洞穴素和洞穴素-1 作为膳食多酚的靶标,可防止血管内皮功能障碍。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-07-01 Epub Date: 2024-03-07 DOI:10.3164/jcbn.24-30
Junji Terao
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引用次数: 0

摘要

洞穴小体由洞穴素-1 蛋白组成,普遍存在于内皮细胞中,作为细胞信号通路以及转运和内吞的平台,有助于发挥正常的心血管功能。然而,人们认为洞穴素-1 可抑制内皮一氧化氮合酶的活性和 Nrf2 的激活,或通过激活 NF-κB 促进炎症,从而起到促动脉粥样硬化的作用。有人认为,膳食多酚通过一种涉及抑制内皮功能障碍的机制来发挥抗动脉粥样硬化的作用,通过这种机制,它们可以调节与 NF-κB 和 Nrf2 激活有关的氧化还原敏感信号通路。一些单体多酚和微生物群衍生的来自单体多酚或聚合单宁酸的代谢产物可能是抑制作用的原因,因为它们可以从消化道进入血液循环。据报道,有几种多酚可以调节洞穴素-1 的表达或其在洞穴中的定位。因此,我们推测循环中的多酚会通过改变洞穴小体的结构来影响洞穴小体的功能,从而导致洞穴小体释放出洞穴素-1,并减弱依赖于氧化还原敏感信号通路的洞穴素-1过表达。有必要在生理相关水平上使用循环多酚开展进一步研究,以明确膳食多酚针对洞穴溶胶和洞穴素-1的作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Caveolae and caveolin-1 as targets of dietary polyphenols for protection against vascular endothelial dysfunction.

Caveolae, consisting of caveolin-1 proteins, are ubiquitously present in endothelial cells and contribute to normal cardiovascular functions by acting as a platform for cellular signaling pathways as well as transcytosis and endocytosis. However, caveolin-1 is thought to have a proatherogenic role by inhibiting endothelial nitric oxide synthase activity and Nrf2 activation, or by promoting inflammation through NF-κB activation. Dietary polyphenols were suggested to exert anti-atherosclerotic effects by a mechanism involving the inhibition of endothelial dysfunction, by which they can regulate redox-sensitive signaling pathways in relation to NF-κB and Nrf2 activation. Some monomeric polyphenols and microbiota-derived catabolites from monomeric polyphenols or polymeric tannins might be responsible for the inhibition, because they can be transferred into the circulation from the digestive tract. Several polyphenols were reported to modulate caveolin-1 expression or its localization in caveolae. Therefore, we hypothesized that circulating polyphenols affect caveolae functions by altering its structure leading to the release of caveolin-1 from caveolae, and attenuating redox-sensitive signaling pathway-dependent caveolin-1 overexpression. Further studies using circulating polyphenols at a physiologically relevant level are necessary to clarify the mechanism of action of dietary polyphenols targeting caveolae and caveolin-1.

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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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