Journal of Cosmetic Dermatology最新文献

{"title":"Research Situation, Hotspots, and Global Trends in Laser Treatment of Acne Scars: A Bibliometric Analysis of Related Research From 2014 to 2024.","authors":"Yang Wen, Yuan Cai, Lanfang Zhang, Lin Li, Jing Wang, Feng Jiang, Nana Sun, Ni Zeng","doi":"10.1111/jocd.16663","DOIUrl":"https://doi.org/10.1111/jocd.16663","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a chronic inflammatory skin condition, commonly resulting in acne scars. Treating acne scars remains a significant challenge in dermatology. With advancements in laser technology, its clinical use for treating acne scars has been increasing annually. However, bibliometric analysis on laser treatment for acne scars is lacking. This study aims to use bibliometrics to comprehensively understand the development trends and research hotspots in laser treatment for acne scars.</p><p><strong>Methods: </strong>Using \"acne scar\" and \"laser\" as search terms, literature on laser treatment of acne scars from 2014 to 2024 was retrieved from the Web of Science Core Collection (WoSCC) database. The literature data were visualized using VOSviewers, CiteSpace, and R software, generating maps of countries, research institutions, authors, journals, references, and keywords.</p><p><strong>Results: </strong>The analysis included 536 articles from 46 countries, with the United States and China leading in publications. Publications focusing on laser treatment of acne scars exhibit a consistent growth trend annually. Key research institutions include Mahidol University in Thailand, Cairo University in Egypt, and Hallym University in South Korea. The \"Journal of Cosmetic Dermatology\" had the highest number of articles in this field, while \"Dermatologic Surgery\" was the most cited publication. These publications involved contributions from 2135 authors, with Professor Manuskiatti Woraphong from Mahidol University in Thailand being the most prolific author in this field. Research on the efficacy of laser treatment for acne scars is a major focus in this field. Among the different types of lasers, CO₂ lasers are the most commonly used. Emerging research focuses include therapies such as platelet-rich plasma, picosecond laser, trichloroacetic acid, and burn scar.</p><p><strong>Conclusions: </strong>Treatment efficacy is the primary focus of research in the field of laser treatment for acne scars. Platelet-rich plasma, and novel picosecond lasers, have emerged as hot topics and trends in this research field. However, it is important to note that the impact factors of journals publishing in this field are currently low. Therefore, clinicians must consider and explore strategies for publishing high-quality clinical research in the future.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anti-acne activity of human whole saliva against acne vulgaris: An in vitro study.","authors":"Tyween Jia Coutinho, Suneel Dodamani, Atrey J Pai Khot, Vaibhav Kumar, Sultan A Almalki, Inderjit M Gowdar","doi":"10.1111/jocd.16369","DOIUrl":"https://doi.org/10.1111/jocd.16369","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris (AV) is a multifactorial inflammatory skin disorder, affecting 9.45% of the world's population. AV can be painful, discomforting, and disfiguring due to scarring, leading to physiological distress, and economic burden. AV pathogenies can be due to various factors, key ones include follicular plugging, colonization by the microorganism, endocrinological factors, and inflammation. Gram-positive bacteria Cutibacterium acnes and Staphylococcus epidermidis are the most common pathogens isolated from patients with AV.</p><p><strong>Aim: </strong>The present study aimed to investigate the anti-acne activity of whole human saliva against bacteria that cause AV.</p><p><strong>Materials and methods: </strong>The saliva sample from four different individuals was collected at three different intervals. These samples were used to perform antimicrobial susceptibility test (AST) against the pathogens. Kirby-Bauer disk diffusion susceptibility test, and Broth dilution method using Resazurin were performed.</p><p><strong>Results: </strong>The human saliva was effective in inhibiting Cutibacterium acnes and Staphylococcus epidermidis those causing AV. The Minimum inhibitory activity and disc diffusion assay depicted potency of saliva. The pH of the saliva samples was found to be more acidic in the morning samples when compared with the evening samples. The afternoon sample was found to be more effective when compared with the other two intervals.</p><p><strong>Conclusions: </strong>Saliva shows effective anti-acne activity by inhibiting the growth and proliferation of acne-causing bacteria.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Afro-Caribbean Childhood Eruption Treated by Topical Erythromycin and Tretinoin.","authors":"Nesrine Ben Salah, Mouna Korbi, Houda Ben Abdelwahed, Ines Lahouel, Samiha Mabrouk, Monia Youssef, Hichem Belhadjali, Jameleddine Zili","doi":"10.1111/jocd.16646","DOIUrl":"https://doi.org/10.1111/jocd.16646","url":null,"abstract":"","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo.","authors":"Alireza Jafarzadeh, Arash Pour Mohammad, Azadeh Goodarzi","doi":"10.1111/jocd.16660","DOIUrl":"https://doi.org/10.1111/jocd.16660","url":null,"abstract":"<p><strong>Aims and objectives: </strong>The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.</p><p><strong>Method: </strong>We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles. After analyzing the studies, we categorized them accordingly.</p><p><strong>Results: </strong>This systematic review analyzed 48 articles involving 2186 patients with vitiligo to assess the effectiveness of regenerative medicine treatments. Key findings revealed that methods such as autologous non-cultured melanocyte-keratinocyte transplantation and platelet-rich plasma (PRP) injection exhibited significant repigmentation, particularly when combined with modalities like NB-UVB phototherapy and laser treatments. Notably, the autologous melanocyte-keratinocyte transplantation achieved over 50% repigmentation within 9 months, while PRP demonstrated an average repigmentation of 58.7%, especially effective with CO₂ laser treatment. Hair follicle-derived cell transplantation also showed impressive response rates, achieving good to excellent results in up to 93.8% of patients. Side effects were noted in 21 of 28 studies, primarily involving pain, with no serious adverse events reported. The risk of bias assessment indicated that 37.21% of studies were low risk, while 48.84% had high risks overall. These findings suggest that while regenerative medicine holds promise for vitiligo treatment, further clinical trials are necessary to explore additional methods like stromal vascular fraction and exosomes.</p><p><strong>Conclusion: </strong>We have concluded that regenerative medicine plays an effective role in the treatment of vitiligo lesions. Furthermore, this treatment method is safe and does not cause serious complications. It can be used alone or in combination with other methods for treating vitiligo. To advance the treatment of vitiligo, we recommend conducting clinical trials on the unexplored branches of regenerative medicine.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin Combined Laser/Light-Based Treatments Versus Isotretinoin Alone for the Treatment of Acne Vulgaris: A Meta-Analysis.","authors":"Shi-Xin He, Yi Wang, Jun Wang, Li Tang, Li Yang, Fei-Lun Ye","doi":"10.1111/jocd.16639","DOIUrl":"https://doi.org/10.1111/jocd.16639","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare the efficacy and safety of oral isotretinoin with and without laser/light-based treatments for acne.</p><p><strong>Methods: </strong>This study was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines; this meta-analysis utilized data from PubMed, EMBASE, ClinicalTrial.gov, and the Cochrane Central Register of Controlled Trials until December 2023. We evaluated clinical improvement, lesion reduction, adverse events, as well as intraoperative and postoperative discomfort rates. Analyses were performed using Review Manager 5.3.</p><p><strong>Results: </strong>This review included six articles with a total of 285 patients. Isotretinoin combined with laser/light therapy outperformed in clinical improvement rates, significantly reducing acne vulgaris and acne scars lesions compared to isotretinoin alone. Additionally, there was no significant difference in the incidence of adverse events between the two groups.</p><p><strong>Conclusion: </strong>The study suggests that combining isotretinoin with laser/light-based therapy for acne yields superior efficacy and satisfaction without increased complications (e.g., dryness, hyperpigmentation, and scarring). However, patients experience notable treatment-related discomfort.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in Aesthetic/Cosmetic Dermatology: Current and Future.","authors":"Sukruthi Thunga, Marius Khan, Soo Ick Cho, Jung Im Na, Jane Yoo","doi":"10.1111/jocd.16640","DOIUrl":"https://doi.org/10.1111/jocd.16640","url":null,"abstract":"<p><strong>Background: </strong>Recent advancements in artificial intelligence (AI) have significantly impacted dermatology, particularly in diagnosing skin diseases. However, aesthetic dermatology faces unique challenges due to subjective evaluations and the lack of standardized assessment methods.</p><p><strong>Aims: </strong>This review aims to explore the current state of AI in dermatology, evaluate its application in diagnosing skin conditions, and discuss the limitations of traditional evaluation methods in aesthetic dermatology. Additionally, the review proposes strategies for future integration of AI to address existing challenges.</p><p><strong>Methods: </strong>A comprehensive review of AI applications in dermatology was conducted, in both diagnostic and aesthetic fields. Traditional methods such as subjective surveys and hardware devices were analyzed and compared with emerging AI technologies. The limitations of current AI models were evaluated, and the need for standardized evaluation methods and diverse datasets was identified.</p><p><strong>Results: </strong>AI has shown great potential in diagnosing skin diseases, particularly skin cancer. However, in aesthetic dermatology, traditional methods remain subjective and lack standardization, therefore limiting their effectiveness. Emerging AI applications in this field show promise, but they have significant limitations due to biased datasets and inconsistent evaluation methods.</p><p><strong>Conclusions: </strong>To develop the potential of AI in aesthetic dermatology, it is crucial to create standardized evaluation methods, collect diverse datasets reflecting various ethnicities and ages, and educate practitioners on AI's utility and limitations. Addressing these challenges will improve diagnostic accuracy, better patient outcomes, and help integrate AI effectively into clinical practice.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser and Skin-Care Synergy: A Post-Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face.","authors":"Marianna Blyumin-Karasik, Jessica Colon, Sylvie Nguyen, Jordan Rosen","doi":"10.1111/jocd.16668","DOIUrl":"https://doi.org/10.1111/jocd.16668","url":null,"abstract":"<p><strong>Background: </strong>Laser procedures are often used for global improvement in skin quality. The state of the skin is under stress after laser treatment, and it is beneficial to utilize topical agents to assist with optimal healing and cosmetic outcomes. Currently, such post-laser-cosmeceutical synergies are being investigated. Skin adaptogens are bioactive ingredients that enhance the skin's resistance and adaptation to stress.</p><p><strong>Aim: </strong>Investigate the use of an adaptogenic moisturizing serum (AMS) in synergy with post-laser treatment recovery.</p><p><strong>Patient/methods: </strong>Eight patients underwent long-pulsed 755-nm alexandrite or 1064-nm picosecond laser treatments on the face, targeting photoaging and pigmentation. After the laser treatment, during their healing process, they utilized a novel AMS twice daily to assist with the post-laser recovery. A blinded expert grader evaluated before and after facial images of each patient using a modified Griffiths photodamage photonumeric scale.</p><p><strong>Results: </strong>The findings revealed that the AMS was well-tolerated with no reported adverse events, and elicited aesthetically pleasing results. There was a significant decrease in photodamage scores following the treatment (p = 0.0078) with a median reduction of 3.5. Patients had improvement in skin photodamage, pigmentation, and skin radiance in clinic and photography after a combination of laser and AMS serum treatments.</p><p><strong>Conclusion: </strong>Utilizing the adaptogen moisturizing serum skin care regimen after the laser treatments likely assisted in the skin's healing process. As a result, we propose that there is a potential benefit of combining certain laser treatments and an adaptogen-based skin care regimen for better aesthetic outcomes and skin recuperation post-procedure.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Effectiveness of Platelet-Rich Plasma Alone Versus Combined With Microneedles or Radiofrequency for Neck Wrinkle Treatment.","authors":"Ke-Cheng Li, Zi-Zhe Lin, Zhi-Dan Zhang, Shan Xie, Guang-Hui Xie","doi":"10.1111/jocd.16651","DOIUrl":"10.1111/jocd.16651","url":null,"abstract":"<p><strong>Background: </strong>Neck wrinkles are a prominent characteristic of skin aging, with recent studies indicating that interventions such as platelet-rich plasma (PRP), microneedling (MN), and radiofrequency (RF) can effectively rejuvenate aging skin.</p><p><strong>Aims: </strong>This study aims to assess and compare the efficacy of three treatment modalities in addressing neck wrinkles.</p><p><strong>Methods: </strong>Fifteen female participants with a neck Lemperle Wrinkle Assessment Scale (WAS) score of 3-4 were enrolled in a randomized clinical trial. The subjects were randomly assigned to three treatment groups: PRP injection, MN + PRP topical PRP application, and RF + PRP injection. They received treatment once a month for three consecutive months, and a clinical outcome evaluation was performed at 1 and 6 months after the final treatment.</p><p><strong>Results: </strong>The WAS scores and global aesthetic improvement score (GAIS) demonstrated notable enhancements 1 month postfinal treatment across all three groups, with a notably greater number of participants experiencing improved outcomes in the RF + PRP group 6 months posttreatment. Specifically, at the 1-month follow-up, the RF + PRP group exhibited a statistically significant enhancement in skin elasticity and collagen, surpassing the improvements observed in the other two groups (p < 0.05). No significant disparities in skin elasticity and collagen were detected in all groups prior to and after 6 months of treatment. Adverse events were mild and transient, such as redness, swelling, bruising, and pain.</p><p><strong>Conclusion: </strong>This study revealed that all the treatments can effectively improve neck wrinkles 1 month after the last treatment. A better therapeutic effect could be observed in the RF + PRP group compared with the other two groups at 6 months after the last treatment.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Chronic Moderate Psychological Stress on Skin Aging: Exploratory Clinical Study and Cellular Functioning.","authors":"Muriel Pujos, Cécile Chamayou-Robert, Marine Parat, Magali Bonnet, Sandra Couret, Alessia Robiolo, Olivier Doucet","doi":"10.1111/jocd.16634","DOIUrl":"10.1111/jocd.16634","url":null,"abstract":"<p><strong>Introduction: </strong>Skin is continuously exposed to environmental external and internal factors, including psychological stress (PS). PS has been reported to trigger different dermatoses such as psoriasis, atopic dermatitis, vitiligo, alopecia areata, and acne through the release of cortisol and epinephrine.</p><p><strong>Objective: </strong>To clinically explore PS-induced measurable skin aging signs in subjects with moderate versus mild chronic PS, and to investigate the effect of chronic PS on DNA damage at cellular level.</p><p><strong>Methods: </strong>In vitro stress tests with cortisol and epinephrine, and with cortisol only on extracellular matrix (ECM) synthesis, as well as on normal human skin fibroblast and keratinocyte functioning, including skin barrier and wound healing were performed.</p><p><strong>Results: </strong>Moderately stressed subjects in the context of the clinical study had a significantly decreased antioxidant potential and impacted skin barrier integrity, as well as significantly increased signs of microrelief alterations (skin texture and fine lines) reaching an increased severity of about 32.9%. At a cellular level, DNA integrity, ECM synthesis, wound healing, and skin barrier parameters were impacted by increased stress hormone levels.</p><p><strong>Conclusion: </strong>The clinical exploratory studies presented herewith, as well as the study of cell functioning under stress, have provided evidence that chronic PS significantly affects skin homeostasis and triggers skin aging.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes and Safety Profile of a Dextranomer-Hyaluronic Acid Hybrid Filler: A Case Series Analysis.","authors":"Nazaret Ruiz, Roberto Miranda Lopez, Ruben Marques, Silvia Fontenete","doi":"10.1111/jocd.16653","DOIUrl":"https://doi.org/10.1111/jocd.16653","url":null,"abstract":"<p><strong>Background: </strong>The demand for aesthetic treatments targeting the middle and lower face is on the rise, especially because of changes in appearance associated with aging.</p><p><strong>Aim: </strong>This study aimed to assess the use of a hybrid filler for sculpting and contouring of the chin, jaw, and malar region.</p><p><strong>Methods and materials: </strong>A retrospective analysis was performed on patients who underwent jaw and chin contouring and cheek augmentation using a hybrid filler (hyaluronic acid and dextranomer). The evaluation focused on the naturalness of appearance, enhancement in volume, and the durability of the results, employing a 5-point scale. Both patient satisfaction and physician evaluations were measured using the Likert scale and the Global Aesthetic Improvement Scale (GAIS), respectively. Follow-up with patients extended up to 6 months after treatment, during which any treatment-related adverse events (AEs) were meticulously recorded and analyzed.</p><p><strong>Results: </strong>Nineteen patients participated in the study, receiving an average injection volume of 2.4 ± 0.9 mL to attain the desired outcomes. The evaluation of natural appearance, volumizing effects, and durability at the analyzed time point consistently scored above 4. All 19 patients' aesthetic improvement was evaluated as \"very much improved\" and \"much improved\", at the GAIS score. All patients report improvement in their appearance, with 89.5% rating it as \"very much improved\" or \"much improved\" on the Likert scale. Only expected AEs such as mild pain and lower swelling were registered.</p><p><strong>Conclusion: </strong>The hybrid filler proved effective and safe for facial contouring, with significant patient satisfaction and minimal adverse effects.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}