Journal of Cosmetic Dermatology最新文献

{"title":"Knowledge, Perceptions, and Practices of Skin-Lightening Products Among Female Medical Students: A Cross-Sectional Study","authors":"Hanadi Qeyam,&nbsp;Rula Al-Shami,&nbsp;Ahmed Al-Rusan,&nbsp;Mohannad Alnaimat","doi":"10.1111/jocd.70380","DOIUrl":"https://doi.org/10.1111/jocd.70380","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The use of skin-lightening products (SLPs) is a widespread phenomenon influenced by cultural, social, and aesthetic perceptions. However, the awareness of their potential dermatological and systemic risks remains inadequate, particularly among young women, including medical students. This study aims to assess the knowledge, perceptions, and practices regarding SLPs among female medical students.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional survey was conducted among 305 female medical students at Jordanian universities. Data on participants' perception of skin color tone, knowledge of active ingredients, and the risks associated with the use of SLPs were collected and analyzed, in addition to exploring the prevalence and the pattern of the use of these products among them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants exhibited good knowledge regarding SLPs, although their perceptions of lighter skin tones varied. 40.7% of participants reported using SLPs, with the majority having Fitzpatrick skin type 3. Vitamin C (72.4%) and niacinamide (38.3%) were the most frequently used active ingredients. The main reasons for SLP use were to treat facial hyperpigmentation (35.5%) and for general skin tone lightening (30.6%). Side effects included acne (30.3%), skin redness (29.4%), and color changes (16.8%). While 34.7% of users were satisfied with the results, 37.1% reported fractional improvement, and 28.2% were disgruntled. Only 43.5% consulted a physician or dermatologist before use, with many depending on social media and friends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings highlight a gap between awareness and practice, suggesting that social and cultural factors significantly influence behavior, potentially outweighing medical knowledge. This demonstrates the need for targeted educational interventions that address societal beauty norms, misinformation, and psychological dependence, as well as strengthening regulatory measures and promoting safe dermatological alternatives to reduce unsafe skin-lightening practices among future healthcare professionals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70380","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Mid-Upper Facial Contours: Hairline Transplant Solutions for East Asian Women With High and Wide Foreheads","authors":"Wei Wu,&nbsp;Chi Liu,&nbsp;Peiqi Zhang,&nbsp;Shunuo Zhang,&nbsp;Qian Liu,&nbsp;Meihua Di,&nbsp;Xiaohui Yang,&nbsp;Siyuan Zhu","doi":"10.1111/jocd.70374","DOIUrl":"https://doi.org/10.1111/jocd.70374","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A high and wide forehead is a common congenital facial characteristic among East Asian women, often resulting in an imbalanced mid-upper facial proportion, diminished three-dimensional contour, and reduced femininity. Although this facial morphology is often congenital, such features frequently lead to appearance-related anxiety, affecting patients' confidence and social interactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate how a personalized hairline design strategy using follicular unit extraction (FUE), tailored to East Asian facial proportions, can enhance mid-upper facial contours in women with high and wide foreheads.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 60 female patients with high and wide foreheads were enrolled, with a mean age of 33.3 ± 7.1 years. Preoperative measurements showed a mean mid-frontal height of 7.48 ± 0.46 cm and a mean intertemporal width of 14.66 ± 0.65 cm. On average, 3243 ± 1038 follicular units were transplanted at a recipient density of 50–60 FUs/cm². Postoperative assessments included improvements in forehead contour, naturalness of the hairline, and documentation of adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average reduction in mid-frontal height was 1.33 ± 1.10 cm, and the intertemporal width was reduced by 1.47 ± 0.57 cm. On a 5-point Likert scale, the average satisfaction score for mid-upper facial contour improvement was 4.70, while the score for the overall hairline appearance was 4.52. Only minor postoperative discomfort was reported, with no severe complications observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hair transplantation via FUE is an effective approach for improving mid-upper facial proportions in East Asian women with high and wide foreheads, resulting in a softer and more three-dimensional forehead contour. Surgical design based on East Asian facial and hair characteristics yields high patient satisfaction and favorable safety outcomes, supporting its broader clinical application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Botulinum Toxin A for the Management of Melasma: A Split-Face, Randomized Control Study","authors":"Sasipim Chaijaras,&nbsp;Suphagan Boonpethkaew,&nbsp;Sonphet Chirasuthat,&nbsp;Nawara Sakpuwadol,&nbsp;Tanat Yongpisarn,&nbsp;Pimsiri Anansiripun,&nbsp;Vasanop Vachiramon","doi":"10.1111/jocd.70376","DOIUrl":"https://doi.org/10.1111/jocd.70376","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma management remains challenging due to its multifactorial nature pathogenesis and recurrent nature. Previous studies showed positive effects of botulinum toxin A (BoNT-A) for treating and preventing ultraviolet-induced hyperpigmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effectiveness of adjunctive incoBoNT-A injection combined with triple combination cream (TCC, 4% hydroquinone, 0.05% tretinoin, and 0.01% fluocinolone acetonide) for treating and preventing melasma recurrence compared to topical therapy alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A split-face study was conducted in 30 female patients with melasma. One side of the face was randomly applied TCC to the melasma-affected areas for 12 weeks (monotherapy), while the contralateral side received TCC and intradermal incoBoNT-A at baseline and week 12 (combination therapy side). Evaluations were performed at baseline and 2, 4, 8, 12, 16, 20, and 24 weeks. Clinical improvement and melanin index were assessed using the MASI score on the malar area (MASI_m), and Colorimeter respectively. Patient satisfaction was also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-eight subjects completed the study. The combination therapy side showed significant MASI_m decrease at week 2 (<i>p</i> = 0.0032), while the monotherapy side showed no significant change. At 4 weeks, a greater reduction of MASI_m was observed in the combination therapy side (MASI_m 14.5 and 11.54, 20.41% reduction) when compared to the monotherapy side (MASI_m 11.68 and 11.79, 0.93% worsening). At week 12, worsening of melasma was observed on both sides during the summer period. At week 24 (3 months after discontinuing TCC), MASI_m was 14.79 on the monotherapy side (worsen 21.03% from baseline) and 9.14 on the combined technique (36.97% improvement, <i>p</i> = 0.0003). Patients' satisfaction was higher for the combination therapy when compared to the monotherapy at the end of the study (8.92 vs. 7.04, <i>p</i> &lt; 0.0001). No serious adverse events occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Intradermal incoBoNT-A injection combined with TCC demonstrated superior efficacy in melasma treatment and recurrence prevention compared to TCC monotherapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Factors, Comorbidities, Quality of Life (DLQI), and Depression (PHQ-9) in Rosacea Patients: A Comprehensive Analysis","authors":"Namrata Kunwar,&nbsp;Dan Jian,&nbsp;He Yan Hui,&nbsp;Bingxue Bai","doi":"10.1111/jocd.70337","DOIUrl":"https://doi.org/10.1111/jocd.70337","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Rosacea is a chronic inflammatory skin condition primarily affecting the face, which greatly influences patients' quality of life and mental well-being.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This research aimed to examine environmental and dietary factors, systemic comorbidities, and their effects on the quality of life and psychological impact of rosacea in Chinese patients.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The study was an observational case–control design involving 200 individuals with rosacea and 200 healthy participants. Participants completed a questionnaire addressing skin color, specific habits, dietary and environmental factors, comorbidities, and assessments of quality of life and depression levels using the Dermatology Life Quality Index (DLQI) and the Patient Health Questionnaire-9 (PHQ-9), respectively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The chi-square test was employed to compare the distribution of general characteristics. Univariate analysis was conducted using Pearson's chi-square test. DLQI is a continuous scale analyzed via independent &lt;i&gt;t&lt;/i&gt;-test and PHQ-9 is an ordinal scale analyzed via Mann–Whitney &lt;i&gt;U&lt;/i&gt; test. Spearman's rank correlation coefficient was used for nonparametric correlation between two ranked variables. A &lt;i&gt;p&lt;/i&gt; value &lt; 0.05 was considered statistically significant. Chi-square results with OR and 95% CI indicated significant associations between rosacea and factors such as female gender, age, smoking, alcohol consumption, environmental influences (sun exposure, use of cosmetics/hair products, exercise, exposure to hot weather, hot baths), dietary factors (dairy products, hot coffee consumption), and comorbidities (diabetes mellitus). No significant links were found with skin colors, dietary factors (fatty food, hot and spicy food, hot tea, sweet food), or other comorbidities (hypertension, high cholesterol, &lt;i&gt;Helicobacter pylori&lt;/i&gt;, cancer, Crohn's/ulcerative colitis, dry eye syndrome, chronic kidney disease, and migraine). The rosacea group showed notably higher DLQI scores with moderate effect (9.0%), large effect (40.5%), and extremely large effect (45.5%), along with elevated PHQ-9 scores for depression compared to controls, highlighting a significant impact on their quality of life and mental health. Spearman's rank correlation coefficient demonstrated a significantly positive correlation between DLQI and PHQ-9 scores among participants (rho = 0.423, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), indicating that greater quality of life impairment is lin","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between External and Internal Skin Aging Markers by Skin Depth","authors":"Hye-Yeon Yang,&nbsp;Sung-Ha Park,&nbsp;Ji-Eun Woo,&nbsp;Byoung-Jun Park","doi":"10.1111/jocd.70354","DOIUrl":"https://doi.org/10.1111/jocd.70354","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The skin is a complex, multilayered organ with diverse structures. Skin aging is a gradual process that begins internally, initially invisible to the eye, and eventually manifests as visible signs such as wrinkles and sagging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the effects of characteristic changes in different skin layers on visible signs of aging, such as wrinkles and sagging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 65 Korean women aged 20–65 years participated in this study. Skin characteristics were categorized into visible external and invisible internal markers. External markers included wrinkles and sagging, whereas internal markers included hydration, elasticity, density, thickness, and dermal-subcutaneous interface length. Internal markers were measured in greater detail at various skin depths. Spearman's correlation was used to analyze relationships between all skin parameters, including age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Visible signs of aging such as wrinkles and sagging increased with age. The elasticity indicators in each skin layer tended to decrease. No correlation was observed between moisture levels and age. The results of the correlation analysis between external and internal markers varied according to skin layer. Negative correlations were observed between skin sagging and epidermal moisture content in the epidermis and between wrinkles and elasticity indicators (Ue and Ur) in the deeper dermis layer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>External markers are most strongly correlated with chronological age. However, visible aging is significantly influenced by changes in internal markers across different skin layers. Sagging is affected by moisture content within the epidermal layer, and wrinkles are affected by elasticity within the dermal layer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Materials for Posterior Facial Frame Injection: Hyaluronic Acid or Polycaprolactone, a Case Report","authors":"Liping Hu,&nbsp;Xi Chen,&nbsp;Guangpeng Liu","doi":"10.1111/jocd.70315","DOIUrl":"https://doi.org/10.1111/jocd.70315","url":null,"abstract":"&lt;p&gt;We reported last year in Journal of Cosmetic Dermatology about an injection method to improve the posterior facial frame (PFF) titled “Area four technique: An effective injection approach to the posterior facial frame esthetic treatment with injectable hyaluronic acid fillers” [&lt;span&gt;1&lt;/span&gt;]. Due to the superior effect on facial lifting and contour improvement, this technology attracted wide attention in China.&lt;/p&gt;&lt;p&gt;More and more patients pay attention to the effect of facial improvement and tightening after PFF injection, making us think about what material is the most appropriate to place in the PFF area. The facial lifting of PFF injection is due to the mechanical support of the fascia by the filling. However, with the degradation of hyaluronic acid (HA) in the body, the mechanical support ability of HA gradually weakens and cannot effectively and sustainably support the fascia or ligaments. As a result, continued facial sagging and other complications such as overfilled syndrome occur [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In 2009, a novel polycaprolactone (PCL) filler (Ellansé, Sinclair Pharma, UK) obtained the CE Marking and was introduced in Europe and many of the leading countries in esthetics worldwide [&lt;span&gt;3&lt;/span&gt;]. The novel filler made up of polycaprolactone (PCL, 30% by volume) and carboxymethyl cellulose (CMC, 70% by volume) owns a dual effect, an immediate effect and a long-term effect [&lt;span&gt;3&lt;/span&gt;]. The immediate effect is related to the CMC gel by the filling capacity of the injected volume and the highly hygroscopic properties of CMC. The CMC gel is resorbed in 2–3 months. The followed sustained effect depends on the collagen production by the evenly distributed PCL microspheres embedded with collagen fibers interacting with the cellular environment [&lt;span&gt;4&lt;/span&gt;]. The collagen deposit that adheres closely to the surrounding tissue leads to the prolongation of the facial improvement and tightening.&lt;/p&gt;&lt;p&gt;To observe the clinical difference between PCL and HA in facial enhancement, we injected 6 mL of PCL (Ellansé, Sinclair Pharma, UK) and 6 mL of HA (Vmonalisa, Dentium, Korea) into the right face (PCL sdie) and the left face (HA side) of the subject according to Area four technique, and recorded photos immediately, 45, 90, and 180 days after surgery (Figure 1).&lt;/p&gt;&lt;p&gt;During the 180 days of follow-up, both sides of the face were improved immediately after the surgery. However, the two sides of the face appeared as an uncoordinated phenomenon gradually (Figure 1A). Because the facial asymmetry of the subject affected the observation of treatment, the left and right lateral faces were cut and re-synthesized (Figure 1B,C). Therefore, we can intuitively observe that the lifting effect of the right face remained stable for 180 days, while the lifting effect of the left face was weakened on day 45 (Figure 1D,E). In addition, the subject experienced the Spring Festival holiday on postoperative day 180 and gained increased weight. However,","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Tolerability and Improved Outcomes in Acne Management: A Real-World Study of Dermocosmetic Adjunctive Therapy","authors":"Aqsa Siddique,&nbsp;Ahmad Furqan Anjum","doi":"10.1111/jocd.70372","DOIUrl":"https://doi.org/10.1111/jocd.70372","url":null,"abstract":"&lt;p&gt;We read with great interest the recently published article titled “Enhanced Tolerability and Improved Outcomes in Acne Management: A Real-World Study of Dermocosmetic Adjunctive Therapy” by Suh et al. [&lt;span&gt;1&lt;/span&gt;], which offers a timely and clinically relevant exploration of dermocosmetics as supportive agents in acne treatment. The authors are to be commended for addressing an important and often overlooked aspect of acne management; improving tolerability and adherence, particularly in patients undergoing retinoid therapy. Their work provides meaningful insights into the potential psychosocial and clinical benefits of adjunctive skincare and highlights a growing need for holistic treatment approaches. In particular, the study's pragmatic, real-world design enhances its external validity, and its focus on improving tolerability and adherence offers valuable insights into patient-centered care; an often underexplored dimension in acne management. However, the study has the following methodological limitations that warrant consideration.&lt;/p&gt;&lt;p&gt;First, a central methodological limitation of the study lies in its absence of a control group, which precluded randomization and blinding; three interrelated design flaws that significantly undermine internal validity. Since participants were assigned based on pre-existing acne treatments rather than randomly allocated, this led to imbalances in baseline characteristics, with more severe cases disproportionately placed in the retinoid group. Without a comparator arm receiving standard therapy alone, it becomes impossible to isolate the independent effect of the dermocosmetic regimen from confounding variables such as natural disease progression, placebo effects, or increased adherence due to monitoring. Furthermore, the lack of blinding—both of participants and investigators—introduces performance and detection bias, especially in dermatology where subjective outcomes like burning, itching, and perceived skin quality are highly susceptible to expectancy effects. Thiboutot et al. [&lt;span&gt;2&lt;/span&gt;] caution that non-randomized, open-label designs tend to overstate dermocosmetic efficacy, underscoring the need for rigorous trial designs. Likewise, Khammari et al. [&lt;span&gt;3&lt;/span&gt;] illustrated that including a control group receiving only a retinoid-based regimen allowed them to directly attribute reduced sensitivity to the dermocosmetic intervention. To enhance methodological rigor in future studies, even if full randomization is not feasible, researchers should consider incorporating matched comparator groups or statistical adjustment for baseline severity, alongside the use of blinded outcome assessors and standardized scoring tools. Second, while the study included three Fitzpatrick skin types (III–V), which adds some diversity, its restriction to a single ethnic population still limits generalizability, which was composed exclusively of Korean participants. This homogeneity restricts the generalizabili","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Combined Topical Lidocaine and Tetracaine Cream for Facial Fractional Laser Resurfacing Compared With Its Reference Product in Chinese Adults: A Multicenter, Randomized, Double-Blind Phase 3 Study","authors":"Wenxin Yu,&nbsp;Zhongling Luo,&nbsp;Yi Zhao,&nbsp;Zhiqi Hu,&nbsp;Aijun Zhang,&nbsp;Yong Li,&nbsp;Juan Tao,&nbsp;Xiaosong Chen,&nbsp;Haiying Wang,&nbsp;Liying Chen,&nbsp;Hanjie Zhu,&nbsp;Xiaoxi Lin","doi":"10.1111/jocd.70358","DOIUrl":"https://doi.org/10.1111/jocd.70358","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>As a potentially effective anesthetic, CU-30101 is comprised of 7% lidocaine and 7% tetracaine and is a generic drug of Pliaglis. This study aimed to investigate the equivalence between CU-30101 and Pliaglis as topical anesthetics for fractional laser.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This Phase 3 trial recruited Chinese adults scheduled for facial fractional laser resurfacing. Participants were randomized to receive opposite treatment sequences of CU-30101 and Pliaglis on contralateral sides of the face prior to laser application. Visual Analog Scale (VAS), participant and investigator satisfaction ratings, local tolerability, and safety were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two hundred eighty-four participants completed the study, with mean VAS scores of 35.3 ± 24.51 for CU-30101 and 37.3 ± 24.17 for Pliaglis. The 95% confidence interval of −3.78 to −0.13 for the VAS difference laid within the predefined equivalence margin of ±4.7, confirming equivalence in efficacy. The results in the per-protocol set further corroborated the equivalence. Both participants and investigators expressed consistently high satisfaction with CU-30101 and Pliaglis. Furthermore, both treatments were well tolerated and exhibited favorable safety profiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrated the equivalent efficacy of CU-30101 to its reference product, Pliaglis, among Chinese adults undergoing facial fractional laser resurfacing. CU-30101 showed commendable local tolerability and safety profiles, consistent with those of Pliaglis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trends and Hotspots in Female Pattern Hair Loss: A Bibliometric Study","authors":"Hongjuan Fu","doi":"10.1111/jocd.70369","DOIUrl":"https://doi.org/10.1111/jocd.70369","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Female pattern hair loss (FPHL) is a common yet understudied condition with significant psychosocial impacts. Understanding global research trends and emerging topics in FPHL is essential for guiding future investigations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This bibliometric analysis aimed to provide an overview of key trends, influential contributors, and evolving research themes in FPHL from 1957 to 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Publications related to FPHL were retrieved from the Web of Science Core Collection. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, and the R package “bibliometrix.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study analyzed 488 publications authored by 2165 researchers across 189 journals. The USA led in publication output and citations, followed by China and South Korea. Leading institutions included the Egyptian Knowledge Bank, University of Melbourne, and National Taiwan University. Shapiro Jerry was the most prolific author. The Journal of Cosmetic Dermatology had the highest publication count, whereas the Journal of the American Academy of Dermatology was the most cited. Keyword analysis identified emerging hotspots, such as “mechanisms,” “management,” and “safety,” with growing interest in “scalp,” “association,” and “telogen effluvium.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights the global research landscape of FPHL, emphasizing the focus on treatment efficacy, safety, and underlying mechanisms. Future research may prioritize accurate diagnostic methods and risk factor exploration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging of the Human Lip: Current Knowledge and Clinical Implications","authors":"Fanghui Sun,&nbsp;Yue Liu,&nbsp;Tao Zhang","doi":"10.1111/jocd.70310","DOIUrl":"https://doi.org/10.1111/jocd.70310","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Comprehensive exploration of lip aging remains limited due to anatomical complexity of the structure, with current investigations predominantly focusing on aspects such as dryness management, cheilitis prevention and treatment, and surgical lifts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This article aims to review multiple aspects of lip aging and to explore anti-aging approaches for the lips, thereby providing actionable insights for the development of cosmetic lip care products.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a literature search in the PubMed database using keywords related to lip aging, and selected the most relevant articles for in-depth reading, summarization, and integration to form the content of this review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Due to the significant differences between lip and facial skin in terms of barrier function, melanin content, transepidermal absorption capacity, physiological activity frequency, and fat distribution, the aging characteristics of lips also exhibit uniqueness. At the same time, there are gender differences in lip aging manifestations, with women typically showing more noticeable perioral wrinkles compared to men.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The clinical manifestations and pathogenic mechanisms of lip aging differ significantly from those of facial aging, requiring distinct priorities in anti-aging product development. For the vermilion, the focus should be on barrier restoration, mild anti-aging approaches, and photoaging prevention. In contrast, perioral anti-aging may be addressed by inhibiting ECM degradation and enhancing tissue volume. Addressing gender differences can guide the development of anti-aging lip products tailored to women, while managing associated pigmentary changes offers a unique avenue for this purpose.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}