Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-04-25 DOI:10.1111/jocd.70196

Sofia Iglesia, Lily I. Jiang, Tatiana Kononov, Alisar S. Zahr

{"title":"Effective Skin Rejuvenation by a Novel Antioxidant Biostimulating Treatment","authors":"Sofia Iglesia, Lily I. Jiang, Tatiana Kononov, Alisar S. Zahr","doi":"10.1111/jocd.70196","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Facial skin aging is a cumulative result of both intrinsic and extrinsic stressors. Chemical peels are commonly performed noninvasive skin rejuvenation procedures targeting these stressors. Innovation in chemical peels has remained limited, creating an opportunity for the industry to evolve with next-generation technology.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>A novel topical antioxidant biostimulating treatment (ABT) was developed that utilizes a typical chemoexfoliation base as a vehicle to deliver a unique blend of antioxidant biostimulating acidic phytocompounds (ABAP). It was hypothesized that controlled delivery of ABAP could occur through a typical AHA/BHA chemical peel vehicle. These ABAPs, such as asiatic, ursolic, madecassic, and oleanolic acids, are known for skin rejuvenation in the papillary dermis.</p>\n </section>\n \n <section>\n \n <h3> Patients/Methods</h3>\n \n <p>The ABT was tested in both ex vivo and in vivo settings to elucidate its mechanism of action and determine its efficacy and safety on 32 female subjects aged 38–60 years with Fitzpatrick skin types I–V.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The ABT upregulated elastin and collagen after superficial wounding of the skin by over 25% when compared to untreated or vehicle controls. Clinical evaluation by an expert grader demonstrated that the ABT significantly improved fine lines, wrinkles, tactile laxity, and overall appearance after three ABT sessions. Clinical photography demonstrated an improvement in fine lines, wrinkles, skin smoothness, laxity, radiance, and overall appearance.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The ABT developed with ABAP technology was efficacious in improving facial skin aging for skin rejuvenation and safe for all skin tones.</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70196","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70196","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Facial skin aging is a cumulative result of both intrinsic and extrinsic stressors. Chemical peels are commonly performed noninvasive skin rejuvenation procedures targeting these stressors. Innovation in chemical peels has remained limited, creating an opportunity for the industry to evolve with next-generation technology.

Aims

A novel topical antioxidant biostimulating treatment (ABT) was developed that utilizes a typical chemoexfoliation base as a vehicle to deliver a unique blend of antioxidant biostimulating acidic phytocompounds (ABAP). It was hypothesized that controlled delivery of ABAP could occur through a typical AHA/BHA chemical peel vehicle. These ABAPs, such as asiatic, ursolic, madecassic, and oleanolic acids, are known for skin rejuvenation in the papillary dermis.

Patients/Methods

The ABT was tested in both ex vivo and in vivo settings to elucidate its mechanism of action and determine its efficacy and safety on 32 female subjects aged 38–60 years with Fitzpatrick skin types I–V.

Results

The ABT upregulated elastin and collagen after superficial wounding of the skin by over 25% when compared to untreated or vehicle controls. Clinical evaluation by an expert grader demonstrated that the ABT significantly improved fine lines, wrinkles, tactile laxity, and overall appearance after three ABT sessions. Clinical photography demonstrated an improvement in fine lines, wrinkles, skin smoothness, laxity, radiance, and overall appearance.

Conclusions

The ABT developed with ABAP technology was efficacious in improving facial skin aging for skin rejuvenation and safe for all skin tones.

Abstract Image

查看原文本刊更多论文

一种新的抗氧化生物刺激治疗有效的皮肤年轻化

面部皮肤老化是内因和外因压力因素共同作用的结果。化学换肤通常是针对这些压力源进行的非侵入性皮肤恢复手术。化学去皮的创新仍然有限，这为行业发展下一代技术创造了机会。研究人员开发了一种新的局部抗氧化生物刺激疗法（ABT），该疗法利用典型的化学去角质碱作为载体，提供独特的抗氧化生物刺激酸性植物化合物（ABAP）混合物。假设ABAP可以通过典型的AHA/BHA化学剥离载体进行控制递送。这些abap，如亚洲酸、熊果酸、马氏酸和齐墩果酸，在乳头状真皮层中具有皮肤年轻化作用。患者/方法对32例年龄38 ~ 60岁、Fitzpatrick皮肤I-V型的女性受试者进行体外和体内试验，以阐明其作用机制，并确定其有效性和安全性。结果与未治疗或对照相比，ABT使皮肤浅表损伤后的弹性蛋白和胶原蛋白上调25%以上。专家评分者的临床评估表明，三次ABT治疗后，ABT显著改善了细纹、皱纹、触觉松弛和整体外观。临床摄影显示细纹，皱纹，皮肤光滑，松弛，光泽和整体外观的改善。结论采用ABAP技术开发的ABT可有效改善面部皮肤老化，实现皮肤年轻化，对所有肤色都是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.