Journal of Cosmetic Dermatology最新文献

{"title":"Innovative Classification of M-Shaped Lips for Enhanced Refill Outcomes: A Case Series","authors":"Dina Moctezuma Villalobos","doi":"10.1111/jocd.70239","DOIUrl":"https://doi.org/10.1111/jocd.70239","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lips are crucial to facial aesthetics, with fuller lips often deemed more attractive. This preference has led to increased demand for non-surgical lip augmentation using dermal fillers. However, there is a gap in the literature regarding the identification and management of a particular anatomical variant colloquially known as “M-shaped lips”, characterized by a central “M” configuration of the upper lip. This anatomical variant presents unique complexities. This study presents the first classification system for M-shaped lips to guide safer, more predictable treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To introduce the first classification system for M-shaped lips, improving diagnostic accuracy, treatment strategies, and minimizing complications in cosmetic lip augmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A case series of nine patients aged 20–45 with M-shaped lips seeking cosmetic augmentation were treated with Aliaxin LV, a hyaluronic acid filler, in multiple sessions. The proposed classification system was based on the angle between the vertical and horizontal midlines of the lips, including three grades: mild (≤ 15°), moderate (16°–25°), and severe (&gt; 25°). Injection techniques and filler volumes were tailored according to patient classification using needles and cannulas for precise placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The classification system facilitated personalized treatments, resulting in satisfactory aesthetic outcomes without significant complications. All the patients showed improved lip symmetry and volume, with no instances of filler migration or vascular complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings suggest that this classification system can significantly improve cosmetic results and reduce risks in treatment. Larger studies with more diverse populations and extended follow-up are needed to validate these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant Type III Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case Series","authors":"Xiaoguang Duan,&nbsp;Chunmei Ding,&nbsp;Jiewei Wu,&nbsp;Weiwei Bao,&nbsp;Yu Gao,&nbsp;Fei Liu,&nbsp;Wei Cai","doi":"10.1111/jocd.70226","DOIUrl":"https://doi.org/10.1111/jocd.70226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Facial erythema and acne scarring are common skin conditions that significantly impair quality of life, necessitating effective treatment options, particularly in Asian populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of intradermal injections of recombinant type III humanized collagen (RhCol-III) solution for alleviating facial erythema, improving skin texture associated with acne scarring, and evening out skin tone issues associated with post-inflammatory hyperpigmentation (PIH) from acne while also searching for potential underlying anti-inflammatory mechanisms of the RhCol-III solution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This case series included six Chinese participants with Fitzpatrick phototypes III/IV, presenting with facial erythema and/or acne scarring. Participants received intradermal injections of 2 mg/mL RhCol-III solution at baseline, 30- and 60- days post-baseline. Clinical evaluations were conducted using VISIA photography and self-assessed Global Aesthetic Improvement Scale (GAIS) scores. Additionally, in vitro testing was performed using the U937 cell line with lipopolysaccharide (LPS) induction to assess the anti-inflammatory effects of the RhCol-III solution on tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) secretion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All participants demonstrated a reduction in facial erythema post-treatment, with significant improvements noted in the zygomatic area. The mean erythema area decreased by 49.3% after 90 days. One case with acne scarring showed visible improvement in scar appearance, skin tone, and texture. Moreover, 0.10 mg/mL RhCol-III solution significantly reduced TNF-α and IL-6 levels in vitro by up to 47.75% and 44.96%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RhCol-III solution injections effectively reduced facial erythema and have the potential to improve acne scarring via reduction in the extent of PIH in this series of Chinese cases. The treatment was well-tolerated, with no significant adverse effects. These findings suggest RhCol-III solution as a promising therapeutic option for skin repair and inflammation reduction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Plasma Treatment for Photoaged Facial Skin: An Investigator-Blinded, Split-Face, Non-Inferiority Trial","authors":"Blanca Estupiñan,&nbsp;Karen Ly,&nbsp;David J. Goldberg","doi":"10.1111/jocd.70208","DOIUrl":"https://doi.org/10.1111/jocd.70208","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet-rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To compare the efficacy and safety of adipose mesenchymal stem cell-derived (ASC) exosomes versus platelet-rich plasma for photoaged facial skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An investigator-blinded, split-face trial was conducted. Participants with mild to moderate photoaging underwent three radiofrequency microneedling treatments with PRP and topical exosomes each applied to one half of the face.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both exosomes and PRP equally improved wrinkling, dyschromia, erythema, texture, and overall skin appearance. Histological analysis confirmed increased collagen I and glycosaminoglycans, without significant differences between treatment arms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ASC exosomes are a promising PRP-alternative that may be attractive to needle-averse patients and can hasten the office visit duration, as phlebotomy and centrifugation are not required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Assessing Efficacy and Satisfaction of CE Ferulic Serum Following Nonablative Fractional Fraxel Laser Treatment for Photoaging Skin in Chinese Population","authors":"Xiaolei Qin,&nbsp;Jinlong Zhai,&nbsp;Chenxi Zhou,&nbsp;Yanmei Wang,&nbsp;Mengjiao Chen,&nbsp;Lin Zhu,&nbsp;Qi Shi,&nbsp;Weiliang Chen,&nbsp;Liyuan Zhang,&nbsp;Xiao Luo,&nbsp;Kai Li","doi":"10.1111/jocd.70251","DOIUrl":"https://doi.org/10.1111/jocd.70251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Following Nonablative fractional Fraxel laser (NAFL), a well-established treatment for skin rejuvenation, immediate post-procedural care is essential to address any potential complications and accelerate the healing process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy and patient satisfaction of a topical skincare regimen containing vitamin C, vitamin E, and ferulic acid—CE Ferulic serum (CEF) following NAFL treatment in the Chinese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this randomized, investigator-blinded, split-face, controlled trial, patients with mild-to-moderate facial photodamage were randomized to receive CEF treatment on one side of the face and normal saline (NS) on the other side immediately after the NAFL procedure and daily during the 7-day follow-up. The primary endpoint was the change from baseline in erythema score on Day 7, with key secondary endpoints including changes from baseline in erythema index (EI), melanin index (MI), transepidermal water loss, skin hydration, skin sebum content, scabbing, edema, overall patient satisfaction, and post-procedure pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 50 patients (female 45/50) were enrolled in this study, with a mean age of 31.6 years. The mean change from baseline in erythema score was significantly lower on the CEF side than on the NS side on Day 7 post-NAFL treatment (0.04 ± 0.40 vs. 0.18 ± 0.48, <i>p</i> = 0.011). The CEF side also exhibited improved changes in EI, MI, and skin hydration, as well as higher overall satisfaction and less pain compared with the NS side.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Applying CEF after NAFL treatment reduced erythema progression, maintained skin hydration, and promoted the healing process compared with NS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Chinese Clinical Trial Registry: ChiCTR2300069246</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of a Highly Purified Polynucleotide for Dry and Chapped Lips: A Prospective, Multicenter Study","authors":"Nark Kyung Rho,&nbsp;Hyun Jun Park,&nbsp;Hei Sung Kim","doi":"10.1111/jocd.70224","DOIUrl":"https://doi.org/10.1111/jocd.70224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dry and chapped lips are a common nuisance. Besides the discomfort, many report feeling embarrassed over the unsightly appearance of their chapped lips. The aim of this study was to determine if polynucleotide (PN) injection helps relieve lip dryness and assess safety in practicing PN in this specific area.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective study, 30 Korean subjects with dry and chapped lips enrolled to receive PN injection on the vermilion zone (a total of 3 injections, each 3 weeks apart). Vermilion wrinkle and roughness were scored based on the photos taken pretreatment (week 0); before the 2nd and 3rd injection (week 3, week 6); and 3 weeks after the 3rd injection (week 9) using the respective severity rating scales. Safety data were obtained throughout the study period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 27 individuals completed the study. PN significantly improved both the vermilion wrinkles (assessed by the Wrinkle Severity Rating Scale (WSRS)) and roughness (assessed by the Lip Roughness Grading Scale (LRGS)) at all time points compared to baseline (<i>p</i> &lt; 0.05). The WSRS response rate (Ratio of subjects whose WRSR decreased by ≥ 1 point compared to baseline) at week 9 was 100%. Lip swelling was experienced by all subjects when examined 30 min after PN injection, followed by pain (90%) and redness (77%). The injection site adverse reactions were mostly mild and transient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results suggest that PN may be a promising option to soothe dry and chapped lips. However, larger studies with long-term follow-up are necessary to confirm the preliminary findings of this study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Frequency Ultrasound Assessment of Skin Thickness Following Lipofilling in Facial Sclerosing Dermatoses: A Case Series","authors":"Sofia Gomez-Martinez,&nbsp;Irene Fuertes,&nbsp;Ada Ferrer Fuertes,&nbsp;Francisco Javier Cuesta Gonzalez,&nbsp;Carlos Martí Pagés,&nbsp;Gema M. Lledó-Ibáñez,&nbsp;Gerard Espinosa,&nbsp;Monica Quintana-Codina,&nbsp;Maribel Iglesias Sancho,&nbsp;M. Dolores Cembrano,&nbsp;Xavier Bosch-Amate,&nbsp;José-Manuel Mascaró,&nbsp;Priscila Giavedoni","doi":"10.1111/jocd.70229","DOIUrl":"https://doi.org/10.1111/jocd.70229","url":null,"abstract":"&lt;p&gt;Facial sclerosing inflammatory dermatoses (FSD) are characterized by irreversible dermal and subcutaneous tissue loss, leading to cosmetic and functional impairment [&lt;span&gt;1&lt;/span&gt;]. Autologous fat grafting or lipofilling improves contour irregularities in facial morphea by restoring volume and promoting tissue remodeling through adipose-derived stem cell activity [&lt;span&gt;2, 3&lt;/span&gt;]. High-frequency cutaneous ultrasound (HFU) is a non-invasive and accessible tool that objectively asseses dermal and subcutaneous tissue thickness and disease activity through echogenicity and vascularity [&lt;span&gt;4, 5&lt;/span&gt;]. We present a multicenter retrospective series of eleven patients with facial atrophy due to progressive facial hemiatrophy (&lt;i&gt;n&lt;/i&gt; = 6), morphea “en coup de sabre” (&lt;i&gt;n&lt;/i&gt; = 2), lupus panniculitis (&lt;i&gt;n&lt;/i&gt; = 2), and dermatomyositis (&lt;i&gt;n&lt;/i&gt; = 1) who underwent lipofilling according to the Coleman technique (median age 44.5 years, IQR 30–52, 81% female; Table 1). The number of lipofilling sessions ranged from one to five, based on clinical evaluation of atrophy. Informed consent was obtained from all participants. HFU was performed at baseline and at a median of 3.1 months after the final lipofilling in all patients, with an additional evaluation at 4.2 months after the first session in nine patients. Ultrasound measurements, acquired with a MyLab Class C Esaote instrument (Genova, Italy) and a 18–22 MHz probe, included thickness from the epidermis to the bone and Doppler activity (Figure 1b,d). Tissue loss was expressed in millimeters and as a percentage relative to the unaffected side, considered 100%. In the dermatomyositis case with bilateral loss, final thickness after the last lipofilling was set at 100% due to complete aesthetic restoration (Figure 1a,c). Statistical analysis was performed using Wilcoxon signed-rank tests in R (version 4.4.0, R Core Team, 2023). The median tissue thickness on the affected side increased from 50% of the unaffected side at baseline (IQR 47–57) to 83% after the final lipofilling session (IQR 74–100; &lt;i&gt;p&lt;/i&gt; &lt; 0.01). In the subgroup of patients with HFU available after the first procedure, median thickness of the affected side increased from 82% after the first lipofilling (IQR 77–94) to 100% after the last session (IQR 99–100; &lt;i&gt;p&lt;/i&gt; = 0.01). The cheek showed the highest average thickness increase (5.04 mm, &lt;i&gt;p&lt;/i&gt; &lt; 0.01), followed by the malar area (3.4 mm, &lt;i&gt;p&lt;/i&gt; = 0.02) and forehead (2.34 mm, &lt;i&gt;p&lt;/i&gt; = 0.03), while the increase in the chin (2.32 mm, &lt;i&gt;p&lt;/i&gt; = 0.06) was not significant. HFU revealed hypoechogenicity or mixed echogenicity in the subcutaneous layer of the treated areas, with poorly defined margins and a loss of clear dermal–subcutaneous differentiation. We did not observe increased vascularization, signs of fat necrosis or cyst formation in any patients. To our knowledge, this is the first study to evaluate lipofilling outcomes in FSD using HFU. In this procedure, facia","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Removal of Unsatisfactory Eyebrow Permanent Cosmetic Pigmentation on the Quality of Life – WHOQOL-BREF-Based Study","authors":"Weronika Pióro,&nbsp;Bogusław Antoszewski,&nbsp;Anna Kasielska-Trojan","doi":"10.1111/jocd.70233","DOIUrl":"https://doi.org/10.1111/jocd.70233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The appearance of the periorbital area can be improved with eyebrow permanent makeup (PMU); however, the effect is not always acceptable, and the patient may seek to remove it. This study aimed to confirm whether the removal of unsatisfactory eyebrow PMU influences quality of life, and to analyze the factors related to any improvement in quality of life after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 75 participants recruited consecutively (mean age: 42.8 ± 10 years); all were female, with Fitzpatrick skin type I-III, who accomplished PMU removal in one Clinic. During an initial visit, the patients indicated their demographic data, motivation, and reasons for dissatisfaction with PMU in a questionnaire and completed the WHO quality of life brief form (WHOQOL-BREF). Two treatment modes were implemented: laser treatment or laser plus chemical remover. The WHOQOL was completed a second time at least three months after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most frequent cause of dissatisfaction was color (43.8%), followed by color and shape (37%), color intensity/saturation (19.2%), and shape alone (11%). Significant differences in the WHO-1, WHO-2, DOM-1, and DOM-3 domains of the WHOQOL-BREF were found between baseline and after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Removal of unsatisfactory PMU in Caucasian women with Fitzpatrick skin types I–III resulted in significant improvements in overall quality of life and its physical and social domains. The physical aspect shows that the patients consider unwanted PMU as a physical impairment, which, although not being disabling, nevertheless affects body-related quality of life. In addition, a significant improvement in the psychological domain was also observed after treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Platelet Rich Plasma Therapy in Melasma Using Microinjections and Microneedling Techniques","authors":"Seema Sitaula,&nbsp;Shree Ram Pokhrel,&nbsp;Prayash Paudel,&nbsp;Aabha Shrestha","doi":"10.1111/jocd.70246","DOIUrl":"https://doi.org/10.1111/jocd.70246","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Melasma is a long-term acquired disorder characterized by symmetrical darkening in facial regions exposed to sunlight. Although some risk factors have been identified, the etiology remains unclear, and interventions frequently do not totally improve outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>It compares the efficacy and side effects of platelet-rich plasma therapy administered by microneedling versus microinjection to detect any difference in the delivery methods, treatment outcomes, and safety profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective, single-center, randomized split-face research, 62 patients' melasma was treated with PRP therapy using microneedling versus microinjection. Microneedling and microinjection were used to apply PRP to the face's two sides. Photographs were obtained before therapy, and the modified Melasma Area and Severity Index (MASI), Physician Global Assessment, and Patient Global Assessment were used for monthly follow-up evaluation. In order to compare safety and efficacy, adverse events were recorded and statistical analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significantly significant difference (<i>p</i> &lt; 0.001) was observed in the mean change in MASI score between microinjection and microneedling. The microneedling group showed a 73.33% improvement while the microinjection group had an 18.33% improvement, both of which were greater than 50%. The microneedling group showed a 46.67% improvement and the microinjection group had a 5% improvement of over 75%. There were no noteworthy negative effects observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PRP therapy with microneedling is superior to microinjection in treating melasma; patients who receive microneedling show noticeably better improvement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Single Application of External V-Y Plasty in Correcting Alar Retraction","authors":"Li-Yu Lai,&nbsp;Hsiu-Cheng Hsu","doi":"10.1111/jocd.70242","DOIUrl":"https://doi.org/10.1111/jocd.70242","url":null,"abstract":"<p>With the rising incidence of basal cell carcinoma, postoperative deformities following Mohs surgery have become increasingly prevalent. Among these, alar retraction represents a particularly challenging complication. Current approaches to its correction have largely centered on grafting techniques, which are often complex and may necessitate multidisciplinary collaboration. External V-Y plasty, by facilitating soft tissue lengthening and tension release, presents a straightforward and effective alternatives for correcting alar retraction, offering favorable aesthetic outcomes.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Benefits of Oral Tranexamic Acid: Reducing Melasma Severity and Inflammation","authors":"Abdullah Demirbas,&nbsp;Gozde Ulutas Demirbas,&nbsp;Esin Diremsizoglu,&nbsp;Mustafa Esen","doi":"10.1111/jocd.70257","DOIUrl":"https://doi.org/10.1111/jocd.70257","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma is a chronic hyperpigmentation disorder influenced by hormonal factors, ultraviolet exposure, and inflammation. While oral tranexamic acid (TXA) is an established treatment, its effects on systemic inflammation remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to evaluate the impact of TXA on melasma severity and inflammatory markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 80 melasma patients and 80 healthy controls. Patients received oral TXA (500 mg/day) for 3 months. Melasma severity was assessed using the Melasma Area and Severity Index (MASI), and inflammatory markers (monocyte, neutrophil, lymphocyte, HDL, MHR, MLR, NLR) were measured at baseline, Month 1, and Month 3. Changes within the melasma group and comparisons with controls were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 3 months, melasma severity significantly improved, with a 65.1% reduction in MASI (from 12.9 to 4.5, <i>p</i> &lt; 0.001). Monocyte, neutrophil, MHR, MLR, and NLR levels significantly decreased, while HDL and lymphocyte levels increased (<i>p</i> &lt; 0.001). Compared to controls, baseline inflammatory marker levels differed significantly; however, at month 3, only monocyte, MHR, and HDL remained significantly different (<i>p</i> &lt; 0.05). Regression analysis identified NLR and HDL as significant predictors of melasma severity reduction (<i>p</i> = 0.045 and <i>p</i> = 0.011, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Oral TXA not only improved melasma severity but also modulated systemic inflammation. The association between NLR, HDL, and treatment response suggests their potential as biomarkers for monitoring therapeutic efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}