Journal of Clinical Biochemistry and Nutrition最新文献

{"title":"Development of a questionnaire-based Dietary Inflammatory Index assessment for clinical implementation.","authors":"Mamiko Yano, Nao Hasuzawa, Natsumi Maruyama, Lixiang Wang, Mizuki Gobaru, Ayako Nagayama, Kenji Ashida, Hitoshi Obara, Kenta Murotani, Yoshinori Moriyama, Masatoshi Nomura","doi":"10.3164/jcbn.25-163","DOIUrl":"https://doi.org/10.3164/jcbn.25-163","url":null,"abstract":"<p><p>The rising incidence of chronic metabolic diseases places a significant economic burden on healthcare systems. Although the efficacy of lifestyle interventions has been reported, clinical nutrition typically emphasizes total energy and macronutrient intake without consensus on ideal dietary patterns. The Dietary Inflammatory Index (DII) assesses the inflammatory potential of diets and has been linked to diseases like cardiovascular disease, cancer, and type 2 diabetes. However, DII use in clinical practice is limited by its complexity. In this study, we developed a method to calculate DII scores using a clinically available food frequency questionnaire (FFQ). Thirty healthy volunteers provided 3-day dietary records (DR) and completed the FFQ. Dietitians calculated the intake of 29 nutrients from the DR. A created table of nutrient content per FFQ item enabled nutrient intake and DII score calculation from the FFQ. Statistical analysis showed significant correlations between 27 of 29 nutrient intakes and DII scores from the DR and FFQ. Regression equations were developed to predict actual nutrient intakes from the FFQ. The estimated DII (eDII) calculated using the equations correlated strongly with the DR-derived DII (<i>r</i> = 0.716, <i>p</i><0.0001). With low bias and variance, our method supports individualized and inflammation-targeted dietary interventions.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 1","pages":"43-51"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a): structural basis, bidirectional risk, and therapeutic frontiers.","authors":"Zeyu Xu, Yi Fang, Yong Peng, Chunhua Zhang, Chunhua Zheng","doi":"10.3164/jcbn.25-94","DOIUrl":"https://doi.org/10.3164/jcbn.25-94","url":null,"abstract":"<p><p>Despite substantial progress in the management of cardiovascular disease (CVD), lipoprotein(a) [Lp(a)] persists as a genetically determined risk factor that remains insufficiently explored. Both extremely high and low levels of Lp(a) are linked to adverse outcomes. Current diagnostic assays for Lp(a) lack standardization, and conventional lipid-lowering therapies exert minimal effects on its levels, resulting in limited treatment options specifically targeting Lp(a). To address these gaps, we conducted a comprehensive molecular and clinical review of Lp(a), examining its unique structure, genetic determinants, metabolic pathways, and the factors influencing its plasma concentration. Furthermore, we discuss emerging therapeutic strategies aimed at targeting Lp(a).</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 1","pages":"19-26"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>N</i>-oxide-based and trioxolane-based fluorescent probes for monitoring labile iron and labile heme: an update.","authors":"Tasuku Hirayama","doi":"10.3164/jcbn.25-146","DOIUrl":"https://doi.org/10.3164/jcbn.25-146","url":null,"abstract":"<p><p>Iron (Fe) and heme are essential for numerous biological processes, but their dysregulation contributes to cancer, neurodegeneration, and ferroptosis. This review summarizes the development and applications of <i>N</i>-oxide chemistry-based fluorescent probes and 1,2,4-trioxolane-based probes for selective monitoring of labile Fe(II) and heme in living systems over the past decade. We describe our discovery that Fe(II) selectively deoxygenates tertiary amine <i>N</i>-oxides, enabling conversion of non-fluorescent <i>N</i>-oxide compounds into highly fluorescent tertiary amines. This approach has yielded a comprehensive palette of Fe(II)-selective probes with diverse colors and organelle-targeting capabilities. Key developments include RhoNox-4 (FerroOrange), a highly sensitive probe demonstrating >100-fold fluorescence enhancement that enabled high-throughput screening applications, and organelle-targeted probes that revealed labile Fe(II) accumulation in lysosomes and endoplasmic reticulum during ferroptosis. We also discuss H-FluNox, the first highly selective heme probe exhibiting >200-fold fluorescence increase, which successfully monitors endogenous heme dynamics and revealed simultaneous upregulation of both labile Fe(II) and heme during ferroptosis. Another approach is based on the chemical reactivity of 1,2,4-trioxolane, where the O-O bond cleavage reaction is induced by Fe(II) or heme. The 1,2,4-trioxolane motif could facilitate ferroptosis, but in contrast, the <i>N</i>-oxide-based probes function as ferroptosis inhibitors through selective depletion of labile Fe(II) involved in lipid peroxidation. We highlight the unexpected discovery that these <i>N</i>-oxide-based probes function as ferroptosis inhibitors through selective Fe(II) depletion, with activity dependent on cellular localization. These chemical tools have provided unprecedented insights into iron and heme biology, offering new opportunities for understanding oxidative stress mechanisms and developing therapeutic strategies for iron-related disorders.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 1","pages":"6-13"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of strength training of large muscle groups on quality of life.","authors":"Tetsuya Takahashi, Juntaro Matsuzaki, Tsuyoshi Enomoto, Yoshimasa Saito","doi":"10.3164/jcbn.25-60","DOIUrl":"https://doi.org/10.3164/jcbn.25-60","url":null,"abstract":"<p><p>Muscle-strengthening activities reduce the risk of various diseases and promote overall health. Physical activities targeting large muscle groups, such as weightlifting or resistance exercises, provide an additional health benefit. The present study investigated the relationship between strength training and health-related quality of life (HRQOL) through a cross-sectional study of 50 adults participating in large muscle group strengthening activities (LMG) and 50 adults who did not (NLMG). HRQOL was assessed using the SF-12v2 questionnaire, and sleep habits were assessed using the PSQI questionnaire. The LMG group had a significantly higher Role/Social component summary (RCS) score than the NLMG group (50.5 ± 7.2 vs 47.2 ± 8.3; respectively, <i>p</i> = 0.040). The physical component summary (PCS) and mental component summary (MCS) scores also tended to be higher in the LMG group than in the NLMG group (52.6 ± 8.4 vs 49.9 ± 10.2, respectively; <i>p</i> = 0.15 and 59.0 ± 7.9 vs 56.7 ± 6.0, respectively; <i>p</i> = 0.10). Linear regression analysis showed that a higher RCS score was significantly associated with LMG training, whereas higher PCS and MCS scores were associated with better sleep quality. These results suggest that strength training targeting large muscle groups may improve the social aspect of HRQOL, highlighting the potential benefits of incorporating such exercises into regular physical activity regimens.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"264-267"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intervention with <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BLa80 on the composition of the gut microbiota of healthy volunteers: a placebo-controlled randomized trial.","authors":"Ruining Han, Chunxiao Gao, Peng Yan, Yigong Tian, Yaokun Yu, Haoyu Li, Senli Li, Yaobin Wang","doi":"10.3164/jcbn.25-99","DOIUrl":"https://doi.org/10.3164/jcbn.25-99","url":null,"abstract":"<p><p>Probiotics are live microorganisms that confer a health benefit on the host. Nevertheless, there is few pertinent research on the impact of probiotics on the healthy individuals. Therefore, a placebo-controlled randomized trial was conducted to investigate the effects of <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BLa80 supplementation on the gut microbiota composition in healthy individuals. A total of 112 participants were assigned to two groups: a placebo group that received maltodextrin, and a BLa80 group that received a combination of maltodextrin and strain BLa80 at a dosage of 1 × 10¹⁰ colony-forming units per day. The study duration was 8 weeks and 16S rRNA sequencing was employed to analyze changes in gut microbiota. Furthermore, the study assessed the metabolic effects of BLa80 by monitoring alanine transaminase (ALT), aspartate aminotransferase (AST), and uric acid (UA). The BLa80 intervention demonstrated the ability to modulate the gut microbiota and significantly increase the proportion of <i>Bifidobacterium</i> spp. The BLa80 intervention markedly reduced metabolic pathways associated with Biofilm formation-<i>Pseudomonas aeruginosa</i>, cationic antimicrobial peptide (CAMP) resistance and other metabolic pathways associated with conditionally pathogenic bacteria and CAMP. No adverse effects were reported throughout the study. Additionally, the BLa80 intervention slowed the increase in uric acid levels compared to the placebo group. For the primary outcome, these results demonstrate that BLa80 is capable of transient enrichment in the human intestine. Additionally, BLa80 was effective in increasing the relative abundance of beneficial bacteria. In conclusion, the observed beneficial effects position BLa80 as a promising probiotic strain.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"288-295"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation.","authors":"Xiaoyan Ding, Jinxi Wang, Xiangning Huang, Juan Huang","doi":"10.3164/jcbn.25-91","DOIUrl":"https://doi.org/10.3164/jcbn.25-91","url":null,"abstract":"<p><p>Diabetic cardiomyopathy (DCM), a life-threatening cardiovascular complication of diabetes, manifested as progressive cardiac dysfunction mediated through oxidative stress, inflammation, and apoptosis. Loganic acid (LA), a natural iridoid compound with anti-inflammatory and antioxidant properties, has demonstrated therapeutic potential in various inflammatory disorders, but its role in DCM remains unexplored. Here, we systematically investigated LA's cardioprotective potential and its mechanisms. Utilizing a high-fat diet/streptozotocin (HFD/STZ)-induced diabetic mouse model, LA (30 ‍mg/kg, oral gavage) was administered for 8 weeks post-diabetes confirmation. Echocardiographic assay indicated that LA improved cardiac function. Histopathologic evaluation displayed that LA attenuated myocardial structural disorders, reduced collagen deposition, and suppressed cardiomyocyte apoptosis. Furthermore, LA treatment normalized redox imbalance (decreased MDA and increased GSH) and reduced inflammatory cytokine levels. <i>In vitro</i>, a diabetic cell model was established with AC16 cardiomyocytes exposed to high glucose (HG; 30 ‍mM). The findings demonstrated that LA (25 or 50 ‍μM) dose-dependently ameliorated HG-induced cardiomyocyte damage, oxidative stress, and inflammatory cytokine release. Mechanistically, LA treatment suppressed HG-induced activation of TLR4 signaling and phosphorylation of p38 MAPK. Collectively, these findings highlight LA as a novel therapeutic candidate in DCM, targeting the TLR4/p38 MAPK axis to attenuate diabetes-induced cardiac damage.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"230-239"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation of CA10 regulates the proliferation and metastasis of bladder cancer.","authors":"Qiwang Mo, Yi Lu, Jizhongrong Wu, Xiao Zhang","doi":"10.3164/jcbn.25-49","DOIUrl":"https://doi.org/10.3164/jcbn.25-49","url":null,"abstract":"<p><p>This study investigated the role of <i>CA10</i> gene DNA methylation in bladder cancer progression, revealing that hypermethylation significantly reduces <i>CA10</i> expression in tumor tissues compared to adjacent tissues. Utilizing TCGA data analysis with the ChAMP package for DMPs/DMRs, alongside qRT-PCR/semiquantitative RT-PCR for methylation and expression validation, researchers found that treatment with the demethylating agent 5-Aza-dC restored <i>CA10</i> expression. Functional assays (flow cytometry, MTT, transwell) demonstrated that this restoration inhibited cancer cell proliferation, migration, and cell cycle progression. Furthermore, <i>in vivo</i> tumor xenograft models confirmed <i>CA10</i>'s tumor-suppressive role and the efficacy of epigenetic therapy in inhibiting tumor growth. The study identifies DNA methylation-driven silencing of <i>CA10</i> as a key mechanism in bladder carcinogenesis and highlights its broader diagnostic potential across cancers.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"240-248"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and stress-reducing effects of rosemary extract: an open-label trial and randomized double-blind crossover study.","authors":"Hidetoshi Kuwata, Kouta Ookoshi, Kyoko Shimazu, Satoshi Fukumitsu, Kazuhiko Aida","doi":"10.3164/jcbn.25-157","DOIUrl":"https://doi.org/10.3164/jcbn.25-157","url":null,"abstract":"<p><p>This study comprised two trials that evaluated the safety and anti-stress effects of rosemary extracts containing rosmarinic acid and diterpenes. Study I was a 4-week, single-arm, open-label safety trial involving 22 healthy adults who consumed high doses of the rosemary extract daily. No clinically relevant adverse events or abnormal laboratory findings were observed, thus confirming its safety. Study II was a randomized, double-blind, placebo-controlled, crossover trial with 40 participants that assessed psychological and physiological stress markers. After four weeks of rosemary extract intake, significant improvements were found in trait anxiety scores measured using the State-Trait Anxiety Inventory and heart rate variability, as indicated by a decreased low-frequency/high-frequency ratio. Additionally, a single dose administered before the mental workload test significantly reduced state anxiety scores. No significant differences were observed in salivary cortisol levels or visual analog scale scores between the groups. These results suggest that rosemary extract is safe for consumption and may effectively reduce chronic and acute stress in healthy individuals. These findings support the use of rosemary extract as a natural dietary supplement for stress management.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"280-287"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked enhancement of synergistic antioxidative activity of astaxanthin and curcumin by co-encapsulation in a liposomal formulation.","authors":"Minori Yamasaki, Shintaro Yoneda, Takashi Maoka, Kentaro Kogure","doi":"10.3164/jcbn.25-53","DOIUrl":"https://doi.org/10.3164/jcbn.25-53","url":null,"abstract":"<p><p>Natural antioxidants may help prevent oxidative stress-mediated aging. Astaxanthin (Asx) is a powerful antioxidant that has been used in various dietary supplements and cosmetics. Previously, we reported that combination of Asx with tocotrienol (T3) or capsaicin (Cap) exhibited synergistic antioxidative effects; however, the synergistic increase in activity was unremarkable. Herein, we employed curcumin (Cur) to more effectively enhance the antioxidant activity of Asx. The antioxidative activity of liposomes co-encapsulating Asx and Cur (Asx/Cur-lipo) showed effective synergism (activity increase of ~2). A shift in peak absorption suggested intermolecular interactions between Asx and Cur. Since synthetic Asx is a mixture of various stereoisomers, we examined the effect of Asx stereochemistry on the effective synergism by investigating liposomes prepared with 3<i>R</i>,3'<i>R</i>-form (Asx-<i>R</i>), and 3<i>S</i>,3'<i>S</i>-form (Asx-<i>S</i>). Antioxidative activities of Asx-<i>R</i>/Cur-lipo and Asx-<i>S</i>/Cur-lipo were evaluated. Only Asx-<i>S</i>/Cur-lipo exhibited a synergistic effect; however, the activity increase of Asx-<i>S</i>/Cur-lipo was lower than that of Asx/Cur-lipo. In conclusion, liposomes co-encapsulating a synthetic mixture of stereochemical isomers of Asx and Cur may be most potent in preventing oxidative stress-mediated aging.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"209-215"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside RK1 inhibits microglial activation and ROS production and alleviates vascular dementia in rats.","authors":"Keyu Bian, Xingqi Zhao, Xiaoli Feng, Lijun Jiang","doi":"10.3164/jcbn.25-27","DOIUrl":"https://doi.org/10.3164/jcbn.25-27","url":null,"abstract":"<p><p>Although ginsenoside RK1 (RK1) possesses neuroprotective properties, it is unknown how it relates to vascular dementia (VD). The purpose of this work was to show that RK1 has a neuroprotective function in VD. First, the VD rat model was established by ligating the carotid artery with two-vessel occlusion (2-VO) surgery. RK1 was given daily for 30 days. A water maze test evaluated the learning and memory functions of the rats in each group. HE staining was used to assess the pathological damage of hippocampal tissue. The microglial marker Iba-1, proinflammatory factors [tumor necrosis factor alpha (TNF-α), Interleukin (IL)-1β, and IL-6], reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), and peroxisome proliferator-activated receptor γ (PPARγ) in the hippocampal tissue were detected. The results show that RK1 reduced the escape latency of VD rats, increased the time VD rats stayed in the target quadrant and the number of times they crossed the platform, and alleviated the pathological damage of hippocampal tissue. In addition, RK1 also inhibited the activation of microglia and ROS production in the hippocampus of VD rats, reduced the content of proinflammatory factors and MDA, increased the content of antioxidant enzyme SOD, and activated PPARγ expression in hippocampal tissue. Overall, RK1 alleviates cognitive dysfunction and hippocampal tissue pathological damage in VD rats and inhibits hippocampal neuroinflammation and ROS production, which may be related to the activation of PPARγ in hippocampal tissue by RK1.</p>","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 3","pages":"223-229"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}