A Comparative Study on the Sensitivity of Establishing Melasma-Like Models in Different Strains of Mice

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-03-31 DOI:10.1111/jocd.70155

Xiaojie Sun, Wenzhu Wang, Hedan Yang, Yunyao Liu, Hui Ding, Xiaoli Zhang, Xiuzhen Li, Siqi Tan, Xing Liu, Yin Yang, Xu Chen, Tong Lin

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Abstract

Background

Melasma is a common disease that is difficult to treat, with no recognized animal model for mechanism research or drug screening.

Objectives

To develop a novel, standardized mouse model of melasma.

Materials and Methods

Three different strains of mice (C57BL/6J, BALB/c, and KM) were used to create a melasma-like model across various body regions. The skin of the mice was removed on Day 28 and subjected to staining to examine histopathological changes. Data were analyzed using SPSS19.0 software.

Results

Compared with KM and BALB/c mice, C57BL/6J mice were identified as the ideal strain for demonstrating hyperpigmentation more sensitively. The head and ear were identified as more appropriate irradiation sites. Furthermore, a lower irradiation dose was determined to be appropriate for modeling.

Conclusion

The C57BL/6J mouse model more accurately simulates the clinical phenotype of melasma.

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.