{"title":"促进皮肤组织中透明质酸自然生成的新技术：人类组织学研究","authors":"David J. Goldberg","doi":"10.1111/jocd.70159","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Combining monopolar radiofrequency (RF) with targeted ultrasound (TUS), this study investigated whether these modalities promote facial rejuvenation through the production of hyaluronic acid (HA) in human skin.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Seven subjects (51–64 years, BMI 21.1–29.8 kg/m<sup>2</sup>) were enrolled and divided into three treatment groups in this single-center study; Group A (<i>n</i> = 3, simultaneous RF + TUS), Group B (<i>n</i> = 3, stand-alone RF), and control (<i>n</i> = 1, no treatment). Both treated groups underwent four (4) 60-min treatments on the face delivered 7–14 days apart. Punch biopsies (3 mm in diameter) were collected from the infra-auricular area at baseline and both follow-up visits and stained for HA by using hyaluronic acid binding protein. Digital photographs were taken to document changes in visual appearance. Finally, the subjects' comfort and satisfaction were assessed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>There was a statistically significant (<i>p</i> < 0.05) average increase at 1 month in the HA-stained area of +112 358.7 μm<sup>2</sup> in group A (RF + TUS) representing an increase of 48.65%. The treatment effect peaked at 3 months with an increase of +156 345.2 μm<sup>2</sup>, corresponding to a 67.69% increase in the HA-stained area. In Group B, there was no significant difference in the average increase of the HA-stained area between 1 month (+14 830 μm<sup>2</sup>) and 3 months (+20 995 μm<sup>2</sup>) corresponding to a 6.76% and 9.56% increase, respectively. The control samples did not indicate any changes throughout the study. Digital photographs of the RF + TUS group showed both a decrease in rhytids and tighter skin. Therapies were comfortable with no adverse events.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Overall, this study has shown that the combination treatment of RF + TUS has a more pronounced and sustained effect on facial rejuvenation compared to RF alone. The measurable increase in the production of HA with simultaneous use of RF + TUS peaked at a 3-month follow-up, suggesting the gradual advancement of the treatment effect and overall improvement in facial appearance.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>ClinicalTrials.gov identifier: NCT05987917</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 4","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70159","citationCount":"0","resultStr":"{\"title\":\"A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study\",\"authors\":\"David J. 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Digital photographs were taken to document changes in visual appearance. Finally, the subjects' comfort and satisfaction were assessed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>There was a statistically significant (<i>p</i> < 0.05) average increase at 1 month in the HA-stained area of +112 358.7 μm<sup>2</sup> in group A (RF + TUS) representing an increase of 48.65%. The treatment effect peaked at 3 months with an increase of +156 345.2 μm<sup>2</sup>, corresponding to a 67.69% increase in the HA-stained area. In Group B, there was no significant difference in the average increase of the HA-stained area between 1 month (+14 830 μm<sup>2</sup>) and 3 months (+20 995 μm<sup>2</sup>) corresponding to a 6.76% and 9.56% increase, respectively. The control samples did not indicate any changes throughout the study. Digital photographs of the RF + TUS group showed both a decrease in rhytids and tighter skin. Therapies were comfortable with no adverse events.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Overall, this study has shown that the combination treatment of RF + TUS has a more pronounced and sustained effect on facial rejuvenation compared to RF alone. The measurable increase in the production of HA with simultaneous use of RF + TUS peaked at a 3-month follow-up, suggesting the gradual advancement of the treatment effect and overall improvement in facial appearance.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Trial Registration</h3>\\n \\n <p>ClinicalTrials.gov identifier: NCT05987917</p>\\n </section>\\n </div>\",\"PeriodicalId\":15546,\"journal\":{\"name\":\"Journal of Cosmetic Dermatology\",\"volume\":\"24 4\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70159\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cosmetic Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70159\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70159","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
A Novel Technology to Boost Natural Production of Hyaluronic Acid in the Skin Tissue: Human Histology Study
Introduction
Combining monopolar radiofrequency (RF) with targeted ultrasound (TUS), this study investigated whether these modalities promote facial rejuvenation through the production of hyaluronic acid (HA) in human skin.
Methods
Seven subjects (51–64 years, BMI 21.1–29.8 kg/m2) were enrolled and divided into three treatment groups in this single-center study; Group A (n = 3, simultaneous RF + TUS), Group B (n = 3, stand-alone RF), and control (n = 1, no treatment). Both treated groups underwent four (4) 60-min treatments on the face delivered 7–14 days apart. Punch biopsies (3 mm in diameter) were collected from the infra-auricular area at baseline and both follow-up visits and stained for HA by using hyaluronic acid binding protein. Digital photographs were taken to document changes in visual appearance. Finally, the subjects' comfort and satisfaction were assessed.
Results
There was a statistically significant (p < 0.05) average increase at 1 month in the HA-stained area of +112 358.7 μm2 in group A (RF + TUS) representing an increase of 48.65%. The treatment effect peaked at 3 months with an increase of +156 345.2 μm2, corresponding to a 67.69% increase in the HA-stained area. In Group B, there was no significant difference in the average increase of the HA-stained area between 1 month (+14 830 μm2) and 3 months (+20 995 μm2) corresponding to a 6.76% and 9.56% increase, respectively. The control samples did not indicate any changes throughout the study. Digital photographs of the RF + TUS group showed both a decrease in rhytids and tighter skin. Therapies were comfortable with no adverse events.
Conclusion
Overall, this study has shown that the combination treatment of RF + TUS has a more pronounced and sustained effect on facial rejuvenation compared to RF alone. The measurable increase in the production of HA with simultaneous use of RF + TUS peaked at a 3-month follow-up, suggesting the gradual advancement of the treatment effect and overall improvement in facial appearance.
期刊介绍：
The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques.
The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.
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