Journal of Cosmetic Dermatology最新文献

{"title":"A Retrospective Cohort Study Comparing the Clinical Outcomes of the Hydrosurgery System and Traditional Single-Incision Surgery for Axillary Osmidrosis","authors":"Lufan Xia,&nbsp;Mu He,&nbsp;Xiaoqiang Liu,&nbsp;Jinghong Zhang,&nbsp;Ying Chen,&nbsp;Jiaping Zhang","doi":"10.1111/jocd.16755","DOIUrl":"10.1111/jocd.16755","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To compare the postoperative scarring, complication rates, and efficacy between the hydrosurgery system and traditional single-incision surgical techniques for treating axillary osmidrosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective collection was conducted of all patients who underwent radical surgery for axillary osmidrosis at the Day Surgery Unit of the Department of Plastic Surgery at the First Affiliated Hospital of the Army Medical University from January 2023 to January 2024. Patients were screened based on inclusion and exclusion criteria and divided into the hydrosurgery group and the traditional surgery group. The evaluation was done through medical records, follow-up records, electronic questionnaires, and photographs. Assessments included 6-month postoperative scarring conditions, comprehensive effectiveness scores, postoperative odor/hair/sweating scores, postoperative dermatological life quality scores, and complication rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 73 patients completed this study: 34 in the hydrosurgery group and 39 in the traditional surgery group. 6 months postoperatively, the hydrosurgery group had significantly lower scores of the Vancouver Scar Scale (VSS), 0.5 (range 0.0–2.0) compared with 1.5 (range 0.5–3.0) in the traditional surgery group (<i>p =</i> 0.018). The incidence of complications such as subcutaneous hematoma, epidermal necrosis, and wound dissidence was also lower (26.5% vs. 51.3%, <i>p =</i> 0.031). Additionally, the surgical incision length in the hydrosurgery group was significantly smaller than in the traditional surgery group (1.200 cm (1.000, 1.275) vs. 2.500 cm (2.500, 3.000), <i>p</i> &lt; 0.001). There were no significant differences between the two groups regarding comprehensive effectiveness scores, postoperative odor/hair/sweating scores, postoperative dermatological life quality index, and surgical duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared with traditional single-incision surgical techniques, patients in the hydrosurgery group exhibited lower scar scores 6 months postsurgery, required smaller surgical incisions, and had lower rates of surgical complications. Thus, the hydrosurgery is suitable for the minimally invasive surgical treatment of axillary osmidrosis, offering a safe, effective, and aesthetically superior treatment method.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Exosomes in Medical Dermatology: Literature Review and Update","authors":"Victoria Dukharan,&nbsp;Milaan Shah,&nbsp;Luke Broughton,&nbsp;Carol Stegura,&nbsp;Luna Samman,&nbsp;Nina Schur,&nbsp;Todd Schlesinger","doi":"10.1111/jocd.16761","DOIUrl":"10.1111/jocd.16761","url":null,"abstract":"<p>January 30, 2025: This article published prematurely in error. The article will republish shortly.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Giant Squamous Cell Carcinoma of the Face Treated by Surgery Combined With Photodynamic Therapy","authors":"Fanfan She,&nbsp;Huiying Wang,&nbsp;Kongchao Yang,&nbsp;Xiaoming Qin,&nbsp;Ruzhi Zhang","doi":"10.1111/jocd.16791","DOIUrl":"10.1111/jocd.16791","url":null,"abstract":"&lt;p&gt;An 86-year-old woman presented with a rapidly growing right facial mass of more than 1 year duration, associated with bleeding, crusting, and occasional pain. Physical examination revealed an 8.0 cm × 8.0 cm mass on the right side of the face with clear margins, mild ulceration, and exudation (Figure 1A). Mild ectropion of the right eyelid was noted. Imaging studies showed no evidence of metastasis. Laboratory tests revealed that blood cell counts and coagulation function tests, including PT, APTT, INR, and D-dimer, were within normal limits. In addition, LDH, an important prognostic marker for various tumors, was measured at 131 U/L, also within the normal range [&lt;span&gt;1&lt;/span&gt;]. Based on the tumor size and the absence of distant metastases, the clinical stage was determined to be T3NxM0 [&lt;span&gt;2&lt;/span&gt;]. Given the patient's age and tumor size, wide local excision (WLE) with a 6 mm margin was performed. However, due to the proximity of the tumor to the orbit, it was difficult to achieve a 6 mm margin in this area and the final margin was 2–4 mm (Figure 1B). Postoperative pathology revealed a moderately to poorly differentiated cutaneous squamous cell carcinoma (cSCC) with no evidence of perineural invasion (PNI) (Figure 1D,E). Immunohistochemistry showed positive staining for CK5/6, p40, Ki67, and p63 (Figure 2). Residual tumor cells were also found around the cutting edge. The wound surface was treated with three consecutive sessions of photodynamic therapy (PDT) starting on postoperative day 2, with each session separated by 1 week. It was treated locally with 20% 5-aminolaevulinic acid (ALA) cream, followed by the application of a dark saran wrap for 3 h. Narrowband red light with a wavelength of 633 ± 10 nm was then applied at an intensity of 150 J/cm&lt;sup&gt;2&lt;/sup&gt;. Each irradiation session lasted approximately 20 min, depending on patient tolerance. Secondary intentional healing (SIH) was chosen for reconstruction, with moist dressings used to facilitate wound healing. Dressings were changed every 2–3 days, starting with a layer of oil emulsion dressing mixed with antibiotic ointment, followed by clean gauze until wound healing was completed. By postoperative day 60, the majority of the wound had healed with no deformation of the surrounding tissue and minimal scarring (Figure 1C). A 6-month follow-up showed no recurrence.&lt;/p&gt;&lt;p&gt;Multivariate analysis of tumor characteristics identified five high-risk factors as statistically independent prognostic indicators for cSCC: poor differentiation, PNI, tumor diameter &gt; 2 cm, invasion of subcutaneous fat, and location in the ear, temple, or genital area. PNI, which is associated with disease-specific mortality, can extend contiguously along with the perineural space to larger nerves before spreading proximally to the skull base [&lt;span&gt;3, 4&lt;/span&gt;]. In this patient, the tumor was located near the temple area of the face and was more than 2 cm in diameter, presenting several high-risk prognostic f","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Gel Formulation and Deep Injection Techniques for Lifting Effects in Cosmetic Dermatology","authors":"Irina Poleva","doi":"10.1111/jocd.16789","DOIUrl":"10.1111/jocd.16789","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>In recent years, the field of aesthetic dermatology has witnessed a surge in demand for minimally invasive procedures aimed at rejuvenating aging skin. This study aims to address this demand by evaluating the effectiveness of the injectable gel in rejuvenating aging skin, particularly by targeting collagen regeneration and lifting effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study involved 43 participants who underwent three monthly injection sessions targeting retaining ligaments. The injections were administered deeply to ensure proper targeting. Follow-up assessments were conducted after each treatment session and three months after the final injection. Evaluation methods included subjective assessments by both patients and investigators using the Global Aesthetic Improvement Scale (GAIS), as well as objective assessments using a 3D photosystem to measure wrinkle conditions and vectors of traction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All participants completed the study, with no significant adverse effects observed apart from mild swelling at the injection sites. Despite the high viscosity of HA necessitating the use of a 27 G needle, the injection process was generally comfortable and minimally painful. Subjective evaluations revealed consistent improvements in skin appearance from the first application, which continued to increase throughout the study and remained high even 3 months post-treatment. Objective evaluations demonstrated significant improvements in wrinkle conditions and lifting effects, with a substantial increase in the standard deviation score for wrinkle conditions and the average traction vector length measuring 1.6 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study findings confirm the safety and efficacy of the injectable formula, with high patient satisfaction, noticeable lifting effects, and significant improvements in wrinkle conditions. These results support the use of the injectable as a promising option for non-invasive skin rejuvenation treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic Dermal Fillers in Treating Acne Scars: A Comparative Systematic Review","authors":"Salma Albargawi","doi":"10.1111/jocd.16752","DOIUrl":"10.1111/jocd.16752","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acne is a common condition observed in adolescents and in most severe acne the scars develop. There are numerous treatment options for acne scars. However, no standardized guidelines have been established to guide physicians in the optimal treatment of acne scars.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>The objective of this systematic review is to evaluate the existing evidence on various fillers used for the treatment of acne scars and to compare their effectiveness with one another.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was designed following PRISMA guidelines, and the information was retrieved in May 2024 using the PubMed database and ClinicalTrials.gov registry. The inclusion criteria were that studies involving patients of any age or gender with acne scars of any type treated with synthetic dermal fillers, and studies published in English. The exclusion criteria were studies with less than 10 participants and studies that did not use synthetic dermal fillers. To assess the risk of bias in the included studies, the Cochrane Collaboration's Risk of Bias tool was used for randomized controlled trials, and in observational studies, the Newcastle–Ottawa Scale was used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-six studies were included with a total of 1121 participants. Fourteen studies evaluated HA on 372 subjects, five studies focused on PMMA on 305 subjects, four on CaHA on 392 subjects, two on PLLA on 42 subjects, and one on PCL on 10 subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most of the studies included in this review were of low quality, as indicated by their scores on quality assessments, lack of high-quality RCTs, and small sample sizes. Future research should focus on conducting randomized, controlled, split-face studies with an adequate number of participants and a detailed examination of different scar subtypes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes: Historical Evolution and Emerging Roles in Dermatology","authors":"Nina Schur,&nbsp;Luna Samman,&nbsp;Milaan Shah,&nbsp;Victoria Dukharan,&nbsp;Carol Stegura,&nbsp;Luke Broughton,&nbsp;Todd Schlesinger","doi":"10.1111/jocd.16769","DOIUrl":"10.1111/jocd.16769","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Exosomes are a nanoscale extracellular vesicles derived from different cell types that have been investigated for various clinical applications, including functioning as biomarkers and use as direct therapeutics. Given the role of exosomes in multiple pathophysiologic pathways and potential practical applications, they have garnered significant interest in the scientific community but much is still unknown about their development and use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This literature review covers the background, mechanisms of action, use as biomarkers, methods of application, and direct therapeutic applications of exosomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature review on the background and uses of exosomes was conducted. Key articles describing the pathophysiologic pathways and applications of exosomes were summarized and described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Exosomes impact several cellular pathways which allow them to function as biomarkers for malignancy and inflammatory dermatoses and may make them useful therapeutics for skin rejuvenation, hair loss, and wound repair. Limitations of exosomes include an incomplete understanding of their functions and impacts and a lack of standardization in their production and application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Exosomes are a unique and novel cellular medium that offer promise as a diagnostic tool and therapy. While there are limitations to the uses of exosomes as well as our current understanding of them, further investigation may yield additional applications and a larger role in medicine for exosomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Roles of Dermal Fibroblasts in Hyperpigmentation and Hypopigmentation: A Review","authors":"Xingyue Gao,&nbsp;Wenzhong Xiang","doi":"10.1111/jocd.16790","DOIUrl":"10.1111/jocd.16790","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin pigmentation disorders may increase patients' psychological burdens. Consequently, they are increasingly attracting attention. Dermal fibroblasts have been shown to regulate pigmentation by secreting soluble factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to summarize recent findings on the effects of dermal fibroblasts on hyperpigmentation and hypopigmentation, enabling the discovery of new therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed was searched for literature on fibroblast factors, hyperpigmentation, and hypopigmentation, and a comprehensive summary and analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fibroblasts secrete both cytokines that promote pigmentation, including stem cell factor (SCF) and keratinocyte growth factor (KGF), and small amounts of those that inhibit pigmentation, such as Dickkopf1 (DKK1) and transforming growth factor (TGF)-β. Fibroblast-derived extracellular matrix (ECM) can also affect melanocyte tyrosinase activity and the transfer of melanosomes. In hyperpigmentation disorders, such as melasma and solar lentigines, the secretion of pigmentation-promoting factors increases, and the activity of key enzymes in melanin production is elevated. In hypopigmentation disorders, including vitiligo, the secretion of melanogenic factors decreases while the factors that inhibit pigmentation increase. Fibroblasts may serve as a new therapeutic target, providing new insights to precisely treat pigmentary disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fibroblasts synthesize and secrete various cytokines and proteins that modify melanin synthesis and transfer through different signaling pathways, playing prominent roles in pigmentary skin disorders, such as photoaging, melasma, solar lentigo, and vitiligo.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional CO2 Laser to Treat Surgical Scars: A System Review and Meta-Analysis on Optimal Timing","authors":"Qiang Ji,&nbsp;Lili Luo,&nbsp;Jun Ni,&nbsp;Xiaolan Pu,&nbsp;He Qiu,&nbsp;Dongmei Wu","doi":"10.1111/jocd.16708","DOIUrl":"10.1111/jocd.16708","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Surgical scars with textural changes can be disfiguring and uncomfortable for patients. Various laser therapies have shown promise in softening and flattening these scars. Therefore, the authors conducted a systematic review and meta-analysis on the efficacy of fractional CO&lt;sub&gt;2&lt;/sub&gt; laser in treating surgical scars.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aims to present evidence from controlled trials investigating the efficacy of ablative carbon dioxide fractional laser in treating surgical scars.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Materials and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A literature search of Medline (via PubMed), Ovid, Web of Science, and Embase for relevant trials was conducted before March 2024. After assessing for inclusion, data extraction was performed using Population, Intervention, Comparison, Outcomes and Study criteria (PICOS). Quality, validity, and risk of bias were assessed using the RevMan5.3 risk of bias assessment tool.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A total of 14 controlled trials involving 492 participants or postsurgical scars were included in the system review and meta-analysis. Both in RCT and non-RCT settings, fractional CO&lt;sub&gt;2&lt;/sub&gt; laser therapy exhibited the same efficacious outcomes, with MD values of −0.63 (95% CI: −1.15 to −0.12; I&lt;sup&gt;2&lt;/sup&gt; = 70%; &lt;i&gt;p&lt;/i&gt; = 0.02) and − 1.86 (95% CI: −2.65 to −1.07; I&lt;sup&gt;2&lt;/sup&gt; = 85%; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), respectively. Moreover, furthermore analysis illustrated that initiating FRACTIONAL CO2 LASER treatment sessions at or within 1 month after surgery significantly reduced postoperative scars compared to control groups and groups on treatments initiated more than 3 months after surgery (MD: -1.66; 95% CI: −2.31 to −1.01; I&lt;sup&gt;2&lt;/sup&gt; = 89%; &lt;i&gt;p&lt;/i&gt; &lt; 0.001 and MD: -1.93; 95% CI: −2.24 to −1.62; I&lt;sup&gt;2&lt;/sup&gt; = 48%; &lt;i&gt;p&lt;/i&gt; &lt; 0.001). However, fractional CO&lt;sub&gt;2&lt;/sub&gt; laser treatment administered over 3 months after surgery did not significantly improve postoperative scars (MD: –0.17; 95% CI: −0.56 to 0.21; I&lt;sup&gt;2&lt;/sup&gt; = 37%; &lt;i&gt;p&lt;/i&gt; = 0.37).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The systematic review and meta-analysis provide robust support for the efficacy of fractional CO&lt;sub&gt;2&lt;/sub&gt; laser in treating surgical scars, particularly when administered at or within 1 month after surgery. One treatment session within 1 month after surgery also can produce significant results, but most clinical tri","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objectification of Skin Firmness: In Vivo Evaluation of 300 Women in Relation to Age","authors":"Alena Roessle,&nbsp;Martina Kerscher","doi":"10.1111/jocd.16773","DOIUrl":"10.1111/jocd.16773","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The concept of “skin quality” (SQ) has gained widespread attention, with a recent international consensus defining it and outlining four “emergent perceptual categories” (EPCs), each accompanied by specific parameters and associated measurement methods. No research has confirmed whether the parameters linked to these EPCs vary objectively with age. This gap in data is significant, as understanding how these parameters correlate with age could be essential for creating an objective, age-adjusted classification of SQ.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to investigate the EPC skin firmness in female facial and non-facial skin in relation to age using biophysical measurements. Reference ranges for objective assessment were determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Three hundred healthy women (20–69 years) were divided into five age groups. The correlation between age and skin firmness measured by Cutometer and Corneometer (Courage+Khazaka electronic GmbH, Cologne, Germany) devices was evaluated across five anatomical sites: forehead, cheek, neck, décolleté, and the hand. Percentiles were used to generate reference ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistical analysis discloses that R2 (<i>U</i>_a/<i>U</i>_f), R5 (<i>U</i>_r/<i>U</i>_e), and R7 (<i>U</i>_r/<i>U</i>_f) correlated with age for all five sites and are preferably assigned to the EPC skin firmness, whereby R2 and R7 showed the strongest correlation. For the neck, significant age-related changes were found in most of the Cutometer parameters. The stratum corneum (SC) hydration showed only low correlations with age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>R2, R5, and R7 are reliable indicators of age-related changes in skin firmness, with established reference ranges that can aid in treatment decisions and SQ assessments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Energy Delicate Pulsed Light Therapy for Sensitive Skin: A Retrospective Study","authors":"Yujie Fu,&nbsp;Yue Quan,&nbsp;Wanxing Zhao,&nbsp;Zhaoyang Liu,&nbsp;Jiao Peng,&nbsp;Xinyue Pang,&nbsp;Boyu Zhao,&nbsp;Lisha Tan,&nbsp;Quan Zhou,&nbsp;Lili Shao,&nbsp;Huiping Wang,&nbsp;Shuping Hou","doi":"10.1111/jocd.16781","DOIUrl":"10.1111/jocd.16781","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sensitive skin (SS) is a multifactorial syndrome that affects about half of the world's population. However, there is no standardized treatment protocol. Photovoltaic technology has been widely used in recent years for the treatment of sensitive skin, but the efficacy of low-energy delicate pulsed light (DPL) in the treatment of sensitive skin is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To explore the efficacy and safety of low-energy DPL treatment for sensitive skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 181 patients with SS who attended the Department of Dermatology from January 2019 to January 2022. All patients were treated with DPL (5.0–6.8 J/cm²). Patients received varying durations of DPL, with 4-week intervals based on the severity of their condition. Sensitivity scores at baseline and final treatment were collected using a 10-item sensitivity scale (SS-10). Facial erythema was assessed through the Clinician Erythema Assessment Scale (CEA) based on facial photographs taken at each visit. VISIA-CR was used to visualize and analyze facial redness at baseline and after the final treatment, and erythema values were recorded. Adverse reactions were documented during each treatment session.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 181 patients, 86 were SS alone, 32 were rosacea with SS, 32 were acne with SS, and 31 were dermatitis with SS. A significant difference was observed between patients' baseline and final SS-10 scores (<i>p</i> &lt; 0.001). Statistically significant differences were found between the patients' CEA scores at different visits (<i>p</i> &lt; 0.001). Clinical photographs demonstrated significant improvements in facial redness and skin color. VISIA-CR analysis showed a considerable reduction in erythema values at the final treatment visit compared to baseline (<i>p</i> &lt; 0.001). No obvious adverse effects were observed in any of the patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Low-energy DPL is an effective and safe treatment for sensitive skin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}