Journal of Cosmetic Dermatology最新文献

{"title":"Cosmetic Lasers in the US: Who's Using Them, the Latest Technology, and What Patients Need to Know","authors":"Kensington Coyle,&nbsp;Katarina R. Kesty","doi":"10.1111/jocd.70235","DOIUrl":"https://doi.org/10.1111/jocd.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The use of laser treatments for cosmetic and medical dermatologic conditions has increased significantly, yet provider training varies widely, raising concerns about patient safety and treatment efficacy. This study examines the availability and practice patterns of fellowship-trained laser dermatologists and compares them to medical spas and plastic surgeons offering laser services.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In September 2024, an online search and telephone survey were conducted to identify board-certified dermatologists who completed an American Society for Dermatologic Surgery (ASDS) Cosmetics and Lasers Fellowship. Data on consultation availability, pricing, provider involvement, technology investment, and treatment customization were collected from dermatology, plastic surgery, and medical spa practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 124 fellowship-trained dermatologists were identified. Compared to medical spas and plastic surgeons, these dermatologists had longer wait times for consultations (23 vs. 4 and 11 days), higher consultation fees ($153 vs. $30 and $78), and a greater number of laser devices per practice. Physician involvement in laser procedures was significantly higher among dermatologists (60%) compared to plastic surgeons (33%) and medical spas (9%). Medical spas relied heavily on nonphysician providers (26%) and laser technicians (56%), with only 41% providing direct on-site supervision. The majority (98%) of dermatologists and plastic surgeons customized laser treatments, compared to 63% of medical spas. Dermatologists dedicated more clinical time to laser procedures, with 19% spending over 50% of their practice on lasers, compared to none at medical spas and plastic surgery offices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Fellowship-trained laser dermatologists provide more direct physician involvement, greater technological resources, and highly customized treatments compared to medical spas and plastic surgeons. While medical spas offer lower costs and shorter wait times, the lack of physician oversight and limited training among providers may represent substandard care. These findings highlight the importance of provider qualifications in ensuring optimal patient outcomes and underscore the value of specialized laser training in dermatology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Modulation of Demodex Density via Isotretinoin: Insights From a Prospective Dermatological Investigation","authors":"Ahmed Muayad Jirjees Chakmakchi,&nbsp;Emine Tugba Alatas,&nbsp;Aslan Yurekli,&nbsp;Ceyda Tetik Aydoğdu,&nbsp;Suzan Demir Pektas","doi":"10.1111/jocd.70249","DOIUrl":"https://doi.org/10.1111/jocd.70249","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p><i>Demodex</i> spp. are ectoparasites that reside in pilosebaceous units, particularly on the face where sebum secretion is prominent. The sebum-reducing effects of isotretinoin play a crucial role in the management of acne vulgaris and rosacea. This study aims to assess the effect of isotretinoin on <i>Demodex</i> density in patients with acne vulgaris and rosacea accompanied by demodicosis. The evaluation includes <i>Demodex</i> mite density, before, during, and after 6 months of isotretinoin treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials Methods</h3>\u0000 \u0000 <p>The study included patients diagnosed with acne vulgaris and rosacea accompanied by demodicosis who were prescribed isotretinoin treatment. Demographic data were collected, and <i>Demodex</i> spp. mites were detected using superficial skin biopsy before treatment initiation. Follow-up samples were obtained at 2 and 6 months. Statistical analysis was performed using SPSS version 23, with a significance level set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 36 patients, 25 with acne and 11 with rosacea, were included in our study. <i>Demodex</i> density was assessed before treatment, at 2 months, and at 6 months. Our findings showed a significant decrease in <i>Demodex</i> density with isotretinoin treatment, especially in relation to the decrease in sebum secretion (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study makes a notable contribution to the existing literature by being the first to assess the impact of isotretinoin treatment on <i>Demodex</i> density. Our results indicate that isotretinoin effectively reduces <i>Demodex</i> density, likely due to a reduction in sebum production. To further explore isotretinoin's effects, future research should involve larger sample sizes and extended follow-up periods. These findings enhance our understanding of isotretinoin's role in managing <i>Demodex</i>-related dermatological conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Topical Timolol on Healing of Immature Breast Scars After Mammoplasty: A Randomized Controlled Trial With Blinded Assessors and Patients","authors":"Nahid Nafissi,&nbsp;Fatemeh Najafi,&nbsp;Alireza Jafarzadeh,&nbsp;Elham Behrangi,&nbsp;Masoumeh Roohaninasab,&nbsp;Seyyedeh Tahereh Rahimi,&nbsp;Sepideh Salehi,&nbsp;Amir Jafari-Nasirmahalleh,&nbsp;Nazanin Hoseini,&nbsp;Azadeh Goodarzi","doi":"10.1111/jocd.70261","DOIUrl":"https://doi.org/10.1111/jocd.70261","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Wound healing is a complex process encompassing four main stages: hemostasis, inflammation, cell proliferation, maturation, and differentiation. Timolol (TM) may influence these stages, particularly re-epithelialization. This study aims to evaluate the 1-month effects of timolol on acute surgical wounds in post-mammoplasty patients.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To investigate the efficacy of topical timolol in improving postoperative breast scars, aiming to guide future treatment protocols and prescriptions.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 12 patients who underwent bilateral mammoplasty were enrolled in this double-blind randomized clinical trial. Treatment commenced 48 h post-surgery; one breast was treated with 0.5% timolol eye drops, while the contralateral breast received distilled water (control). Patients were advised to minimize sun exposure and pressure on the treated area, and no additional oral or topical medications were prescribed. Cleansing with a prescribed cleanser occurred every 3 days. Cosmetic assessments were conducted by a specialist at 10 and 30 days post-surgery using a 10-point Likert scale. Data were analyzed using two-way repeated measures ANOVA.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Timolol significantly reduced erythema over time (Interaction, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001; Treatment, &lt;i&gt;p&lt;/i&gt; = 0.02), with an average decrease of 5.38 points (95% CI: 4.22–6.55) compared to 4.41 points (95% CI: 3.83–5) for placebo. The difference in reduction was 0.972 points (95% CI: 0.18–1.7). A significant improvement in the aesthetic appearance of the breast was also noted (Interaction, &lt;i&gt;p&lt;/i&gt; &lt; 0.0001; Treatment, &lt;i&gt;p&lt;/i&gt; = 0.015), with timolol enhancing the aesthetic score by approximately 5.5 points (95% CI: 4.9–6.2) versus 4.58 points (95% CI: 3.4–5.7) for the placebo. Overall, timolol improved the aesthetic score by 0.972 points (95% CI: 0.23–1.7) more than the placebo.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Topical application of 0.5% timolol significantly improved the aesthetic appearance and reduced erythema of post-mammoplasty breast scars over a 1-month period. The results demonstrate a measurable clinical benefit, with statistically significant differences favoring timolol over placebo. These findings suggest that early intervention with topical timolol may offer a safe, effective, and non-invasive option for optimizing scar ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed Cosmetic Enhancements Guided by Artificial Intelligence","authors":"Marina Landau,&nbsp;Maria Tsoukas,&nbsp;Mohamad Goldust","doi":"10.1111/jocd.70263","DOIUrl":"https://doi.org/10.1111/jocd.70263","url":null,"abstract":"&lt;p&gt;Artificial intelligence (AI) and 3D printing are coming together to transform aesthetic dermatology through personalized, data-driven cosmetic interventions. By integrating facial scans, dermatologic imaging, and predictive algorithms, AI enables the development of patient-specific implants and fillers with remarkable precision. This collaboration creates new opportunities for delivering minimally invasive, efficient, and predictable aesthetic enhancements [&lt;span&gt;1-3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;One significant advantage of AI-guided 3D printing is its ability to customize solutions for each patient's unique facial structure and tissue characteristics. Algorithms can analyze both 2D and 3D data to design implants tailored to a patient's anatomy. For example, platforms like FITme's FACE ON system utilize AI to convert patient scans into surgical-grade 3D models for cheek or jawline augmentation. Such systems facilitate preoperative visualization, allowing patients to preview expected results and encouraging collaborative decision-making. While the potential is promising, peer-reviewed validation of these technologies is still limited and should be approached with caution.&lt;/p&gt;&lt;p&gt;Beyond aesthetic applications, AI-guided 3D printing is also valuable in reconstructive dermatology, particularly for post-trauma and congenital deformity corrections. Soft tissue restoration using customized, bioresorbable materials such as polycaprolactone (PCL) provides a biocompatible alternative to traditional implants. These materials naturally degrade over time, enabling interim solutions and adaptive re-treatments without permanent structural change. AI can assist in selecting appropriate materials and modeling patient-specific degradation profiles, optimizing both functionality and aesthetic longevity [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Additionally, AI facilitates provider workflows by automating implant design, improving surgical planning, and reducing procedural times, which enhances overall efficiency. For instance, rapid prototyping of facial implants may minimize intraoperative adjustments, shorten anesthesia duration, and increase surgical precision.&lt;/p&gt;&lt;p&gt;However, the convergence of these technologies raises regulatory and ethical concerns. AI systems require large datasets containing sensitive biometric and medical information. The lack of robust frameworks regarding data privacy, algorithmic transparency, and validation poses significant challenges. Currently, the US FDA has issued general guidance for AI/ML-based software as a medical device (SaMD), but specific pathways for AI-designed, patient-matched 3D-printed implants are still being developed. Similarly, the European CE marking system does not yet provide detailed criteria for AI-influenced custom manufacturing. Furthermore, clinical guidelines to govern the use of AI-generated implants in aesthetic dermatology remain limited [&lt;span&gt;5&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Algorithmic bias and limited model generalizability also warrant caution","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Face of Emotion: Botulinum Toxin, Emotional Anatomy, and Mood Modulation","authors":"Robert J. Vanaria,&nbsp;Aysham Chaudry,&nbsp;Angelica C. Marrero-Perez,&nbsp;Z. Paul Lorenc,&nbsp;Mark S. Nestor","doi":"10.1111/jocd.70264","DOIUrl":"https://doi.org/10.1111/jocd.70264","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Facial expressions profoundly influence emotional communication and well-being. The facial feedback hypothesis suggests that facial muscle activity can reinforce or modulate emotional experiences. Botulinum toxin type A (BoNT-A), known for its aesthetic applications, is emerging as a modulator of mood through its effects on facial musculature and feedback mechanisms. Its ability to influence mood extends beyond aesthetic improvement, offering potential therapeutic benefits in emotional regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This literature review explores the interplay between facial anatomy, emotional expression, and the potential of BoNT-A to enhance overall mood and well-being, beyond aesthetic improvement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature review was conducted using PubMed with search terms like “botulinum toxin” AND “emotion.” Relevant English-language articles from 2000–present were selected based on their examination of BoNT-A's influence on mood and facial feedback. Articles not in English and lacking relevance were excluded. Citation tracking was used to identify additional studies, and insights from the authors' clinical expertise further informed the review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 46 articles were included based on their relevance to both BoNT-A and emotional states. BoNT-A-induced muscle relaxation can prevent specific muscle contraction and thereby disrupt feedback loops that reinforce mood, potentially enhancing positive emotions and promoting overall wellbeing. Studies suggest that BoNT-A injected into the glabella region can modulate amygdala activity, reduce symptoms of depression and anxiety, and strengthen overall emotional resilience. By modulating facial expressions, BoNT-A can also enhance social interactions, increase positive emotional contagion, and contribute to a more positive self-perception.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>BoNT-A shows promise as a novel approach to mood regulation and enhancement by altering facial feedback mechanisms. Its dual aesthetic and therapeutic benefits highlight its value in both dermatology and mental well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Classification of M-Shaped Lips for Enhanced Refill Outcomes: A Case Series","authors":"Dina Moctezuma Villalobos","doi":"10.1111/jocd.70239","DOIUrl":"https://doi.org/10.1111/jocd.70239","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lips are crucial to facial aesthetics, with fuller lips often deemed more attractive. This preference has led to increased demand for non-surgical lip augmentation using dermal fillers. However, there is a gap in the literature regarding the identification and management of a particular anatomical variant colloquially known as “M-shaped lips”, characterized by a central “M” configuration of the upper lip. This anatomical variant presents unique complexities. This study presents the first classification system for M-shaped lips to guide safer, more predictable treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To introduce the first classification system for M-shaped lips, improving diagnostic accuracy, treatment strategies, and minimizing complications in cosmetic lip augmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A case series of nine patients aged 20–45 with M-shaped lips seeking cosmetic augmentation were treated with Aliaxin LV, a hyaluronic acid filler, in multiple sessions. The proposed classification system was based on the angle between the vertical and horizontal midlines of the lips, including three grades: mild (≤ 15°), moderate (16°–25°), and severe (&gt; 25°). Injection techniques and filler volumes were tailored according to patient classification using needles and cannulas for precise placement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The classification system facilitated personalized treatments, resulting in satisfactory aesthetic outcomes without significant complications. All the patients showed improved lip symmetry and volume, with no instances of filler migration or vascular complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings suggest that this classification system can significantly improve cosmetic results and reduce risks in treatment. Larger studies with more diverse populations and extended follow-up are needed to validate these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant Type III Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case Series","authors":"Xiaoguang Duan,&nbsp;Chunmei Ding,&nbsp;Jiewei Wu,&nbsp;Weiwei Bao,&nbsp;Yu Gao,&nbsp;Fei Liu,&nbsp;Wei Cai","doi":"10.1111/jocd.70226","DOIUrl":"https://doi.org/10.1111/jocd.70226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Facial erythema and acne scarring are common skin conditions that significantly impair quality of life, necessitating effective treatment options, particularly in Asian populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of intradermal injections of recombinant type III humanized collagen (RhCol-III) solution for alleviating facial erythema, improving skin texture associated with acne scarring, and evening out skin tone issues associated with post-inflammatory hyperpigmentation (PIH) from acne while also searching for potential underlying anti-inflammatory mechanisms of the RhCol-III solution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This case series included six Chinese participants with Fitzpatrick phototypes III/IV, presenting with facial erythema and/or acne scarring. Participants received intradermal injections of 2 mg/mL RhCol-III solution at baseline, 30- and 60- days post-baseline. Clinical evaluations were conducted using VISIA photography and self-assessed Global Aesthetic Improvement Scale (GAIS) scores. Additionally, in vitro testing was performed using the U937 cell line with lipopolysaccharide (LPS) induction to assess the anti-inflammatory effects of the RhCol-III solution on tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) secretion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All participants demonstrated a reduction in facial erythema post-treatment, with significant improvements noted in the zygomatic area. The mean erythema area decreased by 49.3% after 90 days. One case with acne scarring showed visible improvement in scar appearance, skin tone, and texture. Moreover, 0.10 mg/mL RhCol-III solution significantly reduced TNF-α and IL-6 levels in vitro by up to 47.75% and 44.96%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RhCol-III solution injections effectively reduced facial erythema and have the potential to improve acne scarring via reduction in the extent of PIH in this series of Chinese cases. The treatment was well-tolerated, with no significant adverse effects. These findings suggest RhCol-III solution as a promising therapeutic option for skin repair and inflammation reduction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose Mesenchymal Stem Cell-Derived Exosomes Versus Platelet-Rich Plasma Treatment for Photoaged Facial Skin: An Investigator-Blinded, Split-Face, Non-Inferiority Trial","authors":"Blanca Estupiñan,&nbsp;Karen Ly,&nbsp;David J. Goldberg","doi":"10.1111/jocd.70208","DOIUrl":"https://doi.org/10.1111/jocd.70208","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exosomes, an emerging treatment of interest to aesthetic dermatology, have therapeutic applications in skin rejuvenation, alopecia, atopic dermatitis, acne scarring, and wound healing. Platelet-rich plasma has been widely utilized for the same indications, among others. Currently, there are no trials comparing the two regenerative modalities in aesthetic dermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To compare the efficacy and safety of adipose mesenchymal stem cell-derived (ASC) exosomes versus platelet-rich plasma for photoaged facial skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An investigator-blinded, split-face trial was conducted. Participants with mild to moderate photoaging underwent three radiofrequency microneedling treatments with PRP and topical exosomes each applied to one half of the face.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both exosomes and PRP equally improved wrinkling, dyschromia, erythema, texture, and overall skin appearance. Histological analysis confirmed increased collagen I and glycosaminoglycans, without significant differences between treatment arms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ASC exosomes are a promising PRP-alternative that may be attractive to needle-averse patients and can hasten the office visit duration, as phlebotomy and centrifugation are not required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Assessing Efficacy and Satisfaction of CE Ferulic Serum Following Nonablative Fractional Fraxel Laser Treatment for Photoaging Skin in Chinese Population","authors":"Xiaolei Qin,&nbsp;Jinlong Zhai,&nbsp;Chenxi Zhou,&nbsp;Yanmei Wang,&nbsp;Mengjiao Chen,&nbsp;Lin Zhu,&nbsp;Qi Shi,&nbsp;Weiliang Chen,&nbsp;Liyuan Zhang,&nbsp;Xiao Luo,&nbsp;Kai Li","doi":"10.1111/jocd.70251","DOIUrl":"https://doi.org/10.1111/jocd.70251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Following Nonablative fractional Fraxel laser (NAFL), a well-established treatment for skin rejuvenation, immediate post-procedural care is essential to address any potential complications and accelerate the healing process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy and patient satisfaction of a topical skincare regimen containing vitamin C, vitamin E, and ferulic acid—CE Ferulic serum (CEF) following NAFL treatment in the Chinese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this randomized, investigator-blinded, split-face, controlled trial, patients with mild-to-moderate facial photodamage were randomized to receive CEF treatment on one side of the face and normal saline (NS) on the other side immediately after the NAFL procedure and daily during the 7-day follow-up. The primary endpoint was the change from baseline in erythema score on Day 7, with key secondary endpoints including changes from baseline in erythema index (EI), melanin index (MI), transepidermal water loss, skin hydration, skin sebum content, scabbing, edema, overall patient satisfaction, and post-procedure pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 50 patients (female 45/50) were enrolled in this study, with a mean age of 31.6 years. The mean change from baseline in erythema score was significantly lower on the CEF side than on the NS side on Day 7 post-NAFL treatment (0.04 ± 0.40 vs. 0.18 ± 0.48, <i>p</i> = 0.011). The CEF side also exhibited improved changes in EI, MI, and skin hydration, as well as higher overall satisfaction and less pain compared with the NS side.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Applying CEF after NAFL treatment reduced erythema progression, maintained skin hydration, and promoted the healing process compared with NS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Chinese Clinical Trial Registry: ChiCTR2300069246</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy and Safety of a Highly Purified Polynucleotide for Dry and Chapped Lips: A Prospective, Multicenter Study","authors":"Nark Kyung Rho,&nbsp;Hyun Jun Park,&nbsp;Hei Sung Kim","doi":"10.1111/jocd.70224","DOIUrl":"https://doi.org/10.1111/jocd.70224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dry and chapped lips are a common nuisance. Besides the discomfort, many report feeling embarrassed over the unsightly appearance of their chapped lips. The aim of this study was to determine if polynucleotide (PN) injection helps relieve lip dryness and assess safety in practicing PN in this specific area.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective study, 30 Korean subjects with dry and chapped lips enrolled to receive PN injection on the vermilion zone (a total of 3 injections, each 3 weeks apart). Vermilion wrinkle and roughness were scored based on the photos taken pretreatment (week 0); before the 2nd and 3rd injection (week 3, week 6); and 3 weeks after the 3rd injection (week 9) using the respective severity rating scales. Safety data were obtained throughout the study period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 27 individuals completed the study. PN significantly improved both the vermilion wrinkles (assessed by the Wrinkle Severity Rating Scale (WSRS)) and roughness (assessed by the Lip Roughness Grading Scale (LRGS)) at all time points compared to baseline (<i>p</i> &lt; 0.05). The WSRS response rate (Ratio of subjects whose WRSR decreased by ≥ 1 point compared to baseline) at week 9 was 100%. Lip swelling was experienced by all subjects when examined 30 min after PN injection, followed by pain (90%) and redness (77%). The injection site adverse reactions were mostly mild and transient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results suggest that PN may be a promising option to soothe dry and chapped lips. However, larger studies with long-term follow-up are necessary to confirm the preliminary findings of this study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}