Journal of Cosmetic Dermatology最新文献

{"title":"Noninvasive Assessment Methods for the Therapeutic Effect Following Facial Rejuvenation","authors":"Shasha Zhao,&nbsp;Meng Wang,&nbsp;Xiaodong Lai,&nbsp;Yan Yan","doi":"10.1111/jocd.70482","DOIUrl":"https://doi.org/10.1111/jocd.70482","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As the demand for facial rejuvenation continues to rise, monitoring the response to therapy is worthy of attention. However, a standardized system for assessing therapeutic effects is currently lacking. This study aims to review the existing noninvasive efficacy evaluation tools for facial rejuvenation and analyze their advantages and disadvantages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An extensive literature search was conducted in PubMed to identify articles on efficacy evaluation tools for facial rejuvenation published between 1995 and 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We classify the available measurement tools as subjective assessment methods, imaging techniques, and biophysical methods. Most subjective scales are based on clear definitions and standardized photographs, which are evaluated by dermatologists. Various scales focusing on different clinical features are continuously being developed, making it challenging to compare study outcomes. Imaging techniques are generally more precise and accurate. The information collected by these techniques is more convenient to store, search, and analyze, indicating their significant potential for monitoring efficacy. However, the high cost of equipment and complexity of operation may limit the application. Biophysical parameters can indirectly measure the severity of skin aging, but their repeatability and accuracy require further validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review offers a comprehensive overview of the existing efficacy evaluation methods for facial rejuvenation and discusses pertinent details. There is no single best assessment method. When selecting outcome measures in clinical practice or scientific research, several factors must be considered, including therapeutic objectives, convenience, and accuracy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Comparison of the Efficacy of 1064- and 730-nm Picosecond Lasers for Acquired Dermal Melanocytosis”","authors":"Michelle J. Chang,&nbsp;Justin W. Marson,&nbsp;Alisen Huang","doi":"10.1111/jocd.70465","DOIUrl":"https://doi.org/10.1111/jocd.70465","url":null,"abstract":"&lt;p&gt;We are writing in response to the recent publication titled “Comparison of the Efficacy of 1064- and 730-nm Picosecond Lasers for Acquired Dermal Melanocytosis” by Kishi et al. [&lt;span&gt;1&lt;/span&gt;]. This study provides valuable insight into the efficacy of treating dermal melanocytosis using a 730-nm picosecond laser. Patients were either treated with the 730-nm or 1064-nm groups, with the 730-nm group showing higher efficacy and fewer cases of hyperpigmentation.&lt;/p&gt;&lt;p&gt;We would like to present a case of Nevus of Ito split tested with L532-nm and 1064-nm picosecond lasers. A 25-year-old female with Fitzpatrick skin type III presented with a congenital gray-blue patch involving the right upper back extending to the chest and lateral neck. The lesion was biopsy-proven Nevus of Ito and had significantly enlarged since birth, growing with the patient to cover the anterior shoulder and reportedly darkening in color. A test spot previously performed at an outside clinic with a picosecond laser showed some improvement in pigmentation; however, the patient moved to the United States shortly afterward. She presented to our clinic requesting further treatment of the lesion.&lt;/p&gt;&lt;p&gt;To compare the efficacy between laser wavelengths, the anterior shoulder was divided into two sections and treated with one pass of either a 532-nm (fluence 2.0 J/cm&lt;sup&gt;2&lt;/sup&gt;, spot size 3 mm) or 1064-nm picosecond laser (fluence of 2.5 J/cm&lt;sup&gt;2&lt;/sup&gt;, spot size 3 mm) with an endpoint of immediate whitening. After 4 weeks, the 532-nm treated area showed greater lightening in pigmentation as subjectively graded by both the clinician and the patient, and the patient expressed higher satisfaction in this test section (Figure 1). The remainder of the shoulder was treated with 532 nm, yielding continued improvement in pigmentation (Figure 2).&lt;/p&gt;&lt;p&gt;Dermal melanocytosis can be challenging to treat in patients with skin of color, as energy-based laser devices utilize photothermolysis to selectively induce thermal damage, in this case, to the chromophore melanin. Due to the increased melanin content in these patients, they are at a higher risk of pigmentary-associated adverse events such as hyperpigmentation. The 532-, 730-, and 1064-nm picosecond lasers have all been shown to be safe in this patient population [&lt;span&gt;1-3&lt;/span&gt;]. Additionally, the short pulse width in picosecond lasers allows for rapid disruption of melanosomes while minimizing damage to surrounding structures [&lt;span&gt;4&lt;/span&gt;]. Both 532 nm and 730 nm are more strongly absorbed by melanin than 1064 nm. Although 1064 nm and 730 nm penetrate deeper into the dermis, the 532-nm wavelength demonstrates greater fragmentation of melanin [&lt;span&gt;5, 6&lt;/span&gt;]. Therefore, in addition to the 730-nm picosecond laser, we propose the 532-nm laser with a short pulse width as another potential treatment option for dermal melanocytosis. Future clinical studies are necessary to compare the efficacy of this wavelength with that of 730-nm l","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition","authors":"Wangyue Dong,&nbsp;Maori Kono,&nbsp;Masayuki Takaishi,&nbsp;Ayumi Kyuka,&nbsp;Hiroko Kato,&nbsp;Fumitaka Fujita","doi":"10.1111/jocd.70392","DOIUrl":"https://doi.org/10.1111/jocd.70392","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sebaceous glands (SGs) secrete sebum to form a protective barrier that maintains skin health. However, exposure to ultraviolet A (UV-A) radiation damages the skin barrier, leading to dryness and inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>In this study, we investigated how UV-A radiation alters SG function, focusing on inflammation and changes in the composition of intracellular sebum-like lipids. We also explored the role of SG-related mechanisms in UVA-radiation-induced skin barrier damage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Human primary sebocytes were cultured from SGs isolated from human skin samples and exposed to different doses of UV-A radiation. Inflammatory cytokines released into the culture medium were measured, followed by gene expression analysis using mRNA extracted from cells to examine specific target genes. Intracellular sebum-like lipid composition was analyzed using liquid chromatography–tandem mass spectrometry, and skin barrier function was evaluated using a three-dimensional reconstructed human epidermis (3D skin) model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>UV-A irradiation increased inflammatory cytokine levels in the culture medium and altered the expression levels of several genes. Intracellular sebum-like lipid composition was also modified following UV-A irradiation, with notable sex differences. Furthermore, the skin barrier function was impaired in 3D skin models cultured with the supernatant from UV-A-irradiated sebocyte cultures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrated that UV-A radiation stimulated sebocytes to release inflammatory cytokines and altered gene expression. Additionally, UV-A irradiation modified the intracellular sebum-like lipid composition in a sex-dependent manner, contributing to skin barrier damage.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70392","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145272298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Educational Interactive Virtual Simulation App in Aesthetic Medicine and Cosmetic Dermatology Preclinical Skills","authors":"Haidar Hassan,&nbsp;Hassan Khalil,&nbsp;Bashar Shatta,&nbsp;Anna Maria Fenech Magrin,&nbsp;Ines Novo Pereira,&nbsp;Atif Matin","doi":"10.1111/jocd.70496","DOIUrl":"10.1111/jocd.70496","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The rapid progress in the field of aesthetic medicine and cosmetic dermatology drives the demand for skilled healthcare practitioners able to provide safe, complex treatments accurately and confidently. Traditional training approaches, which emphasize didactic teaching and little hands-on experience, typically fail to prepare postgraduate students for these challenges. We hypothesized that interactive visual simulation may improve preclinical competency in aesthetic medicine and cosmetic dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of this study is to explore the impact of interactive visual simulations 3D app on the development of preclinical skills in aesthetic medicine and cosmetic dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was designed as a mixed-methods approach, which combined quantitative analysis of simulation performance data with quantitative feedback from participants. The study is based on a purposive sample of 25 healthcare professionals enrolled in aesthetic medicine postgraduate training programs at the Queen Mary University of London (QMUL). Data were collected through post-training assessment questionnaires and performance metrics during simulations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings clearly emphasized an improvement in the proficiency and confidence of participants who trained using interactive visual simulations. Trainees reported a greater sense of realism and immersion in their training, which helped them better understand the spatial relationships and anatomical structures involved in aesthetic procedures. Additionally, participants expressed increased confidence in their ability to perform these procedures on real patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study found that interactive visual simulation may help to improve aesthetic medicine and cosmetic dermatology preclinical competency. This technology has the potential to offer a better training experience than traditional approaches, resulting in more confident and skilled healthcare practitioners who can conduct difficult and safe aesthetic interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Use of Medium-Deep Peelings to Treat Melasma: A Case Series Study","authors":"","doi":"10.1111/jocd.70498","DOIUrl":"10.1111/jocd.70498","url":null,"abstract":"&lt;p&gt;\u0000 &lt;b&gt;RETRACTION&lt;/b&gt;: &lt;span&gt;M. T. Scardua&lt;/span&gt;, &lt;span&gt;N. Scardua&lt;/span&gt;, &lt;span&gt;M. F. Ismail&lt;/span&gt;, &lt;span&gt;W. Bambirra Junior&lt;/span&gt;, &lt;span&gt;I. M. Candeias Carpinteiro&lt;/span&gt;, &lt;span&gt;A. L. Oliveira Costa&lt;/span&gt;, and &lt;span&gt;A. L. Sena Guimarães&lt;/span&gt;, “ &lt;span&gt;The Use of Medium-Deep Peelings to Treat Melasma: A Case Series Study&lt;/span&gt;,” &lt;i&gt;Journal of Cosmetic Dermatology&lt;/i&gt; &lt;span&gt;24&lt;/span&gt;, no. &lt;span&gt;8&lt;/span&gt; (&lt;span&gt;2025&lt;/span&gt;): e70291. https://doi.org/10.1111/jocd.70291.\u0000 &lt;/p&gt;&lt;p&gt;The above article, published online on 18 August 2025 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael H. Gold; and Wiley Periodicals LLC. Multiple third parties reported concerns that the research involves phenol-based products, the use of which has been prohibited in Brazil for general health or aesthetic procedures following a resolution by Brazil's National Health Surveillance Agency (Anvisa) in June 2024 [1]. The research was conducted in Brazil, raising concern about the use of banned products in the study. The third parties expressed concerns that the article validates the use of phenol-croton oil peel by non-medical professionals and that the article does not declare a financial conflict of interest for several of the authors. The authors supplied a substantial response to these concerns, including copies of ethical approval for the retrospective case series from Universidade Estadual de Montes Claros, and documents concerning trademarks held by author M. T. Scardua. The authors declared that the study received proper ethical approval, that all procedures followed Brazil's regulations, and that the study was unrelated to trademarks and branding owned by some authors, therefore no conflict of interest statement was required.&lt;/p&gt;&lt;p&gt;The editor and publisher have determined that, according to the reported treatments presented in Supporting Information File S2, no treatments using phenol-croton peel were provided following Anvisa's prohibition in June 2024. After June 2024, all treatments were reported as having used trichloroacetic acid (TCA), which is not under prohibition by Anvisa. However, the above parties have expressed concerns that Anvisa's June 2024 resolution was not mentioned in the article. Additionally, due to the prohibition of phenol-croton products in Brazil, the treatments of several patients may have been changed from phenol-croton to TCA, which may have affected the interpretation of the methodology and results.&lt;/p&gt;&lt;p&gt;Crucially, the above parties also determined that author M. T. Scardua holds a trademark for related phenol-containing treatments and these treatments have been commercialized and promoted by some authors. These findings constitute financial interests that represent a conflict of interest, according to the policies of the publisher and the Committee on Publication Ethics (COPE). The editors determined that, had these financial","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy and Safety of Combining Cross-Linked Hyaluronic Acid Filler VYC-12L and Energy-Based Devices for Facial Skin Quality Improvement in Asians","authors":"Mikako Oku,&nbsp;Kentaro Oku","doi":"10.1111/jocd.70485","DOIUrl":"10.1111/jocd.70485","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In recent years, treatments using energy-based devices (EBDs) aimed at skin quality improvement have become widely adopted. However, it has been pointed out that treatments using EBDs alone show limited durability of effects and variability in patient-perceived improvements. Therefore, we evaluated skin quality improvement resulting from a combination therapy involving cross-linked hyaluronic acid (CL-HA) filler and EBD treatments tailored to patients' chief concerns.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess the efficacy and safety of combined CL-HA filler and EBD therapies in treating facial skin quality improvement among Asian subjects.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this prospective, evaluator-blinded study, 18 participants aged 32–59 years with decreased skin elasticity, fine wrinkles, uneven texture, pore enlargement, pigmentation, and sagging were enrolled. CL-HA filler (VYC-12L) was injected intradermally into the entire face. One month later, according to each patient's primary concerns and symptoms, EBD treatment (either high intensity, high frequency parallel ultrasound beam [PUB], picosecond alexandrite laser [PSAL], and sequential monopolar bipolar pulsed radiofrequency [SMBPRF]) was administered to the entire face. Evaluations were conducted at three time points: baseline (T0), 4 weeks post-CL-HA injection (T1), and 8 weeks post-EBD treatment (T2). Subjective assessment was performed using the FACE-Q | Aesthetics—Satisfaction with Skin scale. Objective assessment was independently conducted by a dermatologist utilizing three-dimensional image analysis and skin diagnostic imaging with the Global Aesthetic Improvement Scale (GAIS).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;All participants completed the study. Pairwise comparisons of the FACE-Q skin satisfaction scores demonstrated statistically significant improvements at all time points: from T0 to T1 (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), from T0 to T2 (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), and from T1 to T2 (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Objective assessment with the GAIS showed improvement in all cases: very much improved (2 cases), much improved (9 cases), improved (7 cases), no change (0 cases), and worsened (0 cases). Regarding safety, no severe adverse events were reported, and only minor transient post-treatment reactions were observed.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The combination of CL-HA filler and EBD represents a sa","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70485","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Carboxytherapy Mask in Post-Fractional Ablative Laser Recovery: A Randomized Pilot Trial","authors":"Steven Dayan,&nbsp;Catherine Carvajal,&nbsp;Nimit Gandhi,&nbsp;Lander McGinn,&nbsp;Mia Cirrincione,&nbsp;Jose Sanchez-Perez","doi":"10.1111/jocd.70481","DOIUrl":"10.1111/jocd.70481","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Fractional ablative CO&lt;sub&gt;2&lt;/sub&gt; lasers are widely used for skin rejuvenation but are associated with post-procedural erythema, crusting, tenderness, and downtime. Carboxytherapy masks, a modality utilizing carbon dioxide, have been suggested to enhance healing and aesthetic outcomes post CO&lt;sub&gt;2&lt;/sub&gt; laser treatment; however, controlled clinical data remain limited.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the efficacy and safety of a topical carboxytherapy mask in enhancing recovery, reducing adverse effects, and improving patient satisfaction following fractional ablative CO&lt;sub&gt;2&lt;/sub&gt; laser treatment.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Ten subjects (aged 45–70 years, Fitzpatrick skin types I–III) undergoing full-face fractional CO&lt;sub&gt;2&lt;/sub&gt; laser resurfacing were enrolled in this randomized pilot study. Participants were assigned to either the active arm (&lt;i&gt;n&lt;/i&gt; = 8, carboxytherapy mask was applied pre- and post-procedure and at designated intervals for 14 days) or placebo arm (&lt;i&gt;n&lt;/i&gt; = 2, bland moisturizer). Outcomes included blinded investigator assessments of erythema, edema, crusting, healing rate, pigmentation, and wrinkle severity at Days 28 and 84; patient-reported diaries of discomfort and healing parameters; and self-assessments of satisfaction and global aesthetic improvement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The active group demonstrated reduced erythema during the first week (mean scores: Day 1, 3.1 vs. 3.5; Day 7, 0.6 vs. 1.0 for placebo). By Day 7, healing surface area averaged 97% in the active group with no crusting. At Day 28, the active group exhibited fewer fine and coarse lines (mean coarse line score 2 vs. 4 in placebo). At Day 84, coarse line reduction and abnormal pigmentation improvement favored the active group (0.75 vs. 1.5, respectively). Patient-reported tenderness, burning, and crusting were consistently lower in the active group, with higher satisfaction and confidence scores at both Day 28 and 84. No adverse effects were reported.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this pilot study, the carboxytherapy mask enhanced post-laser healing, reduced erythema and discomfort, and improved long-term wrinkle and pigmentation outcomes compared to placebo. These findings support the adjunctive use of the carboxytherapy mask to improve recovery and patient satisfaction after ablative CO&lt;sub&gt;2&lt;/sub&gt; laser resurfacing. L","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of Subcutaneous and Visceral Fat With the Use of Energy-Based Equipment With a High-Power Amplifying Effect Plus an Exercise Regimen","authors":"Jesús Rodriguez Lastra,&nbsp;Sidra Kouser","doi":"10.1111/jocd.70490","DOIUrl":"10.1111/jocd.70490","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The use of electromagnetic energy as an alternative to surgical procedures for subcutaneous fat reduction has gained popularity in recent years. In this pilot study, the effects of using amplified radio-frequency energy in the medium wave delivery range, in conjunction with exercise intervention, were investigated for their potential reduction of abdominal subcutaneous and visceral fat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The study aimed to evaluate the effects of combined intervention on the volume of abdominal fat, analyzing changes in lipid profile, metabolic factors, and inflammatory markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-four participants were selected and assigned to a 10-day intervention utilizing a Capenergy device every weekday except Saturday and Sunday. This involved the application of amplified energy through a belt covering the abdominal area of 800 cm² followed by a 45-min submaximal aerobic exercise. Measurements were conducted pretreatment and after the intervention. Lipid profile, leptin, insulin, and protein C were measured. Body fat was measured by MRI of the entire abdomen. Follow-up measurements were also taken at the 6-month mark.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A statistically significant decrease was noted in both subcutaneous and visceral fat in the abdominal area, as well as a decrease in weight, waist-to-hip, and all biochemical values, without side effects, just a slight redness. These effects on abdominal fat were maintained at the 6-month follow-up with no reports of regaining fat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The utilization of amplified radiofrequency with an abdominal belt with static electrodes and temperature sensors, together with exercise intervention, has significant potential for reducing abdominal subcutaneous and visceral fat, while also improving associated factors safely and effectively, even after a follow-up period.</p>\u0000 \u0000 <p><b>Trial Registration:</b> NCT06377358</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Ultrasound Findings of Mycobacterium abscessus After Cosmetic Procedures: The Four Stages of Evolution","authors":"Leila Riedel,&nbsp;Andrezza Sarli,&nbsp;Daniella Prudente Martins,&nbsp;Maria Claudia Almeida Issa","doi":"10.1111/jocd.70466","DOIUrl":"10.1111/jocd.70466","url":null,"abstract":"&lt;p&gt;High-frequency cutaneous ultrasound (HFUS) is a well-established tool for diagnosing, guiding, and following up on aesthetic procedures and related complications [&lt;span&gt;1, 2&lt;/span&gt;]. Skin US is mainly relevant in vascular obstruction, inflammatory and non-inflammatory nodules, and abscesses [&lt;span&gt;3&lt;/span&gt;]. &lt;i&gt;Staphylococcus aureus&lt;/i&gt;, &lt;i&gt;Streptococcus pyogenes&lt;/i&gt;, and non-tuberculous mycobacteria (NTM) are the most reported pathogens associated with post-procedural skin infections [&lt;span&gt;4&lt;/span&gt;]. Among the NTM, &lt;i&gt;Mycobacterium abscessus&lt;/i&gt; is the most significant species, particularly after liposuction and mammoplasty [&lt;span&gt;5&lt;/span&gt;], probably due to the improper cleaning.&lt;/p&gt;&lt;p&gt;HFUS plays a crucial role in supporting early diagnostic suspicion and treatment, particularly in suspected cases of NTM infection. In the early stages, cutaneous lesions caused by NTM may clinically resemble common bacterial abscesses, presenting with inflammatory signs such as erythema, edema, and firm nodules draining purulent content. However, HFUS reveals distinct features depending on the disease stage. We propose four stages of evolution: Stage I—Granulomatous Phase: Hypoechoic nodular lesion located in the dermis or hypodermis, with increased echogenicity of the surrounding subcutaneous tissue (suggestive of panniculitis) and moderate intralesional and peripheral vascularity (Figure 1a). Stage II—Liquefaction Phase: Heterogeneous iso/hypoechoic collection with nonmobile internal content. Anechoic peripheral zones suggest centripetal liquefaction. Adjacent panniculitis is evident as increased echogenicity and marked vascularity within and around the lesion. These findings support the presence of residual fat lobules within the collection, likely undergoing inflammatory liquefaction (Figure 1b). Stage III—Tunnelization Phase: Interconnected hypoechoic linear tracts extending toward the dermis or skin surface, associated with heterogeneous fluid content and peripheral vascularity. Echogenic subcutaneous fat persists, indicating ongoing panniculitis (Figure 1c). Stage IV—Mixed Phase: Coexistence of linear tracts and nodular lesions, with persistent heterogeneous debris and thickened, irregular walls. Vascular signals are centrally and peripherally present (Figure 1d and Table 1).&lt;/p&gt;&lt;p&gt;HFUS consistently reveals relevant differences between pyogenic and NTM abscesses (Table 2). Pyogenic abscesses are usually solitary, well-circumscribed, and unilocular, with anechoic fluid and mobile internal debris. They exhibit thin, regular walls, intense peripheral vascularity, and no internal flow (Figure 2a–c). Perilesional panniculitis is common, reflected by increased echogenicity of the adjacent fat. In contrast, NTM-related abscesses tend to be multiple and initially present as a dermal thickening. The collections are multiloculated, with nonmobile, reticulated internal content and a peripheral-to-central liquefaction pattern. A central echogenic fat island may re","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over-the-Counter Products for Male Androgenetic Alopecia: A Network Meta-Analysis Study","authors":"Aditya K. Gupta,&nbsp;Mary A. Bamimore,&nbsp;Mesbah Talukder","doi":"10.1111/jocd.70483","DOIUrl":"10.1111/jocd.70483","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Society values a full head of hair. Therefore, androgenetic hair loss (AGA), though medically benign, can cause significant emotional distress. There is strong demand for alternative (nonconventional, over-the-counter) AGA treatments. It is important to have evidence on the efficacy of these treatments for AGA—especially in comparison with treatments that are approved by the United States Food and Drug Administration (FDA), such as oral finasteride and topical minoxidil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Following a systematic review, we conducted a network meta-analysis (NMA) to determine the relative efficacy of conventional monotherapies and selected alternative (nonconventional, over-the-counter) products for male AGA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a Bayesian NMA under a fixed effect model with uniform priors; the NMA estimated relative effects—as per mean difference (MD), along with the 95% credible interval (CI)—and surface under the cumulative ranking curve (SUCRA) values. We also assessed study-level evidence quality. Eligible studies were identified through systematic searches (without date restrictions) in PubMed and Scopus on April 30, 2025. The main outcome measure was change in total hair density at 24 weeks from baseline (in hairs/cm²).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Conclusion</h3>\u0000 \u0000 <p>We found 24 eligible trials—where the relative efficacy of eight conventional monotherapies and seven alternative (nonconventional, over-the-counter) products was determined. The current NMA study confirms the efficacy of conventional monotherapies such as oral dutasteride, topical/oral minoxidil, and oral/topical finasteride for male AGA. We have provided guidance regarding the relative efficacy of some alternative (nonconventional, over-the-counter) agents (e.g., melatonin (topical) and rosemary oil (topical)) compared to conventional treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 10","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}