Journal of Cosmetic Dermatology最新文献

{"title":"Temporal Fat Pad Filler Injection for Lifting Purposes: Shifting of the Superficial Layer of Deep Temporal Fascia","authors":"Kyu-Ho Yi, Jovian Wan, Soo-Bin Kim, Hee-Jin Kim","doi":"10.1111/jocd.70023","DOIUrl":"https://doi.org/10.1111/jocd.70023","url":null,"abstract":"<p>The temporal region is a critical yet often overlooked area in facial aesthetics, contributing to the harmony and balance of the upper face [<span>1, 2</span>]. However, as we age, this region undergoes significant anatomical changes that lead to a hollowed, concave appearance, contributing to an overall aged and tired look. The temporal hollowing often becomes a primary concern for individuals seeking facial rejuvenation, as it disrupts the smooth contours that are characteristic of a youthful appearance [<span>3-5</span>].</p><p>The restoration of volume in the temporal region through the use of dermal fillers has gained popularity as an effective, non-surgical approach to address these age-related changes. However, achieving optimal results requires a comprehensive understanding of the complex anatomy of the temporal region and the dynamic processes involved in aging [<span>1, 2, 5, 6</span>]. This clinical commentary will delve into the anatomical considerations crucial for successful temporal filler injections and discuss the implications of these insights for enhancing the lifting effect and achieving a natural, rejuvenated appearance.</p><p>The anatomy of the temporal region is intricate, with 13 distinct layers contributing to both its function and aesthetic appearance. These layers include the epidermis, dermis, subcutaneous tissue, superficial temporal fascia, innominate fascia, superficial layer of deep temporal fascia (DTF), temporal fat pad, deep layer of DTF, temporal extension of the buccal fat pad, superficial layer of the temporalis muscle, tendinous portion of temporalis, deep layer of the temporalis muscle, and the underlying bony framework. Together, these structures interact dynamically to maintain facial structure and enable movement [<span>1, 4, 7</span>].</p><p>The temporal region contains several distinct fat compartments broadly classified into superficial and deep layers. The superficial compartments, including the subcutaneous fat compartments located just above the superficial temporal fascia, play a vital role in maintaining a smooth, convex contour of the temples by providing volume and support to the overlying skin—contributing to the fullness and youthful appearance of the upper face. In contrast, the deep compartments lie between two layers of the DTF, covering the temporalis muscle and encompassing structures such as the temporal fat pad and the temporal extension of the buccal fat pad above the temporalis muscle. These deeper layers help stabilize the underlying skeletal and muscular framework, preserving overall facial balance.</p><p>As the aging process progresses, the temporal fat compartments—which include both superficial and deep layers—tend to thin in their upper and middle regions while thickening in the lower portion, creating a hollowed, scalloped appearance in the temples. Further atrophic changes across these compartments reduce overall volume, emphasizing the hollowing effect. Recognizing and de","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"A 7-year analysis of complaints related to Asian blepharoplasty\".","authors":"Xueshang Su, Dan Chen, Jun Zhuang, Jintian Hu, Na Cai, Yangxue Ou, Haixia Jiang, Bo Ding","doi":"10.1111/jocd.16271","DOIUrl":"https://doi.org/10.1111/jocd.16271","url":null,"abstract":"<p><strong>Background: </strong>People often have high expectations for blepharoplasty, and patient complaints can serve as a valuable tool to understand their specific requirements and desired outcomes.</p><p><strong>Objectives: </strong>The objective of this study was to analyze blepharoplasty complaints and identify patient concerns regarding postoperative effects, surgical difficulties, and potential pitfalls.</p><p><strong>Methods: </strong>A retrospective analysis of 138 complaints related to blepharoplasty was conducted. We documented demographic information and complaints details, and compared the reason of complaints between primary and revision double eyelid operations.</p><p><strong>Results: </strong>In this study, primary double eyelid operation was found to have the highest number of complaints. \"Asymmetry\" is the most frequent cause of dissatisfaction in both primary and revision double eyelid surgeries, and \"asymmetric crease height\" accounted for the majority of complaints in this category. Compared with primary double eyelid operation, revision double eyelid operation was more likely to be complained for \"asymmetric crease shape\", and the difference was statistically significant (p < 0.05). The most common reasons for complaints following lower blepharoplasty, epicanthoplasty, and eyebrow lift procedures were \"incomplete resection of under-eye puffiness\", \"asymmetry\", and \"upper eyelid laxity\", respectively. Compared to lower blepharoplasty and eyebrow lift, primary and revision double eyelid surgeries as well as epicanthoplasty are more prone to complaints of \"asymmetry\". In contrast, compared to primary double eyelid operation, epicanthoplasty is more likely to result in complaints of \"noticeable scarring\".</p><p><strong>Conclusions: </strong>Complaints regarding blepharoplasty can reflect patients' expectations and requirements, as well as the challenges and pitfalls of the surgical procedure. This information can assist physicians in enhancing their comprehension of patients' needs and paying closer attention to the difficulties and potential complications associated with surgery.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Safety and Efficacy of REGENDIL Infused Hair Growth Promoting Product in Adult Human Subject Having Hair Fall Complaints (Alopecia)”","authors":"","doi":"10.1111/jocd.70064","DOIUrl":"https://doi.org/10.1111/jocd.70064","url":null,"abstract":"<p>A. Merja, N. Patel, M. Patel, S. Patnaik, A. Ahmed, and S. Maulekhi, “Safety and Efficacy of REGENDIL Infused Hair Growth Promoting Product in Adult Human Subjects Having Hair Fall Complaints (Alopecia).” <i>Journal of Cosmetic Dermatology</i> 23 (2024): 938–948, https://doi.org/10.1111/jocd.16084.</p><p>The authors noticed a typographical error in Table 1 on page 940, representing the “Demographic Data of the subjects”. The units for Weight and Height were incorrectly listed as “Weight (cm)” and “Height (kg).” This should be corrected to “Weight (kg)” and “Height (cm).”</p><p>The revised version of Table 1 is shown below.</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Therapeutic Efficacy of Moist Wound Healing After Fractional CO2 Laser Surgery","authors":"Qingmei Jin,&nbsp;Richeng Dong,&nbsp;Jiahui Zhi,&nbsp;Huimin Yin,&nbsp;Meilan Nan,&nbsp;Zhehu Jin,&nbsp;Chenglong Jin","doi":"10.1111/jocd.70079","DOIUrl":"https://doi.org/10.1111/jocd.70079","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;With the popularization of laser therapy, an increasing number of patients are undergoing fractional CO&lt;sub&gt;2&lt;/sub&gt; laser therapy. It is particularly important to exercise caution and accelerate wound healing after laser surgery.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to examine the clinical efficacy of moist wound healing after fractional CO&lt;sub&gt;2&lt;/sub&gt; laser therapy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Patients/Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 15 individuals volunteered to undergo fractional CO&lt;sub&gt;2&lt;/sub&gt; laser therapy. The facial skin was irradiated with a fractional CO&lt;sub&gt;2&lt;/sub&gt; laser in the deep mode, with an energy of 15 mJ/cm&lt;sup&gt;2&lt;/sup&gt; and a density of 5%. The left and right sides of the faces were considered the observation and control groups, respectively. After laser therapy, medical cold compress patches were applied on the skin in the control group once a day for approximately 10–15 min, whereas erythromycin ophthalmic ointment was applied on the skin in the observation group 6 times daily for wound care. The wound healing time, duration of erythema, and occurrence of adverse reactions were monitored in both groups.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The observation and control groups received different nursing interventions. The time to regression of erythema and swelling was significantly shorter in the observation group than in the control group. In addition, the scab formed at the wound site was thinner, and shedding was faster in the observation group than in the control group. The Clinical Erythema Assessment score of the observation group was significantly lower than that of the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The wound healing time was 5.73 ± 0.70 days in the observation group and 7.73 ± 0.72 days in the control group, with the difference being statistically significant (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). After 30 min and 12 h of nursing intervention, the Visual Analog Scale score of the observation group was significantly lower than that of the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). However, after 24 h of treatment, neither group showed significant pain. Both groups showed varying degrees of acne, pustules, and exudation, which subsided within 7 days. Furthermore, the control group had 2 cases of mild pigmentation, which resolved within 3 months. Neither group experienced adverse reactions such as skin infection, depigmentation, or scar formation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Topographic Analysis of the Periorbital Region Including Orbicularis Oculi Muscle Based on Ultrasonography Interpretation”","authors":"","doi":"10.1111/jocd.70065","DOIUrl":"https://doi.org/10.1111/jocd.70065","url":null,"abstract":"<p>K.-L. Lee and H.-J. Kim, “Topographic Analysis of the Periorbital Region Including Orbicularis Oculi Muscle Based on Ultrasonography Interpretation.” <i>Journal of Cosmetic Dermatology</i> 24, no. 1 (2025): e70004, https://doi.org/10.1111/jocd.70004.</p><p>In the published article, the corresponding author's email address was incorrectly listed as “<span>[email protected]</span>”. The correct email address should read: “<span>[email protected]</span>”.</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skincare Benefits of a Postbiotic Ferment Produced Through Djon Djon Mushroom Fermentation by Saccharomyces","authors":"Chunhong Pu,&nbsp;Doudou Shi,&nbsp;Michael Ingrassia,&nbsp;Harvey Gedeon,&nbsp;Tye Chu,&nbsp;Jiachan Zhang,&nbsp;Changtao Wang","doi":"10.1111/jocd.70067","DOIUrl":"https://doi.org/10.1111/jocd.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Djon Djon is a particularly special black mushroom indigenous to Haiti that has a long history in both their cuisine and in traditional medicine. Centuries of folkloric utilization of theses “medicinal” botanicals tend to indicate the presence of a potentially efficacious western medicine entity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>With the advantages afforded by both traditional medicines and fermentation, we endeavored to investigate if fermentation of Djon Djon mushrooms can provide skin care benefits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, active Djon Djon fermentation broth (DDF) was obtained using <i>Saccharomyces</i>, and anti-inflammatory efficacy was assessed in cultured systems using human keratinocytes and fibroblasts, exposed to either UVB or H₂O₂ respectively. In addition, RNA-Seq technology was employed to further characterize the mechanisms of DDF following ultraviolet irradiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Characterization of the DDF displayed a high number of polysaccharides and peptides present following fermentation, that function to scavenge intracellular ROS, decrease MDA content, while increasing the levels of CAT, COL-I, and HA in HSF induced by H₂O₂. In addition, levels of pro-inflammatory factors (IL-6, IL-1β, and TNF-α) were decreased in UVB irradiated HaCaT cells that had been treated with DDF. Analysis of cellular RNA indicated that DDF altered the DEGs involved in the AGE-RAGE signaling pathway suggesting that this signaling cascade is inhibited by DDF. Additionally, DDF also influenced the metabolism of arachidonic acid, histidine, and phenylalanine, which are involved in inflammatory processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DDF can alleviate oxidative stress damage caused by hydrogen peroxide and photodamage caused by UVB, and the mechanism by which DDF protects skin cells is revealed, displaying the potential benefits of fermented DjonDjon in skincare.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Virtual and Augmented Reality in Advancing Drug Discovery in Dermatology","authors":"Leon Kircik,&nbsp;Mohamad Goldust","doi":"10.1111/jocd.70071","DOIUrl":"https://doi.org/10.1111/jocd.70071","url":null,"abstract":"&lt;p&gt;Virtual and augmented reality (VR/AR) technologies are expanding various medical fields, and their application in dermatology is gaining momentum [&lt;span&gt;1, 2&lt;/span&gt;]. These advanced tools have proven effective in enhancing patient education, surgical planning, and diagnostics, but their potential to transform dermatological drug discovery is particularly remarkable. This letter aims to provide an overview of how VR/AR can accelerate drug development, personalize treatments, and improve patient outcomes while addressing key challenges and highlighting real-world examples.&lt;/p&gt;&lt;p&gt;Virtual reality (VR) creates immersive digital environments that simulate real-world scenarios, allowing users to interact with and manipulate virtual objects. Augmented reality (AR) overlays digital information onto the real world, enhancing the user's perception of their environment. These technologies are increasingly being adopted in medicine for applications such as surgical simulations and medical training. In dermatology, VR and AR can provide valuable insights into complex skin diseases and drug interactions, leading the way for innovative therapeutic strategies.&lt;/p&gt;&lt;p&gt;The traditional drug discovery process is lengthy, expensive, and resource-intensive. VR/AR technologies offer a promising alternative by enabling researchers to visualize and interact with detailed 3D models of skin anatomy, cellular structures, and molecular interactions. For instance, VR can recreate disease models, such as psoriasis or eczema, allowing researchers to simulate drug responses in a controlled virtual environment. This capability reduces reliance on animal models and traditional wet-lab experiments, facilitating preclinical research.&lt;/p&gt;&lt;p&gt;One practical example is the use of AR to visualize molecular docking in drug discovery. AR applications, such as Molecular Rift, enable scientists to interact with 3D molecular models, facilitating a better understanding of drug-target interactions. By using AR to simulate drug penetration and cellular response, researchers can optimize compound formulations before proceeding to costly clinical trials [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The variability in skin structure and function among individuals highlights the need for personalized treatments in dermatology. VR/AR technologies can create patient-specific 3D models derived from imaging data, such as biopsies. These models allow researchers to simulate drug interactions with unique skin compositions, helping to identify the most effective therapies for individual patients. For example, VR systems like Nanome provide platforms for collaborative exploration of molecular interactions, enabling personalized drug design based on patient-specific data [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;VR/AR technologies also hold promise for optimizing clinical trial design and execution. AR can monitor treatment effects by overlaying digital data onto patients' skin, enabling real-time visualization of lesion changes and drug penetrati","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Nature to Nurture: The Science and Applications of Snail Slime in Health and Beauty","authors":"Muhammad Rashad,&nbsp;Simone Sampò,&nbsp;Amelia Cataldi,&nbsp;Susi Zara","doi":"10.1111/jocd.70002","DOIUrl":"https://doi.org/10.1111/jocd.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Snail slime (SS), a complex biological substance produced by various snail species, has garnered significant attention in recent years due to its diverse applications in health, cosmetics, and biotechnology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Our previous review focused on the biological activities of SS, while the current one explores the science behind SS with a special focus on environmental factors affecting its quality and quantity, non-lethal extraction methods, its composition, current applications in health and cosmetics followed by its emerging applications, and future prospects while achieving sustainability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature review on background, uses in health and cosmetics, and future prospects of SS was conducted. PubMed and Google Scholar were used to find the key articles exploring SS and the data is summarized and described here.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Extraction methods range from traditional farming practices to advanced, non-invasive techniques aimed at minimizing stress on snails. Emerging applications include potential use in sustained and targeted drug delivery systems, tissue engineering, and as components in advanced biomaterials. Future perspectives involve technological advancements in production, such as precision farming and biotechnology-enhanced mucin production. The development of synthetic alternatives and sustainable practices is crucial for the industry's long-term viability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>As research continues to uncover new properties and applications, SS is poised to play an increasingly important role in the health and beauty industries, highlighting the need for balanced exploitation, standardization, quality control, and regulatory compliance in its production and use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Different High-Intensity-Focused Ultrasound Frequencies Have Different Effects? A Histological Analysis Correlated With Patients' Subjective Assessments","authors":"Yousun Hwang,&nbsp;Jovian Wan,&nbsp;Kyu-Ho Yi","doi":"10.1111/jocd.70069","DOIUrl":"https://doi.org/10.1111/jocd.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>High-intensity-focused ultrasound (HIFU) has emerged as a noninvasive approach for facial rejuvenation, offering benefits such as collagen synthesis and subcutaneous fat reduction. However, the differential effects of varying HIFU frequencies on specific skin layers remain underexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the histological effects of different HIFU frequencies and correlate these findings with patient-reported outcomes, thereby optimizing clinical applications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Histological analysis was performed on pig skin treated with HIFU at specific depths (2.0, 3.0, 4.5, and 6.0 mm) using the Ultraformer MPT device. Collagen types I and III, elastin fibers, and fat reduction were assessed using immunohistochemistry, Victoria blue staining, and Oil Red O staining. Additionally, 50 Asian female participants aged 30–60 years with skin laxity underwent HIFU treatment. Clinical outcomes were evaluated using standardized photographs, the Global Aesthetic Improvement Scale (GAIS), and a modified Rosenberg Self-Esteem Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histological analysis revealed increased collagen and elastin fiber synthesis and significant fat reduction post-HIFU. Clinical outcomes corroborated these findings, with 85.3% of participants reporting overall satisfaction and 70.6% noting improvements in facial contouring. Self-esteem assessments indicated a positive psychological impact, with 64.7% of participants expressing enhanced confidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>HIFU treatment at varying frequencies induces significant histological and clinical improvements, demonstrating its efficacy for skin rejuvenation. This study underscores HIFU's dual role in enhancing physical appearance and psychological well-being, supporting its integration into patient-centric aesthetic care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea","authors":"Zihan Wang,&nbsp;Yutong Wu,&nbsp;Fatemeh Nozzari Varkani,&nbsp;Xian Su,&nbsp;Ziping Yang,&nbsp;Xinghua Gao,&nbsp;Li Zhang","doi":"10.1111/jocd.70046","DOIUrl":"https://doi.org/10.1111/jocd.70046","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Rosacea is a chronic skin condition that affects millions of people worldwide, and its management continues to pose a significant challenge in dermatology.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this study, we investigated the efficacy and safety of 30% supramolecular salicylic acid (SSA) as a treatment for papulopustular rosacea, with a particular focus on improving skin lesions, reducing persistent erythema, and enhancing skin barrier function.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Thirty-four patients diagnosed with papulopustular rosacea were randomly divided into an experimental group treated with 30% SSA and a control group receiving a placebo. Clinical outcomes were evaluated based on lesion reduction rates, investigator severity assessment (ISA) scores, VISIA red area scores, and skin barrier, including trans-epidermal water loss (TEWL), sebum levels, stratum corneum hydration, and pH values.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 34 patients were collected for both the experimental and control groups, with no statistical differences in age or disease severity between the groups (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). The effective rate was 68.75% in the experimental group (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). After treatment, the ISA score was 1.75 ± 0.68 in the experimental group and 2.40 ± 0.83 in the control group, indicating significant improvement (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The improvement rate of the VISIA redness score was 25.1% in the experimental group (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). Among the 17 patients who underwent skin barrier function testing. Skin hydration significantly improved on left cheek (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), right cheek (&lt;i&gt;p&lt;/i&gt; &lt; 0.01), and nose (&lt;i&gt;p&lt;/i&gt; &lt; 0.05) after 30% SSA treatment in experimental group. Sebum levels were significantly reduced on both cheeks and forehead (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). No statistical differences were observed in other locations. Skin TEWL and pH value showed no changes.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;30% SSA reduced papules and pustules in rosacea, improved persistent erythema, and enhanced stratum corneum hydration in the 30% SSA-treated group compared to the placebo group. No significant differences were observed in TEWL and skin pH values between the two groups. Our findings suggest that 30% SSA is an effective and safe option for managing papulopustular rosacea, offering a well-tolerated alternative to traditional treatments.&lt;/p&gt;\u0000 ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}