Journal of Cosmetic Dermatology最新文献

{"title":"Biodegradability and Efficacy of Porous Polycaprolactone Microsphere Dermal Filler for Fine Lines","authors":"Jin-Su Kim,&nbsp;Ji-Hyun Sung,&nbsp;Doo-Yeon Kwon,&nbsp;Jeong-Eun Park,&nbsp;Helen Cho,&nbsp;Hye-Sung Yoon","doi":"10.1111/jocd.70156","DOIUrl":"https://doi.org/10.1111/jocd.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Among various filler products designed to improve facial wrinkles, those using biodegradable polymer microspheres have gained attention. Recently, a filler composed of porous polycaprolactone (PCL) microspheres was introduced.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to evaluate and understand the mechanism of PCL biodegradability, safety, and efficacy in reducing wrinkles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To examine the degradation characteristics in vitro, the filler product was incubated in phosphate-buffered saline (pH 7.4) at 37°C, 45°C, and 55°C. Samples from 1 to 104 weeks were obtained to determine changes in the morphology and molecular weight of the porous PCL microspheres. In addition, the product was administered to rabbits to evaluate its in vivo degradability. Treated tissues were sampled at 6, 12, 18, 24, and 30 months to examine the biodegradability of the microspheres. Tissue safety and collagen fiber production were evaluated at the same time points. The anti-wrinkle effect was evaluated using PRIMOS to measure changes in skin surface roughness in a photoaging mouse model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In vitro testing revealed that the porous PCL microspheres degraded progressively over time, forming cracks on the surface and showing a decrease in molecular weight. In vivo studies demonstrated that the product degraded safely in tissues and induced collagen formation. Furthermore, skin roughness evaluation using a photoaging mouse model confirmed its anti-wrinkle effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The filler product based on porous PCL microspheres was found to be safely biodegraded in vivo and effectively improved wrinkles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Causal Relationship Between Extensive Lipid Profiles and Various Hair Loss Diseases: Evidence From Univariable and Multivariable Mendelian Randomization Analyses","authors":"Yuhan Xie,&nbsp;Ruimin Bai,&nbsp;Landong Ren,&nbsp;Hengtong Fan,&nbsp;Huihui Tuo,&nbsp;Longmei Duan,&nbsp;Xiaolin Zhou,&nbsp;Chengyu Fang,&nbsp;Ziyan Li,&nbsp;Yan Zheng","doi":"10.1111/jocd.70176","DOIUrl":"https://doi.org/10.1111/jocd.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hair loss disorders, including non-cicatricial forms such as alopecia areata (AA) and androgenetic alopecia (AGA), as well as cicatricial forms, represent significant dermatological concerns influenced by various factors, including lipid metabolism. While observational studies and clinical trials have suggested a link between lipid levels and hair loss, the causal relationship remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a comprehensive analysis of 983 lipid variables [including triglycerides (TG), fatty acids, cholesterol, cholesterol esters, phospholipids, and lipoproteins] and 4 hair loss disorders. Two-sample univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) analyses were employed to investigate the causal effects of lipids on hair loss disorders. Sensitivity analyses were performed to ensure the robustness of our findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The UVMR analysis identified 56 significant causal associations between lipid levels and hair loss disorders, with cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TG, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) emerging as key contributors. The MVMR analysis evaluated the independent effects of HDL-C, LDL-C, and TG on alopecia disorders, identifying significant associations only between HDL-C, TG, and AA. Sensitivity analyses confirmed the consistency and robustness of these results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides strong evidence for potential causal associations between lipids and hair loss disorders, highlighting potential therapeutic targets and the importance of lipid management in affected patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Reprogramming Induced by Benzo[a]pyene in Skin Keratinocytes and Protective Effects of Glutathione Amino Acid Precursors","authors":"Xiao Cui,&nbsp;Tingyan Mi,&nbsp;Xue Xiao,&nbsp;Yiying Dong,&nbsp;Hong Zhang,&nbsp;Guoqiang Chen,&nbsp;Xuelan Gu","doi":"10.1111/jocd.70168","DOIUrl":"https://doi.org/10.1111/jocd.70168","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pollutant particles can penetrate and accumulate in skin, leading to excessive oxidative stress, inflammation, and skin disorders. Reduced glutathione (GSH) is considered as “the master antioxidant” and major detoxification agent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To characterize the metabolomic changes of skin keratinocytes under the pollutant benzo[a]pyrene (BaP) challenge and investigate the interventional effects of glutathione amino acid precursors (GAP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Normal human epidermal keratinocytes (NHEKs) were challenged with BaP with or without GAP treatment. GSH/GSSG levels were measured by UPLC–MS/MS. Non-targeted metabolome analysis was conducted with UPLC-QTOF mass spectrometry. Transcriptomics analysis was performed using RNA-seq. DNA damage biomarker γ-H2AX was analyzed by western blot. Reconstructed pigmented skin equivalent models (pLSE) were used for evaluating phenotypical changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One micromolar BaP exposure induced widespread metabolic reprogramming in in vitro NHEKs with over-represented differential metabolites in pathways including purine and pyrimidine nucleotide metabolism, xenobiotic metabolism, methylation, and RNA modification, etc. GAP co-treatment improved GSH/GSSG ratio, reduced reactive BaP metabolites, and partially reversed BaP induced metabolic and transcriptomic alterations. Western blotting further confirmed that GAP treated samples showed reduced γ-H2AX staining. In pLSE models, GAP treatment significantly ameliorated BaP induced skin darkness and hyperpigmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In summary, GAP shows in vitro protective effects against BaP by maintaining GSH homeostasis, helping metabolic detoxification, reducing DNA damage, and is effective in preventing hyperpigmentation of skin models under pollution challenge.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging","authors":"Xinya Xu,&nbsp;Xinhua Lu,&nbsp;Xinling Chen,&nbsp;Amin Yao,&nbsp;Wei Lai","doi":"10.1111/jocd.70098","DOIUrl":"https://doi.org/10.1111/jocd.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>CD47 could negatively regulate macrophage-mediated phagocytosis and contribute to senescent cells accumulation in aging. However, it remains unknown whether CD47 is overexpressed in photoaged skin and involved in photoaging pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the expression, clinical significance, and mechanism of CD47 in photoaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sun-exposed (<i>n</i> = 10) and sun-protected (<i>n</i> = 10) skin samples were collected from elderly subjects and stained for CD47, and its association with collagen and elastin content and p16 expression was subsequently analyzed. A cellular photoaging model was then established to examine CD47 expression in photoaged fibroblasts. Furthermore, the influence of photoaged fibroblasts on macrophage-mediated phagocytosis and elimination was assessed by constructing a co-culture system. SiRNA was applied to block the CD47/SIRPα axis to determine its role in this process. Finally, the activation of the CD47/SIRPα axis was evaluated in skin samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We showed the increased dermal CD47 expression in sun-exposed aged skin, which was closely correlated with the reduced collagen content and enhanced elastin accumulation and dermal p16 expression. Next, elevated CD47 was detected in both sun-exposed aged skin-derived fibroblasts and photoaged ones. We discovered that photoaged fibroblasts impaired the phagocytotic function of co-cultured macrophages via CD47/SIRPα axis, and blocking the CD47/SIRPα axis could improve their elimination. Moreover, the CD47/SIRPα axis was found to be activated in the sun-exposed aged skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The present study demonstrated for the first time that CD47 was highly expressed and involved in mediating photoaged fibroblasts accumulation, providing important evidence for CD47 as a potential biomarker and therapeutic target for photoaging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of a “High and Low Molecular Weight Hyaluronic Acid Hybrid Complex” Injection for Face Rejuvenation","authors":"Taraneh Yazdanparast,&nbsp;Azin Ayatollahi,&nbsp;Aniseh Samadi,&nbsp;Araz Sabzvari,&nbsp;Hamidreza Kafi,&nbsp;Alireza Firooz","doi":"10.1111/jocd.70117","DOIUrl":"https://doi.org/10.1111/jocd.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Hyaluronic acid (HA)-based formulations could have remarkable efficacy in treating a wide range of skin defects, including skin aging. The purpose of the study was the evaluation of the clinical safety and efficacy of a high and low molecular weight HA hybrid complex injection for skin rejuvenation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In this single-arm, before-and-after clinical study, 20 subjects with wrinkled, dry, or rough skin were enrolled. They received two treatment sessions, each of 2 mL of stabilized high- and low-molecular-weight HA through intradermal injections in five bioaesthetic points with an interval of 4 weeks. Efficacy assessment measures included biophysical and sonographic parameters and the Global Aesthetic Improvement Scale (GAIS) score. Pain assessment, safety profile, and subject satisfaction were also reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant improvement in skin firmness was demonstrated in both follow-up visits. The Transepidermal water loss (TEWL) and the dermis ecodensity improved significantly in the first follow-up visit. A statistically significant increase in the dermis thickness was seen in the second follow-up visit. The median GAIS score indicated an average improvement of 51%–75%. The median overall satisfaction score was 7 and 6 in the first and second follow-up visits. No important side effects were observed. The average pain VAS score was 2 out of 10.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This new HA-based formulation is a safe and efficient treatment option to restore the vitality and turgidity of the skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: IRCT20150101020514N17 with ethics code IR.TUMS.TIPS.REC.1401.083</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Skin Acceptability of a Cosmetic Cream for Nasolabial Dryness and Irritation","authors":"Constance Prime,&nbsp;William Hooper,&nbsp;Yosra Ghrib Ben Sassi,&nbsp;Nejib Doss,&nbsp;Oliver Chen","doi":"10.1111/jocd.70107","DOIUrl":"https://doi.org/10.1111/jocd.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Rhinorrhea is a widespread condition related to common upper respiratory insults such as influenza and rhinitis, often accompanied by frequent nose cleansing resulting in skin irritation. This study evaluated the cutaneous acceptability and nourishing, soothing, protecting, and moisturizing effects of Sterimar Soothing Nose Cream on the skin around the nose in healthy adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted an exploratory single-arm clinical trial in 33 adults (mean age 46 years) who blow their nose often (&gt; 5 times/day) due to a cold or allergies and have sensitive, irritated/dry nose. Participants applied the cream topically on their noses twice daily for 14 days. Cutaneous acceptability and efficacy measures were assessed by participants and by the study dermatologist before, during, and after 14 days. Skin imaging analysis via the Visia camera system and skin hydration via Corneometer were also assessed. Participants also completed a questionnaire about overall product performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The dermatologist noted reduced (<i>p</i> &lt; 0.001) redness, swelling, dryness, roughness, and itchiness, with improved (<i>p</i> &lt; 0.001) hydration, softness, and flexibility after 7 and 14 days. Participants reported less (<i>p</i> &lt; 0.05) dryness, redness, and discomfort, with 97% rating the cream's soothing effect as moderate to strong. The cream also increased (<i>p</i> &lt; 0.0001) skin hydration by 14%, measured by Corneometer 30 min postapplication. No worsening of symptoms or adverse effects was reported. All participants found the cream pleasant, with most intending to purchase and continue use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results indicate that Sterimar soothing nose cream is effective in nourishing, soothing, protecting, and moisturizing the nasolabial zone, and is well tolerated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lip Sonoanatomy and Relevance to Aesthetic Filler Injections: A Pictorial Review","authors":"Wei-Ting Wu,&nbsp;Ke-Vin Chang,&nbsp;Ondřej Naňka,&nbsp;Hsiang-Chi Chang,&nbsp;Vincenzo Ricci,&nbsp;Kamal Mezian,&nbsp;Levent Özçakar","doi":"10.1111/jocd.70164","DOIUrl":"https://doi.org/10.1111/jocd.70164","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lips are central to facial aesthetics, influencing overall balance and harmony. Ultrasound has become a key tool for assessing lip musculature and neurovascular structures, particularly in aesthetic filler injections. By enhancing precision and safety, ultrasound is valuable in procedures addressing age-related lip changes, yet standardized scanning protocols remain underexplored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This review examined lip anatomy, summarized ultrasound applications in aesthetic procedures, introduced a structured scanning protocol, and highlighted its role in guiding filler injections.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search of PubMed, Scopus, Embase, and Web of Science was conducted up to August 1, 2024, using keywords related to ultrasound and lip anatomy. Studies involving human subjects or cadavers using ultrasound for lip assessment and injection guidance were included, whereas nonhuman studies, alternative imaging methods, and research unrelated to the lip region were excluded. Six studies met the criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ultrasound improves precision in lip injections by identifying key structures, including the superior and inferior labial arteries and the orbicularis oris muscle, reducing vascular risks. A structured scanning approach enhances procedural safety and efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ultrasound is a valuable tool in aesthetic lip procedures, improving accuracy and minimizing complications. Further research is needed to refine protocols and establish ultrasound as a standard practice in lip augmentation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy and Safety of Cryolipolysis in Reducing Local Adipose Tissue in Women—A Randomized Pilot Study","authors":"Wioleta Faruga-Lewicka,&nbsp;Wiktoria Staśkiewicz-Bartecka,&nbsp;Marek Kardas","doi":"10.1111/jocd.70149","DOIUrl":"https://doi.org/10.1111/jocd.70149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cryolipolysis was developed in 2007 as a method of reducing excessive adipose tissue using low temperatures. During the procedure, lipid crystallization occurs at temperatures much higher than the freezing point of water in the tissues. This is followed by the recruitment of macrophages, the number of which peaks at 4 weeks and disappears at about 3 months after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The study involved 15 women who were divided into a control group and a study group. All subjects completed the QEB questionnaire, had body circumference measurements taken, and had a body composition analysis performed before the start of therapy and 1 month after the end of therapy. The study group underwent three cryolipolysis treatments to the abdominal area, with a treatment duration of 45 min and a temperature of −8°C. Approval from the bioethics committee was obtained prior to the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing the results of the control group and the study group after 3 months of the study, differences in mean values of body fat, abdominal circumference, and BMI values are evident, while statistical analysis showed a significant difference in changes in BMI values (<i>p</i> &lt; 0.05), while changes in body fat were on the borderline of statistical significance (<i>p</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study confirms that cryolipolysis is a safe method of reducing locally accumulated fat, especially in the abdominal area in women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Port Wine Birthmark With Nude Tattoo Using Multiple Laser Modalities","authors":"Vincent Pecora,&nbsp;Emily Murphy,&nbsp;Pooja Sodha","doi":"10.1111/jocd.70178","DOIUrl":"https://doi.org/10.1111/jocd.70178","url":null,"abstract":"&lt;p&gt;Port wine birthmarks (PWB) are congenital capillary malformations that frequently occur on the face and neck [&lt;span&gt;1, 2&lt;/span&gt;]. Activating mutations in GNAQ and PI3K, along with other predisposing mutations in PWB, lead to dysregulated MAPK and PI3K signaling, triggering vascular ectasia and dilation [&lt;span&gt;2&lt;/span&gt;]. PWB are initially flat red macules or patches, but they progressively darken, undergo soft tissue hypertrophy, and develop vascular nodules into late childhood and adulthood [&lt;span&gt;2&lt;/span&gt;]. PWB are important to recognize given their cosmetic impact, especially on the face, and possible associations with genetic syndromes, like Sturge–Weber. First-line treatments of PWB include the pulsed dye laser (PDL), which targets and destroys hemoglobin, causing necrosis of vessel walls [&lt;span&gt;2, 3&lt;/span&gt;]. One alternative treatment is medical tattooing to alter the skin color and camouflage the PWB [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;However, the use of pulsed dye laser therapy to treat cutaneous pathologies with tattoo overlays has remained controversial. High energy, short-pulsed dye lasers have specifically been found to increase the risk of irreversibly darkening cosmetic medical tattoos, leading to gray-black hyperpigmentation [&lt;span&gt;4&lt;/span&gt;]. In order to prevent adverse cosmetic outcomes in patients with pre-existing tattoos, recent therapies have utilized multimodal pulsed-dye laser therapy to selectively target dilated blood vessels and reduce diffuse erythema without destroying surrounding tissue [&lt;span&gt;5&lt;/span&gt;]. To date, there are no studies utilizing more than two simultaneous forms of multimodal laser therapy in the treatment of PWB. Here, we present a patient with a nude tattoo over a facial PWB that was successfully treated with multiple treatments of multimodal long-pulsed 755 nm Alexandrite, 595 nm pulsed dye laser, and 10 600 nm fractional carbon dioxide (CO&lt;sub&gt;2&lt;/sub&gt;) laser therapy on the same day. These results demonstrate that the presence of medical tattoos should not deter physicians from utilizing multimodal laser therapy to treat PWB.&lt;/p&gt;&lt;p&gt;A 64-year-old female presented with a facial PWB on the left temple, cheek, nose, and cutaneous upper lip. Six rounds of multimodal laser therapy were utilized, consisting of long-pulsed 755 nm Alexandrite (Lutronic Clarity) (Table 1) and long-pulsed 595 nm (Candela Vbeam) PDL (Table 2) with the addition of a 10 600 nm fractional CO&lt;sub&gt;2&lt;/sub&gt; laser (Candela Co2RE or DEKA DOT) laser three times (lasers were applied in this order). The treatments took place over 22 months.&lt;/p&gt;&lt;p&gt;During the third, fifth, and sixth treatment sessions, a 10 600 nm fractional CO&lt;sub&gt;2&lt;/sub&gt; laser was applied to the entire lesion in addition to the 755 nm Alexandrite and 595 nm PDL. The endpoint for the Alexandrite laser, which was applied to the purple hypertrophic tissue only, was a slow faint bluish darkening of the PWB, and the endpoint for the pulsed dye laser, applied to the entire lesion, was sustai","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Body Dysmorphic Disorder: A Systematic Review and Meta-Analysis","authors":"Angel Pérez-Buenfil,,&nbsp;Alejandra Morales-Sánchez","doi":"10.1111/jocd.70121","DOIUrl":"https://doi.org/10.1111/jocd.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Body dysmorphic disorder (BDD) is characterized by a preoccupation with ≥ 1 perceived defects in physical appearance, which leads to social anxiety and avoidance. This excessive focus on appearance is linked to dissatisfaction with physical features, disappointment with cosmetic treatments, or frustration from not meeting perceived beauty standards.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to determine the prevalence of BDD in dermatology, psychiatric, plastic surgery, general population, and world regions, as well as the prevalence of BDD using different diagnostic tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The authors conducted a systematic review of the literature in Medline via PubMed, Embase, and Latin American databases using MeSH terms “body dysmorphic disorder” and “prevalence” with filters for original and cross-sectional studies. Statistical analysis was performed using RStudio, and bias assessment was made using JBI Critical appraisal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall prevalence of BDD in the general population was 17%, with higher rates in females than in males. The prevalence in plastic surgery patients was 24%. The highest prevalence of BDD was found in Latin America compared to other world regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BDD is a highly prevalent disorder, and increased awareness of the disease could improve its approach in plastic surgery and other medical fields.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}