Journal of Cosmetic Dermatology最新文献

{"title":"Correction to “TriHex 2.0—Advancing Skin Health Science and the TriHex Technology”","authors":"","doi":"10.1111/jocd.71122","DOIUrl":"https://doi.org/10.1111/jocd.71122","url":null,"abstract":"<p>\u0000 <span>A.D. Widgerow</span>, <span>M.E. Ziegler</span>, and <span>F. Shafiq</span>, “ <span>TriHex 2.0—Advancing Skin Health Science and the TriHex Technology</span>,” <i>Journal of Cosmetic Dermatology</i> <span>24</span>, (<span>2025</span>): e16690, https://doi.org/10.1111/jocd.16690.\u0000 </p><p>In Abstract section, the “Results” subsection, a transcription error was identified where the value “69%” should be updated to be “59%” in the following line:</p><p>“HA levels (CD44 intensity) significantly increased with TriHex (69%; <i>p</i> &lt; 0.01)”</p><p>This should be updated to be as follows:</p><p>“HA levels (CD44 intensity) significantly increased with TriHex (59%; <i>p</i> &lt; 0.01)”</p><p>We apologize for this error.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Reconstitution Behaviors of Two Poly-L-Lactic Acid Biostimulator Formulations: A Mechanistic Hypothesis","authors":"Chuan-Yuan Lin,&nbsp;QianZhong Zhang,&nbsp;Jui-Yu Lin,&nbsp;Qiong Meng","doi":"10.1111/jocd.71081","DOIUrl":"https://doi.org/10.1111/jocd.71081","url":null,"abstract":"&lt;p&gt;Poly-L-lactic acid (PLLA)–based biostimulators are increasingly used in the aesthetic field. Lyophilized formulations containing carboxymethyl cellulose (CMC) must be reconstituted with sterile water for injection to form a homogeneous suspension prior to administration, and the dissolution behavior of CMC can influence the gross appearance and handling characteristics of the resulting suspension [&lt;span&gt;1, 2&lt;/span&gt;]. In our repeated routine reconstitution observations involving more than 1000 vials of each formulation, PLLA-SCA (Sculptra; Galderma Laboratories) and PLLA-SIF (Sifuyan; Meiyan Space, Sihuan Pharm, Beijing, China) consistently appeared to show different gross reconstitution behaviors despite having the same labeled amounts of PLLA, CMC, and mannitol per vial. Here, we compare these observed reconstitution behaviors and discuss one possible physicochemical explanation.&lt;/p&gt;&lt;p&gt;A vial of PLLA-SCA contains 150 mg of PLLA microparticles, 90 mg of CMC, and 127.5 mg of mannitol. Upon reconstitution, the CMC dissolves to form a viscous solution that suspends the water-insoluble PLLA microparticles. However, CMC has an inherent tendency to form lumps when hydrated. Pre-mixing CMC with mannitol helps distribute CMC molecules and reduce large-lump formation, yet small micro-lumps—often termed “CMC micro-fisheyes,” consisting of partially hydrated particles with dry cores—may still develop. These micro-lumps tend to float on the suspension surface and may be relevant to needle clogging; they have also been discussed as a possible contributing factor to delayed-onset nodules or papules following injection [&lt;span&gt;2, 3&lt;/span&gt;]. Prolonging hydration time reduces micro-lump formation but does not reliably eliminate it [&lt;span&gt;1-3&lt;/span&gt;] (Figure 1A). Historically, longer hydration times were recommended to reduce this problem, although more recent analytical and clinical studies suggest that immediate use of PLLA-SCA can also be feasible under specific reconstitution protocols [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A vial of PLLA-SIF also contains 150 mg of PLLA microparticles, 90 mg of CMC, and 127.5 mg of mannitol. In our observations, the suspension became grossly homogeneous almost immediately upon reconstitution and showed no obvious CMC micro-fisheyes. However, the suspension remained homogeneous for only 2–3 min after shaking, after which gradual particle sedimentation became apparent (Figure 1B). One possible explanation is that differences in CMC-related structural parameters may contribute to the distinct reconstitution behaviors observed in these two formulations.&lt;/p&gt;&lt;p&gt;CMC is produced by substituting hydroxyl groups on the cellulose backbone with carboxymethyl groups, thereby conferring water solubility. In general, a higher degree of substitution (DS) and greater substitution uniformity are expected to enhance solubility. The degree of polymerization (DP) also influences solubility: a higher DP yields longer polymer chains with greater chain entanglem","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of Hyaluronic Acid and Calcium Hydroxylapatite Fillers—A Comprehensive Narrative Review of Clinical Presentation and Current Management Strategies","authors":"Natalia Sukmanskaya,&nbsp;Sebastian Cotofana,&nbsp;Michael Alfertshofer","doi":"10.1111/jocd.71104","DOIUrl":"https://doi.org/10.1111/jocd.71104","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) fillers are among the most widely used injectable materials in aesthetic medicine. Although both exhibit favorable safety profiles, concomitant with increasing use comes a broader spectrum of reported complications, ranging from mild, self-limited reactions to rare but potentially dramatic events.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To provide a comprehensive narrative review of the clinical presentation and current evidence-based management strategies for common and uncommon complications associated with HA and CaHA fillers.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A narrative review of the dermatologic, plastic surgery, ophthalmologic, and aesthetic medicine literature was conducted, focusing on peer-reviewed studies, systematic reviews, expert consensus statements, and illustrative case reports addressing complications of HA and CaHA fillers. Complications were categorized by timing, pathophysiology, and clinical severity, and management approaches were synthesized accordingly. Relevant English-language articles were identified through PubMed/MEDLINE and Scopus up to 2025 using combinations of the different search terms supplemented by hand-searching of reference lists; evidence was weighted qualitatively, giving precedence to consensus statements and larger studies over individual case reports.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;HA and CaHA fillers share overlapping complication profiles, including bruising, swelling, vascular occlusion, infection, nodules, granulomas, and delayed inflammatory reactions. Key differences arise from their inherent product properties: HA complications benefit from enzymatic reversibility with hyaluronidase, which underpins established treatment algorithms for vascular occlusion, Tyndall effect, chronic edema, and nodules. In contrast, CaHA-related complications rely more heavily on prevention, supportive care, and, in select cases, mechanical removal through surgical intervention, as no enzymatic reversal is available. Early recognition and prompt intervention are critical determinants of outcome, particularly in ischemia-related complications.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;HA and CaHA fillers are effective and generally safe filler materials, yet not without risk. A thorough understanding of complication patterns, material-specific management strategies, and preventive tec","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Polycaprolactone Filler-Induced Ischemia With “THIS and FAT” Protocol: A Case Series","authors":"Shahriar Nazari,&nbsp;Mohammad Reza Pourani,&nbsp;Foroohe Bayatparidary,&nbsp;Mohammad Saleh Sadeghi,&nbsp;Nabil Fakih-Gomez","doi":"10.1111/jocd.71116","DOIUrl":"https://doi.org/10.1111/jocd.71116","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Polycaprolactone (PCL)–based fillers demonstrate clinical advantages and favorable aesthetic outcomes. However, due to the nature of their constituents, they present unique and serious challenges, particularly regarding vascular adverse events such as embolism, tissue necrosis, and visual loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study presents a case series of five patients with PCL filler–induced vascular complications treated using the “THIS and FAT” protocol. This protocol includes botulinum toxin, high-dose hyaluronidase, injectable platelet-rich fibrin (iPRF), solid platelet-rich fibrin (sPRF), antibiotics and adjunctive medications, nanofat injection, debridement, and nanofat membrane application. The objective was to assess its clinical utility and explore potential therapeutic options in the absence of a definitive reversal agent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Results</h3>\u0000 \u0000 <p>All five patients were successfully treated with the “THIS and FAT” protocol, and no major complications were observed. The protocol provides a stepwise therapeutic strategy offering targeted interventions for each stage of ischemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Managing vascular complications secondary to PCL fillers requires early recognition, rapid implementation of multimodal therapy, and a comprehensive understanding of facial anatomy. In this case series, the “THIS and FAT” protocol guided treatment through a structured, ultrasound-assisted approach that integrates vascular, enzymatic, anti-inflammatory, and regenerative modalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Intradermal Versus Subdermal Injection of Polynucleotide for Facial Improvement: A Prospective Split-Face Study","authors":"Hyungkyu Bae,&nbsp;Soo-Bin Kim,&nbsp;Yu-Ran Heo,&nbsp;Hyoun Jun Park,&nbsp;Jong Seo Kim,&nbsp;Nark-Kyoung Rho,&nbsp;Hee-Jin Kim","doi":"10.1111/jocd.71108","DOIUrl":"https://doi.org/10.1111/jocd.71108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Polynucleotide-based injectables are increasingly used to improve periocular and midface skin quality, but the optimal delivery approach remains uncertain. Because intradermal and subdermal administration differ in tissue placement and short-term procedure-related reactions, clarifying whether subdermal delivery can achieve comparable objective improvement with better tolerability is clinically relevant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to compare the efficacy and safety of intradermal versus subdermal delivery of polynucleotide for facial skin improvement using a prospective split-face clinical design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>In this prospective split-face study, adults seeking facial wrinkle improvement received three treatment sessions at 3-week intervals. The left cheek received intradermal injection and the right cheek received subdermal delivery. The primary endpoint was percentage improvement from baseline to Week 12 in the Antera 3D fineline index. A prespecified non-inferiority margin of −15% (SD − ID) was evaluated using baseline-adjusted linear mixed-effects modeling. Secondary objective outcomes included additional Antera 3D skin-quality indices and skin elasticity (Cutometer R2). GAIS, post-procedure pain (VAS), injection-site embossing, and adverse events were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty participants received at least one treatment, and 37 contributed imaging-based efficacy data. Both approaches improved wrinkle- and texture-related parameters from baseline. Subdermal delivery met the non-inferiority criterion for fineline improvement at Week 12 and also showed non-inferior results at Week 9. At Week 12, the fineline index was lower on the subdermal side than on the intradermal side. Subdermal delivery was associated with lower pain scores at all sessions and no injection-site embossing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Subdermal delivery was non-inferior to intradermal injection for objective skin-quality outcomes and demonstrated a more favorable tolerability profile.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Trichloroacetic Acid in Treatment of Atrophic Acne Scars: A Scoping Review","authors":"Mariana Garcia da Ponte Melo,&nbsp;Joyce Magalhães de Barros,&nbsp;Ramille Araújo Lima","doi":"10.1111/jocd.71110","DOIUrl":"https://doi.org/10.1111/jocd.71110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atrophic acne scars represent a significant aesthetic and therapeutic challenge due to their multifactorial nature and morphological diversity. Trichloroacetic Acid (TCA) stands out as a versatile option, either through chemical peels or the Chemical Reconstruction of Skin Scars (CROSS) technique.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To map scientific evidence regarding clinical protocols, concentrations, and efficacy of TCA, alone or in combined therapies, for atrophic acne scars.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This scoping review followed the Joanna Briggs Institute (JBI) methodology and PRISMA-ScR guidelines. Search strategies were applied across nine databases using the PCC strategy. Thirty-four studies published between 2002 and 2025 were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The CROSS technique was the most evaluated protocol (58.8% of studies), with concentrations ranging from 50% to 100%; it demonstrated high selectivity and efficacy, particularly for ice-pick and deep boxcar scars. Chemical peels accounted for 41.2% of studies, with superficial concentrations (10%–20%) used for texture improvement and medium concentrations (25%–50%) for shallow atrophic lesions. Combined therapies (52.9%) highlighted the synergy between TCA (15%–20%), microneedling, and subcision. Reported adverse events were primarily transient, including post-inflammatory hyperpigmentation (PIH) and prolonged erythema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TCA is a versatile, cost-effective, and evidence-backed tool. The findings highlight a definitive shift toward personalized multimodal approaches, where the CROSS-technique's precision and the synergistic effects of combined therapies optimize dermal remodeling and patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanotransduction of Collagen Biostimulators: Comparative Signaling and Implications for GLP-1 RA–Associated Facial Aging","authors":"Chang-Hwan Cho,&nbsp;Atsuko Yanagawa,&nbsp;Beomjoon Kim","doi":"10.1111/jocd.71105","DOIUrl":"https://doi.org/10.1111/jocd.71105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>GLP-1 receptor agonists (GLP-1 RAs) can induce rapid weight reduction, often associated with facial volume loss. However, optimal regenerative strategies remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To compare the mechanotransduction profiles of the major injectable collagen biostimulator classes in GLP-1 RA–induced facial aging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A structured narrative review with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-informed search and reporting was conducted across PubMed, Embase, Web of Science, and Cochrane Library (January 1, 2000—March 31, 2026).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-three studies met the inclusion criteria. Each of the six biostimulator classes—PLLA, PDLLA, PDO, CaHA, particulate PCL, and liquid-type PCL—exhibits a distinct mechanotransduction profile, though the strength of supporting evidence varies substantially across agents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Mechanotransduction-active collagen biostimulators provide a biologically plausible rationale for addressing facial volume loss, although current clinical evidence remains limited and no studies have directly enrolled GLP-1 RA–associated facial aging patients. A conceptual severity-stratified framework warrants prospective validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indocyanine Green Angiography for Objective Perfusion Monitoring After Hyaluronic Acid Filler-Induced Facial Vascular Occlusion","authors":"Guangdi Li,&nbsp;Guiwen Zhou,&nbsp;Miao Wang,&nbsp;Hongfan Ding,&nbsp;Chongli Yu,&nbsp;Qiang Fu,&nbsp;Minliang Chen","doi":"10.1111/jocd.71097","DOIUrl":"https://doi.org/10.1111/jocd.71097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyaluronic acid (HA) filler-induced facial vascular occlusion may cause cutaneous ischemia, necrosis, and disfigurement. Clinical assessment and imaging-guided hyaluronidase-based intervention remain central, but vessel-level localization does not directly quantify downstream tissue perfusion after rescue treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate indocyanine green angiography (ICGA) as an adjunctive tissue-level tool for monitoring perfusion changes after initial rescue treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This exploratory single-center retrospective feasibility study included patients with clinically diagnosed HA filler-induced facial vascular occlusion who underwent paired ICGA before and after initial rescue treatment between July 2025 and March 2026. ICGA-derived parameters included ingress rate, time to peak (TPP), and curve ingress. Curve ingress percent change was calculated as the change in curve ingress divided by baseline curve ingress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-six patients were included. After initial rescue treatment, median ingress rate increased from 12.50 to 16.20, with a median change of 4.85 (IQR, 3.00–8.57; <i>p</i> &lt; 0.001). Median TPP shortened from 31.46 to 23.87 s, with a median change of −6.09 s (IQR, −11.69 to −3.93; <i>p</i> &lt; 0.001). Median curve ingress increased from 63515.95 to 77862.55, with a median change of 14432.45 (IQR, 9891.28–20269.65; <i>p</i> &lt; 0.001). The two patients requiring treatment escalation showed the lowest percent changes in curve ingress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ICGA demonstrated early tissue-level perfusion changes after initial rescue treatment. Limited early curve ingress improvement may support closer surveillance or timely escalation when interpreted with clinical findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov, NCT07581652</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Genioplasty Versus Hyaluronic Acid Injection for Chin Retrusion in Asian Chinese Female Patients: A One-Year Outcome Evaluation Combining Eye-Tracking and Scale Assessment","authors":"Xinyi Gao,&nbsp;Xianglong Zu,&nbsp;Chi Zhang,&nbsp;Jingping Shi,&nbsp;Zexiong Cheng","doi":"10.1111/jocd.71117","DOIUrl":"https://doi.org/10.1111/jocd.71117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study compared 1-year postoperative visual attention patterns and lay-rated aesthetic outcomes after genioplasty and hyaluronic acid (HA) injection for moderate-to-severe chin retrusion in Asian Chinese women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixteen female patients with comparable baseline severity according to the China (Allergan) Chin Retrusion Scale (CACRS) were included, with eight patients in the genioplasty group and 8 in the HA injection group. Forty-six lay observers assessed standardized 12-month postoperative facial photographs in frontal, lateral, and 45° oblique views. Eye-tracking was used to quantify fixation duration across predefined facial regions, and the Merz Aesthetic Rating Scales (MARS) were used for structured postoperative aesthetic assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The HA injection group showed longer fixation durations in the chin region across all three views, whereas the genioplasty group showed relatively longer fixation durations in the perioral region in the frontal view and in the periorbital region in the 45° oblique view. MARS assessment showed lower postoperative scores for symmetry and contour in the genioplasty group, with no significant between-group difference in skin quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>At 1 year postoperatively, genioplasty was associated with lower MARS scores for symmetry and contour and a less chin-focused fixation pattern compared with HA injection. However, the observed fixation differences were modest and should be interpreted cautiously. Eye-tracking analysis combined with MARS may provide a quantifiable framework for evaluating postoperative facial aesthetic perception.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Outcomes of Microwave Thermolysis for Axillary Hyperhidrosis and Bromhidrosis in Adolescents: A Retrospective Study","authors":"Sheng-Ni Chen,&nbsp;Sindy Hu,&nbsp;Chun-Yu Cheng,&nbsp;Shyue-Luen Chang,&nbsp;Chau-Yee Ng,&nbsp;Ya-Ching Chang,&nbsp;Min-Hui Chi,&nbsp;Jennifer Wu,&nbsp;Sze-Wen Ting,&nbsp;Fang-Ying Wang,&nbsp;Yau-Li Huang","doi":"10.1111/jocd.71114","DOIUrl":"https://doi.org/10.1111/jocd.71114","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primary axillary hyperhidrosis and bromhidrosis in adolescents cause significant physical discomfort and psychosocial distress, negatively impacting emotional well-being and social function. While microwave thermolysis is effective in adults, its psychological benefits in adolescents remain understudied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To evaluate the clinical efficacy of microwave thermolysis in adolescents and investigate its impact on quality of life, anxiety, and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>This retrospective study included 21 adolescents (mean age 15.21 years) treated with microwave thermolysis. Clinical severity was assessed using the Hyperhidrosis Disease Severity Scale (HDSS) and a bromhidrosis grading scale. Psychosocial outcomes were evaluated using the Dermatology Life Quality Index (DLQI), a modified Quality of Life (QoL) questionnaire, and the Hospital Anxiety and Depression Scale (HADS) at baseline and 1 month post-treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The treatment yielded significant clinical improvement, with HDSS scores decreasing from 3.19 to 1.33 (<i>p</i> &lt; 0.0001) and bromhidrosis severity dropping from 4.19 to 0.48 (<i>p</i> &lt; 0.0001). Psychosocial burden was markedly reduced: DLQI scores improved from 17.38 to 10.71 (<i>p</i> &lt; 0.0001), and QoL scores increased from 52.10 to 84.95 (<i>p</i> = 0.027). Significant reductions were observed in HADS-anxiety (14.05 to 1.67, <i>p</i> &lt; 0.0001) and HADS-depression scores (7.48 to 1.05, <i>p</i> &lt; 0.0001). All cases reported no major side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Microwave thermolysis is a highly effective treatment for adolescent axillary hyperhidrosis and bromhidrosis. Beyond symptom relief, it significantly alleviates anxiety and depression while enhancing quality of life and social function. These findings support its use as a primary therapeutic option for this vulnerable population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148752464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}