Journal of Clinical Biochemistry and Nutrition最新文献

Adiponectin inhibits chemokine-induced cell migration via direct interaction with platelet factor 4. 脂联素通过与血小板因子4的直接相互作用抑制趋化因子诱导的细胞迁移。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-03-27 DOI: 10.3164/jcbn.24-230

Mohamed Elfeky, Shima Goto, Ali El-Far, Yuko Okamatu-Ogura, Kazuhiro Kimura

引用次数: 0

Regulating effect of serum selenium on diabetic kidney disease related all-cause mortality: evidence from NHANES database. 血清硒对糖尿病肾病相关全因死亡率的调节作用：来自NHANES数据库的证据

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-04-05 DOI: 10.3164/jcbn.25-25

Ruolan Lin, Yurong Xian, Miaoling Tan, Guoqin Liu

{"title":"Regulating effect of serum selenium on diabetic kidney disease related all-cause mortality: evidence from NHANES database.","authors":"Ruolan Lin, Yurong Xian, Miaoling Tan, Guoqin Liu","doi":"10.3164/jcbn.25-25","DOIUrl":"10.3164/jcbn.25-25","url":null,"abstract":"To explore the interaction between Diabetic kidney disease (DKD) and serum selenium (Se) on mortality from all-cause. Information from the National Health and Nutrition Examination Surveys database (2011-2016) were retrospectively extracted for this cohort study. Associations of DKD and serum Se level with all-cause mortality were evaluated by weighted uni- and multi-variate COX regression analyses, with 95% confidence intervals (CIs) and hazard ratios (HRs). The interaction was measured by attributable proportion of interaction (APAB), relative excess risk due to interaction (RERI), synergy index (S) and 95% CIs. Among 793 adult patients, 98 died from all cause. DKD was linked to an increased all-cause mortality risk [HR = 3.69, 95% CI (1.75-7.81)], while elevated serum Se levels were linked to a decreased all-cause mortality risk [HR = 0.49, 95% CI (0.28-0.86)], after adjusting for co-variables including age, education level, physical activity (PA), CVD, WBC, neutrophil, HB, ALB, and Zn. Additionally, there was a potential antagonistic interaction between DKD and serum Se level on all-cause mortality, with the S value of 0.228. Se may play a protective role in all-cause mortality related to DKD in patients with DM, but this interaction effect needed further exploration.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"182-188"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced phase angle as a potential indicator of mild cognitive impairment. 相角减小作为轻度认知障碍的潜在指标。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-22 DOI: 10.3164/jcbn.25-70

Mika Hasegawa, Hidenori Onishi, Yasutaka Mizukami, Yuki Niida, Tomoko Okamoto, Masafumi Kubota, Yuya Nakajima, Taisei Inoue, Hirohiko Ohama, Tokuharu Tanaka, Shinya Sugawara, Fumie Maeda, Akemi Koujimoto, Yuta Shimoura, Osamu Muto, Naohiro Konoshita, Akiko Matsunaga, Masamichi Ikawa, Hiroyuki Hayashi, Osamu Yamamura

{"title":"Reduced phase angle as a potential indicator of mild cognitive impairment.","authors":"Mika Hasegawa, Hidenori Onishi, Yasutaka Mizukami, Yuki Niida, Tomoko Okamoto, Masafumi Kubota, Yuya Nakajima, Taisei Inoue, Hirohiko Ohama, Tokuharu Tanaka, Shinya Sugawara, Fumie Maeda, Akemi Koujimoto, Yuta Shimoura, Osamu Muto, Naohiro Konoshita, Akiko Matsunaga, Masamichi Ikawa, Hiroyuki Hayashi, Osamu Yamamura","doi":"10.3164/jcbn.25-70","DOIUrl":"10.3164/jcbn.25-70","url":null,"abstract":"In this study, we investigated the relationship between phase angle (PhA), measured using bioelectrical impedance analysis (BIA), and mild cognitive impairment (MCI). A cross-sectional analysis was conducted on 290 community residents (83.7% female, average age 74.9 years). Cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J), with MCI defined as a score of ≤25. Body composition, including PhA, was measured using BIA. Multiple regression analysis was used to examine the association between PhA and MCI presence, adjusting for potential confounders. MCI was found in 168 participants. The PhA (leg) was significantly lower in those with MCI than in those without (p = 0.013). A significant association between leg PhA and MCI was identified in the regression model (β = 0.103, p = 0.015), with an adjusted R 2 value of 0.50. These findings suggested that PhA may serve as an indicator of MCI. Longitudinal and intervention studies are needed to explore the potential of PhA in dementia prevention strategies. In addition, future research should focus on developing dementia prevention strategies that utilize PhA through longitudinal and interventional studies.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"189-194"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mallotus japonicus extract suppresses ferroptosis by inhibiting transferrin receptor-mediated ferrous ion uptake in human tubular epithelial HK2 cells. 马蹄莲提取物通过抑制人小管上皮HK2细胞转铁蛋白受体介导的铁离子摄取来抑制铁凋亡。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.3164/jcbn.25-42

Tetsuro Kamiya, Misaki Nishimura, Tomohiro Otsuka, Hiroki Yoshinaka, Hiroe Maruyama, Hiroyuki Kono, Hirokazu Hara

{"title":"Mallotus japonicus extract suppresses ferroptosis by inhibiting transferrin receptor-mediated ferrous ion uptake in human tubular epithelial HK2 cells.","authors":"Tetsuro Kamiya, Misaki Nishimura, Tomohiro Otsuka, Hiroki Yoshinaka, Hiroe Maruyama, Hiroyuki Kono, Hirokazu Hara","doi":"10.3164/jcbn.25-42","DOIUrl":"10.3164/jcbn.25-42","url":null,"abstract":"Iron (Fe) is the most abundant metal ion in the body, but its excess accumulation causes Fe2+-dependent and lipid peroxidation-dependent cell death (ferroptosis) via the production of reactive oxygen species (ROS). It is thought that ferroptosis is related to the progression of various kidney problems, including acute kidney injury and diabetic nephropathy. Mallotus japonicus (M. japonicus), a deciduous shrub belonging to the Euphorbiaceae family, contains ellagitannins such as corilagin, geraniin, mallotinic acid, and mallotusinic acid, which have antioxidant properties. Here, we investigated whether M. japonicus leaf extract inhibits ferroptosis in human proximal tubular epithelial HK2 cells. M. japonicus extract suppressed HK2 cell death caused by erastin, a ferroptosis inducer; this was accompanied by a reduction in intracellular Fe2+, ROS accumulation, and lipid peroxidation. Our findings suggested that the inhibitory effect of M. japonicus extract was due to the inhibition of transferrin receptor (CD71)-mediated Fe3+/2+ uptake. Furthermore, we determined that mallotinic acid is a key compound that exhibits anti-ferroptosis effects. Overall, our results provide useful information for the use of M. japonicus extract in the treatment of kidney injuries.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"153-161"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell sequencing analysis reveals the promotion of ELR CXCL genes on angiogenesis and the influence on malignant progression in glioblastoma. 单细胞测序分析揭示了ELR CXCL基因对胶质母细胞瘤血管生成的促进作用和对恶性进展的影响。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.3164/jcbn.25-26

Fanyong Gong, Yi Huang, Junjun Zhang, Jianfei Zhang, Haifeng Wang

{"title":"Single-cell sequencing analysis reveals the promotion of ELR CXCL genes on angiogenesis and the influence on malignant progression in glioblastoma.","authors":"Fanyong Gong, Yi Huang, Junjun Zhang, Jianfei Zhang, Haifeng Wang","doi":"10.3164/jcbn.25-26","DOIUrl":"10.3164/jcbn.25-26","url":null,"abstract":"Glioblastoma (GBM) is a highly aggressive cancer that significantly impacts human health. Myeloid cells and bone marrow-derived macrophages (BMDMs) are major components of tumor microenvironment; however, their roles in GBM tumorigenesis, progression, and treatment response remain unclear due to considerable heterogeneity. Single-cell sequencing data for GBM were collected from the Gene Expression Omnibus (GEO) database to analyze the heterogeneity of GBM cell subpopulations. Trends in myeloid cell subpopulations were examined, identifying cancer-associated BMDMs and key genes that were specifically overexpressed in this subgroup. Validation was performed through experiments in vitro, including quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to measure mRNA expressions of chemokine (C-X-C motif) ligand 3 (CXCL3), vascular endothelial growth factor A (VEGF-A), and matrix metallopeptidase 9 (MMP9); angiogenesis assays to observe endothelial cell tube formation; Cell Counting Kit-8 (CCK-8) assays to assess cell viability; colony formation assays for cell proliferation; Transwell assays to evaluate cell migration and invasion; and flow cytometry to measure apoptosis. Eight distinct cell types were identified in GBM, with a notable proportion of myeloid cells. Cancer-related BMDMs were characterized within the myeloid cell population, revealing specific overexpression of Glu-Leu-Arg (ELR) CXCL genes associated with angiogenesis and tumor development. Experiments in vitro confirmed that the ELR CXCL-related gene CXCL3 derived from BMDMs promoted angiogenesis and influenced GBM malignancy. The ELR CXCL + BMDM subgroup represented a critical cell type associated with the rapid growth of GBM, as the secreted CXCL3 enhanced angiogenesis and impacted GBM malignant progression.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"144-152"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newly developed evaluation for intestinal permeability using Caenorhabditis elegans: protective effects of agaro-oligosaccharides on intestinal permeability. 用秀丽隐杆线虫评价肠道通透性的新进展：琼脂寡糖对肠道通透性的保护作用。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.3164/jcbn.24-149

Natsumi Desaka, Yuji Naito, Yasuki Higashimura

{"title":"Newly developed evaluation for intestinal permeability using Caenorhabditis elegans: protective effects of agaro-oligosaccharides on intestinal permeability.","authors":"Natsumi Desaka, Yuji Naito, Yasuki Higashimura","doi":"10.3164/jcbn.24-149","DOIUrl":"10.3164/jcbn.24-149","url":null,"abstract":"The intestinal barrier represents the first line of host defense. Its dysfunction, defined as increased intestinal permeability, is widely recognized as an important factor in the clinical manifestation of various diseases. Consequently, maintenance of the intestinal barrier is necessary for human health. Caenorhabditis elegans has recently been used frequently as a model organism in studies of gut bacteria-host interactions and in screening for probiotics and prebiotics that promote gut health. Nevertheless, no quantitative method for evaluating the intestinal permeability of Caenorhabditis elegans has yet been established. This study assesses a newly developed evaluation method to assess the intestinal permeability of Caenorhabditis elegans quantitatively using liposomes encapsulating fluorescein isothiocyanate-dextran. The usefulness of this method was confirmed by measuring the intestinal permeability of Pseudomonas aeruginosa-infected or oxidative stress-induced worms. Furthermore, our method found that agaro-oligosaccharides, the hydrolysis products of agarose, have a beneficial function of preventing increased intestinal permeability. This approach can expand the utility of Caenorhabditis elegans for functional food discovery and drug candidate screening, with specific examination of their effects on gut function.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"113-119"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-derived exosomes containing circ_0008039 promote the stemness of colorectal cancer cells by inhibiting ferroptosis. 含有circ_0008039的肿瘤源性外泌体通过抑制铁下垂促进结直肠癌细胞的干性。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-04-11 DOI: 10.3164/jcbn.24-240

Mengjun Shen, Shenghong Wan, Xianwei Yang, Xiaoling Liu, Lin Ma, Xin Liao

{"title":"Tumor-derived exosomes containing circ_0008039 promote the stemness of colorectal cancer cells by inhibiting ferroptosis.","authors":"Mengjun Shen, Shenghong Wan, Xianwei Yang, Xiaoling Liu, Lin Ma, Xin Liao","doi":"10.3164/jcbn.24-240","DOIUrl":"10.3164/jcbn.24-240","url":null,"abstract":"This study was to investigate the impact of exosomes-derived circ_0008039 on ferroptosis and stemness in colorectal cancer cells, as well as its associated molecular mechanisms. The cell colony formation ability was evaluated using the MTT assay and colony formation assay, respectively. Additionally, the sphere formation assay was employed to examine the cells' ability to aggregate into spheres. The targeting relationship between circ_0008039, miR-302e, and SLC7A11 was verified through dual luciferase assay. Furthermore, RNA immunoprecipitation (RIP) analysis of circ_0008039 and miR-302e was conducted. Western blotting was utilized to detect the protein expression of exosome surface antigens (TSG101 and CD63), stem cell markers (CD133, Nanog, and SOX-2), as well as SLC7A11 in both exosomes and cell lysates. The levels of glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), and Fe2+ were determined using corresponding kits. Circ_0008039 exhibited significant downregulation in cancer tissues and cells. Furthermore, exosome-derived circ_0008039 played a crucial role in promoting cell viability, clone formation, and resistance to ferroptosis by inhibiting MDA, ROS, and Fe2+ levels. Additionally, circ_0008039 acted as a miR-302e sponge to regulate SLC7A11 expression. In colorectal cancer (CRC) tissues, miR-302e was negatively correlated with SLC7A11 expression while circ_0008039 was negatively correlated with miR-302e expression. Mechanistic validation demonstrated that circ_0008039 regulated CRC cell proliferation, stemness maintenance and ferroptosis through the modulation of the miR-302e/SLC7A11 axis. The Circ_0008039/miR-302e/SLC7A11 axis plays a pivotal role in facilitating the proliferation and maintenance of stemness in CRC cells, while enhancing resistance to ferroptosis.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"120-130"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of transarterial chemoembolization on serum opsonic activity in hepatocellular carcinoma measured by chemiluminescence. 化学发光法测定经动脉化疗栓塞对肝癌患者血清opsonic活性的影响。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-14 DOI: 10.3164/jcbn.25-80

Satoshi Sato, Daisuke Chinda, Misa Ozaki, Naoki Akimoto, Tetsu Arai, Kenta Yoshida, Chikara Iino, Shinya Kakehata, Fumiyasu Tsushima, Shingo Kakeda, Hirotake Sakuraba

{"title":"Influence of transarterial chemoembolization on serum opsonic activity in hepatocellular carcinoma measured by chemiluminescence.","authors":"Satoshi Sato, Daisuke Chinda, Misa Ozaki, Naoki Akimoto, Tetsu Arai, Kenta Yoshida, Chikara Iino, Shinya Kakehata, Fumiyasu Tsushima, Shingo Kakeda, Hirotake Sakuraba","doi":"10.3164/jcbn.25-80","DOIUrl":"10.3164/jcbn.25-80","url":null,"abstract":"This study aimed to evaluate the physical stress associated with transarterial chemoembolization (TACE), a catheter-based treatment for hepatocellular carcinoma, by examining changes in serum opsonic activity (SOA). SOA was examined by measuring reactive oxygen species (ROS) produced by neutrophils using lucigenin-dependent chemiluminescence (LgCL) and luminol-dependent chemiluminescence (LmCL). Sixty-four patients were enrolled, and SOA was measured at admission, the following day, and 3 days after TACE. The area under the curve (AUC) for LgCL did not change significantly from baseline to the day after TACE but increased significantly from the following day to 3 days post-TACE. In contrast, no changes were observed in the AUC of LmCL. Subgroup analyses revealed a significant increase in LgCL from day 1 to day 3 post-TACE among patients aged >75 years, males, body mass index (BMI) <25 ‍kg/m2, those with a FIB-4 index of ≥2.67, cisplatin use, Hepatitis B virus/Hepatitis C virus-related liver disease, or a procedure time ≥120 ‍min. Multivariate analyses identified BMI <25 ‍kg/m2 and cisplatin use as significant risk factors for increased LgCL. Although TACE is considered a minimally invasive procedure, low BMI and cisplatin use have been identified as notable sources of significant physical stresses.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"195-201"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect. 线粒体氧化应激、细胞损伤和干细胞衰老在复合体II电子传递缺陷早衰模型中的作用。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-07-02 DOI: 10.3164/jcbn.25-62

Takamasa Ishii, Kayo Yasuda, Masaki Miyazawa, Hiromi Onouchi, Sumino Yanase, Naoaki Ishii

{"title":"Mitochondrial oxidative stress, cellular damages and stem cell aging in premature aging models with complex II electron transport defect.","authors":"Takamasa Ishii, Kayo Yasuda, Masaki Miyazawa, Hiromi Onouchi, Sumino Yanase, Naoaki Ishii","doi":"10.3164/jcbn.25-62","DOIUrl":"10.3164/jcbn.25-62","url":null,"abstract":"Mitochondria which are the major intracellular reactive oxygen species (ROS) sources produce especially superoxide anion (O2 •-) as a byproduct of energy production. It has been well known that O2 •- is converted from oxygen (O2) and is overproduced by excessive electron leakage from the mitochondrial electron transport chain (ETC), mainly complexes I and III. However we have previously reported that several point mutations (specifically G71E in C. elegans, I71E in Drosophila and V69E in mouse) in succinate dehydrogenase C subunit (SDHC) of complex II cause mitochondrial electron transport defect leading to O2 •- overproduction from mitochondria. These mutations can cause endogenous oxidative stress resulting in tumorigenesis and apoptosis as well as premature death. Recently, we have also demonstrated that premature aging of hematopoietic stem cell with a mutation in SDHC is developed after the growth phase and normal development. Here, we review cellular damages by complex II electron transport defect-induced endogenous oxidative stress in premature aging models.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"101-112"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the serum ratio of l-cysteine to glutathione for the prediction of cardiovascular events. 血清l-半胱氨酸/谷胱甘肽比值预测心血管事件的有效性。

IF 1.7 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.3164/jcbn.24-156

Yuki Ishinoda, Nobuyuki Masaki, Yasuhiro Hitomi, Ryota Nakazawa, Akira Taruoka, Akane Kawai, Midori Iwashita, Yasuo Ido, Yusuke Yumita, Kazuki Kagami, Risako Yasuda, Yukinori Ikegami, Takumi Toya, Yuji Nagatomo, Bonpei Takase, Takeshi Adachi

{"title":"Effectiveness of the serum ratio of l-cysteine to glutathione for the prediction of cardiovascular events.","authors":"Yuki Ishinoda, Nobuyuki Masaki, Yasuhiro Hitomi, Ryota Nakazawa, Akira Taruoka, Akane Kawai, Midori Iwashita, Yasuo Ido, Yusuke Yumita, Kazuki Kagami, Risako Yasuda, Yukinori Ikegami, Takumi Toya, Yuji Nagatomo, Bonpei Takase, Takeshi Adachi","doi":"10.3164/jcbn.24-156","DOIUrl":"10.3164/jcbn.24-156","url":null,"abstract":"Aminothiols play an important role in the antioxidant defense system. Their serum profile may be a predictor of prognosis and cardiovascular events. This study followed-up 262 patients (202 men; age, 65 ± 13 years) who had been treated for cardiovascular disease. The patients were divided into two groups by the median total l-cysteine to total glutathione (tCySH/tGSH) ratio in serum at enrollment. There were 32 (11%) all-cause deaths, 20 (8%) cardiovascular deaths, and 32 (12%) major cardiovascular events in 5.5 ± 3.2 years. Twenty-nine (11%) patients were hospitalized for heart failure. The high tCySH/tGSH ratio group (≥80.70) had a higher incidence of all-cause death than the low tCySH/tGSH ratio group (<80.70; log-rank test, p = 0.025). Multivariate Cox regression analysis adjusted for age, sex, body mass index, current smoking, renal function, and log10-transformed brain natriuretic peptide showed that the tCySH/tGSH ratio had predictive value for all-cause death, cardiovascular death, and heart failure. The adjusted hazard ratio for heart failure for the high versus low tCySH/tGSH ratio groups was 3.071 (95% confidence interval: 1.186-7.952; p = 0.021). The tCySH/tGSH ratio may be an useful biomarker to assess prognosis, cardiovascular events, and heart failure.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"77 2","pages":"174-181"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0