Journal of Cosmetic Dermatology最新文献

{"title":"Correction to “Cosmetic Use and Its Hidden Risks: An Assessment of Public Awareness and Attitudes in Punjab, India”","authors":"","doi":"10.1111/jocd.71226","DOIUrl":"https://doi.org/10.1111/jocd.71226","url":null,"abstract":"<p>\u0000 <span>S. Kumari</span>, <span>B. Pal</span>, <span>S. K. Sahu</span>, and <span>A. K. Sah</span>, “ <span>Cosmetic Use and Its Hidden Risks: An Assessment of Public Awareness and Attitudes in Punjab, India</span>,” <i>Journal of Cosmetic Dermatology</i> <span>25</span>, no. <span>7</span> (<span>2026</span>): e71057, https://doi.org/10.1111/jocd.71057.\u0000 </p><p>The first affiliation was incorrect and has been corrected to “School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India” to accurately reflect the institutional affiliation associated with the work.</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Parametric Biophysical Analysis for Evaluating Suitability of Energy-Based Devices and Injectables","authors":"Jin Ho Kim,&nbsp;Nark-Kyoung Rho,&nbsp;Jiyeoun Shin,&nbsp;Won Seok Choi","doi":"10.1111/jocd.71224","DOIUrl":"https://doi.org/10.1111/jocd.71224","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The paradigm of cosmetic dermatology has shifted heavily toward combination therapies involving energy-based devices (EBDs) and injectable biostimulators. However, conventional efficacy assessments remain largely limited to subjective clinical grading or single-parameter, uni-dimensional approaches. Given the complex cross-talk within the epidermal-dermal microenvironment, a multi-dimensional objective framework is required to achieve evidence-based precision medicine.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study introduces a multi-parametric biophysical stratification model to evaluate baseline patient suitability, reveal hidden antagonistic interferences (negative synergy), and establish an optimized treatment sequence for combined treatments.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A retrospective cohort of 93 patients who underwent skin rejuvenation treatments was analyzed. Baseline (T0) biophysical profiles were measured via SKENA (V&amp;Co., Seoul, Korea) with eight quantitative parameters: hydration, trans-epidermal water loss (TEWL), dermal thickness via 10-MHz ultrasound, erythema index, and elasticity parameters (R0, R2, R6/R5, R7). To eliminate multi-collinearity and physiological cross-talk, a Mahalanobis distance metric tensor utilizing the inverse covariance matrix was established. Modality-specific suitability scores (&lt;span&gt;&lt;/span&gt;&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;S&lt;/mi&gt;\u0000 &lt;mi&gt;m&lt;/mi&gt;\u0000 &lt;/msub&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt;$$ {mathrm{S}}_m $$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;) and non-linear combination synergy margins (Ω) were algebraically derived. A 12-week longitudinal kinetic simulation was performed to compare concurrent and sequential treatment pathways.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Baseline stratification identified distinct phenotypic cohorts. EBD solo analysis separated patients into HIFU-dominant (&lt;i&gt;N&lt;/i&gt; = 51) and RF-dominant (&lt;i&gt;N&lt;/i&gt; = 42) cohorts, partitioned significantly by erythema (&lt;i&gt;p&lt;/i&gt; = 0.0004) and viscoelastic creep (R6/R5, &lt;i&gt;p&lt;/i&gt; = 0.0183). Scaffold analysis partitioned PN-dominant (&lt;i&gt;N&lt;/i&gt; = 48) and PLLA-dominant (&lt;i&gt;N&lt;/i&gt; = 45) cohorts via barrier integrity and dermal thinning (&lt;i&gt;p&lt;/i&gt; = 0.0039). Incorporating an unclamped synergy model revealed robust supralinear synergy (Ω &gt; 0) in barrier-compromised phenotypes, ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Sequential Long-Pulsed 1060-nm and 805-nm Laser Treatment for Mid- and Lower-Face Aging: A Single-Arm Prospective Study","authors":"Li Wang,&nbsp;Xu Yuan,&nbsp;Li Liu,&nbsp;Lin Gao","doi":"10.1111/jocd.71225","DOIUrl":"https://doi.org/10.1111/jocd.71225","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mid- and lower-face aging involves skin laxity, textural deterioration, and contour changes. Sequential long-pulsed 1060- and 805-nm laser treatment has been proposed as a noninvasive rejuvenation approach, but evidence regarding its clinical outcomes remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To assess the clinical outcomes and tolerability of sequential long-pulsed 1060- and 805-nm laser treatment for mid- and lower-face aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-eight patients with mid- and lower-face aging changes underwent three treatment sessions at 4-week intervals using sequential long-pulsed 1060- and 805-nm diode lasers. Assessments were performed at baseline and 12 weeks after the final treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At 12 weeks after the final treatment, significant reductions were observed in wrinkle scores, indentation index, and visible pore count, while skin elasticity improved significantly compared with baseline. GAIS assessment showed that 96.43% of patients achieved at least mild improvement, and 71.43% achieved marked or greater improvement. Treatment was well-tolerated. No serious adverse events were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This preliminary, uncontrolled single-arm study suggests sequential long-pulsed 1060- and 805-nm laser treatment may provide a safe, well-tolerated noninvasive option for improving mid- and lower-face aging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Atrophic Scars, Maturation Time and Therapeutic Outcomes Following Microneedling: A Post Hoc Analysis of a Randomized Clinical Trial”","authors":"","doi":"10.1111/jocd.71214","DOIUrl":"https://doi.org/10.1111/jocd.71214","url":null,"abstract":"<p>\u0000 <span>L. G. de Souza</span>, <span>M. R. Silva</span>, <span>D. Steiner</span>, and <span>G. Viana de Oliveira</span>, “ <span>Atrophic Scars, Maturation Time and Therapeutic Outcomes Following Microneedling: A Post Hoc Analysis of a Randomized Clinical Trial</span>,” <i>Journal of Cosmetic Dermatology</i> <span>25</span>, no. <span>6</span> (<span>2026</span>). https://doi.org/10.1111/jocd.70943\u0000 </p><p>The authors have notified us of an error in the second author's name. The name “Márcio Rodrigues da Silva” should be corrected to “Marcio Roberto Silva.”</p><p>The online version of this article has been corrected accordingly.</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Behaviors Regarding Laser Hair Removal of Medical Students: A Cross-Sectional Study","authors":"Emrah Atay,&nbsp;Hilal Kaya Erdoğan,&nbsp;Sibel Sert,&nbsp;Büşra Yeni Yıldız,&nbsp;Esra Ağaoğlu,&nbsp;Selma Metintaş","doi":"10.1111/jocd.71173","DOIUrl":"https://doi.org/10.1111/jocd.71173","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Laser hair removal (LHR) has become one of the most common procedures among non-invasive cosmetic treatments. The structured training on cosmetic dermatological procedures may be limited during medical education. The aim of this study is to evaluate medical students' knowledge, attitudes, and practices regarding LHR.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study was conducted with 973 medical students at a medical school. They were asked to complete a questionnaire related to the history of LHR, sources of information about LHR and 12 statements in a 3-point Likert scale format to assess students' knowledge levels named “LHR-K-Scale”. As the data were not normally distributed, non-parametric tests (Mann–Whitney U and Kruskal–Wallis) were used for group comparisons. Univariate and multivariable binary logistic regression analyses were performed to identify factors associated with sufficient knowledge.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of the students, 484 (49.7%) were female and 489 (50.3%) were male; their ages ranged from 17 to 31, with a mean ± SD of 20.9 ± 2.2 years. The total LHR-K Scale score ranged from 0 to 24, with a mean score of 13.5 ± 6.5. Overall, 527 students (54.2%) were classified as having a sufficient level of knowledge (≥ 15 points). In the logistic regression analysis, correctly knowing the definition of LHR increased the likelihood of having a sufficient level of knowledge on the LHR-K Scale by 2.50 times (OR = 2.50; 95% CI: 1.90–3.30). Participants who had undergone LHR were 1.98 times more likely to have a sufficient level of knowledge than those with no history of LHR and no intention to undergo the procedure (OR = 1.98; 95% CI: 1.37–2.87). In addition, participants who used social media as a source of information were 1.54 times more likely to have a sufficient level of knowledge than those who did not (OR = 1.54; 95% CI: 1.15–2.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study revealed that while medical students' knowledge levels regarding LHR are heterogeneous, they are generally limited; significant knowledge gaps exist in areas such as mechanism of action, radiation, pregnancy, breastfeeding, cancer, and infertility. The topic should be addressed not only as a matter of individual aesthetic preference but also from the perspectives of health literacy. It is recommended that the medical curriculum include up-to-date and evidence-based content regarding cosmetic dermatology practices, particularly LHR.&lt;/p&gt;\u0000 ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Facial Contour and Localized Submental Fat Using Multilayer Microneedling Radiofrequency","authors":"Xavier Eduardo Garzon Garzon,&nbsp;Gustavo Robertson Filippo,&nbsp;Bibiana Florian da Costa,&nbsp;Paula Regazzi de Gusmão,&nbsp;Alexandre de Almeida Filippo","doi":"10.1111/jocd.71160","DOIUrl":"https://doi.org/10.1111/jocd.71160","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Microneedling radiofrequency has gained prominence in the treatment of cervical skin laxity and localized submental fat, offering promising aesthetic outcomes; however, further clinical evidence is needed to support its efficacy and safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of the Megaderme Duo platform in improving facial contour and reducing submental fat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen participants (12 women and 4 men) with localized submental fat classified as Grades 1–4 according to the PASMFRS underwent three microneedling radiofrequency sessions at four-week intervals using the Megaderme Duo RF Multi-Layer Eletroderme XL LMG platform. Dermal, subcutaneous, and subplatysmal fat thickness were assessed using high-frequency Doppler ultrasound. Statistical analyses were performed using SPSS software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant reductions were observed in subcutaneous tissue thickness (<i>p</i> = 0.001) and subplatysmal fat thickness (<i>p</i> = 0.034). A significant bilateral reduction in subcutaneous thickness at the mandibular angles was also detected (<i>p</i> &lt; 0.001). Comparative analysis of pre- and post-treatment photographs using the PASMFRS revealed significant improvement (<i>p</i> = 0.001), with 68.75% of participants showing a reduction of at least one grade. Participant satisfaction was high, with 93.8% reporting favorable outcomes. No severe or difficult-to-manage adverse effects were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Multilayer microneedling radiofrequency using the Megaderme Duo platform proved to be effective in improving facial contour and reducing submental fat, demonstrating a favorable safety profile and high participant satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrolyzed Collagen for Skin Aging Meta-Analyses Are Unreliable","authors":"David Robert Grimes,&nbsp;Anjali Mahto","doi":"10.1111/jocd.71208","DOIUrl":"https://doi.org/10.1111/jocd.71208","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scientific evidence for oral collagen supplementation in skin aging remains controversial and limited, with various trials finding conflicting results on skin parameters such as reduction in wrinkle depth, increases in hydration and elasticity. These parameters are measured with a variety of methodologies, and recent meta-analyses have attempted to synthesize existent evidence to ascertain potential benefits. The question of whether these measures are readily comparable, however, has led to concerns about the internal validity and interpretability of these efforts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate major existing meta-analyses on oral collagen supplementation and perform a technical re-analysis of both methodology and reported results, as well as a full meta-regression of constituent collagen studies accounting for dose effects to ascertain evidence quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data investigation and evidence appraisal of the methodology of existing meta-analyses of collagen supplementation and implementation of meta-regression accounting for cumulative dose effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In both identified meta-analyses, we find inaccurate reporting of data from primary studies and inappropriate combinations of measures likely to give rise to spurious results. Meta-regression of collagen studies accounting for dose variations in primary studies found no evidence of benefit from collagen supplementation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In sharp contrast to the reported results from prior meta-analysis, this investigation does not find evidence of benefit for supplementation from existing collagen studies. Evidence synthesis for collagen studies needs a stronger methodological underpinning if results are to be clinically relevant.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Skin-Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review","authors":"Siting Yang,&nbsp;Mingning Ding,&nbsp;Chenglong Ye,&nbsp;Jingning Shen,&nbsp;Lihua Zhang,&nbsp;Anquan Yang,&nbsp;Lihao Gu","doi":"10.1111/jocd.71213","DOIUrl":"https://doi.org/10.1111/jocd.71213","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin-lightening agents. This review evaluates their efficacy, mechanisms, and safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature review was conducted to synthesize evidence on the skin-lightening effects and mechanisms of botanical extracts and their bioactive constituents. Evidence was organized into six major pathways: attenuation of ultraviolet and environmental damage; regulation of the microphthalmia-associated transcription factor (MITF) pathway; tyrosinase (TYR) inhibition; inhibition of melanosome transfer; modulation of redox processes involved in melanin formation; and regulation of epidermal renewal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The reviewed literature indicates that botanical extracts and phytochemicals can regulate pigmentation through multiple complementary mechanisms. Polyphenols, flavonoids, terpenoids, alkaloids, and other plant-derived constituents have been reported to influence the MITF/TYR/TRP axis, melanosome transport, oxidative stress, and pigment metabolism. These findings suggest that botanical skin-lightening activity extends beyond direct TYR inhibition and may involve coordinated regulation of pigment homeostasis. However, evidence strength varies among botanical materials, and much of the available evidence is derived from in vitro, cellular, or animal models. Safety concerns, including melanocytotoxicity and potential leukoderma, also require careful consideration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Botanical extracts show promise as multifunctional skin-lightening agents. Future research should emphasize standardized characterization, mechanism-based evaluation, comprehensive safety assessment, and validation in human skin and clinical settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color-Guided Long-Pulsed 532/1064-nm KTP/Nd:YAG Laser for Post-Acne Erythema: A Real-World Study","authors":"Jiayi Jiang,&nbsp;Ying Yang,&nbsp;Xiaoqing Wang,&nbsp;Jingwen Jiang,&nbsp;Yan Tang,&nbsp;Bingrong Zhou","doi":"10.1111/jocd.71205","DOIUrl":"https://doi.org/10.1111/jocd.71205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Post-acne erythema (PAE) is a common sequela of inflammatory acne. Pulsed dye laser is effective for vascular erythema but is associated with purpura and downtime. This study evaluated the real-world effectiveness and tolerability of a standardized, color-guided long-pulsed 532/1064-nm KTP/Nd:YAG protocol for PAE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center retrospective cohort study screened 147 patients and included 136 eligible patients. All patients completed three sessions at 4-week intervals. Each session comprised low-fluence full-face 532-nm KTP scanning followed by lesion-targeted treatment: 532-nm KTP for pink-to-red lesions and 1064-nm Nd:YAG for violaceous lesions, with both wavelengths used when both color patterns were present. Outcomes included an adapted CAT score, erythematous area percentage, Investigator Global Assessment, satisfaction, pain, 6-month quantitative stability, clinical worsening, and adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median CAT score decreased from 5 to 1, and the median erythematous area percentage decreased from 4.50% to 1.00% (both <i>p</i> &lt; 0.001). Median CAT improvement rates were 58.34%, 84.52%, and 87.50% in low-, intermediate-, and high-severity groups, respectively; the between-group difference was not significant (<i>p</i> = 0.10). All patients in this cohort achieved at least 25% improvement on Investigator Global Assessment. Satisfaction was 97.79%, and the median pain score was 2/10. Transient erythema resolved within 1–3 days. One patient (0.74%) developed purpura with a small blister; no pigmentary sequelae or scarring occurred. At 6 months, CAT score and erythematous area percentage remained comparable with the 1-month posttreatment values in the overall cohort (<i>p</i> = 0.285 and <i>p</i> = 0.346, respectively) and across baseline severity subgroups (all <i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that a standardized three-session, color-guided long-pulsed 532/1064-nm KTP/Nd:YAG protocol may be an effective and well-tolerated option for PAE, with exploratory 6-month quantitative stability, warranting confirmation in prospective controlled studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Carrier Effect to Collagen Remodeling: Toward Endpoint-Specific Longevity Assessment in Polycaprolactone-Based Collagen-Stimulating Fillers","authors":"Chuan-Yuan Lin,&nbsp;Jui-Yu Lin","doi":"10.1111/jocd.71204","DOIUrl":"https://doi.org/10.1111/jocd.71204","url":null,"abstract":"&lt;p&gt;The growing use of polycaprolactone (PCL)-based collagen-stimulating fillers has intensified interest in treatment longevity [&lt;span&gt;1, 2&lt;/span&gt;]. Yet, “longevity” is often used as if it represents a single measurable outcome. In PCL-based fillers, early visible correction, maintained clinical improvement, objective volumetric change, and tissue-level remodeling are related but not interchangeable [&lt;span&gt;1-3&lt;/span&gt;]. Although the immediate carrier effect and later collagen-mediated remodeling of PCL-based fillers have been described [&lt;span&gt;1-3&lt;/span&gt;], the implications of this sequence for endpoint selection and time-window-specific assessment remain insufficiently separated. To address this gap, we propose endpoint-specific longevity assessment as a practical interpretive framework, not a validated outcome instrument.&lt;/p&gt;&lt;p&gt;PCL-based fillers provide a useful example because available evidence spans clinical, imaging, and tissue domains. Controlled clinical studies have demonstrated sustained nasolabial fold improvement using validated scales such as the Wrinkle Severity Rating Scale and Global Aesthetic Improvement Scale [&lt;span&gt;1, 4, 5&lt;/span&gt;]. These outcomes are clinically meaningful; however, they primarily describe patient- or investigator-rated correction rather than the amount of tissue volume created or maintained. In contrast, three-dimensional (3D) imaging can provide objective volumetric information. In a Vectra 3D case series, measured midface volume was maintained at 24 months and, in some patients, exceeded the initially injected volume [&lt;span&gt;2&lt;/span&gt;]. However, persistence of surface-derived volumetric change does not establish the underlying biological mechanism. Complementary data further support this biologic pathway, with ultrasound demonstrating dermal thickening and histology showing neocollagenesis after PCL injection [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;On this basis, Table 1 presents a proposed tri-phasic framework for time-specific endpoint interpretation. In the early carrier-dominant phase, apparent volume is influenced by the carboxymethylcellulose carrier, immediate contour change, and procedure-related edema [&lt;span&gt;1, 2, 6&lt;/span&gt;]. Accordingly, safety, tolerability, and early swelling are more relevant than durability. During the transitional phase, carrier dissipation and edema resolution may make reassessment more reliable, and staged dosing may be considered when clinically appropriate. Finally, in the late remodeling phase, durability claims should be anchored to the endpoint being measured: clinical scales for fold correction, 3D imaging for volumization, and ultrasound or histology for tissue remodeling [&lt;span&gt;1-5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;This temporal separation also has safety implications. In a large retrospective series of PCL-based filler treatments, prolonged edema was associated with higher injection volume [&lt;span&gt;6&lt;/span&gt;]. Delayed nodules and inflammatory reactions remain recognized potential complications, and management ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 10","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}