p&gt;&lt;p&gt;A search of the PubMed, EMBASE, and Web of Science databases was conducted using the search terms “pediatric hyperhidrosis” or “childhood hyperhidrosis” or “adolescent hyperhidrosis” and “psychosocial” or “mental health” or “psychological” or “emotional” or “social impact” or “quality of life” or “self-esteem” or “anxiety” or “depression” or “well-being” or “social functioning.” After removal of duplicate articles, our search yielded 277 studies for screening. Studies were included if they discussed the appropriate topic, were the correct study type (e.g., clinical trials, cohort studies, case–control studies, cross-sectional studies, case reports, case series, or interview studies), and were published in peer-reviewed journals in English. Exclusion criteria consisted of studies irrelevant to the topic, incorrect publication types (i.e., review articles, commentaries, protocols, or letters to the editor), and publications in languages other than English. Ultimately, 12 studies were included in our review, from which data was extracted and synthesized. Quality assessment included validating study methodologies, population characteristics and any diagnostic tools used for psychological diagnoses. A PRISMA diagram is outlined in Figure 1, with detailed findings of each study in Table 1.&lt;/p&gt;&lt;p&gt;Our results highlight that the majority of pediatric and adolescent patients with primary hyperhidrosis report severe impacts on quality of life and emotional well-being [&lt;span&gt;2, 3&lt;/span&gt;]. Specific symptoms include poor interpersonal functioning, personal isolation and loneliness, issues with work or school-related tasks, perceived stigma, and high social visibility [&lt;span&gt;3-5&lt;/span&gt;]. A cross-sectional study of 1671 pediatric and adolescent patients with chronic skin conditions found that children with hyperhidrosis had the highest rates of depression (40.9%) and anxiety (31.8%) [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Studies have examined the psychosocial benefits of treatment options, including anticholinergics, neurotoxins, and surgery. Within a cohort of 121 adolescents, Glaser et al. demonstrated that OnabotulinumtoxinA significantly improved emotional distress (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) [&lt;span&gt;2&lt;/span&gt;]. Thoracic sympathectomy, typically reserved for refractory disease, also enhanced psychosocial functionin","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Dosing Matters: A Closer Look at the Dose–Response Relationship With OnabotulinumtoxinA","authors":"Wolfgang G. Philipp-Dormston,&nbsp;John H. Joseph,&nbsp;Jean D. A. Carruthers,&nbsp;John P. Fezza,&nbsp;Mansi Mukherjee,&nbsp;Ahmed Yasin,&nbsp;Maria Musumeci","doi":"10.1111/jocd.70170","DOIUrl":"https://doi.org/10.1111/jocd.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>OnabotulinumtoxinA is licensed in many countries for simultaneous treatment of three areas of the upper face: glabellar lines, 20 U; lateral canthal lines, 24 U; and forehead lines, 20 U.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To assess the onabotulinumtoxinA dosing science and dose–response relationship in the treatment of upper facial lines (UFL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Key practical questions are addressed using available data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>OnabotulinumtoxinA doses were selected for Phase 3 registrational trials based on rigorous dose-ranging studies. In clinical practice, it is important to consider the relationship between dose and efficacy outcomes, duration, and safety. Interstudy comparison of duration analyses is complicated by the lack of a single comprehensive definition, but trial data with standard onabotulinumtoxinA dosing in the glabella suggest a median effect duration of ~4 months. Treatment of UFL at below the approved dose is associated with a shorter duration, inferior response rates, and lower patient satisfaction; there is no evidence that underdosing reduces adverse event risk. It may therefore be advisable to avoid going below the licensed dose unless there is a clear clinical rationale. By contrast, there is growing evidence that treatment outcomes can be further improved using doses above those currently licensed, without adversely affecting safety—as demonstrated in the glabella. Further studies are needed to assess this in lateral canthal and forehead lines. Additional work is also required to examine potential ceiling doses and better understand the dose–response relationship in patient subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Appropriate dosing of onabotulinumtoxinA is essential for maximizing benefit and ensuring patient satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Center Clinical Trial to Evaluate the Efficacy of the Next Generation TriHex Technology Antiaging Regimen","authors":"Michael Gold,&nbsp;Charles Boyd,&nbsp;Deanne Mraz,&nbsp;Tiffany Robison,&nbsp;Faiza Shafiq,&nbsp;Alan D. Widgerow","doi":"10.1111/jocd.70192","DOIUrl":"https://doi.org/10.1111/jocd.70192","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alastin Restorative Skin Complex Serum with TriHex Technology (Alastin Skincare Inc., Carlsbad, CA) has undergone reformulation to add Octapeptide-45 and magnolol for improving facial skin hydration, elasticity, plumping, and overall skin quality. Detailed science on TriHex Technology 2.0 and magnolol has been recently published. This open-label study was conducted to validate the science and demonstrate product efficacy and tolerability in individuals with moderate to severe facial skin aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multi-center clinical study was conducted from February to August 2024. A total of 44 eligible participants (43 female, 1 male), ages 35–69 years, and Fitzpatrick skin Types I–VI were enrolled in and completed the study following 12 weeks of Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology (RSC 2.0) use twice daily, along with an Alastin Skincare Inc. supportive regimen (cleanser, moisturizer, sunscreen used as needed). A 1-week run-in phase using the supportive regimen only was conducted, and eligibility was reassessed at baseline. Follow-up visits were performed at Weeks 4, 8, and 12, where facial skin quality parameters were evaluated clinically and subject assessments and satisfaction questionnaires, biopsy collection, photography, and hydration and elasticity measurements were completed. Participants also maintained a study diary over the 12-week treatment period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant improvements for all clinically evaluated facial skin parameters were achieved at Week 12. Histology revealed increased stimulation of new adipocytes, epidermal keratinocyte HA (CD44), and new dermal collagen and elastin fibers post treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology has been demonstrated to be safe and effective for improving overall facial skin quality, achieving notable improvements in volume, plumping, hydration, and extracellular matrix (ECM) collagen and elastin stimulation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Evaluation of Androgenetic Alopecia: Demographic Characteristics, Psychosocial Impact, and the Role of Social Media in Treatment Choices","authors":"Arzu Ferhatosmanoğlu,&nbsp;Zeynep Karaca Ural,&nbsp;Leyla Baykal Selçuk,&nbsp;İbrahim Etem Arıca,&nbsp;Deniz Aksu Arıca","doi":"10.1111/jocd.70167","DOIUrl":"https://doi.org/10.1111/jocd.70167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Androgenetic alopecia (AGA) has a significant psychosocial impact on both genders. This study investigated AGA severity, psychosocial burden, sociodemographic factors, and the influence of social media on treatment-seeking behavior.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 390 patients diagnosed with AGA at a university hospital in Turkey between January 2023 and 2024 were included. Data on disease severity, psychological impact, treatment awareness, and social media engagement were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean AGA onset age was 23.9 years in men and 29.46 years in women. Severe AGA was observed in 38.5% of men and 41% of women, with men experiencing significantly higher emotional and functional distress (<i>p</i> = 0.05, <i>p</i> = 0.003). Early-onset AGA (before age 20) was associated with increased psychological distress, including higher emotion, function, and stigma scores, along with lower self-confidence (<i>p</i> = 0.007, <i>p</i> &lt; 0.001, <i>p</i> = 0.037, <i>p</i> &lt; 0.001). Social media was used by 69.3% of participants for hair loss information, mainly on Google, Instagram, and TikTok, but had no significant impact on treatment choices (<i>p</i> = 0.971) or psychological distress (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AGA significantly affects psychological well-being, particularly in men with severe hair loss and individuals with early-onset AGA. While social media is a primary information source, it does not influence treatment decisions or psychological distress. These findings highlight the need for evidence-based digital health communication to counter misinformation. Future research should examine the long-term psychological effects of AGA and further explore the role of social media in patient education and treatment behaviors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}