Journal of Cosmetic Dermatology最新文献

{"title":"Calcium Hydroxylapatite-Based Fillers in Dorsal Hand Rejuvenation: A Practical Checklist for Formulation and Protocol Specificity","authors":"Chuan-Yuan Lin","doi":"10.1111/jocd.71024","DOIUrl":"https://doi.org/10.1111/jocd.71024","url":null,"abstract":"<p>Calcium hydroxylapatite (CaHA)-based fillers are widely used for dorsal hand rejuvenation because they can provide immediate camouflage of tendons and veins [<span>1, 2</span>]. Depending on protocol, they may also improve skin quality over time [<span>3</span>]. However, CaHA-based fillers are not necessarily formulation-equivalent, with measurable differences across products and variants that can alter handling behavior [<span>4-6</span>]. In the thin dorsal hand envelope, such differences may translate into clinically relevant variation in spread, cohesivity, palpability, contour regularity, and tolerability [<span>3, 4</span>]. Accordingly, we offer a brief, practical checklist to help readers verify key formulation and protocol details when interpreting dorsal hand CaHA studies and to assist practitioners in contextualizing formulation and protocol selection for individual treatment goals.</p><p>In the dorsal hand literature, authors may describe the injected material simply as “CaHA,” even though formulation context and postmixing state may differ meaningfully across products and protocols [<span>4-6</span>]. In hand-specific studies, outcomes depend on the exact injected state and technique [<span>1-3</span>]. For example, a randomized, blinded trial demonstrated clinically meaningful improvement in dorsal hand volume loss through 12 months using CaHA-based fillers and standardized outcome assessment [<span>1</span>]. Separately, a prospective evaluator-blinded, side-to-side study of diluted CaHA-based fillers reported improvements in the Merz Hand Grading Scale and the Global Aesthetic Improvement Scale. It also showed improvements in objective parameters such as ultrasound-based dermal measures, viscoelasticity, and collagen density [<span>3</span>]. These findings suggest that CaHA-based fillers for the hands can reflect different therapeutic intents, including volumization and biostimulation, and different handling behavior [<span>1, 3</span>].</p><p>In parallel, contemporary CaHA-based products and variants may not be formulation-equivalent because they can differ in carrier matrix, CaHA loading, and postmixing handling characteristics, and CaHA–carrier systems show dilution- and mixing-dependent rheologic shifts [<span>4-6</span>]. A previous study using carboxymethylcellulose as the carrier matrix demonstrated systematic changes in viscoelastic properties, cohesivity, and extrusion force with aqueous dilution, supporting the idea that dilution moves the material along a continuum from “filling” toward “regenerative” handling characteristics [<span>4</span>]. A subsequent report further differentiated dilutional rheology among Radiesse, Radiesse (+), and a lidocaine-mixed preparation—illustrating that even within a familiar brand family, small formulation or mixing differences can produce distinct material profiles [<span>5</span>].</p><p>Accordingly, when interpreting dorsal hand CaHA-based filler studies, readers and practitione","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Concise Clinical Application Strategy for Hyaluronic Acid Fillers in Facial Contouring and Rejuvenation","authors":"Hao Feng, Ting Wang, Caijin Xiang, Xiang Liu, Haihua Li, Yong Liao, Liangsen Zhao, Donghui Wu","doi":"10.1111/jocd.71011","DOIUrl":"https://doi.org/10.1111/jocd.71011","url":null,"abstract":"<p>Hyaluronic acid (HA) is the most widely used filler in aesthetic practice, with hundreds of brands and an even greater variety of formulations available worldwide. In China alone, more than 60 HA products have been officially approved for clinical use. The abundance of products inevitably presents both physicians and patients with complex choices. At times, selections are guided by brand reputation, as patients may request specific products recommended by friends or social media influencers. Price is another key factor. 1 mL syringes vary over twenty times in cost, so selections should fit patients' budgets. Physicians may also rely on habit and inventory, favoring products they use frequently and know well.</p><p>However, beyond brand and cost, the fundamental consideration in selecting HA fillers should be the ability to achieve optimal contour restoration and volumization. From this perspective, clinical indications for HA injection should be rationally categorized, with product selection guided by physicochemical properties appropriate to each indication. Drawing on personal clinical experience, the author classifies HA filler indications into five categories: contouring, volumization, smoothening, lifting, and revitalization. Contouring indications aim to accentuate osseous curves such as the supraorbital ridge, nasal dorsum, and mandibular line; volumization indications address soft tissue augmentation of areas like the temples and maxillary; smoothening indications include transitions in the forehead and subzygomatic hollow, where subtle smoothening rather than concentrated deposition is required; lifting indications involve lateral–superior injections to reposition inferomedial soft tissues; and revitalization indications refer specifically to dermal and superficial subdermal microinjections, focusing on fine replenishment and skin quality improvement.</p><p>The physicochemical properties of HA fillers encompass degree of crosslinking, elastic modulus (<i>G</i>′), viscous modulus (<i>G</i>″), cohesivity, swelling ratio, and particle size [<span>1, 2</span>]. In clinical practice, it is unrealistic for physicians to recall detailed parameters for every product, underscoring the need for a simplified classification to facilitate indication-based selection. Classical studies have generally endorsed a two-category system according to crosslinking technology and morphology: gel-type (monophasic) and granular-type (biphasic) fillers [<span>3-6</span>]. These two groups display distinct macroscopic appearances, rheological behavior, and distribution patterns in tissue. In brief, granular fillers have higher <i>G</i>′ and lower cohesivity, tending to localize vertically in tissue, making them suitable for support and contouring. Gel fillers exhibit lower <i>G</i>′ and higher cohesivity, distributing more horizontally and thus better suited for volumization.</p><p>Granular HA fillers can be further subdivided by particle size into large, medium","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydeoxyribonucleotide in Female Pattern Hair Loss: Current Evidence and Knowledge Gaps","authors":"Nika Bakshi, Andrea Dai, Elham T. Tabatabaei, Steven Daveluy","doi":"10.1111/jocd.71028","DOIUrl":"https://doi.org/10.1111/jocd.71028","url":null,"abstract":"<p>Ten years ago, a study by Lee et al. reported polydeoxyribonucleotide (PDRN), a mixture of deoxyribonucleotide polymers, as a promising therapeutic option for female pattern hair loss. The randomized controlled trial showed meaningful improvements in both hair density and thickness, suggesting a potential role for PDRN as a regenerative treatment in alopecia [<span>1</span>]. However, these findings were derived from a small sample size of a single study and require validation before they can be considered for clinical practice. This commentary revisits Lee et al.'s work in the context of growing interest in regenerative injectables and highlights the importance of further studies to confirm reproducibility before clinical application can be contemplated.</p><p>PDRN consists of low molecular weight deoxyribonucleotides derived from <i>Oncorhynchus mykiss</i> (Salmon trout) or <i>Oncorhynchus keta</i> (Chum Salmon) [<span>2</span>]. Along with its longer-chain counterpart, polynucleotide (PN), PDRN has gained increased visibility in aesthetic medicine, particularly in East Asian dermatologic practice. Most commonly, it is delivered via intradermal or subdermal injections to improve skin hydration, texture, and overall dermal quality [<span>3</span>].</p><p>Recently, PDRN has been grouped with a broader class including platelet-rich plasma (PRP), exosomes, and stem-cell-derived vesicles that act by promoting angiogenesis, growth factor signaling, and fibroblast activation [<span>4</span>]. Unlike PRP, whose composition varies based on patient physiology and preparation technique, PDRN is a chemically defined and consistently manufactured product.</p><p>The biologic plausibility for PDRN in female pattern hair loss stems from its capacity to address two key pathophysiologic features: microvascular dysfunction and chronic low-grade inflammation [<span>5</span>]. By activating the adenosine A2A receptor, PDRN upregulates vascular endothelial growth factor (VEGF), driving neovascularization and enhancing oxygen and nutrient delivery to the dermal papilla [<span>2</span>]. Additionally, PDRN downregulates proinflammatory mediators such as TNF-α and IL-6, reducing perifollicular inflammation and supporting a more favorable environment for anagen-phase maintenance [<span>6, 7</span>]. Together, these mechanisms provide a biologic rationale for its use in hair restoration.</p><p>Polynucleotides (PNs), which are structurally related to PDRN but consist of longer DNA fragments, have also been explored in regenerative dermatology [<span>8</span>]. In contrast to PDRN, which primarily exerts its effects through adenosine A2A receptor–mediated signaling, PNs are thought to provide a more structural, scaffold-like role in tissue repair [<span>2, 8</span>]. While PNs have been studied in aesthetic and wound-healing contexts, there are no randomized controlled trials evaluating their efficacy in female pattern hair loss. As such, whether PNs offer any clinical ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Treatment With Juvéderm Hyaluronic Acid Injectables for ≥ 10 Years: Expert Considerations for Natural Outcomes","authors":"Yuexing Song,&nbsp;Rami Abadi,&nbsp;Gabriela Cella,&nbsp;Stefania Roberts,&nbsp;Fernando Urdiales-Gálvez,&nbsp;Steve G. Yoelin,&nbsp;Carola de la Guardia","doi":"10.1111/jocd.71015","DOIUrl":"https://doi.org/10.1111/jocd.71015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Juvéderm is one of the most widely studied and broadly used hyaluronic acid (HA) product portfolios worldwide. Long-term treatment can contribute greatly to positive aging, but clinical data over many cycles of injection are currently lacking. Following key principles of best practice can help to ensure natural outcomes are maintained over time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To provide clinical expert considerations for long-term and multiple treatments with Juvéderm, and present case studies treated for ≥ 10 years demonstrating effective and natural outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six clinicians with various specialties and extensive experience with Juvéderm completed a written questionnaire. Their collective clinical expertise and experience form the basis of these considerations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Maintenance of natural results over long-term Juvéderm treatment may be facilitated by: (i) strong technical fundamentals (e.g., optimized injection technique and in-depth anatomical knowledge); (ii) correct product selection (e.g., understanding their composition, properties, preferred injection depths, and key clinical data); and (iii) long-term planning (e.g., thorough patient assessment, consideration of the whole face, use of an initially conservative approach, combining Juvéderm products with other treatments in an individualized and multimodal strategy, and tracking appearance over time).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Following these key principles of best practice may help clinicians to achieve well-tolerated and natural outcomes over long-term treatment with Juvéderm HA injectables.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Efficacy and Safety of Topical Phenytoin in Androgenetic Alopecia: A Clinical Investigation","authors":"Sina Maskoukian,&nbsp;Atefeh Naeimifar,&nbsp;Aniseh Samadi,&nbsp;Hamid Akbari Javar,&nbsp;Afsaneh Sadeghzadeh Bazargan,&nbsp;Saman Ahmad Nasrollahi,&nbsp;Alireza Firooz","doi":"10.1111/jocd.71016","DOIUrl":"https://doi.org/10.1111/jocd.71016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Phenytoin, a widely used antiepileptic drug, is known for its proliferative effects on fibroblasts and keratinocytes, as well as its stimulatory influence on angiogenesis. One of its notable side effects is hirsutism, which suggests a potential role in hair growth promotion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to evaluate the safety and efficacy of a topical 5% phenytoin solution in men with androgenetic alopecia (AGA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this 16-week, open-label clinical trial, adult male participants with AGA applied a 5% phenytoin solution twice daily. TrichoScan analysis and standardized global photographs were employed at baseline, week 8, and week 16 to assess changes in total hair count, hair density, anagen-to-telogen ratio, and follicular units. Subjective assessments of hair condition and scalp oiliness were obtained at each visit using a patient satisfaction scale. Adverse events were monitored throughout the study period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant improvements were observed in total hair count from baseline (158.07 ± 37.65) to week 16 (183.21 ± 44.63) (<i>p</i>-value = 0.010). Similarly, hair density significantly increased from baseline (174.99 ± 41.70 number/cm²) to week 16 (202.39 ± 49.67 number/cm²) (<i>p</i>-value = 0.011). Number of total follicular units also exhibited a significant increase from baseline (90.07 ± 16.85) to week 16 (98.07 ± 19.67) (<i>p</i>-value = 0.013), as did follicular unit density from baseline (99.71 ± 18.66 FU/cm²) to week 16 (108.65 ± 20.94 FU/cm²) (<i>p</i>-value = 0.012). The average hair unit and the anagen rate showed slight increases from baseline to week 16, but these changes were not statistically significant. Subjective assessments indicated improvements in scalp oiliness and hair texture. The treatment was well tolerated, with only mild and transient adverse events reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Topical 5% phenytoin solution appears to be a safe and potentially effective therapeutic option for AGA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond PRP: Recognizing the Evolving Generations of Platelet Concentrates in Androgenetic Alopecia Treatment—A Letter in Response to Zhong Et al","authors":"Luo Ruiyu,&nbsp;Zhao Changjiang,&nbsp;Li Yufei","doi":"10.1111/jocd.71002","DOIUrl":"https://doi.org/10.1111/jocd.71002","url":null,"abstract":"&lt;p&gt;We read with great interest the comprehensive review by Zhong et al. regarding the application of platelet-rich plasma (PRP) for androgenetic alopecia (AGA) [&lt;span&gt;1&lt;/span&gt;]. The authors have provided a thorough synthesis of PRP preparation techniques, mechanisms of action, clinical efficacy, and safety, and have rightly emphasized the need for standardized protocols. We wish to extend this discussion by noting that platelet concentrate technology has evolved substantially beyond PRP over the past decade, and that a broader generational framework may offer a more complete perspective for clinicians and researchers.&lt;/p&gt;&lt;p&gt;Platelet concentrates for hair restoration are now widely recognized as spanning multiple generations. Building upon the first-generation PRP, platelet-rich fibrin (PRF) was introduced as a second-generation product that eliminated the need for anticoagulants and provided a three-dimensional fibrin scaffold for sustained growth factor release [&lt;span&gt;2&lt;/span&gt;]. More recently, concentrated growth factor (CGF), a third-generation preparation produced through variable-speed centrifugation, has been shown to contain high concentrations of growth factors and preserve CD34+ progenitor cells within a denser fibrin matrix [&lt;span&gt;3, 4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The evolution did not stop at CGF. Further physical refinement has yielded a purified derivative—termed CGF-purified fraction (CGF-PF) or concentrated purified fraction (CPF)—that differs fundamentally from its predecessors. The purification process preferentially retains nanometer-sized bioactive components, particularly extracellular vesicles and exosomes, while reducing larger particulate matter [&lt;span&gt;5, 6&lt;/span&gt;]. Unlike the predominantly growth factor–based mechanism of PRP and PRF, CGF-PF appears to mediate its effects through vesicle-associated signaling. Studies have shown that exosomal microRNAs can significantly regulate hair follicle cycling and dermal papilla cell function [&lt;span&gt;7&lt;/span&gt;], suggesting that the enhanced vesicle content of CGF-PF may offer a distinct mechanism of action.&lt;/p&gt;&lt;p&gt;Preliminary clinical observations suggest that CGF-PF offers improved injection tolerability and potentially more targeted modulation of hair follicle stem cell pathways. However, we acknowledge that prospective, controlled comparisons between CGF-PF and conventional CGF are needed to establish its relative efficacy.&lt;/p&gt;&lt;p&gt;In summary, we commend Zhong et al. for their timely review of PRP therapy for AGA and suggest that the field may benefit from recognizing the full spectrum of platelet concentrate generations—PRP (first), PRF (second), CGF (third), and CGF-PF/CPF (fourth)—as a useful reference framework. We look forward to future studies that may validate this classification through comparative clinical and mechanistic investigations.&lt;/p&gt;&lt;p&gt;This work was supported by the Ministry of Education of the People's Republic of China, No. 231103242232720, No. 2408271251. Clinical Research Plan, N","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ashwagandha Root Extract and Its Potential Modulation of CCN1-Associated Pathways in Sensitive-Skin Aging","authors":"Liying Kang,&nbsp;Yanhong Liu,&nbsp;Yuchen Xin,&nbsp;Lin Geng,&nbsp;Shaochun Cai,&nbsp;Jianfang Luo,&nbsp;Shaojie Gu,&nbsp;Shuangyan Wang,&nbsp;Zhiting Zhang,&nbsp;Yan Huang,&nbsp;Guixuan Zhou,&nbsp;Li Ye,&nbsp;Dongcui Li,&nbsp;Naisheng Jiang","doi":"10.1111/jocd.71010","DOIUrl":"https://doi.org/10.1111/jocd.71010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cellular Communication Network Factor 1 (CCN1) has been identified as a key regulator of oxidative stress-induced skin aging and sensitivity. Ashwagandha root extract (ARE) is a promising candidate for modulating CCN1-associated pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate whether ARE can mitigate sensitive-skin aging by modulating CCN1 expression and its downstream effects, and to evaluate the clinical efficacy and tolerability of an ARE-containing formulation in individuals with sensitive skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Human foreskin fibroblasts (HFF-1) exposed to hydrogen peroxide (H₂O₂) were assessed for viability using the Cell Counting Kit-8 (CCK-8) assay, and for CCN1, integrin α₆β₁, MMP-1, COL-1, IL-6, and IL-1β expression using enzyme-linked immunosorbent assay (ELISA). A 28-day open-label clinical study was performed in 31 Chinese women with sensitive skin to evaluate changes in skin hydration, elasticity, firmness, wrinkle severity, and facial contour.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>H₂O₂ exposure significantly decreased fibroblast viability and upregulated CCN1 expression. Treatment with ARE dose-dependently restored cell viability, suppressed the expression of CCN1, integrin α₆β₁, MMP-1, IL-6, and IL-1β, and promoted COL-1 synthesis. Clinical evaluation demonstrated that 28 days of ARE-containing cream application significantly improved skin hydration (+49.0%) and elasticity (+27.2%), improved skin firmness, as evidenced by a 32.4% reduction in the F4 parameter compared with baseline (<i>p</i> &lt; 0.001), and reduced wrinkle depth and facial sagging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ARE can alleviate oxidative stress-induced skin aging at least in part by downregulating CCN1 and its downstream inflammatory mediators and by inhibiting matrix-metalloproteinase-mediated extracellular matrix (ECM) degradation. The combined biological and clinical evidence supports ARE as a promising and well-tolerated active ingredient for improving signs of skin aging in individuals with sensitive skin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 1064-nm Picosecond and Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Lasers for Melasma in Asian Women: A Randomized Double-Blind Split-Face Trial","authors":"Ying Wu,&nbsp;Qixuan Wang,&nbsp;Jiayi Feng,&nbsp;Zehua Chen,&nbsp;Lvping Huang,&nbsp;Yongqiang Feng,&nbsp;Xiaojing Li","doi":"10.1111/jocd.71008","DOIUrl":"https://doi.org/10.1111/jocd.71008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma is a chronic, relapsing facial hyperpigmentation that remains challenging to treat in medium-to-dark phototypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To compare the efficacy, safety, tolerability, and recurrence of 1064-nm picosecond neodymium-doped yttrium aluminum garnet laser treatment versus 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser treatment in Asian women with melasma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective, randomized, double-blind, split-face trial, 16 Asian women with Fitzpatrick skin types III–IV received three treatment sessions at 4-week intervals. Laser allocation was randomized by hemi-face, and outcome assessors were blinded. The primary endpoint was the hemi-modified Melasma Area and Severity Index (hemi-mMASI), assessed at baseline and at 1, 2, 3, and 6 months after the final treatment session. Secondary outcomes included the Global Aesthetic Improvement Scale (GAIS), recurrence, and pain intensity measured using a visual analog scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both 1064-nm picosecond Nd:YAG and 1064-nm Q-switched Nd:YAG laser treatments were associated with significant reductions in hemi-mMASI over time. No statistically significant between-treatment differences in hemi-mMASI or GAIS were detected during follow-up. Pain scores after the first treatment session were significantly lower on the picosecond-treated side. Recurrence rates at 6 months did not differ significantly between treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In Asian women with Fitzpatrick skin types III–IV, both 1064-nm picosecond Nd:YAG and 1064-nm Q-switched Nd:YAG laser treatments were associated with clinical improvement in melasma. No statistically significant between-treatment differences in hemi-mMASI or GAIS were detected in this small split-face trial, whereas picosecond treatment was associated with lower pain scores after the first treatment session.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Chinese Clinical Trial Registry registration number: ChiCTR2000030886</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the SkinConnect Nomadic Multi-Parametric Device for Assessing Stratum Corneum Hydration","authors":"Frédéric Flament,&nbsp;Thomas Dauxerre,&nbsp;Juliette Rengot,&nbsp;Marie Cherel,&nbsp;Ghislain François,&nbsp;Matthieu Jomier,&nbsp;Guive Balooch","doi":"10.1111/jocd.70998","DOIUrl":"https://doi.org/10.1111/jocd.70998","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hydration is an essential skin parameter measurable by only a few nomadic devices. Focusing on personalized skincare in retail environments, we designed the SkinConnect, a compact, all-in-one device capable of analyzing skin color, microrelief, and hydration. This study constitutes the initial assessment of the SkinConnect, evaluating repeatability, reproducibility, and sensitivity to detect hydration changes, and benchmarking it against the Corneometer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An independent Contract Research Organization recruited 22 females and 22 males and measured skin hydration in triplicate on six body areas (the forehead, a cheek, the chest, both forearms, and a calf). Measurements were taken at one-hour intervals, including before and after applying a hydrating cream to one forearm. Parallel measurements were conducted using a Corneometer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 4665 SkinConnect measurements, 0.2% displayed aberrantly high values while 3.1% were null. The mean standard deviation for intra-device repeatability was 3.68 and inter-device measurements showed a correlation coefficient of 0.917–0.941. Intra-device reproducibility showed a correlation coefficient of 0.86–0.88, slightly lower than that of the Corenometer. When benchmarked against the Corneometer, correlation was best described by a logarithmic regression (<i>r</i> = 0.73), indicating lower sensitivity to low hydration levels. Nonetheless, the SkinConnect device effectively detected cream-induced hydration increases and more subtle hydration differences across body areas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although further studies are warranted, this work indicates that the SkinConnect enables reliable skin hydration monitoring, making it a compact and efficient solution for multi-parametric skin assessment and providing access to professional-grade skin analysis. It may also prove valuable in assessing skin disorders.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 7","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70998","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"","doi":"10.1111/jocd.71006","DOIUrl":"https://doi.org/10.1111/jocd.71006","url":null,"abstract":"<p>The cover image is based on the article <i>Micro-EVLA—Micro-Endovenous Laser Ablation of Bulging Temporal and Periorbital Facial Veins—A Report of a New Technique</i> by Mark S. Whiteley https://doi.org/10.1111/jocd.70954.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 6","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}