Journal of Cosmetic Dermatology最新文献

{"title":"NoTox Tweakments: Evidence for Topical Neurocosmetic Peptides as Needle-Free Neuromodulators for Facial Wrinkle Reduction—A Systematic Review","authors":"Phyo Zaw Aung, Thamthiwat Nararatwanchai","doi":"10.1111/jocd.71137","DOIUrl":"https://doi.org/10.1111/jocd.71137","url":null,"abstract":"<p>“NoTox Tweakments” is a term that captures an emerging class of topical neurocosmetic peptides designed to mimic the wrinkle-relaxing mechanism of botulinum toxin type A (BoNT-A) without the need for injections. The name derives from the combination of <i>nontoxic</i>, <i>non-injection</i>, and tweak-level aesthetic adjustment. As patient demand for needle-free aesthetic procedures continues to grow, compounds such as acetyl hexapeptide-8 (AHP-8, Argireline), Leuphasyl, Syn-Ake, and Myoxinol have entered the cosmeceutical market with claims of SNARE-complex inhibition and consequent reduction of dynamic and static facial wrinkles. Despite commercial proliferation, a rigorous synthesis of their evidence base relative to the established gold standard of injectable BoNT-A has been lacking.</p><p>Injected BoNT-A represents the current gold standard for dynamic facial wrinkle reduction. In pivotal phase III trials, a single treatment with onabotulinumtoxinA (20 U) achieved responder rates of 63.9%–89.5% at day 30 for glabellar lines and crow's feet, with effects sustained for approximately 3–6 months before reinjection is required [<span>1, 2</span>]. Its mechanism involves complete, localized neuromuscular blockade, producing rapid paralysis of targeted mimetic muscles. However, injectable BoNT-A carries known limitations: requirement for trained administration, risk of ptosis or adjacent muscle paralysis, contraindications in pregnancy, and the need for repeated procedures every 3–5 months to maintain effect.</p><p>We conducted a PRISMA 2020-compliant systematic review registered with PROSPERO (CRD420261405299) to evaluate the efficacy and safety of topical botulinum toxin-like peptides. We searched PubMed, Scopus, Web of Science, and CENTRAL from inception to June 2026, retrieving 847 records. After deduplication and screening, 11 studies met eligibility criteria: 7 randomized controlled trials, 3 prospective observational studies, and 1 single-group uncontrolled trial, enrolling 412 participants total. The PRISMA flow is presented in Figure 1.</p><p>Efficacy findings were clinically meaningful, though quantitatively more modest than injectable BoNT-A. AHP-8 at 10% concentration produced a 48.9% reduction in periorbital wrinkle depth versus 0% in placebo controls at 4 weeks (<i>n</i> = 60) [<span>3</span>]. A multi-peptide serum demonstrated a 100% responder rate for fine-line improvement and 67% for deeper wrinkles versus placebo at 12 weeks (<i>p</i> < 0.001; <i>n</i> = 56) [<span>4</span>]. A dual-peptide serum combining AHP-8 and Syn-Ake achieved a 35%–69% improvement in static wrinkles and 10%–13% reduction in dynamic wrinkle depth at 12 weeks [<span>5</span>]. These gains are lower in absolute magnitude than the 64%–90% responder rates achieved with injectable BoNT-A at 4 weeks [<span>1, 2</span>], yet are particularly notable for static wrinkles, which injectable BoNT-A addresses less effectively [<span>6</span>]. Topical peptides also","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of a Hydrolyzed Collagen Formulation (HYCOS) for Facial Skin Elasticity and Wrinkles: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Sutthinee Wisutthathum, Preeyanuch Pimjuk, Nitina Yeesibsean, Katechan Jampachaisri, Panlop Chakkavittumrong, Warisara Pasri, Pichet Kittikun, Supaporn Tuanthai, Thanwarat Suebwongfag, Tanyarat Sutti, Jew Puay Tay, Anjana Fuangchan, Neti Waranuch","doi":"10.1111/jocd.71121","DOIUrl":"https://doi.org/10.1111/jocd.71121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral collagen supplements are widely marketed for improving skin aging parameters, however, high-quality clinical evidence for multi-ingredient formulations in Asian populations remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study evaluated the safety and efficacy of a hydrolyzed collagen formulation (HYCOS) on facial skin parameters in healthy Thai volunteers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A 12-week double-blind, randomized placebo-controlled trial was conducted in 140 Thai participants aged 30–60 with mild-to-moderate facial wrinkles. Participants were received either HYCOS collagen (hydrolyzed collagen with Glutathione and Vitamin E) or a placebo drink. Skin hydration, elasticity, and crow's feet wrinkle roughness were measured using Corneometer, Cutometer, and 3D skin imaging (PRIMOS<sup>CR</sup>), respectively. Dermatologist wrinkle grading and participant self-assessment were collected. Safety was evaluated through adverse event monitoring and blood/urine biochemical testing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 135 participants completed the study (test product, <i>n</i> = 66; placebo, <i>n</i> = 69). After 12 weeks, both groups showed significant increases in skin hydration (<i>p</i> < 0.001), with no between-group difference. The test product group demonstrated greater improvements in skin elasticity; gross elasticity (R2), net elasticity (R5), and overall elasticity (R7) compared with placebo (<i>p</i> < 0.05). Crow's feet wrinkle roughness analysis revealed significantly greater reductions in wrinkle roughness in the test product group than in the placebo group at week 12. No product-related adverse events were observed, and laboratory values remained within normal ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Daily supplementation with HYCOS collagen formula for 12 weeks was safe and well tolerated, with significant improvements in skin elasticity and wrinkle roughness. Increases in skin hydration were observed in both groups, suggesting that this effect may be influenced by hydration-related or behavioural factors rather than the supplement alone. Overall, HYCOS supplementation may provide beneficial effects on skin aging parameters in healthy adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Thai Clinical Trial","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Post-Inflammatory Hyperpigmentation: Molecular Mechanisms and Advances in Dermocosmetic Management","authors":"","doi":"10.1111/jocd.71159","DOIUrl":"https://doi.org/10.1111/jocd.71159","url":null,"abstract":"<p>\u0000 <b>RETRACTION</b>: <span>R. Li</span>, <span>B. Li</span>, <span>Q. Zhang</span>, <span>C. Zhao</span>, <span>C. Ye</span>, <span>Y. Chen</span>, <span>C. Huguet</span>, <span>W. Xiong</span>, <span>V. Beguin</span>, <span>D. Kerob</span>, and <span>Y. Zheng</span>, “ <span>Post-Inflammatory Hyperpigmentation: Molecular Mechanisms and Advances in Dermocosmetic Management</span>,” <i>Journal of Cosmetic Dermatology</i> <span>25</span>, no. <span>6</span> (<span>2026</span>): e70738, https://doi.org/10.1111/jocd.70738.\u0000 </p><p>The above article, published online on 28 May 2026 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Michael H. Gold; and Wiley Periodicals LLC. The retraction has been agreed upon following a request from the authors. The authors acknowledged that not all authors had reviewed and approved the final version of the manuscript prior to submission. Furthermore, the article contains incorrect information, including the misclassification of a UV-induced pigmentation model as post-inflammatory hyperpigmentation (PIH), which resulted in a systematic bias in the pooled effect size and the GRADE evidence assessment. The authors acknowledge that this error may mislead clinical decision-making regarding the efficacy of dermocosmetic products for the treatment of PIH. The editors agree with the authors that retraction of the article is appropriate.</p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective, Active-Controlled Split-Face Clinical Trial Evaluating the Incremental Aesthetic Benefits of a Glutathione-Containing Booster in a GHK-Conjugated Spicule Regimen","authors":"Seongmin Noh,&nbsp;Wonkyu Hong,&nbsp;Hosung Choi,&nbsp;Youngjin Park,&nbsp;Do Young Rhee","doi":"10.1111/jocd.71129","DOIUrl":"https://doi.org/10.1111/jocd.71129","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Transdermal delivery of hydrophilic peptides such as GHK remains limited by the stratum corneum barrier and the classical 500 Da rule. Spicule-based systems and redox-responsive linkages have been investigated as strategies to enhance epidermal delivery, but in vivo glutathione-triggered cleavage remains a proposed mechanism rather than a clinically proven process.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aimed to evaluate the clinical efficacy and safety of a GHK-conjugated spicule regimen and to determine whether adding a multi-ingredient, glutathione-containing booster provides incremental aesthetic benefit compared with the shared base regimen alone.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this prospective, active-controlled split-face clinical trial, 20 healthy Asian women received five weekly facial treatments. One prespecified facial side received the base regimen consisting of a GHK-conjugated spicule system and base concentrate, while the contralateral side received the same base regimen plus a separate multi-ingredient booster containing 1% glutathione. Wrinkle depth, pore parameters, skin elasticity, dermal density, surface roughness, and pigmentation were evaluated at baseline, after one and three treatment sessions, and 4 weeks after the fifth session. Between-side comparisons were performed using change-from-baseline values, with prespecified primary endpoints, multiplicity adjustment, and effect-size reporting.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Both sides showed improvements from baseline. At the final timepoint, the intensive regimen produced greater improvements than the base regimen in periorbital wrinkle depth (−0.0144 vs. −0.0084 mm), nasolabial wrinkle depth (−0.0227 vs. −0.0173 mm), dermal density (+7.27 vs. +4.49), roughness (−1.23 vs. −0.73 μm), and mean pore volume (−0.0007 vs. −0.0005 mm&lt;sup&gt;3&lt;/sup&gt;). Multiplicity-adjusted between-side differences remained significant for the prespecified primary endpoints and secondary endpoints. No adverse effects were reported.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The GHK-conjugated spicule base regimen improved multiple facial aging indicators, and the booster-inclusive intensive regimen produced statistically greater short-term improvements in this small split-face trial. Because the booster was multi-ingredient and the release mechanism was not directly measured in vivo, these findings should ","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polynucleotides HPT-Based Dermal Filler for Skin Rejuvenation: A Prospective Clinical Investigation","authors":"Chiara Teramo,&nbsp;Andrea Mattioli,&nbsp;Carolina Prussia","doi":"10.1111/jocd.71154","DOIUrl":"https://doi.org/10.1111/jocd.71154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Polynucleotides (PN)-based dermal fillers are increasingly used for skin rejuvenation due to their biocompatibility and regenerative properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to confirm the efficacy and safety of Plinest (Mastelli) in improving skin hydration of the face, neck, and décolleté over 4 months follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients/Methods</h3>\u0000 \u0000 <p>Participants received three injections at 2-week intervals (at visits V0, V1, and V2), with follow-up at two (V3) and 4 months (V4) after last injection. The primary outcome was aesthetic improvement measured by the Global Aesthetic Improvement Scale (GAIS), while secondary outcomes included skin hydration, elasticity, turgor, patient satisfaction, and tolerability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-eight subjects were enrolled. GAIS scores showed significant improvement across all areas from baseline to V4, with a median increase of 2 points, as reported by subjects and investigator. At V1, facial skin hydration increased from 48.8% ± 5.9% to 50.4% ± 6.9%, with similar trends in neck and décolleté. A slight decline was observed at V2, followed by a peak at V3 before stabilizing at V4 (face: 49.6% ± 6.2%, neck: 50.6% ± 7.3%, décolleté: 47.4% ± 4.1%). Skin elasticity improved between V0 and V4, with mean differences ranging from 5 to 11 N/m. Pain was moderate, with higher intensity in the face and neck compared to the décolleté. Despite this, participants were highly satisfied, with scores between 4 and 5 at V3 and V4. Adverse events were mild and transient.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings confirm the efficacy and safety of the device in improving skin hydration and demonstrate high patient satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148848819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Vitiligo: FDA Adverse Events Reporting System (FAERS) and Canada Vigilance Adverse Reaction (CAVR) Database Analysis and Literature Review","authors":"Yuhao Li,&nbsp;Yi Ou,&nbsp;Luyue Chang,&nbsp;Ruiyao Wang,&nbsp;Xinyi Shao,&nbsp;Jingbo Zhang,&nbsp;Jin Chen","doi":"10.1111/jocd.71149","DOIUrl":"https://doi.org/10.1111/jocd.71149","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitiligo is a common chronic acquired pigmentation disease, that usually occurs with an asymptomatic whitish patch or macule. Although previous studies have reported several cases of drug-induced vitiligo, there are few comprehensive studies determining the drugs that induce vitiligo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study investigated the risk factors for drug-induced vitiligo by analyzing a large dataset from the FDA Adverse Event Reporting System (FAERS) and the Canada Vigilance Adverse Reaction (CVAR) database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Disproportionality analysis using the reporting odds ratio (ROR) method, with <i>p</i>-values adjusted via Bonferroni correction, identified significant signals. Drugs with positive signals were analyzed for annual reporting trends using linear regression. Time-to-onset analysis was also performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 1910 reports in FAERS and 316 reports in the CAVR database related to vitiligo. Disproportionality analysis revealed significant signals for 57 drugs in FAERS and 7 drugs in the CAVR database. Most were antineoplastic drugs and immune inhibitors with significant annual increases in vitiligo reports. Through reviewing reports of immune inhibitors induced vitiligo, we found that the severity of the disease may be related to the occurrence of vitiligo AE. The median time to onset of vitiligo was 86 days, with over half of the cases occurring within 90 days of initiating medication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study confirmed safety signals associated with various antineoplastic agents and immune inhibitors, highlighting the importance of ongoing pharmacovigilance. Further mechanistic investigations are needed to clarify the pathological pathways underlying drug-induced vitiligo.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Yellow Light Monotherapy Versus Yellow Light Combined With 20% Vitamin C for the Treatment of Melasma: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Study","authors":"Dan Du,&nbsp;Xu Liu,&nbsp;Yuwei Huang,&nbsp;Shuwei Wu,&nbsp;Xian Jiang","doi":"10.1111/jocd.71146","DOIUrl":"https://doi.org/10.1111/jocd.71146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melasma treatment remains challenging due to limited effective and safe options. This study evaluated the efficacy and safety of yellow light phototherapy alone versus combined with 20% vitamin C in treating melasma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventy-one patients were randomly assigned to receive twice-weekly yellow light phototherapy combined with either 20% vitamin C solution (<i>n</i> = 35) or its corresponding vehicle (<i>n</i> = 36). The primary outcome was the change from baseline in modified Melasma Area and Severity Index (mMASI) score. Secondary outcomes consisted of changes relative to baseline in Physician Global Assessment (PGA), Subjective Satisfaction Assessment (SA), melanin index (MI), individual typology angle (ITA°), transepidermal water loss (TEWL), skin hydration content (SCH), skin pore and skin texture parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At Week 12, the combination group exhibited significantly greater reductions in mMASI scores (−1.95 ± 2.11 vs. −0.69 ± 2.19, <i>p</i> = 0.027) and lower Physician Global Assessment (PGA) scores (4.48 ± 0.80 vs. 5.06 ± 0.54, <i>p</i> = 0.002) compared with the monotherapy group. The combination group exhibited a more remarkable decrease in melanin index (MI) (−13.07, 95% CI: −17.82, −8.32 vs. −3.16, 95% CI: −7.86, 1.54, <i>p</i> = 0.005) and a more prominent elevation in individual typology angle (ITA°) (6.23, 95% CI: 4.38, 8.08 vs. 1.23, 95% CI: −0.60, 3.05) (<i>p</i> &lt; 0.001). Moreover, significant improvements in skin pore status and skin texture were noted in the combination group (<i>p</i> &lt; 0.05). No statistically significant between-group differences were found in transepidermal water loss (TEWL) and skin hydration (SCH). No adverse events occurred throughout the trial. The participant treatment satisfaction rate reached 60.00% in the combination group, which was significantly higher than 22.55% in the control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combined 20% vitamin C plus yellow light phototherapy yielded statistically superior melasma improvements relative to yellow light monotherapy, though the absolute reduction in mMASI was modest. The combination regimen preserved skin barrier function and exhibited good tolerability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discharge Mode Enhances the Energy Efficiency of Radiofrequency Microneedle: An In Vivo Porcine Study of Optimized Histological Responses Under Constant Total Energy","authors":"Jiayi Feng,&nbsp;Xuelai Wang,&nbsp;Ling Zhang,&nbsp;Shize Ma,&nbsp;Lvping Huang","doi":"10.1111/jocd.71158","DOIUrl":"https://doi.org/10.1111/jocd.71158","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To explore the immediate histological effects of insulated (IMRF) and non-insulated (NMRF) radiofrequency microneedles across different discharge modes under a constant total energy, and to evaluate long-term collagen remodeling specifically in the classical discharge mode.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The backs of Bama pigs (&lt;i&gt;n&lt;/i&gt; = 3) were assigned to the classical and sequential discharge modes under IMRF and NMRF treatments at a fixed total energy (1000 mJ). The classical discharge mode group was set as follows: high power and short pulse width (Group A), medium power and medium pulse width (Group B), low power and long pulse width (Group C), and the sequential discharge mode group (ultra-high power and ultra-short pulse width). IMRF and NMRF were used for treatment. The microthermal zone (MTZ) was evaluated and quantified by hematoxylin and eosin (HE) staining immediately after the treatment. Three months after the procedure, the skin lesions were extracted, and the mRNA expression of collagen type I and III was quantitatively evaluated by real-time PCR.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Under the classical discharge mode with constant total energy delivery, a higher power level in IMRF resulted in greater MTZ density (&lt;i&gt;p&lt;/i&gt; = 0.014), whereas no significant differences were observed in the depth and width of sub-damage lesions and coagulation zones. In contrast, NMRF failed to produce typical MTZs under any of the three parameter settings. At the 3-month follow-up, type I collagen expression was significantly upregulated in both A and B groups of IMRF (I-A &lt;i&gt;p&lt;/i&gt; = 0.002, I-B &lt;i&gt;p&lt;/i&gt; = 0.001), while type III collagen expression showed no notable change among all groups (&lt;i&gt;p&lt;/i&gt; = 0.671). Under the sequential discharge mode, a sharp increase in single-needle peak power led to the formation of dense MTZs in both IMRF and NMRF. Compared with the medium-power classic mode in the classical discharge mode, the sequential discharge mode resulted in significantly higher MTZ density (IMRF &lt;i&gt;p&lt;/i&gt; = 0.002; NMRF &lt;i&gt;p&lt;/i&gt; = 0.011). Furthermore, the sub-damage lesion depth was significantly greater with IMRF than with NMRF (NMRF vs. I-B &lt;i&gt;p&lt;/i&gt; = 0.017; NMRF vs. IMRF &lt;i&gt;p&lt;/i&gt; = 0.01).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;MTZ formation is highly dependent on the per-needle power threshold rather than the total energy applied, and is closely associated with the upregulation of type I collagen. The sequential discharge mode, via a “high-power ultrashort pulse width” me","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148807797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"","doi":"10.1111/jocd.71142","DOIUrl":"https://doi.org/10.1111/jocd.71142","url":null,"abstract":"<p>The cover image is based on the article <i>Different Reconstitution Behaviors of Two Poly-L-Lactic Acid Biostimulator Formulations: A Mechanistic Hypothesis</i> by Chuan-Yuan Lin et al., https://doi.org/10.1111/jocd.71081.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"","doi":"10.1111/jocd.71134","DOIUrl":"https://doi.org/10.1111/jocd.71134","url":null,"abstract":"<p>The cover image is based on the article <i>Calcium Hydroxylapatite-Based Fillers in Dorsal Hand Rejuvenation: A Practical Checklist for Formulation and Protocol Specificity</i> by Chuan-Yuan Lin, https://doi.org/10.1111/jocd.71024.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"25 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.71134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}