Journal of Cosmetic Dermatology最新文献

{"title":"Rhinomodelation With Polycarpolactone—A Safer and Effective Solution for the Future","authors":"Kamran Izhar Qureshi,&nbsp;Franco Vercesi,&nbsp;Hina Farooq Qureshi","doi":"10.1111/jocd.70001","DOIUrl":"https://doi.org/10.1111/jocd.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Nonsurgical rhinoplasty or rhinomodelation is a sought-after procedure in aesthetic practice. The current product of choice remains hyaluronic acid (HA) because of its ease of use and reversibility. However, it does carry some risks. Polycaprolactone (PCL) fillers hold a lot of promise in aesthetic practice. It has an established safety profile and a longer duration of action. Because of its unique properties, it may hold the key to the future of nonsurgical rhinomodelation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twelve patients were enrolled in the study. Ten out of these were not willing to ask for surgery and had no breathing problems. Two were post-surgical rhinoplasty complications who did not want another surgery. 0.2 mL of PCL filler was injected at each site according to the need (radix, spine, and or tip). The Global Aesthetic Improvement Scale (GAIS; 3 = very much improved, 2 = considerably improved, 1 = improved, 0 = no change, and −1 = worse) was used along with a patient satisfaction scale (highly satisfied, satisfied, dissatisfied) were used. The sum of the GAIS ratings was quantified as total improvement (TMI). The patients were followed up for 12 months before and 12 months after procedures were taken and documented.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The GAIS score was 98% for the study and all patients were highly satisfied with their treatment right after procedure and 12 months later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PCL fillers may be the way forward for long-term sustained results in nonsurgical rhinomodelation. Expert injection techniques and knowing the side effects and handling them is mandatory.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Efficacy and Safety of Oral Cicaglocal on Wound Healing After Mohs Surgery in Patients With Skin Cancer: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial","authors":"Ali Asilian,&nbsp;Parisa Mohammadian,&nbsp;Hadiseh Mahram,&nbsp;Reza Shahriarirad,&nbsp;Mohammad Bigham","doi":"10.1111/jocd.16784","DOIUrl":"https://doi.org/10.1111/jocd.16784","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Mohs micrographic surgery is the gold standard treatment for skin cancers in cosmetically sensitive anatomic areas, with a cure rate close to 100%. Managing post-Mohs surgery wounds can pose challenges, particularly in elderly patients. This study evaluates the Cicaglocal drug, a supplement with bromelain, <i>Centella asiatica</i>, hyaluronan, vitamins, and minerals, for enhancing wound healing post-Mohs surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This double-blinded, randomized clinical trial conducted at Al-Zahra Hospital in 2023 involved 24 patients aged 50–80 with SCC or BCC undergoing Mohs surgery. Patients were randomized into two groups Cicaglocal and placebo. Treatments were administered postoperatively, and outcomes such as erythema reduction, early healing score (EHS), full recovery, and patient and physician satisfaction levels were evaluated 7 and 14 days after initiation. Data were collected through clinical assessments and standardized wound photographs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Oral Cicaglocal demonstrated significantly improved outcomes compared to their respective placebo groups in terms of erythema score, EHS, full recovery score, and patient and physician satisfaction levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cicaglocal can enhance wound healing and lead to improved clinical outcomes following Mohs micrographic surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Combined Use of Home-Based Radiofrequency Device and Arbutin Cream in Melasma and Facial Rejuvenation","authors":"Lei Zhang,&nbsp;Qian Zhao,&nbsp;Qilei Che,&nbsp;Wenju Wang,&nbsp;Tao Chen,&nbsp;Xiao Tang,&nbsp;Xin Zhao,&nbsp;Nianou Wang,&nbsp;Ke Li,&nbsp;Qingbiao Wa","doi":"10.1111/jocd.70007","DOIUrl":"https://doi.org/10.1111/jocd.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma and facial aging are prevalent dermatological concerns. The combined use of a home-based radiofrequency (RF) device and a topical depigmentation agent, such as an arbutin-based cream, has shown potential in addressing both conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study evaluated the effectiveness and safety of combining a home-based RF device with arbutin cream to treat melasma and facial aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center, open-label study included 38 participants. The treatment involved using a home-based RF device alongside an arbutin cream three times a week for 4 weeks, followed by a 4-week rest period. Key outcomes included changes in modified Melasma Area and Severity Index (mMASI) scores, melanin index (MI), erythema index (EI), facial wrinkles, skin texture, and periorbital dermal thickness. The participants also provided a self-assessment of the treatment efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 4 and 8 weeks of treatment, compared with baseline, the mMASI scores decreased by 20.8% and 25.6%, whereas the MI decreased by 22.0% and 22.8%, respectively. The EI decreased by 5.94% and 6.86%, facial wrinkles decreased by 30.9% and 35.9%, and skin texture scores decreased by 19.7% and 21.4% at 4 and 8 weeks posttreatment, respectively. Significant improvements in periorbital dermal thickness and subcutaneous tissue thickness were observed after combined RF and arbutin cream treatment. None of the 38 participants experienced adverse events, and all reported satisfaction with the results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of a noninvasive home-based RF device and arbutin cream is effective in improving melasma and achieving facial rejuvenation, offering a safe and patient-friendly treatment option.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporary Facial Blanching After Botulinum Toxin Injection in Asian: A Case Report and Review of the Literature","authors":"Hao Chen,&nbsp;Qiuyue Fu,&nbsp;Tianqi Zhang,&nbsp;Gang Chen","doi":"10.1111/jocd.16794","DOIUrl":"https://doi.org/10.1111/jocd.16794","url":null,"abstract":"&lt;p&gt;Localized facial blanching usually resolves shortly after the botulinum toxin injection. Herein, we report the case of a patient who experienced localized blanching on her forehead and outer canthus following Botulinum toxin type A (BTX-A) injection for a longer time. This is the first documented occurrence of such a side effect in Asians in the literature. We have conducted a brief analysis of possible reasons for this phenomenon.&lt;/p&gt;&lt;p&gt;We present a case study of a 34-year-old Asian female who developed localized blanching on her forehead and outer canthus several hours after receiving BTX-A (BoNT A, Allergan) injections (Figure 1). The patient received 35U of BTX-A for forehead wrinkles (C-line, 14U; four distinct wrinkle areas, 6U) and female pattern hair loss (5 points, 15U) and 6U per side for canthus wrinkles (3 points) at the outer canthus. We performed injection with a (34G, 4 mm) needle. Upon review of the patient's medical history, it was confirmed that she had not received any BTX-A prior to this incident. The patient notice this change within a few hours of the injection. However, 12 h later, there was still no improvement. The dermatologist conducted a thorough examination and relevant tests (such as blood routine, tests of the coagulation cascade, and Digital Subtraction Angiography), and advised her to continue monitoring and exercising cautiously. The condition was mostly resolved 96 h after the injection. The blanching area near the surrounding skin color did not cause any discomfort to the patient during the procedure.&lt;/p&gt;&lt;p&gt;We reviewed the factors that may contribute to complications throughout the injection process, from preoperative preparation to postoperative management. These factors include the anesthetic gel, disinfectants, saline, and the postoperative application of ice packs. Subsequently, these potential factors were re-evaluated in relation to the patient, and no blanching were observed.&lt;/p&gt;&lt;p&gt;The patient denied blanching elsewhere on her body and had not received any additional injections, undergone cosmetic surgery, or experienced facial trauma prior to the onset of symptoms. She is currently not taking any medications and has no family history related to this phenomenon.&lt;/p&gt;&lt;p&gt;We here present a case of a temporary facial blanching after BTX-A. To the best of our knowledge, this is the first report of this complication which has features of spontaneous remission in Asian. As a rare complication, we aim to elucidate its cause through an examination of the mechanisms of botulinum toxin. Before delving into the mechanism of botulinum toxin, it is essential to have a comprehensive understanding of its function and common complications.&lt;/p&gt;&lt;p&gt;Botulinum toxin injection subcutaneously or intramuscularly to temporarily block nerve impulses between nerves and muscles [&lt;span&gt;1&lt;/span&gt;]. This helps weaken muscle strength, reduce facial wrinkles, improve skin elasticity, and shape muscles in a targeted manner. The procedure","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Peel Treats Nodular Lesions Following Mesotherapy: A Report of Three Cases","authors":"Siru Wu,&nbsp;Yanli Tian","doi":"10.1111/jocd.16785","DOIUrl":"https://doi.org/10.1111/jocd.16785","url":null,"abstract":"&lt;p&gt;As mesotherapy becomes increasingly popular, there is growing attention to nodular skin lesions after treatment. The persistent occurrence of these lesions may lead to the formation of foreign body granulomas. Here, we report three cases where chemical peel effectively relieved persistent nodular lesions following mesotherapy.&lt;/p&gt;&lt;p&gt;A 41-year-old female received intradermal injections of “collagen product” at a clinic for face rejuvenation. Within 1 week, erythema, edema, itching, and a burning sensation appeared on her face, followed by well-defined and evenly distributed red nodules at the injection sites. Oral antibiotics and methylprednisolone (20 mg) per day were given at another clinic. The lesions subsided gradually but recurred after the discontinuation of the medication. After 15 days of injection, microneedling combined with 30% supramolecular salicylic acid (SSA)chemical peel (Broda, Shanghai Rui Zhi Medicine Technology) was performed at our clinic. The lesions gradually subsided and then resolved completely at the 1-month follow-up after three treatments (Figure 1).&lt;/p&gt;&lt;p&gt;A 38-year-old female received intradermal injections of “collagen products” at a clinic for face rejuvenation. Shortly after the treatment, erythema, edema, and a burning sensation developed at the injection sites, followed by well-defined red nodules. She was given oral antihistamine and methylprednisolone (24 mg) per day at another clinic. The edema subsided, but nodules remained prominent. One month after the injections, she received microneedling combined with 30% SSA therapy at our clinic. The lesions completely resolved at the 3-month follow-up after three sessions of combined treatments.&lt;/p&gt;&lt;p&gt;A 28-year-old female received intradermal injections of “collagen products” at a clinic for neck rejuvenation. Three days after the treatment, well-defined red nodules accompanied by itching developed at some injection sites. She was given oral antihistamines, prednisone (10 mg), and topical hydrocortisone butyrate cream per day at another clinic. Some of the lesions subsided gradually but recurred after discontinuing the medication. Thirty-five days after the mesotherapy, the aforementioned treatment was performed at our clinic. The lesions subsided significantly at the 1-month follow-up after three treatments. She was unable to continue the treatment due to traveling abroad.&lt;/p&gt;&lt;p&gt;It is widely known that the adverse reaction of nodular lesions can be treated with systemic or intralesional corticosteroids or surgical excision [&lt;span&gt;1, 2&lt;/span&gt;]. However, the use of these methods is often limited, as patients may refuse long-term medication use due to concerns about its adverse effects or they may refuse intralesional therapy due to fears of local atrophy. Additionally, surgical excision may not be suitable for cases with numerous or widely distributed lesions. As a result, attention has gradually shifted to physical therapies, such as radiofrequency, ultrasound, and","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolutionary Trends and Research Focal Points on Port Wine Stains: A Scientometric and Meta-Analysis","authors":"Zheren Su,&nbsp;Xuanfeng Chen,&nbsp;Rui Zhang,&nbsp;Jing Li,&nbsp;Zifu Zhou,&nbsp;Jianhai Bi,&nbsp;Ran Huo","doi":"10.1111/jocd.16770","DOIUrl":"https://doi.org/10.1111/jocd.16770","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite numerous studies over the past two decades, clinical treatment for port wine stains (PWS) has shown limited progress. Analyzing evolutionary trends and research focal points can illuminate current deficiencies and guide future investigations. We aim to conduct a scientometric analysis and meta-analysis to uncover the historical trajectory, research hotspots, and future directions of PWS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a scientometric analysis of articles related to PWS published between 2000 and 2023. Data were retrieved from the Web of Science Core Collection (WoSCC) and analyzed using R software, VOSviewer, and CiteSpace. Furthermore, we retrieved articles reporting therapeutic clearance rates for PWS from PubMed, Embase, Web of Science, and Cochrane search engines. A meta-analysis was performed using Stata/MP to assess whether treatment outcomes for PWS have improved in the 21st century.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The annual scientific output was stable from 2000 to 2023. The top three countries in terms of document production were the United States, China, and the United Kingdom. Pulsed dye laser (PDL) and photodynamic therapy (PDT) were the two primary modalities used in the treatment of PWS. A notable difference exists in the preference for these treatment modalities between China and Western countries. The meta-analysis shows improvement in treatment outcomes for PWS from 2000 to 2023.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although limited, treatment outcomes for PWS have shown improvement in the 21st century. However, there is a critical need for research directions that could revolutionize current treatment practices. Genetic discoveries have suggested promising therapeutic targets for potential breakthroughs in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absorbable Dermal Filler for Saddle Nose Deformity Associated With Wegener's Granulomatosis","authors":"Iris Alla,&nbsp;Felice Lorusso,&nbsp;Sergio Alexandre Gehrke,&nbsp;Sergio Rexhep Tari,&nbsp;Antonio Scarano","doi":"10.1111/jocd.70014","DOIUrl":"https://doi.org/10.1111/jocd.70014","url":null,"abstract":"&lt;p&gt;Granulomatosis with polyangiitis, also known as Wegener granulomatosis (WG), is a necrotizing autoimmune disorder associated with vasculitis that could affect several different regions in humans, more frequently with multi-organ inflammation of the kidneys, lungs, and respiratory tracts of Caucasian subjects [&lt;span&gt;1, 2&lt;/span&gt;]. The head and neck implications range from 70% to 90% of the patients, with a higher frequency of nasal/paranasal, ear, and throat involvements with different grades of damage [&lt;span&gt;1-3&lt;/span&gt;]. The most common clinical symptoms could include crusting, smell alterations, epistaxis, rhinorrhea, necrosis, septum perforation, sinusitis, and saddle-nose deformity [&lt;span&gt;4-8&lt;/span&gt;]. Saddle nose represents a clinical condition that could produce relevant functional and psychological distress with a decrease in the patient's quality-of-life [&lt;span&gt;9, 10&lt;/span&gt;]. The granulomatosis with polyangiitis progression is able to sustain a chronic granulomatous inflammation able to determine a significant cartilage and facial bone basis resorption associated with soft tissues and mucosal structures changes [&lt;span&gt;11&lt;/span&gt;]. The damage to the nasal and nasal sinuses could differ in severity grade, inflammation, and tissue thickening [&lt;span&gt;3&lt;/span&gt;]. The loss of the cartilage and bone support is able to generate a significant collapse of the nasal framework, with the consequent requirement of a regenerative and grafting approach for the restoration of the natural profile [&lt;span&gt;8, 11, 12&lt;/span&gt;]. The nasal framework is supported by a complex of vessel circulation [&lt;span&gt;13&lt;/span&gt;] that should be considered in clinical practice. The main blood supply of the dorsal nose region is supported by the anterior ethmoid artery, while the lateral nose, ala, and the columella are supplied by the facial artery terminal arteries [&lt;span&gt;13&lt;/span&gt;]. The most common complications of dermal filler treatment are pain, ulcerations, hypersensitivity, ecchymosis, swelling, graft migration [&lt;span&gt;14&lt;/span&gt;], and nodule formation [&lt;span&gt;15&lt;/span&gt;]. The learning curve requires a thorough understanding of the anatomical blood circulation variants and the intrinsic characteristics of the graft and the operative technique. We describe a clinical case of granulomatosis with polyangiitis saddle nose deformity treated with hyaluronic acid dermal filler for the restoration through a case report.&lt;/p&gt;&lt;p&gt;The patient presents a medical history of autoimmune granulomatosis with polyangiitis of over 25 years. From previous rheumatologic medical records, the patient was found to have oligoexpressed Wegener's granulomatosis, thus undergoing methotrexate administration. The tomography imaging of the paranasal sinuses shows modest thickening of the parietal mucosa of the maxillary sinuses, especially on the left, and some ethmoidal cells and the left sphenoidal sinus, hypertrophy of the left inferior turbinates. The last visit record of 2023 reported granulomatosis with pol","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Response of Patients' Immune System After Facial Mesotherapy","authors":"Olga Bobowska-Guglas,&nbsp;Michał Chalcarz,&nbsp;Beniamin Oskar Grabarek,&nbsp;Tomasz Sirek,&nbsp;Jakub Żurawski","doi":"10.1111/jocd.16792","DOIUrl":"https://doi.org/10.1111/jocd.16792","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Facial mesotherapy is a minimally invasive cosmetic procedure involving the injection of active substances into the dermis and subcutaneous tissue. Although generally considered safe, complications such as granulomatous inflammation can arise due to improper techniques or unregulated products. This case report highlights the immune response to facial mesotherapy and its clinical management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A 50-year-old woman presented with erythematous, hard, and painless facial nodules three weeks after undergoing mesotherapy in a non-medical setting. A detailed clinical examination, laboratory tests, histopathological analysis, and immunohistochemical evaluation were performed. Tissue expression of CD3, CD20, and CD68 markers was quantified using morphometric analysis. Statistical analysis was conducted to compare the expression of immune markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histopathological examination revealed granulomatous inflammation dominated by macrophages. Immunohistochemical analysis showed significantly higher macrophage activity (CD68, mean reaction area: 5,982.76 µm²) compared to T lymphocytes (CD3, 1,775.12 µm²) and B lymphocytes (CD20, 187.55 µm²) (<i>p</i> &lt; 0.001). Initial treatment included antibiotics, corticosteroids, and topical therapies. Subsequent interventions involved intralesional triamcinolone, oral glucocorticoids, and platelet-rich plasma therapy. Significant clinical improvement was observed within three months, with satisfactory cosmetic outcomes achieved after one year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Granulomatous inflammation is a potential complication of facial mesotherapy, particularly when performed in non-medical settings. Effective management requires timely diagnosis, a combination of systemic and topical treatments, and long-term follow-up. This case underscores the need for standardized mesotherapy protocols and medical oversight to minimize risks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming Aesthetic Medicine With Generative Artificial Intelligence","authors":"Marina Landau,&nbsp;Martin Kassir,&nbsp;Mohamad Goldust","doi":"10.1111/jocd.70015","DOIUrl":"https://doi.org/10.1111/jocd.70015","url":null,"abstract":"&lt;p&gt;The combination of generative artificial intelligence (AI) into cosmetic dermatology represents a transformative advancement in patient care, bridging the gap between expectations and outcomes [&lt;span&gt;1, 2&lt;/span&gt;]. By providing virtual simulations, generative AI is expanding consultations, procedural planning, and clinician training [&lt;span&gt;3, 4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Generative AI tools such as Modiface (acquired by L'Oréal), and Crisalix have redefined patient consultations. By analyzing high-resolution facial scans, these platforms generate dynamic 3D models that simulate potential changes from dermal fillers, neurotoxins, or laser treatments. For instance, Crisalix allows patients to visualize the results of facial contouring or breast augmentations, helping set realistic expectations and matching with their aesthetic goals (Table 1).&lt;/p&gt;&lt;p&gt;These simulations are critical in reducing patient dissatisfaction and post-procedure regret. By informed decision-making, these tools also help decrease potential medicolegal conflicts. This clarity provides trust and confidence, enhancing the overall patient experience.&lt;/p&gt;&lt;p&gt;Generative AI applications analyze skin elasticity, volume deficits, and facial features to assist in creating customized treatment plans. For example, dermatologists can predict the cumulative effects of dermal fillers, laser treatments, and resurfacing procedures in a single simulation, optimizing procedural strategies.&lt;/p&gt;&lt;p&gt;Generative AI also addresses safety concerns by visualizing vascular anatomy to guide filler placement, thereby minimizing risks such as vascular occlusion. AnatomyNEXT integrates augmented reality (AR) and AI to offer real-time anatomical insights during procedures, ensuring precision and reducing complications.&lt;/p&gt;&lt;p&gt;Platforms like Touch Surgery VR and the Fundamentals of Aesthetic Injectable Training (FAIT) provide virtual environments for practitioners to enhance their skills. Generative AI enhances these training programs by simulating realistic outcomes and complications. For instance, trainees can practice filler injections on virtual models that respond dynamically to their techniques, building their confidence before treating live patients.&lt;/p&gt;&lt;p&gt;Generative AI simulations also aid in postoperative planning by modeling recovery trajectories and potential side effects, ensuring proactive care.&lt;/p&gt;&lt;p&gt;Generative AI addresses gaps in inclusivity, particularly for individuals with skin of color, where traditional tools often fall short. Platforms like Dermanostic and Perfect365 utilize diverse datasets, enabling accurate simulations for patients across various demographics.&lt;/p&gt;&lt;p&gt;Moreover, AI-powered virtual consultations facilitate access to care. Remote consultations, supported by tools like YouCam Makeup, allow patients in underserved areas to receive personalized assessments, expanding access to expert cosmetic advice.&lt;/p&gt;&lt;p&gt;While the potential of generative AI is significant, challenges remain. Algorithmic b","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot Study Demonstrates Tetramethylhexadecenyl Succinoyl Cysteine (TSC) Reduces Tretinoin-Induced Erythema and Dryness in Human Subjects","authors":"Eduardo Pérez,&nbsp;José R. Fernández,&nbsp;Yasanuri Sato,&nbsp;Corey Fitzgerald,&nbsp;Karl Rouzard,&nbsp;Jason Healy,&nbsp;Masanori Tamura,&nbsp;Jeffry B. Stock,&nbsp;Tsuyoshi Ishii","doi":"10.1111/jocd.70026","DOIUrl":"https://doi.org/10.1111/jocd.70026","url":null,"abstract":"&lt;p&gt;Isoprenylcysteine (IPC) molecules represent a novel, safe class of compounds with a broad range of anti-inflammatory, antimicrobial, wound healing, and moisturizing properties. These molecules are primarily synthesized with two distinct long tail fatty acid chains attached to a cysteine residue, either possessing a 15-carbon farnesyl or a 20-carbon phytyl moiety. We previously reported that novel IPC compounds, diosodium tetramethylhexadecenyl succinoyl cysteine (TSC aka SIG1273) and acetylglutaminoyl farnesylcysteine (QFC aka SIG1191), possess several skin-protecting properties, including the inhibition of UVA, UVB, Ni&lt;sup&gt;+2&lt;/sup&gt;, toll-like receptor, and T-cell receptor-induced inflammation [&lt;span&gt;1-3&lt;/span&gt;]. Moreover, other farnesyl cysteine derivatives have been shown to reduce erythema when topically applied to human subjects [&lt;span&gt;4&lt;/span&gt;], while phytyl cysteine–derived compounds have been shown to be well tolerated and reduce signs of aging and are effective in subjects with acne-prone skin [&lt;span&gt;5, 6&lt;/span&gt;]. Topical retinoids, such as all-trans retinoic acid (tretinoin) and retinol, are commonly utilized in both the prescription and cosmetic space to treat acne and skin aging. Per Verified Market Reports, the global market size for tretinoin is currently valued at USD $7.64 billion and projected to surpass $10 billion by 2030. However, despite their effectiveness, the topical use of retinoids can cause burning, itching, stinging, and redness for consumers. Given their previous skin health–promoting activities, we sought to perform a pilot clinical study to assess whether TSC and/or QFC could effectively reduce tretinoin-induced irritation and thus ameliorate the negative side effects that come with its use.&lt;/p&gt;&lt;p&gt;This study was a 5-day efficacy evaluation with five subjects performed at a third party CRO (Validated Claim Support, Teaneck, NJ). There were four female and one male participant with a mean age of 35 years ranging from 31 to 42 years. No adverse events were observed. Four test sites on the subjects' backs were utilized: Test site 1—negative control (untreated), Test site 2—positive control (tretinoin 0.2%), Test site 3—(0.5% TSC + 0.2% tretinoin), and Test site 4—(0.5% QFC + 0.2% tretinoin). In addition to the actives, the only other ingredients used in each formulation were isopropyl palmitate (74.3%–74.8%) and pentylene glycol (25%). Test samples (0.1 mL) were applied topically under an occlusive patch at Days 0 and 1. No application was made on Days 3 or 4. Objective tolerance grading and clinical photography were captured from Day 1 to 4. Clinical results demonstrate that 0.5% TSC +0.2% tretinoin elicited a milder response and faster reduction in both dryness and erythema as compared to the positive control, tretinoin 0.2%, and 0.5% QFC + 0.2% tretinoin (Table 1; Figure 1). Increase in dryness persisted through the final evaluation day (Day 4) for the positive control, while 0.5% TSC + 0.2% tretinoin showed a decr","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}