Journal of Cosmetic Dermatology最新文献

{"title":"In Vitro and In Vivo Evaluation of an Emollient-Rich Moisturizer Developed to Address Three Critical Elements of Natural Moisturization","authors":"Zoe D. Draelos,&nbsp;Diane B. Nelson","doi":"10.1111/jocd.70085","DOIUrl":"https://doi.org/10.1111/jocd.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A new, emollient-rich moisturizing cream has been developed to support three critical elements of natural skin moisturization—hyaluronic acid, natural moisturizing factors, and lipids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of this study was to evaluate in vitro biomarkers associated with skin hydration and barrier support, followed by in vivo clinical hydration assessment and tolerability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using an in vitro epidermal skin model, tissues were treated with the study moisturizer or control (saline) for 24 h. Genes associated with hydration and barrier support were analyzed: claudin 4 (CLD4), aquaporin 3 (AQP3), hyaluronic acid synthase 2 (HAS2), and hyaluronidase 1 (HYAL1). The clinical study evaluated twice-daily use of the study moisturizer in subjects with moderate-to-severe dry skin. Subject satisfaction and skin hydration measurements were captured at baseline, 2, 4, and 8 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Increased expression of CLD4, AQP3, and HAS2 and reduced activity of HYAL1 were demonstrated after 24 h. In subjects applying the study moisturizer, significant mean percent improvements from baseline in skin hydration occurred at Weeks 2 (41%; <i>p</i> &lt; 0.0001), 4 (38%; <i>p</i> &lt; 0.0001), and 8 (116%; <i>p</i> &lt; 0.0001). Ninety-six percent of subjects reported their skin felt hydrated after 8 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An emollient-rich moisturizing cream developed to support three critical elements of natural skin moisturization increased the expression of biomarkers associated with skin barrier support and hydration, and reduced the expression of HA-degrading enzymes. Early, significant increases in skin hydration were observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro, Ex Vivo, Instrumental, and Clinical Assessment of a Novel Anti-aging Serum Targeting Oxidative Stress","authors":"Sayantani Goswami,&nbsp;Jin Namkoong,&nbsp;Marwa El Hajoui,&nbsp;Ewelina Lesniak,&nbsp;Joanna Wu","doi":"10.1111/jocd.16664","DOIUrl":"https://doi.org/10.1111/jocd.16664","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primarily driven by oxidative stress, aging results from the attrition of cells, aggravated by environmental stressors. Therefore, protection from oxidative stress is the main target of antiaging cosmetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy of a unique cosmetic serum combining five antioxidants and hyaluronic acid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The inactivation of reactive oxygen species by the serum was evaluated <i>in-tubo</i>. IL-1α release was evaluated using EpiDerm^TM skin models, while gene expression analysis and elastin fiber length were evaluated on human skin explants. Finally, the effect of twice daily serum application for 28 days was compared to those induced by a control serum, focusing on instrumental and assessor evaluations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>In-tubo</i>, the serum reduces reactive oxygen species by 45.2%. A single topical application on EpiDerm^TM skin models limits UV-induced ROS-mediated IL-1α release. Compared to untreated explants, HB-EGF (heparin-binding epidermal growth factor) skin homeostasis marker expression increases by 22-fold with treatment. Additionally, the serum increases elastin fiber length by 40.2%. Clinically, twice daily application of the serum over a period of 7 days revealed significant improvements in clinical scoring of skin's wrinkle (−12.8%), smoothness (+12.5%), and radiance (+22.2%). The serum also leads to a rapid and long-lasting increase in skin hydration (30 min: +50.5%, 28 days: +19.9%) and reduced transepidermal water loss (30 min: −7.7%, 28 days: −8.7%). The serum is highly efficacious and well tolerated by the subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The serum has antioxidant, soothing, photoprotective, and moisturizing properties that can be explained by the individual properties of its unique blend of actives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel (Main Components: Onion Extract Quercetin) for the Treatment of Rosacea","authors":"Zining Xu,&nbsp;Biao Yu,&nbsp;Yuxin Qing,&nbsp;Shuhong Ye,&nbsp;Bingyang Xu,&nbsp;Yuanqin Wang,&nbsp;Bin Zhao,&nbsp;Hong Sun,&nbsp;Na Wu,&nbsp;Jiawen Wu","doi":"10.1111/jocd.70129","DOIUrl":"https://doi.org/10.1111/jocd.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The management of papulopustular rosacea presents a significant clinical challenge. Anti-inflammatory and vasoconstrictive treatments are ineffective in the rapid amelioration of the dryness, burning, and itching caused by skin barrier damage in patients with papulopustular rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To assess the efficacy and safety of the topical application of compound heparin sodium allantoin gel to treat rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-two patients participated in this randomized, prospective, single-center, and controlled trial. The Clinician Erythema Assessment score, Investigator Global Assessment score, transepidermal water loss, and skin hydration were evaluated at 0, 2, 4, 8, and 12 weeks. Rosacea-specific quality of life score, itching, dryness, burning, Global Aesthetic Improvement Scale, and Patient Self-Assessment grades were also assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the traditional therapy group, the 8-week and 12-week topical application of compound heparin sodium allantoin gel to treat rosacea significantly decreased Clinician Erythema Assessment/Investigator Global Assessment grades, burning and itching grades, and rosacea-specific quality of life scores. Compound heparin sodium allantoin gel significantly improved the skin barrier with hydration and significantly decreased trans-epidermal water loss. For patients with Demodex infestation, externally applied compound heparin sodium allantoin gel was associated with better rosacea treatment outcomes and improved skin barrier function than externally applied hyaluronic acid. This may be attributable to the inhibition of abnormal demodex, improved skin barrier, and repair of minor skin wounds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compound heparin sodium allantoin gel effectively improved facial erythema, alleviated ithching and burning sensations, and improved patients' quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trail Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: ChiCTR2400087948</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Delayed-Onset Hypersensitivity Reaction and Complete Secondary Treatment Failure Following Repeated Cosmetic Botulinum Toxin Type A Injections","authors":"Yan Bian,&nbsp;Chi Zhang,&nbsp;Shaohua Wang,&nbsp;Lili Zhang,&nbsp;Hong Cai","doi":"10.1111/jocd.70145","DOIUrl":"https://doi.org/10.1111/jocd.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cosmetic botulinum toxin type A (BTX-A) injections have been widely used for improving facial aesthetics. Although the procedure is generally safe, immune-mediated adverse events, such as hypersensitivity reactions and secondary treatment failures, may rarely occur. We report the first case in which repeated BTX-A injections resulted in both a delayed-onset cutaneous hypersensitivity reaction and complete secondary treatment failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report/Methods</h3>\u0000 \u0000 <p>A 42-year-old female, with a history of successful BTX-A treatments for glabellar lines and masseter hypertrophy, experienced diminished efficacy following a treatment session. Ten hours after a touch-up injection, she developed facial swelling and edematous erythema localized to the injection sites. These manifestations persisted for over one month without any observable aesthetic improvement, indicating complete secondary treatment failure. The therapeutic effect was not restored even after switching to an alternative BTX-A formulation. We hypothesize that the patient's local hypersensitivity reaction represents a type III immune complex-mediated response (Arthus reaction) driven by IgG antibodies. The repeated BTX-A injections may have induced neutralizing IgG antibodies that, in concert with the cutaneous hypersensitivity reaction, contributed synergistically to both the cutaneous reaction and the complete treatment failure. The short interval between the injections may have facilitated these immunologic events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case underscores the importance for clinicians to remain vigilant regarding the potential for delayed-onset cutaneous allergic reactions and complete secondary treatment failure following repeated BTX-A injections.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsurgical Facial Contouring With a Novel Radiofrequency and Vacuum Device: A Multicenter Retrospective Study With 33 Patients","authors":"Mimi Ehrenraich,&nbsp;Ety Wolff,&nbsp;Suzy Roffe Grumer,&nbsp;Olalla Calvo Lozano,&nbsp;Reyna Vargas,&nbsp;Inna Belenky","doi":"10.1111/jocd.70127","DOIUrl":"https://doi.org/10.1111/jocd.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aging process reflects decreased tissue elasticity and a rearrangement of subcutaneous volume, resulting in superficial wrinkles and three-dimensional changes in skin topography. Radiofrequency (RF)-based approaches have become increasingly adopted in recent decades due to their relatively short downtime and significantly reduced risk of adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the safety and efficacy of the V-FC handpiece through a multicenter retrospective study as well as ex vivo and in vivo analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The V-FC handpiece was used once a week for a treatment course of 3–6 sessions. The clinical evaluation of 33 patients included demographics, BMI, assessment of skin laxity, and rate of improvement. An ex vivo study with porcine tissue assessed the penetration depth of RF, while device performance was evaluated in an in vivo animal histological analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant adverse effects were recorded during the treatment course or at short- and long-term follow-ups (1, 3, and 52 months). The average skin laxity grade baseline was 34% lower at the end of the treatment course, with the average rate of improvement assessed as moderate. The ex vivo minimal and maximal penetration depths were 3.2–11.3 mm (±10%). The in vivo histopathological analysis showed no signs of acute heat injury at any treatment setting, including the maximum RF power. Additionally, staining showed a power-related progressive proliferation of fibroblasts, elastin fibers, and neocollagenesis, which was significantly higher 4 weeks after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The new RF device demonstrates an effective treatment for facial contouring with a proven short- and long-term high safety profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Ceramide Profile of Facial Sensitive Skin: Disordered Intercellular Lipid Structure Is Linked to Skin Hypersensitivity","authors":"Taisei Joichi,&nbsp;Hiroyuki Yoshida,&nbsp;Hiroaki Katsukura,&nbsp;Lili Zhai,&nbsp;Daisuke Watanabe,&nbsp;Naohito Yamamoto,&nbsp;Mai Haneoka,&nbsp;Shun Nakamura,&nbsp;Akane Kawamoto,&nbsp;Hiromitsu Nakazawa,&nbsp;Motoaki Suka","doi":"10.1111/jocd.70154","DOIUrl":"https://doi.org/10.1111/jocd.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although sensitive skin (SS) is a syndrome characterized by cutaneous hypersensitivity to environmental factors, its pathophysiology remains elusive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We aimed to explore the characteristics of ceramides (CERs) and intercellular lipid (ICL) structures of individuals with and without facial SS and their relationship with skin hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Healthy Japanese females were divided into SS or non-SS groups based on self-perception and lactic acid stinging test (LAST). Stratum corneum (SC) lipids were analyzed using a liquid chromatograph-mass spectrometer, and the orthorhombic-hexagonal lateral packing structure of ICLs was assessed using electron diffraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>According to the mean LAST score, individuals with SS (<i>n</i> = 48) had mild-to-moderate skin hypersensitivity. SS exhibited not significantly but slightly impaired skin barrier function (<i>p</i> = 0.072) and lower levels of CER[NH], [NP], [EOS], [EOH] (all <i>p</i> &lt; 0.05), and [EOP] (<i>p</i> = 0.073) in the SC compared with non-SS (<i>n</i> = 18). Notably, the CER[NP]/[NS] ratio, a marker of skin barrier function, was positively correlated with the orthorhombic-hexagonal lateral packing ratio of ICLs (<i>p</i> = 0.002), whereas it was negatively correlated with the LAST score (<i>p</i> = 0.015) and the interleukin (IL)-1 receptor antagonist/IL-1α ratio (<i>p</i> = 0.003) in the SC, an indicator of chronic inflammation. Moreover, corneocyte size was reduced in SS (<i>p</i> &lt; 0.001), suggesting inferior SC maturation, and was positively correlated with the CER[NP]/[NS] (<i>p</i> &lt; 0.001) and the orthorhombic-hexagonal ratios (<i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Individuals with SS showed an abnormal CER profile, particularly the altered CER[NP]/[NS] ratio, which was in turn associated with disordered ICL structure and skin hypersensitivity. Abnormal epidermal turnover may be an underlying mechanism of the abnormalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model","authors":"Xufeng Jiang,&nbsp;Weiguo Wang,&nbsp;Yuqing Wei,&nbsp;Wenxuan Cheng,&nbsp;Shoulin Li,&nbsp;Linjing Du,&nbsp;Wenping Xu,&nbsp;Yang Zhang","doi":"10.1111/jocd.70128","DOIUrl":"https://doi.org/10.1111/jocd.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The biological activity of both alone or in combination was evaluated based on the zebrafish model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Zebrafish embryos were induced to form models using different methods. Add BAK and Argireline YOUth peptide oil solution MB (ARG, containing 0.125% acetyl hexapeptide-8) to treat zebrafish embryos, and they were evaluated for their restorative effects on preexisting damage in zebrafish embryos.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BAK and ARG were able to reduce water loss from the caudal fin of zebrafish induced by 0.9% NaCl solution. They were able to alleviate the UVB-induced decrease in the expression level of the skin tightness-related gene (<i>ELN</i>/<i>COL1a1b</i>) in zebrafish embryos, and BAK or ARG effectively reversed the increase in β-galactosidase activity induced by exposure to H₂O₂ solution and restored telomerase activity in zebrafish embryos. In addition, both were able to counteract oxidative stress and mitochondrial damage in zebrafish embryos as a result of LPS treatment. Finally, BAK and ARG were also effective in suppressing the increase in neutrophil counts and inflammatory cytokine levels in zebrafish embryos due to LPS exposure. Notably, BAK and ARG were more effective when used in combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Acetyl hexapeptide-8 promotes the bioactivity of BAK in zebrafish embryos (<i>Danio rerio</i>). BAK and ARG have moisturizing, anti-inflammatory, antioxidant, and antioxidant bioactivities in the zebrafish model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Porphyria Cutanea Tarda Scarring With Combination Laser Treatment and a Pilot Use of Artificial Intelligence to Quantify Laser Results","authors":"Chelsea E. Kesty,&nbsp;Katarina R. Kesty","doi":"10.1111/jocd.70056","DOIUrl":"https://doi.org/10.1111/jocd.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Porphyria cutanea tarda (PCT) is the most common subtype of porphyria and results from a deficiency of the enzyme uroporphyrinogen decarboxylase. Even after successful treatment, patients can be left with significant scarring, and there is little published data on the safety and efficacy of light-based or laser-based therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This report examines a case of a 47-year-old male with PCT secondary to HCV, treated with a combination of fractionated erbium-doped yttrium-aluminum-garnet (Er:YAG), intense pulsed light (IPL), and carbon dioxide (CO₂) lasers to address significant scarring and residual skin damage. An artificial intelligence model was used to quantify the results of the laser procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After combination laser treatment, the patient exhibited marked improvements in skin texture, reduction in scar visibility, and diminished hyperpigmentation. The artificial intelligence algorithm quantified the laser results and showed improvements in the scores used in the large language model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this patient, customizing a combination of lasers to target different layers of the skin to achieve comprehensive improvement: erbium primarily addressed superficial irregularities and pigmentation, while CO₂ promoted deeper collagen remodeling. The use of artificial intelligence to quantify the positive results in this case is in line with the clinical evaluations and photos.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Oxymetazoline 1% Cream for the Treatment of Mild to Moderate Facial Rosacea","authors":"Fatemeh Sajdeh,&nbsp;Aniseh Samadi,&nbsp;Atefeh Naeimifar,&nbsp;Taraneh Yazdanparast,&nbsp;Maryam Ahmadi,&nbsp;Fatemeh Amiri,&nbsp;Martin Kassir,&nbsp;Alireza Firooz,&nbsp;Saman Ahmad Nasrollahi","doi":"10.1111/jocd.16782","DOIUrl":"https://doi.org/10.1111/jocd.16782","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Rosacea is a common skin condition that affects the physical and mental health of the patient. The objective of this study was to evaluate the efficacy and safety of oxymetazoline 1% cream, a specific α1A-adrenoceptor agonist, for the treatment of mild to moderate facial rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In phase II of the before–after study, 15 patients with mild to moderate rosacea were enrolled and treated with oxymetazoline 1% cream twice daily for 4 weeks. The clinician's erythema assessment (CEA) and patient's self-assessment (PSA), as well as the skin biometric parameters (transepidermal water loss, sebum, stratum corneum hydration, temperature, erythema, melanin, and pH), dermal and epidermal thickness and echo-density, and capillaroscopic pattern were assessed and compared before and after treatment. <i>p</i>-Value &lt; 0.05 was considered significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CEA and PSA indexes decreased significantly 2 and 4 weeks after the treatment (<i>p</i>-value: 0.001). The erythema index also decreased significantly in both 2 weeks (<i>p</i>-value: 0.001) and 4 weeks (<i>p</i>-value: 0.001) after the treatment. The capillaroscopic pattern of lesions showed a decrease in telangiectasia and a reddish background of skin. No side effects of treatment were experienced by any of the patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Oxymetazoline 1% cream was safe and effective in treating mild to moderate facial rosacea. The reduction in the skin's vascularity was also objectively confirmed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16782","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Mesotherapy Induced Granuloma Annulare With Baricitinib","authors":"Li Wang,&nbsp;Shang Shen Chen,&nbsp;Ming Yuan Xu,&nbsp;Ye Qiang Liu,&nbsp;Jun Ting Tang","doi":"10.1111/jocd.70162","DOIUrl":"https://doi.org/10.1111/jocd.70162","url":null,"abstract":"&lt;p&gt;Mesotherapy is a dermatological treatment that involves injections into the dermal layer to achieve effects such as pore reduction, enhanced hydration, improved skin tone, and wrinkle removal [&lt;span&gt;1&lt;/span&gt;]. Although generally regarded as safe, its widespread use and the absence of standardized procedures have led to various adverse reactions, including granuloma formation, infections, fat necrosis, and abscesses. Systemic corticosteroids are considered the primary treatment; however, consensus is lacking regarding alternative therapeutic options [&lt;span&gt;2&lt;/span&gt;]. Granuloma annulare is a benign inflammatory condition associated with various comorbidities, including thyroid disease, malignancy, trauma, diabetes mellitus, and HIV infection [&lt;span&gt;2&lt;/span&gt;]. While systemic corticosteroids are effective in managing granuloma annulare, the condition frequently recurs following the cessation of treatment. Baricitinib, an inhibitor of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, exhibits promising therapeutic effects on granuloma annulare (GA). In this context, we report on a patient with Mesotherapy-induced Granuloma Annulare whose lesions significantly improved with the administration of the JAK1/2 inhibitor, Baricitinib.&lt;/p&gt;&lt;p&gt;A 32-year-old female exhibited diffuse red papules and nodules on her face following mesotherapy injections intended for facial aesthetic enhancement with one-week history. The injectant, hyaluronic acid, was procured by the patient and administered using a handheld needle. Verification of the substance's nature and chemical composition was not feasible. A skin biopsy was obtained from a singular lesion on the forehead.&lt;/p&gt;&lt;p&gt;Upon physical examination, diffuse papules and subcutaneous nodules were observed bilaterally on the cheeks, forehead, and lower jaw, aligning with the mesotherapy injection sites (Figure 1a,b). Dermoscopic examination revealed multifocal yellow-orange areas along with several globular white regions, indicative of the histologic subtype of granuloma (Figure 1d). Histopathological examination showed accumulation of palisading granuloma, which was characterized by histiocytes and lymphocytes surrounding irregular zones of altered collagen and deposited mucus in the dermis; no obvious foreign body deposition was found (Figure 1e,f). Positive for Alcian blue staining (Figure 1g). These findings supported a diagnosis of granuloma annulare, grounded on characteristic clinical and pathological features.&lt;/p&gt;&lt;p&gt;The initial treatment regimen included doxycycline, administered orally at 100 mg twice daily for 1 month, and intramuscular administration of 7 mg betamethasone was performed once monthly, totaling two injections. However, these measures resulted in minimal improvement. Subsequently, the patient commenced treatment with oral baricitinib at a dose of 2 mg/day. A marked reduction in lesions was noted 1 month post-initiation, with near-complete resolution observe","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}