Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-04-21 DOI:10.1111/jocd.70195

Koo Chul Kwon, Mi Jung Kim, Sang A. Yoon

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Abstract

Background

_L-glutamine and linoleic acid (LA) can suppress inflammatory cytokine expression; however, studies on their simultaneous application are limited due to polarity differences.

Aims

To investigate the effect of glutamine linoleate vesicles (QLAsomes) on skin sensitization by assessing their impact on sensitization-related protein expression, bacterial growth, and clinical efficacy in relieving skin itchiness.

Methods

After synthesizing and analyzing QLAsomes, their inhibitory effects on capsaicin-induced cytokine expression and Staphylococcus aureus growth were evaluated. In a double-blind clinical trial, 24 participants (ages 22–63) with sensitized skin applied 10 wt% QLAsome cream on one side and a vehicle or no cream on the other twice daily for 2 weeks. Itchiness in the elbow area was assessed using a visual analog scale and expert evaluation. Skin barrier changes were measured using transepidermal water loss (TEWL), skin erythema, and stratum corneum (SC) hydration.

Results

QLAsomes, formed by _L-glutamine and LA through hydrogen bonding, were spherical vesicles (164.6 ± 3.1 nm). Based on the inhibitory effects of _L-glutamine and LA on inflammation-related factors, QLAsomes inhibited the capsaicin-induced expression of these factors more effectively than the individual components. IL-4 inhibition was improved by over 26%. Matrix metalloproteinase-1, which degrades collagen, showed 32% and 23% improvements compared to _L-glutamine and LA, respectively. In a clinical evaluation, 10 wt% QLAsome cream reduced itching by 45% compared to before application, which is a 67% improvement compared to placebo. Skin evaluations revealed improvements in erythema (12%), TEWL (15%), and SC hydration (19%), suggesting that QLAsomes enhance the skin barrier function.

Conclusions

QLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.

Abstract Image

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通过谷氨酰胺亚油酸酯的自组装开发出用于敏感性皮肤护理的纳米微粒

背景l -谷氨酰胺和亚油酸（LA）可以抑制炎症细胞因子的表达；然而，由于极性差异，对其同时应用的研究受到限制。目的探讨谷氨酰胺亚油酸囊泡（QLAsomes）对致敏相关蛋白表达、细菌生长及缓解皮肤瘙痒的临床疗效的影响，探讨其对皮肤致敏的影响。方法通过对qlassomes的合成和分析，评价其对辣椒素诱导的细胞因子表达和金黄色葡萄球菌生长的抑制作用。在一项双盲临床试验中，24名皮肤敏感的参与者（年龄22-63岁）在一侧涂抹10% QLAsome乳膏，在另一侧涂抹或不涂乳膏，每天两次，持续2周。使用视觉模拟量表和专家评估肘部瘙痒。通过经皮失水（TEWL）、皮肤红斑和角质层（SC）水化来测量皮肤屏障的变化。结果l -谷氨酰胺与LA通过氢键形成的qlasome为球形囊泡（164.6±3.1 nm）。基于l -谷氨酰胺和LA对炎症相关因子的抑制作用，QLAsomes比单个成分更有效地抑制辣椒素诱导的这些因子的表达。IL-4抑制率提高26%以上。与l -谷氨酰胺和LA相比，降解胶原蛋白的基质金属蛋白酶-1分别提高了32%和23%。在临床评估中，与使用前相比，10% QLAsome霜减少了45%的瘙痒，与安慰剂相比改善了67%。皮肤评估显示，红斑（12%）、TEWL（15%）和SC水化（19%）得到改善，表明qlassomes增强了皮肤屏障功能。结论qlasome对关键皮肤致敏相关因子的表达抑制比单个成分高32%，基于此，瘙痒症状的改善比安慰剂高67%。作为具有皮肤舒缓特性的纳米囊泡，它们在制药和化妆品行业中用于药物包封和控制皮肤敏感性是有效的。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.