BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-04-02 DOI:10.1111/jocd.70128

Xufeng Jiang, Weiguo Wang, Yuqing Wei, Wenxuan Cheng, Shoulin Li, Linjing Du, Wenping Xu, Yang Zhang

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Abstract

Background

Bakuchiol (BAK) and acetyl hexapeptide-8 have favorable biological activities and have promising applications in the cosmetic industry. However, the evaluation of the biological activity of both alone or in combination has not been reported.

Aims

The biological activity of both alone or in combination was evaluated based on the zebrafish model.

Methods

Zebrafish embryos were induced to form models using different methods. Add BAK and Argireline YOUth peptide oil solution MB (ARG, containing 0.125% acetyl hexapeptide-8) to treat zebrafish embryos, and they were evaluated for their restorative effects on preexisting damage in zebrafish embryos.

Results

BAK and ARG were able to reduce water loss from the caudal fin of zebrafish induced by 0.9% NaCl solution. They were able to alleviate the UVB-induced decrease in the expression level of the skin tightness-related gene (ELN/COL1a1b) in zebrafish embryos, and BAK or ARG effectively reversed the increase in β-galactosidase activity induced by exposure to H₂O₂ solution and restored telomerase activity in zebrafish embryos. In addition, both were able to counteract oxidative stress and mitochondrial damage in zebrafish embryos as a result of LPS treatment. Finally, BAK and ARG were also effective in suppressing the increase in neutrophil counts and inflammatory cytokine levels in zebrafish embryos due to LPS exposure. Notably, BAK and ARG were more effective when used in combination.

Conclusions

Acetyl hexapeptide-8 promotes the bioactivity of BAK in zebrafish embryos (Danio rerio). BAK and ARG have moisturizing, anti-inflammatory, antioxidant, and antioxidant bioactivities in the zebrafish model.

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在斑马鱼模型中，BAK和ARG具有保湿、抗炎、抗氧化和抗氧化的生物活性

背景白屈菜醇（BAK）和乙酰六肽-8 具有良好的生物活性，在化妆品行业具有广阔的应用前景。然而，对这两种物质单独使用或混合使用的生物活性评估尚未见报道。目的以斑马鱼模型为基础，评估二者单独或联合使用的生物活性。方法使用不同方法诱导斑马鱼胚胎形成模型。添加 BAK 和 ARG（含 0.125% 乙酰基六肽-8）治疗斑马鱼胚胎，并评估它们对斑马鱼胚胎原有损伤的修复作用。结果 BAK 和 ARG 能够减少 0.9% NaCl 溶液引起的斑马鱼尾鳍失水。BAK 和 ARG 还能有效逆转暴露在 H2O2 溶液中诱导的 β-半乳糖苷酶活性的增加，并恢复斑马鱼胚胎中端粒酶的活性。此外，二者还能对抗斑马鱼胚胎因 LPS 处理而产生的氧化应激和线粒体损伤。最后，BAK 和 ARG 还能有效抑制斑马鱼胚胎因暴露于 LPS 而导致的中性粒细胞数量和炎症细胞因子水平的增加。值得注意的是，BAK 和 ARG 联合使用时效果更好。结论乙酰基六肽-8 能促进 BAK 在斑马鱼胚胎（Danio rerio）中的生物活性。BAK 和 ARG 在斑马鱼模型中具有保湿、抗炎、抗氧化和抗氧化的生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.