Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-04-24 DOI:10.1111/jocd.70198

Rongli Yang, Yiyang Bai, Chang Liu, Jintian Luo, Yajie Yang, Shaoli Cheng, Muyan Zou, Xin Mu

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引用次数: 0

Abstract

Background

Acne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement.

Objective

This study aimed to explore the clinical efficacy and safety of botulinum toxin A combined with hyaluronic acid in improving facial pore enlargement.

Method

A retrospective study was conducted on 40 acne patients with enlarged pores. Botulinum toxin A and non-cross-linked hyaluronic acid compound were injected into the patient's face using mesotherapy with nine 32-gauge microneedles. VISIA was used to record the conditions of facial pores, texture, and porphyrins. The physician's assessment of the improvement score and the patient satisfaction evaluation are used to evaluate the treatment effect.

Result

One month after treatment, the combination of botulinum toxin and non-cross-linked hyaluronic acid compound significantly improved facial pore enlargement. Although the effects decreased, the conditions of facial pores, texture, and porphyrins 4 months after treatment still had a significant difference from those at baseline.

Conclusion

The combination of botulinum toxin A and non-cross-linked hyaluronic acid compound is safe and effective in treating enlarged pores, indicating its promotional value.

Abstract Image

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肉毒毒素A和透明质酸联合使用，改善粉刺引起的面部毛孔肿大

痤疮往往导致面部皮肤毛孔扩大，严重影响患者的外观。局部和口服药物治疗对一些严重毛孔肿大的病例疗效不佳。目的探讨A型肉毒毒素联合透明质酸治疗面部毛孔肿大的临床疗效和安全性。方法对40例毛孔肿大的痤疮患者进行回顾性研究。肉毒毒素A和非交联透明质酸化合物通过9根32号微针注射到患者面部。使用VISIA记录面部毛孔、纹理和卟啉的状况。采用医师评价的改善评分和患者满意度评价来评价治疗效果。结果治疗1个月后，肉毒杆菌毒素联合非交联玻尿酸复合物可显著改善面部毛孔肿大。虽然效果有所下降，但治疗4个月后面部毛孔、质地和卟啉的状况与基线相比仍有显著差异。结论肉毒毒素A联合非交联玻尿酸复合物治疗毛孔粗大安全有效，具有推广价值。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.