Clinical Efficacy and Safety of a Highly Purified Polynucleotide for Dry and Chapped Lips: A Prospective, Multicenter Study

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-05-22 DOI:10.1111/jocd.70224

Nark Kyung Rho, Hyun Jun Park, Hei Sung Kim

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引用次数: 0

Abstract

Background

Dry and chapped lips are a common nuisance. Besides the discomfort, many report feeling embarrassed over the unsightly appearance of their chapped lips. The aim of this study was to determine if polynucleotide (PN) injection helps relieve lip dryness and assess safety in practicing PN in this specific area.

Methods

In this prospective study, 30 Korean subjects with dry and chapped lips enrolled to receive PN injection on the vermilion zone (a total of 3 injections, each 3 weeks apart). Vermilion wrinkle and roughness were scored based on the photos taken pretreatment (week 0); before the 2nd and 3rd injection (week 3, week 6); and 3 weeks after the 3rd injection (week 9) using the respective severity rating scales. Safety data were obtained throughout the study period.

Results

A total of 27 individuals completed the study. PN significantly improved both the vermilion wrinkles (assessed by the Wrinkle Severity Rating Scale (WSRS)) and roughness (assessed by the Lip Roughness Grading Scale (LRGS)) at all time points compared to baseline (p < 0.05). The WSRS response rate (Ratio of subjects whose WRSR decreased by ≥ 1 point compared to baseline) at week 9 was 100%. Lip swelling was experienced by all subjects when examined 30 min after PN injection, followed by pain (90%) and redness (77%). The injection site adverse reactions were mostly mild and transient.

Conclusion

Our results suggest that PN may be a promising option to soothe dry and chapped lips. However, larger studies with long-term follow-up are necessary to confirm the preliminary findings of this study.

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高纯度多核苷酸治疗干裂唇部的临床疗效和安全性：一项前瞻性、多中心研究

嘴唇干燥和干裂是一种常见的麻烦。除了不舒服之外，许多人还对嘴唇干裂的不美观感到尴尬。本研究的目的是确定多核苷酸（PN）注射是否有助于缓解嘴唇干燥，并评估在这一特定区域实施PN的安全性。方法本前瞻性研究选取韩国30例唇干干裂患者，在朱红色区注射PN（共注射3次，间隔3周）。根据预处理（第0周）拍摄的照片对朱砂皱纹和粗糙度进行评分；第2、3次注射前（第3周、第6周）；第三次注射后3周（第9周）使用各自的严重程度评定量表。在整个研究期间获得了安全性数据。结果共有27人完成了研究。与基线相比，PN在所有时间点显著改善了朱砂皱纹（由皱纹严重性评定量表（WSRS）评估）和粗糙度（由唇粗糙度评定量表（LRGS）评估）（p < 0.05）。第9周的WSRS反应率（与基线相比WRSR下降≥1点的受试者比例）为100%。所有受试者在注射PN后30分钟检查时均出现唇部肿胀，随后出现疼痛（90%）和发红（77%）。注射部位不良反应多为轻微和短暂性。结论：我们的研究结果表明，PN可能是一个有希望的选择，以缓解干燥和干裂的嘴唇。然而，需要更大规模的长期随访研究来证实本研究的初步结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.