Journal of Cosmetic Dermatology最新文献

{"title":"Nasal Reshaping Using Barbed Threads Combined With Hyaluronic Acid Filler and Botulinum Toxin A","authors":"G. Ziade,&nbsp;R. Saade,&nbsp;D. Daou,&nbsp;D. Karam,&nbsp;A. Bendito,&nbsp;M. Tsintsadze","doi":"10.1111/jocd.70047","DOIUrl":"https://doi.org/10.1111/jocd.70047","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rhinoplasty is a prominent procedure in facial aesthetics, but extended surgical downtime remains its significant limitation. Nonsurgical rhinoplasty has gained popularity as an alternative, offering significant aesthetic improvements with minimal downtime. This study evaluates the clinical efficacy and safety of three nonsurgical rhinoplasty techniques combined, including hyaluronic acid (HA) filler, botulinum toxin type A (BTX), and barbed lifting threads.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 85 patients were included into three groups: 63 subjects received HA filler and BTX injections, 9 subjects received barbed threads followed by BTX injections, and 13 received threads followed by HA filler and BTX injections. Patients assessed their satisfaction 1 month and a year posttreatment as well as adverse effects 48 h and 1 week after treatment using FACE-Q questionnaire for nose.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both 1 month and a year after treatment, the triple combination of barbed threads with HA filler and BTX demonstrated superior nose FACE-Q scores compared to the two other groups, showing highest patient satisfaction and minimal efficacy decay over time. No significant difference in FACE-Q scores was observed between the two groups receiving HA filler + BTX and barbed threads + BTX at either 1 month or a year posttreatment. Adverse effects were reported by subjects in all three groups 48 h posttreatment and completely resolved by 1 week after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combining nonsurgical rhinoplasty techniques—such as lifting threads, HA fillers, and botulinum toxin—can deliver effective aesthetic improvements with minimal downtime. Among these, the triple combination of HA filler, BTX, and lifting threads results in the highest and most sustained patient satisfaction, lasting no less than 1 year.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal Tranexamic Acid Injections: A Potential Therapy for Complex Cases of Drug-Induced Postinflammatory Hyperpigmentation","authors":"Juan He,&nbsp;Shinan Hou,&nbsp;Yi Yang","doi":"10.1111/jocd.70061","DOIUrl":"https://doi.org/10.1111/jocd.70061","url":null,"abstract":"&lt;p&gt;Generally, postinflammatory hyperpigmentation (PIH) from fixed drug eruptions (FDE) can resolve spontaneously [&lt;span&gt;1&lt;/span&gt;]. However, various underlying factors may impede this process. Here, we present a complex patient with severe perioral hyperpigmentation due to FDE, who showed marked improvement after six sessions of intradermal tranexamic acid (TXA) injections.&lt;/p&gt;&lt;p&gt;A 50-year-old female patient presented with a 1-year persistent hyperpigmentation on her lips and perioral area after repeatedly taking Ibuprofen to manage fever during the COVID-19 pandemic. The pigmentation worsened with continued use of the medication (Figure 1A). Despite discontinuing ibuprofen and using topical hydroquinone and tretinoin for over 6 months, her hyperpigmentation became even more severe. A diagnosis of PIH caused by FDE was made. After discussing with her, we advised strict sun protection and avoidance of physical irritation of the lips. Additionally, we introduced intradermal injections of TXA due to its anti-inflammatory and anti-melanin-producing properties. The TXA solution was prepared by diluting 0.2 mL of a 500 mg/5 mL ampoule in sterile water to a 10 mg/mL concentration, yielding a total of 2 mL. The injections were administered intradermally at a 15°–20° angle, targeting the superficial dermis and creating small semicircular wheals. During each session, 0.1 mL doses were injected 5 mm apart across 14 sites, totaling 1.4 mL per session. After six monthly TXA sessions, the patient's perioral hyperpigmentation showed significant improvement (Figure 1B).&lt;/p&gt;&lt;p&gt;The type IV hypersensitivity reaction caused by FDE leads to damage to keratinocytes and melanocytes. Following drug withdrawal, dermal macrophages then phagocytize extravasated melanin, causing persistent PIH [&lt;span&gt;1&lt;/span&gt;]. Basically, PIH from FDE is self-limiting [&lt;span&gt;1&lt;/span&gt;]. However, in this case, the patient's hyperpigmentation not only failed to resolve but also worsened progressively after treatment. Hence, we considered there were additional factors that contributed to her atypical progression. First, her lesion is located on the lip, an area exposed to UV radiation and friction from eating. Second, she was in her perimenopausal period, also with skin type IV—a combination of skin type and fluctuating hormones that likely exacerbated her hyperpigmentation. Third, we can find that she also had melasma (Figure 1A), indicating a preexisting pigment metabolism abnormality. Collectively, factors such as UV exposure, mechanical friction, skin type, hormonal changes, and pigment metabolism issues likely intensified the pigmentation [&lt;span&gt;2&lt;/span&gt;]. Therefore, for this patient, discontinuing the offending drug alone was insufficient; effective anti-inflammatory and antipigment treatments were necessary to counteract these ongoing factors contributing to persistent hyperpigmentation.&lt;/p&gt;&lt;p&gt;Topical treatments, such as retinoids, hydroxy acids, and broad-spectrum photoprotection, are th","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models in Cosmetic Dermatology","authors":"Marina Landau,&nbsp;George Kroumpouzos,&nbsp;Mohamad Goldust","doi":"10.1111/jocd.70044","DOIUrl":"https://doi.org/10.1111/jocd.70044","url":null,"abstract":"&lt;p&gt;Artificial intelligence (AI), particularly large language models (LLMs) like ChatGPT and Gemini, is expanding healthcare, specifically in the field of cosmetic dermatology. These advanced AI systems are designed to process and generate human-like text by analyzing vast amounts of data. Through natural language processing (NLP), LLMs offer innovative solutions that improve patient care, facilitate clinical workflows, and accelerate research efforts. However, while these models hold significant potential, it is crucial to address their limitations, as well as the ethical considerations and regulatory challenges associated with their use, to ensure responsible implementation [&lt;span&gt;1, 2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;At their core, LLMs are sophisticated computer programs capable of understanding and generating human-like text. Imagine conversing with a knowledgeable assistant who can quickly summarize medical research, suggest treatment options, or answer complex questions. LLMs achieve this by learning patterns from extensive datasets, including books, articles, and scientific journals. With this training, they can synthesize information and provide coherent responses to user inquiries [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;LLMs are expanding several aspects of cosmetic dermatology. One key application lies in patient education. By simplifying complex medical terminology, LLMs make cosmetic procedures, such as dermal fillers, neurotoxins, and laser therapies, more accessible to patients. This improved communication enables patients to make informed decisions about their care. Additionally, these tools have the potential to bridge knowledge gaps in underserved communities, although challenges like limited digital proficiency and internet access still persist.&lt;/p&gt;&lt;p&gt;Another critical application is personalized treatment planning. LLMs can analyze patient histories, procedural risks, and desired outcomes to provide evidence-based recommendations. For instance, they may suggest combining microneedling with platelet-rich plasma therapy to achieve optimal skin rejuvenation. While this personalization can enhance treatment outcomes, it requires clinician oversight to ensure that recommendations match individual patient needs and are free from bias.&lt;/p&gt;&lt;p&gt;LLMs also contribute to administrative efficiency in dermatology practices. Integrating these tools into electronic medical record (EMR) systems can automate tasks such as clinical note-taking, scheduling, and insurance coding. This automation reduces administrative burdens, allowing clinicians to devote more time to direct patient care [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Follow-up care and monitoring are additional areas where LLMs show efficiency. These models can interact with patients' postprocedure, ensuring adherence to recovery protocols, identifying potential complications, and assessing satisfaction levels. These capabilities enhance continuity of care and provide valuable feedback for clinicians to improve their services.&lt;/p&gt;&lt;p&gt;In tr","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Topical Formulation Containing Trihydroxybenzoic Acid Glucoside and α-Arbutin, Applied Along With a Sunscreen: A Noncomparative, Prospective, Interventional Study in Indian Females With Facial Melasma or Dark Spots","authors":"Mukesh Gabhane,&nbsp;Raji Patil,&nbsp;Shruti Dharmadhikari,&nbsp;Priyank Shah,&nbsp;Chintan Khandhedia,&nbsp;Suyog Mehta","doi":"10.1111/jocd.70017","DOIUrl":"https://doi.org/10.1111/jocd.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin hyperpigmentation is a dermatological concern for pigmented skin phototypes. Despite availability of multiple treatment options, hyperpigmentation management continues to be a challenge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Efficacy and safety assessment of the skincare regimen [topical formulation of trihydroxybenzoic acid glucoside 10% (THBG) and α-arbutin 2% (twice-daily) + sunscreen (once daily)] in Indian females with pigmentary spots (facial dark spots or melasma).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, open-label, single-arm, interventional study was conducted in Indian females (<i>n</i> = 124), aged 18–45 years, having FitzPatrick skin type III–IV, dull skin, and facial dark spots or melasma. Efficacy of 90-day skincare regimen was evaluated using mexameter, modified melasma area and severity index (mMASI) score, cross-polarized light photography, chromameter, and color–luminosity–brightness–transparency (CLBT) technique. Student's <i>t</i>-test (paired data) was used for statistical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In efficacy analysis [modified intention-to-treat (mITT) population], 120 subjects were included. Melanin content of pigmentary spots (on mexametry) significantly reduced (−16.3%, <i>p</i> &lt; 0.001) at Day 90 versus baseline. Significant reduction in severity of melasma was observed (−18.4% in mMASI score) at Day 90. Significant improvement in ΔEab (−8.7%) (change in color difference between pigmentary spot and normal skin) on cross-polarized photographs, in skin-brightening parameters <i>L</i>* (relative brightness/lightness) (−2.7%), ITA° (individual typology angle) (−37.7%), and Δ<i>E</i>* (skin-tone evenness) (−19.0%) using chromameter. Significant improvement in skin radiance was observed in CLBT parameters, color (pink: 32.8%, yellow: –5.5%, and olive: −7.8%), luminosity (6.0%), brightness (4.6%), and transparency (0.2%). Regimen did not cause itching, burning, or irritation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Skincare regime of 10% THBG and 2% α-arbutin along with sunscreen was effective in reducing pigmentary spots (dark spots and melasma) and was well tolerated in Indian women.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Clinical Trial Registry of India (CTRI Reg. No. CTRI/2021/11/038345; date: 30/11/2021)</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parotitis Induced by Botulinum-Toxin Injections to the Masseter Muscle","authors":"Nadav Grinberg,&nbsp;Oren Peleg","doi":"10.1111/jocd.70052","DOIUrl":"https://doi.org/10.1111/jocd.70052","url":null,"abstract":"&lt;p&gt;We would like to thank Nishikawa et al. for their comprehensive review of adverse events following botulinum toxin (BTX) injections for treating masseter muscle hypertrophy [&lt;span&gt;1&lt;/span&gt;]. While Nishikawa et al. [&lt;span&gt;2&lt;/span&gt;] focused on adverse events such as paradoxical bulging, sunken cheeks, and facial asymmetry, we would like to propose parotitis as an additional adverse effect based on recent literature.&lt;/p&gt;&lt;p&gt;Research on the impact of BTX injections into masticatory muscles in the parotid gland is limited. While some reports observed no severe adverse effects or mild xerostomia accompanied by normal salivary flow rates [&lt;span&gt;3&lt;/span&gt;], other studies report patients having reduced salivary volume and thicker saliva [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;The proximity of the masseter muscle to the parotid gland suggests that any neuromodulator injection to this area could inadvertently affect the parotid gland. Several mechanisms have been proposed for this effect. Anatomically, the proximity of the injection site to critical structures could lead to inadvertent influence on salivary output [&lt;span&gt;4&lt;/span&gt;]. Additionally, the complex and variable branching of the facial nerve, including the potential secretomotor branch, could be affected and thereby altering salvation [&lt;span&gt;5&lt;/span&gt;]. Physical factors such as gravitational flow, injection pressure, or diffusion of the neuromodulator across fascial planes could further promote unintended BTX spread [&lt;span&gt;5-7&lt;/span&gt;]. Reduced muscular support around the gland may also alter intraglandular pressure and decrease salivary flow [&lt;span&gt;7&lt;/span&gt;]. Physiological factors, for instance, efficient local uptake or systemic neurotoxin spread may impair salivary production as well [&lt;span&gt;8&lt;/span&gt;]. All of which may lead to hyposalivation, causing stasis in the gland and potential retrograde infection [&lt;span&gt;9&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Parotitis induced by BTX injection, although rare, should be carefully considered by clinicians performing these procedures. Given the increasing use of BTX in both therapeutic and aesthetic practices, even rare complications may occur. When administering BTX, it is vital to pay attention to the accuracy of the injection site. Palpation should be used to delineate the bulk of the masseter muscle, targeting its hypertrophic region while avoiding the posterior border of the muscle [&lt;span&gt;4&lt;/span&gt;]. The needle should be inserted perpendicularly. The appropriate injection depth has a crucial role as well. The needle should be inserted deep and encounter the ramus, minimizing the risk of invading the parotid gland [&lt;span&gt;10&lt;/span&gt;]. In order to avoid unwanted results, two fundamental pillars need to be preserved. First, proper case selection is mandatory. Thorough anamnesis and medical history should be taken before considering any treatment plan. Second, adequate and continuous clinical training will improve the clinician's ability to perform the procedure. Additionally, when addressing highly ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumcision-Associated Penile Papules: A Novel Complication With Unclear Etiology","authors":"Mingshuang Zhang,&nbsp;Rongqing Yang,&nbsp;Jie Huang","doi":"10.1111/jocd.70034","DOIUrl":"https://doi.org/10.1111/jocd.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To report six patients with penile papules after circumcision to attract the attention of clinicians and patients to the complication associated with circumcision.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reported several clinical cases presenting with these papules following circumcision. Cases were reassessed for clinical characteristics, histopathological features, and potential risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A series of six adult male cases were identified, with papules appearing asymptomatically months to years after circumcision. The papules were larger, exhibited uneven distribution, and lacked the typical arrangement of pearly penile papules, posing a cosmetic concern and a risk of misdiagnosis as genital warts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study presents a previously unreported complication of circumcision with significant implications for patient care. Further investigation is warranted to understand the etiology and develop strategies for prevention and management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and Living Environment as Novel Etiological Factors for Melasma: The Results Form a Retrospective Case–Control Study of 150 Chinese Patients","authors":"Yue Shi,&nbsp;Shun Guo,&nbsp;Cheng Tan","doi":"10.1111/jocd.70038","DOIUrl":"https://doi.org/10.1111/jocd.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma, a condition with complex and multifactorial pathogenesis, has traditionally been linked to factors such as ultraviolet (UV) exposure, hormonal changes, and genetic predisposition. Despite societal advances and shifts in lifestyle, updates on causal factors remain limited. Our study aims to address this gap by investigating emerging pathogenic factors that differ from those conventionally reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We conducted a case–control study to explore novel etiological factors contributing to the onset of melasma in Chinese patients, with an emphasis on how these differ from previously established causes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 150 patients (144 women and 6 men) diagnosed with melasma at Jiangsu Province Hospital of Chinese Medicine from April to October 2023. A control cohort of individuals without melasma was enrolled from the community. Demographic and clinical characteristics were collected, along with exogenous factors and histories of related dermatoses and non-dermatoses, through a questionnaire administered with the guidance of a dermatologist. Etiological factors were assessed using univariate analysis followed by multivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, our results were consistent with previous studies. In addition, alcohol intake (OR: 20.05, 95% CI: 1.17–343.17) and breast cystic hyperplasia (OR: 15.98, 95% CI: 4.28–59.72) were found to be novel triggering factors of melasma, whereas change of residence (OR: 0.03, 95% CI: 0.00–0.30), house renovation (OR: 0.13, 95% CI: 0.03–0.58) and soft drink intake (OR: 0.04, 95% CI: 0.00–0.83) were protective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that diet and the living environment are novel etiological factors for melasma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Skin Lesions Determine the Therapeutic Response of Facial Café Au Lait Macules Laser Therapy","authors":"Yuanzhi Liu,&nbsp;Wanshan Yang,&nbsp;Yuan Ding,&nbsp;Bin Yang,&nbsp;Zhenfeng Liu","doi":"10.1111/jocd.70062","DOIUrl":"https://doi.org/10.1111/jocd.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The efficacy of laser treatment for facial café au lait macules (CALMs) is random.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the response of different characteristics of CALMs skin lesions to laser treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>In this single-center retrospective case series, patients with café au lait macules who received laser treatment between 2015 and 2022 at our clinic were reviewed. A total of 319 consecutive patients were eligible and were treated with either a 755-nm-alexandrite picosecond laser or a quality-switched 755-nm-alexandrite laser. Observers were blinded to the final patient groups. Efficacy was graded according to four levels of treatment response: poor (Grade 1, 0%–25% improvement), fair (Grade 2, 26%–50% improvement), good (Grade 3, 51%–75% improvement), and excellent (Grade 4, 76%–100% improvement). Treatment effects evaluated as Grades 2–4 were considered effective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 319 patients, excellent and good responses were observed in 80 (25.08%) and 66 (20.69%) cases, respectively. Fifty-two patients (16.30%) displayed an outcome of Grade 2 (26%–50% improvement), whereas 121 (37.93%) cases showed an outcome of Grade 1 (0%–25% improvement). The overall treatment effective rate (Grades 2–4) was 62.07%. Binary logistic regression analysis showed a significant association of therapeutic efficacy with lesion distribution (segmental vs. non-segmental CALMs) and lesion border (irregular vs. regular) (<i>p</i> &lt; 0.05 for both).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Segmental and irregular border CALMs tended to respond well to laser therapy. Clinicians can leverage these characteristics to predict efficacy and manage patient expectations more effectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Plant Concentrated Powder Improved Skin Whitening: A Double-Blinded, Randomized, and Placebo-Controlled Clinical Study","authors":"Yuxiang He,&nbsp;Yongshi Bu,&nbsp;Chi-Fu Chiang,&nbsp;Yung-Hsiang Lin,&nbsp;Chia-Hua Liang,&nbsp;Leong-Perng Chan,&nbsp;Jiawen Sun","doi":"10.1111/jocd.70011","DOIUrl":"https://doi.org/10.1111/jocd.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>With the growing demand for skin-enhancing products in the market, research into edible plants has expanded significantly. Numerous studies have shown that plant extracts rich in phytochemicals can effectively improve skin issues such as wrinkles, pigmentation, and dullness. However, clinical studies focusing on the effects of combined ingredients are still limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study combined three plant ingredients known for their skin-beautifying effects and clinically tested their functional properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty healthy subjects were screened and randomly divided into two groups: a test group (TG) and a placebo group (PG). TG took two tablets of multi-plant concentrated powder daily, while PG took placebo tablets without active ingredients. The study lasted 12 weeks. Plasma Trolox equivalent antioxidant capacity (TEAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were measured at week 0 (W0), week 8 (W8), and week 12 (W12). Skin brightness (<i>L</i>* value), skin tone (Individual Typological Angle (ITA°)), erythema (<i>a</i>* value), skin spots, and wrinkles were assessed at week 0 (W0), week 4 (W4), week 8 (W8), and week 12 (W12).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study showed significant improvements in all three antioxidant markers in the blood after consuming the compound ingredient tablets compared to the PG (<i>p</i> &lt; 0.01). <i>L</i>* value and ITA° significantly increased from 8 weeks (<i>p</i> &lt; 0.1). Skin spots significantly decreased at W8 and W12 (<i>p</i> &lt; 0.1). While <i>a</i>* value and skin wrinkles showed noticeable reductions within the group in week 12 (<i>p</i> &lt; 0.1), there were no significant differences compared to the PG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Consumption of multi-plant concentrated powder improved skin whitening, brightened skin tone, reduced skin spots, and showed some improvement in wrinkles and erythema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT05988567</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Fluence Q-Switch 1064 Nm Laser Combined With Oral Tranexamic Acid: A Quicker Treatment for Laser-Induced Postinflammatory Hyperpigmentation","authors":"Wei Feng,&nbsp;Lichang Yang","doi":"10.1111/jocd.70018","DOIUrl":"https://doi.org/10.1111/jocd.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Laser-induced post-inflammatory hyperpigmentation (PIH)is a common adverse reaction in Asian individuals. Dark skin and incorrect laser parameters are common causes, but PIH is often unexpected for patients. Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser-induced PIH is necessary. In this article, we attempted to demonstrate that a low-fluence Q-switch (QS) 1064 nm laser combined with oral tranexamic acid (TXA) is a quick and safe method for the clearance of laser-induced PIH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective cohort study, adhering to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines, spanning 2 years (2021–2023) was conducted on 23 patients aged between 29 and 58 years. These patients were diagnosed with laser-induced PIH for &lt; 3 months. The treatment regimen was a low-fluence QS1064 nm laser combined with oral TXA, oral TXA was first taken, and a low-fluence QS1064 nm laser was used for at least 1 month after the last laser was applied. Three to six laser treatments were subsequently applied. After treatment, the pigment color and patient satisfaction were assessed to evaluate the effectiveness of the treatment options.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty patients were enrolled in the study, the average laser treatments were 4.3 ± 0.865 times. The Melasma Area and Severity Index (MASI) score decreased from 9.325 ± 3.38 before treatment to 5.97 ± 2.37. After the first treatment, the MASI score decreased by approximately 40%. Two months after the last treatment, the MASI score decreased to 0.93 ± 1.06, and there was a statistically significant difference in the MASI score before and after treatment (<i>p</i> &lt; 0.05). Patient satisfaction scores revealed that 95% of patients were highly or strongly satisfied with the decrease in the intensity of the PIH color, with a moderate response rate of 1 (5%). The patients thought that the pigment removal speed was 75% (15) very fast or fast, 20% (4) moderate, and 5% (1) slow.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of this study demonstrated the quick and safe removal of laser-induced PIH following treatment with low-fluence QS1064 nm laser combined with oral TXA. Providing such a protocol is indeed one of the primary objectives of this article.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}