A Multi-Center Clinical Trial to Evaluate the Efficacy of the Next Generation TriHex Technology Antiaging Regimen

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-04-25 DOI:10.1111/jocd.70192

Michael Gold, Charles Boyd, Deanne Mraz, Tiffany Robison, Faiza Shafiq, Alan D. Widgerow

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引用次数: 0

Abstract

Background

Alastin Restorative Skin Complex Serum with TriHex Technology (Alastin Skincare Inc., Carlsbad, CA) has undergone reformulation to add Octapeptide-45 and magnolol for improving facial skin hydration, elasticity, plumping, and overall skin quality. Detailed science on TriHex Technology 2.0 and magnolol has been recently published. This open-label study was conducted to validate the science and demonstrate product efficacy and tolerability in individuals with moderate to severe facial skin aging.

Methods

A multi-center clinical study was conducted from February to August 2024. A total of 44 eligible participants (43 female, 1 male), ages 35–69 years, and Fitzpatrick skin Types I–VI were enrolled in and completed the study following 12 weeks of Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology (RSC 2.0) use twice daily, along with an Alastin Skincare Inc. supportive regimen (cleanser, moisturizer, sunscreen used as needed). A 1-week run-in phase using the supportive regimen only was conducted, and eligibility was reassessed at baseline. Follow-up visits were performed at Weeks 4, 8, and 12, where facial skin quality parameters were evaluated clinically and subject assessments and satisfaction questionnaires, biopsy collection, photography, and hydration and elasticity measurements were completed. Participants also maintained a study diary over the 12-week treatment period.

Results

Significant improvements for all clinically evaluated facial skin parameters were achieved at Week 12. Histology revealed increased stimulation of new adipocytes, epidermal keratinocyte HA (CD44), and new dermal collagen and elastin fibers post treatment.

Conclusion

Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology has been demonstrated to be safe and effective for improving overall facial skin quality, achieving notable improvements in volume, plumping, hydration, and extracellular matrix (ECM) collagen and elastin stimulation.

Abstract Image

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评估新一代TriHex技术抗衰老方案疗效的多中心临床试验

背景 Alastin Restorative Skin Complex Serum with TriHex Technology（Alastin Skincare Inc.有关 TriHex Technology 2.0 和 magnolol 的详细科学信息已于近期公布。这项开放标签研究的目的是验证这些科学依据，并证明产品对中度至重度面部皮肤老化患者的疗效和耐受性。方法 2024 年 2 月至 8 月期间进行了一项多中心临床研究。共有 44 名符合条件的参与者（43 名女性，1 名男性）参加了研究，他们的年龄在 35-69 岁之间，皮肤类型为 Fitzpatrick I-VI 型，在使用 Alastin 采用 TriHex 技术的皮肤修复复合精华素 2.0（RSC 2.0）12 周后，每天使用两次，同时使用 Alastin 护肤公司的辅助疗法（根据需要使用清洁剂、保湿霜和防晒霜）。在为期一周的试运行阶段，只使用支持性疗法，并在基线时重新进行资格评估。在第 4 周、第 8 周和第 12 周进行随访，对面部皮肤质量参数进行临床评估，并完成受试者评估和满意度问卷、活组织切片采集、摄影以及水合作用和弹性测量。在为期 12 周的治疗期间，受试者还要坚持写研究日记。结果第 12 周时，所有临床评估的面部皮肤参数都有显著改善。组织学检查显示，治疗后对新脂肪细胞、表皮角质细胞 HA (CD44) 以及真皮胶原蛋白和弹性纤维的刺激增加。结论含有 TriHex 技术的 Alastin Restorative Skin Complex Serum 2.0 已被证明可安全有效地改善面部皮肤的整体质量，在体积、丰满度、水合作用、细胞外基质（ECM）胶原蛋白和弹性蛋白刺激方面都有显著改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.