Partially hydrolyzed guar gum ingestion suppresses atopic dermatitis-like symptoms through prebiotic effect in mice.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-05-01 Epub Date: 2025-02-06 DOI:10.3164/jcbn.24-219
So Morishima, Aya Abe, Saki Okamoto, Mahendra P Kapoor, Shiho Matsuura, Kenji Kuriya, Makoto Ozeki, Masahiro Nishio, Hiroto Miura, Ryo Inoue
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引用次数: 0

Abstract

Growing knowledge reveals the association between the gut microbiome and skin, rendering the gut microbiome an appealing potential therapeutic target for atopic dermatitis (AD). In this study, we assessed the effect of partially hydrolyzed guar gum (PHGG) on AD-like symptoms induced by topical 1-Chloro-2,4-dinitrobenzene (DNCB) in BALB/c mice. Four weeks of PHGG feeding prevented the loss of epidermal barrier integrity and epithelial hyperplasia in the AD lesion (p<0.05, effect size >0.80), indicating a reduction in AD-like symptoms. According to the postulated mechanism, PHGG ingestion modulates the gut microbiome resulting in enhanced butyrate production (p<0.05). Butyrate suppresses Th2 function in gut immunity, which is believed to have significance in systemic immune regulation. The lowering of blood Th2 cytokines (IL-4 and IL-10, p<0.05) in the PHGG-fed group confirmed the existence of such a pathway, and butyrate can possibly be considered to have an indirect involvement in the suppression of Th2 immune response in the AD lesions. These findings encourage support for an association between gut microbiome and skin through the immune system, implying that daily PHGG ingestion may be beneficial for suppressing AD symptoms across the gut-immune-skin axis.

部分水解瓜尔胶摄入通过益生元效应抑制小鼠特应性皮炎样症状。
越来越多的知识揭示了肠道微生物群与皮肤之间的联系,使肠道微生物群成为特应性皮炎(AD)的潜在治疗靶点。在本研究中,我们评估了部分水解瓜尔胶(PHGG)对外用1-氯-2,4-二硝基苯(DNCB)引起的BALB/c小鼠ad样症状的影响。四周的PHGG喂养阻止了AD病变中表皮屏障完整性和上皮增生的丧失(p0.80),表明AD样症状减轻。根据假设的机制,摄入PHGG调节肠道微生物组,从而增强丁酸盐的产生
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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