Journal of Cosmetic Dermatology最新文献

{"title":"An Automatic AI-Based Algorithm That Grades the Scalp Surface Exfoliating Process From Video Imaging. Application to Dandruff Severity and Its Validation on Subjects of Different Ages and Ethnicities","authors":"Frederic Flament,&nbsp;Ava Mondji,&nbsp;Chengda Ye,&nbsp;Zeneng Sun,&nbsp;Panagiotis-Alexandros Bokaris,&nbsp;Benjamin Askenazi,&nbsp;Emmanuel Malherbe,&nbsp;Romain Roncin,&nbsp;Aldina Suwanto,&nbsp;Adrien Chretien,&nbsp;Maxime De Boni,&nbsp;Angeline Young,&nbsp;Bianca Maria Piraccini,&nbsp;Victoria Barbosa,&nbsp;Guive Balooch","doi":"10.1111/jocd.70013","DOIUrl":"https://doi.org/10.1111/jocd.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the technical assets of a new imaging device that, wifi linked to a AI based algorithm, automatically grades in vivo the exfoliating process of the skin, taking dandruff as model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>The hand portable device comprises a camera that possibly uses three illuminating conditions (white LED diffused lamp, cross-polarized white light and UVA rays). The learning phase of the algorithm was built on 3600 images of the vertex area of 234 subjects of different ages and three ethnicities with and without dandruff. This learning phase allowed 15 experts and dermatologists to score regarding a 6-point atlas of dandruff severities, taken as reference. In a second validation phase, 460 images from 192 subjects of different ages and ethnic background/phototypes, were automatically analyzed by the AI based device, allowing to calculate the correlation between expert's assessments and the gradings provided by the device, and, as second indicator, to compute the Mean Average Error (MAE) between both variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The values were found significantly correlated (<i>r</i>² = 0.952; <i>p</i> &lt; 0.001) with an overall MAE of 0.16 grading units, although presenting some differences according to ethnic background and phototypes (0.12–0.24).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This new imaging device coupled with AI-based analysis allows a valid, rapid, and easy determination of the scalp exfoliating process and may represent a complementary help in the diagnosis of dermatologists in some other scalp disorders. Its versatility, easy handling, and immediate AI-based analysis suggest that it may be applied to other cosmetic areas (skincare, makeup, haircare, etc.).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OS-01 Peptide Topical Formulation Improves Skin Barrier Function and Reduces Systemic Inflammation Markers: A Pilot 12-Week Clinical Trial","authors":"Alessandra Zonari,&nbsp;Lear E. Brace,&nbsp;Luiza Brunelli Buhrer,&nbsp;Nathaniel H. O. Harder,&nbsp;Claire Harker,&nbsp;Adam B. Aronson,&nbsp;Caitlyn N. Tse,&nbsp;Carolina R. Oliveira,&nbsp;Mariana Boroni,&nbsp;Juliana L. Carvalho","doi":"10.1111/jocd.70169","DOIUrl":"https://doi.org/10.1111/jocd.70169","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>As the body's largest organ, the skin plays a crucial role in defending against external stressors. Skin characteristics change with age, decreasing skin barrier integrity and compromising skin and body health. This study aimed to investigate the potential of a topical formulation containing OS-01 (a.k.a. Peptide 14), a senotherapeutic peptide, to counteract age-related skin changes and their systemic consequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomized, double-blinded clinical trial involving 60 female volunteers aged 60–90 was conducted over 12 weeks. Participants received either an OS-01 topical formulation or a commercially available moisturizer control formulation. Skin parameters, subjective perceptions, and circulating cytokine levels were assessed. Skin instrumental analysis included transepidermal water loss (TEWL), skin hydration, and pH measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants treated with the OS-01 topical formulation displayed significantly improved skin barrier function and hydration compared to the control group. Participant perceptions aligned with objective findings: after 12 weeks, 70% of participants in the OS-01 group noticed an improvement in general skin appearance versus 42% for the control group. The systemic levels of proinflammatory cytokines tended to normalize, with a significant decrease in IL-8 in the blood analysis of participants from the OS-01 group. On the other hand, the control group demonstrated an increase in a few circulating cytokines, particularly TNF-ɑ and IFN-γ. Moreover, GlycanAge analysis measuring participants' biological age suggested the slowing of systemic aging in the group treated with the OS-01 topical formulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study suggests that the OS-01 formulation can impact skin health by improving the skin barrier function, potentially influencing systemic inflammation and biological age. In conclusion, the study supports that targeting skin health may contribute to better longevity outcomes, underscoring the skin's pivotal role in systemic aging and supporting an integrated approach to health management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro and In Vivo Evaluation of an Emollient-Rich Moisturizer Developed to Address Three Critical Elements of Natural Moisturization","authors":"Zoe D. Draelos,&nbsp;Diane B. Nelson","doi":"10.1111/jocd.70085","DOIUrl":"https://doi.org/10.1111/jocd.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A new, emollient-rich moisturizing cream has been developed to support three critical elements of natural skin moisturization—hyaluronic acid, natural moisturizing factors, and lipids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of this study was to evaluate in vitro biomarkers associated with skin hydration and barrier support, followed by in vivo clinical hydration assessment and tolerability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using an in vitro epidermal skin model, tissues were treated with the study moisturizer or control (saline) for 24 h. Genes associated with hydration and barrier support were analyzed: claudin 4 (CLD4), aquaporin 3 (AQP3), hyaluronic acid synthase 2 (HAS2), and hyaluronidase 1 (HYAL1). The clinical study evaluated twice-daily use of the study moisturizer in subjects with moderate-to-severe dry skin. Subject satisfaction and skin hydration measurements were captured at baseline, 2, 4, and 8 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Increased expression of CLD4, AQP3, and HAS2 and reduced activity of HYAL1 were demonstrated after 24 h. In subjects applying the study moisturizer, significant mean percent improvements from baseline in skin hydration occurred at Weeks 2 (41%; <i>p</i> &lt; 0.0001), 4 (38%; <i>p</i> &lt; 0.0001), and 8 (116%; <i>p</i> &lt; 0.0001). Ninety-six percent of subjects reported their skin felt hydrated after 8 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An emollient-rich moisturizing cream developed to support three critical elements of natural skin moisturization increased the expression of biomarkers associated with skin barrier support and hydration, and reduced the expression of HA-degrading enzymes. Early, significant increases in skin hydration were observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro, Ex Vivo, Instrumental, and Clinical Assessment of a Novel Anti-aging Serum Targeting Oxidative Stress","authors":"Sayantani Goswami,&nbsp;Jin Namkoong,&nbsp;Marwa El Hajoui,&nbsp;Ewelina Lesniak,&nbsp;Joanna Wu","doi":"10.1111/jocd.16664","DOIUrl":"https://doi.org/10.1111/jocd.16664","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primarily driven by oxidative stress, aging results from the attrition of cells, aggravated by environmental stressors. Therefore, protection from oxidative stress is the main target of antiaging cosmetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the efficacy of a unique cosmetic serum combining five antioxidants and hyaluronic acid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The inactivation of reactive oxygen species by the serum was evaluated <i>in-tubo</i>. IL-1α release was evaluated using EpiDerm^TM skin models, while gene expression analysis and elastin fiber length were evaluated on human skin explants. Finally, the effect of twice daily serum application for 28 days was compared to those induced by a control serum, focusing on instrumental and assessor evaluations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>In-tubo</i>, the serum reduces reactive oxygen species by 45.2%. A single topical application on EpiDerm^TM skin models limits UV-induced ROS-mediated IL-1α release. Compared to untreated explants, HB-EGF (heparin-binding epidermal growth factor) skin homeostasis marker expression increases by 22-fold with treatment. Additionally, the serum increases elastin fiber length by 40.2%. Clinically, twice daily application of the serum over a period of 7 days revealed significant improvements in clinical scoring of skin's wrinkle (−12.8%), smoothness (+12.5%), and radiance (+22.2%). The serum also leads to a rapid and long-lasting increase in skin hydration (30 min: +50.5%, 28 days: +19.9%) and reduced transepidermal water loss (30 min: −7.7%, 28 days: −8.7%). The serum is highly efficacious and well tolerated by the subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The serum has antioxidant, soothing, photoprotective, and moisturizing properties that can be explained by the individual properties of its unique blend of actives.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.16664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Topical Compound Heparin Sodium Allantoin Gel (Main Components: Onion Extract Quercetin) for the Treatment of Rosacea","authors":"Zining Xu,&nbsp;Biao Yu,&nbsp;Yuxin Qing,&nbsp;Shuhong Ye,&nbsp;Bingyang Xu,&nbsp;Yuanqin Wang,&nbsp;Bin Zhao,&nbsp;Hong Sun,&nbsp;Na Wu,&nbsp;Jiawen Wu","doi":"10.1111/jocd.70129","DOIUrl":"https://doi.org/10.1111/jocd.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The management of papulopustular rosacea presents a significant clinical challenge. Anti-inflammatory and vasoconstrictive treatments are ineffective in the rapid amelioration of the dryness, burning, and itching caused by skin barrier damage in patients with papulopustular rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To assess the efficacy and safety of the topical application of compound heparin sodium allantoin gel to treat rosacea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-two patients participated in this randomized, prospective, single-center, and controlled trial. The Clinician Erythema Assessment score, Investigator Global Assessment score, transepidermal water loss, and skin hydration were evaluated at 0, 2, 4, 8, and 12 weeks. Rosacea-specific quality of life score, itching, dryness, burning, Global Aesthetic Improvement Scale, and Patient Self-Assessment grades were also assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the traditional therapy group, the 8-week and 12-week topical application of compound heparin sodium allantoin gel to treat rosacea significantly decreased Clinician Erythema Assessment/Investigator Global Assessment grades, burning and itching grades, and rosacea-specific quality of life scores. Compound heparin sodium allantoin gel significantly improved the skin barrier with hydration and significantly decreased trans-epidermal water loss. For patients with Demodex infestation, externally applied compound heparin sodium allantoin gel was associated with better rosacea treatment outcomes and improved skin barrier function than externally applied hyaluronic acid. This may be attributable to the inhibition of abnormal demodex, improved skin barrier, and repair of minor skin wounds.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compound heparin sodium allantoin gel effectively improved facial erythema, alleviated ithching and burning sensations, and improved patients' quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trail Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: ChiCTR2400087948</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Delayed-Onset Hypersensitivity Reaction and Complete Secondary Treatment Failure Following Repeated Cosmetic Botulinum Toxin Type A Injections","authors":"Yan Bian,&nbsp;Chi Zhang,&nbsp;Shaohua Wang,&nbsp;Lili Zhang,&nbsp;Hong Cai","doi":"10.1111/jocd.70145","DOIUrl":"https://doi.org/10.1111/jocd.70145","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cosmetic botulinum toxin type A (BTX-A) injections have been widely used for improving facial aesthetics. Although the procedure is generally safe, immune-mediated adverse events, such as hypersensitivity reactions and secondary treatment failures, may rarely occur. We report the first case in which repeated BTX-A injections resulted in both a delayed-onset cutaneous hypersensitivity reaction and complete secondary treatment failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report/Methods</h3>\u0000 \u0000 <p>A 42-year-old female, with a history of successful BTX-A treatments for glabellar lines and masseter hypertrophy, experienced diminished efficacy following a treatment session. Ten hours after a touch-up injection, she developed facial swelling and edematous erythema localized to the injection sites. These manifestations persisted for over one month without any observable aesthetic improvement, indicating complete secondary treatment failure. The therapeutic effect was not restored even after switching to an alternative BTX-A formulation. We hypothesize that the patient's local hypersensitivity reaction represents a type III immune complex-mediated response (Arthus reaction) driven by IgG antibodies. The repeated BTX-A injections may have induced neutralizing IgG antibodies that, in concert with the cutaneous hypersensitivity reaction, contributed synergistically to both the cutaneous reaction and the complete treatment failure. The short interval between the injections may have facilitated these immunologic events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case underscores the importance for clinicians to remain vigilant regarding the potential for delayed-onset cutaneous allergic reactions and complete secondary treatment failure following repeated BTX-A injections.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsurgical Facial Contouring With a Novel Radiofrequency and Vacuum Device: A Multicenter Retrospective Study With 33 Patients","authors":"Mimi Ehrenraich,&nbsp;Ety Wolff,&nbsp;Suzy Roffe Grumer,&nbsp;Olalla Calvo Lozano,&nbsp;Reyna Vargas,&nbsp;Inna Belenky","doi":"10.1111/jocd.70127","DOIUrl":"https://doi.org/10.1111/jocd.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aging process reflects decreased tissue elasticity and a rearrangement of subcutaneous volume, resulting in superficial wrinkles and three-dimensional changes in skin topography. Radiofrequency (RF)-based approaches have become increasingly adopted in recent decades due to their relatively short downtime and significantly reduced risk of adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the safety and efficacy of the V-FC handpiece through a multicenter retrospective study as well as ex vivo and in vivo analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The V-FC handpiece was used once a week for a treatment course of 3–6 sessions. The clinical evaluation of 33 patients included demographics, BMI, assessment of skin laxity, and rate of improvement. An ex vivo study with porcine tissue assessed the penetration depth of RF, while device performance was evaluated in an in vivo animal histological analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant adverse effects were recorded during the treatment course or at short- and long-term follow-ups (1, 3, and 52 months). The average skin laxity grade baseline was 34% lower at the end of the treatment course, with the average rate of improvement assessed as moderate. The ex vivo minimal and maximal penetration depths were 3.2–11.3 mm (±10%). The in vivo histopathological analysis showed no signs of acute heat injury at any treatment setting, including the maximum RF power. Additionally, staining showed a power-related progressive proliferation of fibroblasts, elastin fibers, and neocollagenesis, which was significantly higher 4 weeks after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The new RF device demonstrates an effective treatment for facial contouring with a proven short- and long-term high safety profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Ceramide Profile of Facial Sensitive Skin: Disordered Intercellular Lipid Structure Is Linked to Skin Hypersensitivity","authors":"Taisei Joichi,&nbsp;Hiroyuki Yoshida,&nbsp;Hiroaki Katsukura,&nbsp;Lili Zhai,&nbsp;Daisuke Watanabe,&nbsp;Naohito Yamamoto,&nbsp;Mai Haneoka,&nbsp;Shun Nakamura,&nbsp;Akane Kawamoto,&nbsp;Hiromitsu Nakazawa,&nbsp;Motoaki Suka","doi":"10.1111/jocd.70154","DOIUrl":"https://doi.org/10.1111/jocd.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although sensitive skin (SS) is a syndrome characterized by cutaneous hypersensitivity to environmental factors, its pathophysiology remains elusive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We aimed to explore the characteristics of ceramides (CERs) and intercellular lipid (ICL) structures of individuals with and without facial SS and their relationship with skin hypersensitivity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Healthy Japanese females were divided into SS or non-SS groups based on self-perception and lactic acid stinging test (LAST). Stratum corneum (SC) lipids were analyzed using a liquid chromatograph-mass spectrometer, and the orthorhombic-hexagonal lateral packing structure of ICLs was assessed using electron diffraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>According to the mean LAST score, individuals with SS (<i>n</i> = 48) had mild-to-moderate skin hypersensitivity. SS exhibited not significantly but slightly impaired skin barrier function (<i>p</i> = 0.072) and lower levels of CER[NH], [NP], [EOS], [EOH] (all <i>p</i> &lt; 0.05), and [EOP] (<i>p</i> = 0.073) in the SC compared with non-SS (<i>n</i> = 18). Notably, the CER[NP]/[NS] ratio, a marker of skin barrier function, was positively correlated with the orthorhombic-hexagonal lateral packing ratio of ICLs (<i>p</i> = 0.002), whereas it was negatively correlated with the LAST score (<i>p</i> = 0.015) and the interleukin (IL)-1 receptor antagonist/IL-1α ratio (<i>p</i> = 0.003) in the SC, an indicator of chronic inflammation. Moreover, corneocyte size was reduced in SS (<i>p</i> &lt; 0.001), suggesting inferior SC maturation, and was positively correlated with the CER[NP]/[NS] (<i>p</i> &lt; 0.001) and the orthorhombic-hexagonal ratios (<i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Individuals with SS showed an abnormal CER profile, particularly the altered CER[NP]/[NS] ratio, which was in turn associated with disordered ICL structure and skin hypersensitivity. Abnormal epidermal turnover may be an underlying mechanism of the abnormalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model","authors":"Xufeng Jiang,&nbsp;Weiguo Wang,&nbsp;Yuqing Wei,&nbsp;Wenxuan Cheng,&nbsp;Shoulin Li,&nbsp;Linjing Du,&nbsp;Wenping Xu,&nbsp;Yang Zhang","doi":"10.1111/jocd.70128","DOIUrl":"https://doi.org/10.1111/jocd.70128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The biological activity of both alone or in combination was evaluated based on the zebrafish model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Zebrafish embryos were induced to form models using different methods. Add BAK and Argireline YOUth peptide oil solution MB (ARG, containing 0.125% acetyl hexapeptide-8) to treat zebrafish embryos, and they were evaluated for their restorative effects on preexisting damage in zebrafish embryos.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>BAK and ARG were able to reduce water loss from the caudal fin of zebrafish induced by 0.9% NaCl solution. They were able to alleviate the UVB-induced decrease in the expression level of the skin tightness-related gene (<i>ELN</i>/<i>COL1a1b</i>) in zebrafish embryos, and BAK or ARG effectively reversed the increase in β-galactosidase activity induced by exposure to H₂O₂ solution and restored telomerase activity in zebrafish embryos. In addition, both were able to counteract oxidative stress and mitochondrial damage in zebrafish embryos as a result of LPS treatment. Finally, BAK and ARG were also effective in suppressing the increase in neutrophil counts and inflammatory cytokine levels in zebrafish embryos due to LPS exposure. Notably, BAK and ARG were more effective when used in combination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Acetyl hexapeptide-8 promotes the bioactivity of BAK in zebrafish embryos (<i>Danio rerio</i>). BAK and ARG have moisturizing, anti-inflammatory, antioxidant, and antioxidant bioactivities in the zebrafish model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Porphyria Cutanea Tarda Scarring With Combination Laser Treatment and a Pilot Use of Artificial Intelligence to Quantify Laser Results","authors":"Chelsea E. Kesty,&nbsp;Katarina R. Kesty","doi":"10.1111/jocd.70056","DOIUrl":"https://doi.org/10.1111/jocd.70056","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Porphyria cutanea tarda (PCT) is the most common subtype of porphyria and results from a deficiency of the enzyme uroporphyrinogen decarboxylase. Even after successful treatment, patients can be left with significant scarring, and there is little published data on the safety and efficacy of light-based or laser-based therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This report examines a case of a 47-year-old male with PCT secondary to HCV, treated with a combination of fractionated erbium-doped yttrium-aluminum-garnet (Er:YAG), intense pulsed light (IPL), and carbon dioxide (CO₂) lasers to address significant scarring and residual skin damage. An artificial intelligence model was used to quantify the results of the laser procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After combination laser treatment, the patient exhibited marked improvements in skin texture, reduction in scar visibility, and diminished hyperpigmentation. The artificial intelligence algorithm quantified the laser results and showed improvements in the scores used in the large language model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this patient, customizing a combination of lasers to target different layers of the skin to achieve comprehensive improvement: erbium primarily addressed superficial irregularities and pigmentation, while CO₂ promoted deeper collagen remodeling. The use of artificial intelligence to quantify the positive results in this case is in line with the clinical evaluations and photos.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}