Journal of Cosmetic Dermatology最新文献

{"title":"Reverse Knot Technique for Face Lifting With Polydioxanone Thread.","authors":"Ana Paula Dornelles Manzoni, Alessandra Haddad, Andréia Fogaça, Valeska Ronsoni","doi":"10.1111/jocd.70878","DOIUrl":"https://doi.org/10.1111/jocd.70878","url":null,"abstract":"<p><strong>Background: </strong>The use of polydioxanone thread has grown substantially for facial soft-tissue repositioning and collagen biostimulation, with a well-established safety profile and favorable tissue integration.</p><p><strong>Aims: </strong>To describe the reverse knot technique, a novel method for the implantation of polydioxanone suspension threads.</p><p><strong>Patients/methods: </strong>We present an original polydioxanone thread-lifting technique designed primarily for patients with a \"heavy face.\" The reverse knot technique positions the knot in the anterior portion of the face, below the zygomatic cutaneous ligament, whereas anchoring the distal end of the thread in the temporal fascia, creating a lever mechanism that enhances lifting of the middle and lower thirds of the face.</p><p><strong>Conclusions: </strong>The technique provides immediate and effective midface soft-tissue support, representing a minimally invasive alternative for face lifting and resulting in high patient satisfaction and minimal morbidity. The procedure should be performed by professionals experienced in thread lifting, as positioning the knot in the medial portion of the face increases support but also raises the risk of localized depressions at the knot site.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70878"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits.","authors":"Peter Bjerring, Zoe D Draelos, Sabrina G Fabi, Greg J Goodman, Kwun Cheun Hau, Ariel Haus, Izolda Heydenrych, Jihee Kim, Liang-Chen Lin, Karim Sayed, Hema Sundaram, Rieko Tsubouchi, Yan Wu, Patricia Brieva, Hina Choudhary, Leihong Flora Xiang","doi":"10.1111/jocd.70880","DOIUrl":"10.1111/jocd.70880","url":null,"abstract":"<p><strong>Background: </strong>Integrated skincare (ISC) combines dermocosmetics with medical aesthetic procedures to improve outcomes. However, guidance on selecting appropriate active ingredients across different procedure types and phases remains limited.</p><p><strong>Aims: </strong>To provide international guidance on appropriate ISC actives for use with aesthetic procedures.</p><p><strong>Methods: </strong>In a simplified Delphi study, 14 experts evaluated 44 actives for use across four procedure categories (ablative energy-based, non-ablative energy-based, non-energy-based procedures with or without skin barrier disruption) at four time points (pretreatment, peri-treatment, aftercare, and follow-up ≥ 1 week post-procedure). The panelists also ranked their top five preferred actives for each procedure category and time point.</p><p><strong>Results: </strong>Ceramides, cholesterol, hyaluronic acid, niacinamide, and peptides were deemed appropriate across all procedure categories and all time points. Azelaic acid, benzoyl peroxide, cysteamine, glycolic acid, hydroquinone, lactic acid, retinoids, and salicylic acid were identified as unsuitable for use on treatment day. Ceramides and hyaluronic acid were highly ranked for pre-treatment, peri-treatment and aftercare, while retinoids and ferulic acid were highly ranked for pretreatment and followup. Vitamin C was ranked in the top 5 across all procedure categories and time points, except at pretreatment for non-energy-based without skin barrier damage.</p><p><strong>Conclusions: </strong>Safety and tolerability are primary considerations when selecting ISC actives. Ingredients with higher irritation potential, such as retinoids and acids, should be avoided during the healing phase (on treatment day and during short-term aftercare) due to risk of irritation, as well as post-inflammatory hyperpigmentation in skin of color.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70880"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound as a Therapeutic Option to Treat Biostimulator's Nodules: A Case Report.","authors":"Airá Novello Vilar, Vitoria Azulay, Estevão Vargas, Rubem David Azulay, Luara Lis Boson, Lismary De Forville Mesquita, Annia Cordeiro","doi":"10.1111/jocd.70902","DOIUrl":"10.1111/jocd.70902","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70902"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting the Standard for Peer-Reviewed Published Studies on Regenerative Products in Aesthetic Medicine and Post-Procedure Wound Care.","authors":"Michael H Gold, Terrence C Keaney, Rebecca Fitzgerald","doi":"10.1111/jocd.70877","DOIUrl":"10.1111/jocd.70877","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70877"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Oral Lasering for the Treatment of Nasolabial Folds, Marionette Lines, and Jowls: Case Examples and Protocol Methodology.","authors":"Richard J Miron, Elsa McGilvray, Ana De Gomez Paz, Paras Ahmad","doi":"10.1111/jocd.70890","DOIUrl":"10.1111/jocd.70890","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70890"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial.","authors":"Di Zhang, Yuan Chang, Yue Bai, Ansheng Tan, Zixuan He, Yu Han, Anxin Chen, Fenglin Zhuo","doi":"10.1111/jocd.70813","DOIUrl":"10.1111/jocd.70813","url":null,"abstract":"<p><strong>Background: </strong>Post-acne erythema (PAE) is one of the most common inflammatory sequelae of acne. Although various therapeutic approaches are currently available, many are limited by suboptimal efficacy, poor tolerability, or high costs. This trial aims to evaluate the clinical efficacy and safety of non-cross-linked hyaluronic acid (HA) mesotherapy for the treatment of PAE.</p><p><strong>Methods: </strong>A total of 25 patients aged 18-35 years with clinically diagnosed PAE and bilaterally symmetrical facial lesions were enrolled. Three treatment sessions were performed at 4-week intervals. The primary outcome was the Clinician Erythema Assessment Scale (CEAS) score assessed at baseline and week 12. Secondary endpoints included the Dermatology Life Quality Index (DLQI), Patient Self-Assessment (PSA), VISIA skin analysis (red areas, pores, texture), CK measurement parameters (erythema index, melanin index, skin hydration, transepidermal water loss), dermoscopic imaging, adverse effects, and relapse.</p><p><strong>Results: </strong>Finally, 23 patients completed all treatment sessions. By week 12, the mesotherapy group showed significantly lower CEAS scores compared to the control group. In addition, patients in the mesotherapy group reported higher satisfaction levels. Improvements in red areas, pores, texture, erythema index, skin hydration, transepidermal water loss, and dermoscopic imaging were also more marked in the mesotherapy group. There was a significant change in the DLQI score, too. No serious adverse events or erythema flares occurred during the study. Among the 23 patients who completed the trial, only one experienced acne relapse.</p><p><strong>Conclusion: </strong>According to the results of this study, non-cross-linked HA mesotherapy is a promising and useful therapeutic option for PAE.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70813"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.","authors":"Yusha Zi, Jianwei Liu, Qi Liu, Yao Pan, Xiuyu Jiang","doi":"10.1111/jocd.70888","DOIUrl":"10.1111/jocd.70888","url":null,"abstract":"<p><strong>Background: </strong>Skin glycation, oxidation, carbonylation, and excessive inflammation are well-recognized factors contributing to skin aging and pigmentation. Previous in vitro studies have confirmed vitamin C's antioxidant, anti-glycation, and anti-inflammatory properties, but its in vivo effects remain to be further verified.</p><p><strong>Aims: </strong>To investigate the in vivo effects of topical vitamin C serum on skin anti-glycation, anti-carbonylation, antioxidation, and anti-inflammation, and to provide evidence for its anti-aging and skin-brightening applications.</p><p><strong>Patients/methods: </strong>A randomized, double-blind, controlled trial was conducted, enrolling 66 healthy Chinese females, with 31 in the blank group and 35 in the topical group. Participants applied 10% vitamin C serum for 12 weeks. Skin glycation, carbonylated protein content, interleukin-1α (IL-1α) levels, free radical scavenging capacity, and skin color parameters were evaluated before and after treatment.</p><p><strong>Results: </strong>After 12 weeks, the topical group showed significant improvements: AGEs reduced by 17.65%, carbonylation fluorescence intensity decreased by 49.22%, IL-1α content dropped by 58.73%, and ABTS free radical scavenging rate increased by 12.14%. Skin yellowness (b* value) and redness (a* value) decreased by 6.13% and 16.46%, respectively (all p < 0.001).</p><p><strong>Conclusions: </strong>Topical 10% vitamin C serum can effectively mitigate skin glycation, carbonylation, and inflammation, enhance skin antioxidant capacity, and improve skin color, supporting its clinical value in anti-aging and skin-brightening.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70888"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions.","authors":"Farid KarkonShayan, Nasim Saderi, Iman Morshedi, Behnaz Ghamari, Sepideh KarkonShayan","doi":"10.1111/jocd.70866","DOIUrl":"10.1111/jocd.70866","url":null,"abstract":"<p><strong>Background: </strong>Biotechnology has significantly impacted the cosmetics industry, particularly through the incorporation of plant stem cells, which possess regenerative properties beneficial for skincare.</p><p><strong>Aims: </strong>This review aims to evaluate the potential benefits and challenges of using plant stem cells in cosmetics, while discussing future directions for their application in skin care products.</p><p><strong>Patients/methods: </strong>The review synthesizes existing literature on the regenerative capabilities of plant stem cells, their role in combating aging, promoting skin repair, and providing protection against ultraviolet damage. It also examines biotechnological methods such as plant cell cultures that mitigate issues associated with raw plant materials.</p><p><strong>Results: </strong>Plant stem cells demonstrate self-renewal and differentiation capabilities, crucial for tissue regeneration and skin healing. Despite their advantages, the cosmetic industry faces hurdles including inconsistent terminology, regulatory challenges, high production costs, and the prevalence of marketing strategies lacking clinical validation.</p><p><strong>Conclusions: </strong>While plant stem cell technology offers promising advancements in skincare, the cosmetic industry must address regulatory and validation concerns to ensure consumer safety and product efficacy. Future research should focus on establishing standardized practices and clinical trials to substantiate the claims of stem cell-based products in cosmetics.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70866"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Specificity of Reflectance Confocal Microscopy and Dermoscopy in Assessing Vitiligo Staging.","authors":"Jiyuan Wu, Wenjing Liu, Miaomiao Sun, Qian Jiang, Hongying Chen, Liuqing Chen","doi":"10.1111/jocd.70892","DOIUrl":"10.1111/jocd.70892","url":null,"abstract":"<p><strong>Background: </strong>Accurate staging of vitiligo is essential for effective treatment. Current staging primarily relies on clinical manifestations, patients' subjective reports, and physicians' assessments, which may introduce inaccuracies. Reflectance confocal microscopy (RCM) and dermoscopy are auxiliary diagnostic tools in dermatology that support the diagnosis and differentiation of vitiligo; they also assist in staging and evaluating therapeutic efficacy.</p><p><strong>Aims: </strong>This study aimed to compare the sensitivity and specificity of RCM and dermoscopy in vitiligo staging, providing a more reliable reference for clinical application.</p><p><strong>Methods: </strong>A retrospective review was conducted of clinical and imaging data from 218 patients with vitiligo who attended the Department of Dermatology at Wuhan No. 1 Hospital between December 2023 and November 2024. Clinical assessment methods-clinical features, Vitiligo Disease Activity score, Wood's lamp examination, and Koebner phenomenon-served as the reference standard for staging. Blinded evaluators independently conducted staging using RCM and dermoscopy. Each modality's sensitivity and specificity were calculated.</p><p><strong>Results: </strong>Staging results based on RCM and dermoscopy showed strong concordance with clinical evaluation; Kappa values were 0.74 and 0.718, respectively (p < 0.01). The positive percent agreement and negative percent agreement of RCM staging with clinical assessment were 94.16% and 78.12%, respectively; those metrics for dermoscopy were 87.01% and 89.06%. RCM demonstrated significantly higher sensitivity than dermoscopy (p = 0.013), whereas dermoscopy showed significantly higher specificity than RCM (p = 0.039).</p><p><strong>Conclusions: </strong>RCM and dermoscopy provide significant clinical value in vitiligo staging. RCM shows higher positive percent agreement for detecting progressive disease, whereas dermoscopy shows higher negative percent agreement for confirming stable disease. These tools offer an objective foundation for assessment and support clinical decision-making.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70892"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tracy Technique: A Systems-Based Paradigm Shift in Upper Face Neurotoxin Treatment.","authors":"Benjamin Tracy, Kylie Moe","doi":"10.1111/jocd.70867","DOIUrl":"10.1111/jocd.70867","url":null,"abstract":"<p><strong>Background: </strong>The Tracy Technique is a novel systems-based method for upper face neurotoxin treatment. It challenges the traditional area-based model by approaching the frontalis, glabella, and orbicularis oculi as a single dynamic complex.</p><p><strong>Objective: </strong>To describe the anatomical rationale and clinical application of the Tracy Technique and its ability to produce natural, balanced aesthetic outcomes.</p><p><strong>Methods: </strong>Patients were treated with onabotulinumtoxinA reconstituted with 2.5 mL bacteriostatic saline per 100 U vial (4 U per 0.1 mL). Injections were performed intramuscularly using a 32-gauge, ½ inch needle at a 30-degree angle, targeting the lower one-third of the frontalis with lateral extension into the orbicularis oculi while sparing the middle third and minimizing treatment in the upper third. Clinical photographs were taken using the Alma IQ photo system under standardized conditions.</p><p><strong>Results: </strong>Three representative cases demonstrated effective rhytid reduction and maintenance of natural brow position without heaviness or ptosis. Both injectors and patients reported balanced, comfortable outcomes.</p><p><strong>Conclusion: </strong>The Tracy Technique reframes upper face neurotoxin treatment as a dynamic force balancing system. By treating both elevator and depressor muscles simultaneously, it optimizes aesthetic results and may establish a foundation for future evidence-based refinement.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 5","pages":"e70867"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}