Marcelo Germani, Victor R. M. Munoz-Lora, Jeremy B. Green, Brain S. Biesman, Galen Perdikis, Rod J. Rohrich, Arthur Swift, Michael Alfertshofer, Sebastian Cotofana
{"title":"探讨glabella神经调节剂注射收缩模式的临床价值-一项基于3点glabella注射技术的临床回顾性研究","authors":"Marcelo Germani, Victor R. M. Munoz-Lora, Jeremy B. Green, Brain S. Biesman, Galen Perdikis, Rod J. Rohrich, Arthur Swift, Michael Alfertshofer, Sebastian Cotofana","doi":"10.1111/jocd.70147","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Since the introduction of glabellar contraction patterns as a guide for neuromodulator treatments, feedback regarding its clinical utility has been mixed. Recent studies have cast doubt on the value of such contraction-pattern-driven treatment paradigms.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>The aim of this retrospective study is to evaluate the clinical outcome of identical glabellar injections independent of glabellar contraction pattern types.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Forty-two Brazilian, multi-ethnic, consecutive patients with moderate to very severe glabellar lines were included in this retrospective analysis. The same 3-point glabellar injection technique was utilized, administering a total of 37.5 sU (=15 IU) to the procerus and corrugator supercilii muscles. Glabellar severity was assessed at 20 and 90 days after the initial treatment.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Across the entire study sample, a highly statistically significant improvement was observed at all investigated follow-up time points (<i>p</i> < 0.001). When comparing the treatment outcome across the five different glabellar contraction patterns, there was no statistically significant difference detected at either 20 days follow-up (<i>p</i> = 0.373) or 90 days follow-up (<i>p</i> = 0.311). Multivariate analyses confirmed that neither age, BMI, Fitzpatrick skin type, nor glabellar contraction patterns statistically influenced the outcome at 90 days (all <i>p</i> > 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results of this retrospective analysis revealed that in the sample investigated, no statistically significant differences were detected between patients with different glabellar contraction patterns at any of the conducted follow-up visits when the same glabellar injection technique with the same amount of toxin units was administered.</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70147","citationCount":"0","resultStr":"{\"title\":\"Investigating the Clinical Merit of Contraction Patterns for Glabellar Neuromodulator Injections—A Clinical Retrospective Investigation Following the 3-Point Glabellar Injection Technique\",\"authors\":\"Marcelo Germani, Victor R. M. Munoz-Lora, Jeremy B. Green, Brain S. Biesman, Galen Perdikis, Rod J. Rohrich, Arthur Swift, Michael Alfertshofer, Sebastian Cotofana\",\"doi\":\"10.1111/jocd.70147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Since the introduction of glabellar contraction patterns as a guide for neuromodulator treatments, feedback regarding its clinical utility has been mixed. Recent studies have cast doubt on the value of such contraction-pattern-driven treatment paradigms.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The aim of this retrospective study is to evaluate the clinical outcome of identical glabellar injections independent of glabellar contraction pattern types.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Forty-two Brazilian, multi-ethnic, consecutive patients with moderate to very severe glabellar lines were included in this retrospective analysis. The same 3-point glabellar injection technique was utilized, administering a total of 37.5 sU (=15 IU) to the procerus and corrugator supercilii muscles. Glabellar severity was assessed at 20 and 90 days after the initial treatment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Across the entire study sample, a highly statistically significant improvement was observed at all investigated follow-up time points (<i>p</i> < 0.001). When comparing the treatment outcome across the five different glabellar contraction patterns, there was no statistically significant difference detected at either 20 days follow-up (<i>p</i> = 0.373) or 90 days follow-up (<i>p</i> = 0.311). Multivariate analyses confirmed that neither age, BMI, Fitzpatrick skin type, nor glabellar contraction patterns statistically influenced the outcome at 90 days (all <i>p</i> > 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The results of this retrospective analysis revealed that in the sample investigated, no statistically significant differences were detected between patients with different glabellar contraction patterns at any of the conducted follow-up visits when the same glabellar injection technique with the same amount of toxin units was administered.</p>\\n </section>\\n </div>\",\"PeriodicalId\":15546,\"journal\":{\"name\":\"Journal of Cosmetic Dermatology\",\"volume\":\"24 4\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70147\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cosmetic Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70147\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70147","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Investigating the Clinical Merit of Contraction Patterns for Glabellar Neuromodulator Injections—A Clinical Retrospective Investigation Following the 3-Point Glabellar Injection Technique
Background
Since the introduction of glabellar contraction patterns as a guide for neuromodulator treatments, feedback regarding its clinical utility has been mixed. Recent studies have cast doubt on the value of such contraction-pattern-driven treatment paradigms.
Objective
The aim of this retrospective study is to evaluate the clinical outcome of identical glabellar injections independent of glabellar contraction pattern types.
Methods
Forty-two Brazilian, multi-ethnic, consecutive patients with moderate to very severe glabellar lines were included in this retrospective analysis. The same 3-point glabellar injection technique was utilized, administering a total of 37.5 sU (=15 IU) to the procerus and corrugator supercilii muscles. Glabellar severity was assessed at 20 and 90 days after the initial treatment.
Results
Across the entire study sample, a highly statistically significant improvement was observed at all investigated follow-up time points (p < 0.001). When comparing the treatment outcome across the five different glabellar contraction patterns, there was no statistically significant difference detected at either 20 days follow-up (p = 0.373) or 90 days follow-up (p = 0.311). Multivariate analyses confirmed that neither age, BMI, Fitzpatrick skin type, nor glabellar contraction patterns statistically influenced the outcome at 90 days (all p > 0.05).
Conclusion
The results of this retrospective analysis revealed that in the sample investigated, no statistically significant differences were detected between patients with different glabellar contraction patterns at any of the conducted follow-up visits when the same glabellar injection technique with the same amount of toxin units was administered.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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