Ischemia/reperfusion-associated oxidative stress is an aggravating factor for pressure ulcers.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-05-01 Epub Date: 2025-03-04 DOI:10.3164/jcbn.25-28
Eri Murata, Junichi Fujii
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引用次数: 0

Abstract

Prolonged compression restricts blood flow, which can result in an insufficient supply of the oxygen and nutrients that are necessary for cells to live and thrive. A pressure ulcer (PU) is a pathological condition of prolonged ischemia and is associated with a loss of epidermis, which could expose the dermis and deeper tissues. It is necessary to remove the causative pressure and resume blood flow, but injurious damage to the ischemic area could occur with a delay after blood reflow, which could result in reperfusion injury. In the early stages of compression, muscle cells, which are highly dependent on aerobic respiration, are preferably damaged, and then the injury could spread to other dermal and epithelial cells. Infiltrated leukocytes release a variety of substances such as cytokines and reactive oxygen species (ROS) that act as anti-microorganisms, but these could also aggravate inflammation. The ROS are deeply involved in the pathogenesis of this condition, and, hence, antioxidant compounds and enzymes play a vital role in preventing the progression of PUs. We focus on oxidative stress in PUs, which is exacerbated by the actions of ischemia/reperfusion, and we discuss effective prevention and treatment from the perspectives of micronutrients and antioxidants.

缺血/再灌注相关的氧化应激是压疮的加重因素。
长时间的压迫限制了血液流动,这可能导致细胞生存和繁荣所必需的氧气和营养供应不足。压疮(PU)是一种长期缺血的病理状态,与表皮的丧失有关,可暴露真皮和更深的组织。虽然有必要去除致病压,恢复血流,但血液回流后可能出现缺血区域的损伤,导致再灌注损伤。在压迫的早期阶段,高度依赖有氧呼吸的肌肉细胞最好受到损伤,然后损伤可能扩散到其他真皮和上皮细胞。浸润的白细胞释放多种物质,如细胞因子和活性氧(ROS),作为抗微生物,但这些也可能加重炎症。ROS深入参与了这种疾病的发病机制,因此抗氧化化合物和酶在预防脓毒症的进展中起着至关重要的作用。我们将重点关注脓肿的氧化应激,并从微量营养素和抗氧化剂的角度讨论有效的预防和治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
8.30%
发文量
57
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical Biochemistry and Nutrition (JCBN) is an international, interdisciplinary publication encompassing chemical, biochemical, physiological, pathological, toxicological and medical approaches to research on lipid peroxidation, free radicals, oxidative stress and nutrition. The Journal welcomes original contributions dealing with all aspects of clinical biochemistry and clinical nutrition including both in vitro and in vivo studies.
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