Journal of Clinical Biochemistry and Nutrition最新文献_第3页

Effects of an 8-week intake of lysolecithin on cognitive function and concentrations of blood choline and lysophosphatidylcholine: a randomized, double-blinded, placebo-controlled trial.

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-08-24 DOI: 10.3164/jcbn.24-105

Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada

{"title":"Effects of an 8-week intake of lysolecithin on cognitive function and concentrations of blood choline and lysophosphatidylcholine: a randomized, double-blinded, placebo-controlled trial.","authors":"Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada","doi":"10.3164/jcbn.24-105","DOIUrl":"10.3164/jcbn.24-105","url":null,"abstract":"Choline is an essential nutrient for normal brain function, but its bioavailability is not as high as choline esters. Among choline esters, lysophosphatidylcholine (LPC) has unexplored potential as a choline source and cognitive enhancer in humans. This placebo-controlled, double-blinded study, involving healthy participants aged 40-74 years, aimed to assess the effects of an 8-week intake of lysolecithin containing 480 ‍mg LPC on cognitive function and plasma levels of choline and LPC. Twenty-three participants were assigned to both the placebo and lysolecithin groups, and memory was assessed as the primary outcome. Additionally, subjective mental function was assessed. Plasma levels of derivatives of reactive oxygen metabolites were also evaluated for a safety assessment. No significant between-group differences were observed in the memory or mental function score, but a post-hoc analysis yielded significant within-group increases from baseline in subjective mental acuity and calmness in the lysolecithin group. Lysolecithin intake slightly increased plasma choline and LPC18:2 concentrations over 8 weeks, but plasma levels of saturated and total LPC concentrations, associated with inflammation, and derivatives of reactive oxygen metabolites remained unchanged. No adverse events were attributed to lysolecithin supplementation. This study demonstrated lysolecithin's good tolerability and potential as a new choline supplement.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"59-63"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prune extract prevents disuse osteoporosis by inhibiting the decrease in osteoblast-related gene expression in sciatic-denervated rats.

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI: 10.3164/jcbn.24-139

Fumiaki Hanzawa, Kohei Kiriyama, Ayano Nakashima, Akari Iwami, Hirotaka Yamamoto

{"title":"Prune extract prevents disuse osteoporosis by inhibiting the decrease in osteoblast-related gene expression in sciatic-denervated rats.","authors":"Fumiaki Hanzawa, Kohei Kiriyama, Ayano Nakashima, Akari Iwami, Hirotaka Yamamoto","doi":"10.3164/jcbn.24-139","DOIUrl":"10.3164/jcbn.24-139","url":null,"abstract":"In sedentary modern society, disuse osteoporosis is a health issue. Here, we investigate whether prune extract prevents disuse osteoporosis in rats. After feeding a control diet or 10% (wt/wt) prune extract-containing diet for 14 ‍days, we performed sham operation in the left leg and sciatic denervation in the right leg to induce disuse osteoporosis in rats. The rats were fed the same diet prior to surgery for 7 days. The rats fed a control diet before sham operation on both legs were set as the control group, and those with sciatic denervation in the right leg fed a control diet or prune extract containing diet were set as the denervation with control diet and denervation with prune extract diet groups, respectively. Femoral bone volume/tissue volume, trabecular number, and trabecular thickness were reduced in the right leg of denervation with control diet group; however, this reduction was not observed in the denervation with prune extract diet group. Similar results were obtained for mRNA levels of osteoblast-related genes, such as osteocalcin. Overall, prune extract inhibited bone loss by preventing the decrease in osteoblast-related gene expression in disuse osteoporosis, thus showing to improve the bone metabolism and quality of life.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"42-49"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between serum zinc level and clinical features in patients with inflammatory bowel disease.

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.3164/jcbn.24-64

Tatsushi Omatsu, Tomohisa Takagi, Takeshi Yasuda, Yuki Nakahata, Sadanari Hayashi, Rieko Mukai, Takuya Kurobe, Yuriko Yasuda, Nobuhiro Fukuta, Naoyuki Sakamoto, Kazuhiko Uchiyama, Akihiro Obora, Yoshiki Murakami, Takao Kojima, Yuji Naito, Yoshito Itoh, Nobuaki Yagi

{"title":"The association between serum zinc level and clinical features in patients with inflammatory bowel disease.","authors":"Tatsushi Omatsu, Tomohisa Takagi, Takeshi Yasuda, Yuki Nakahata, Sadanari Hayashi, Rieko Mukai, Takuya Kurobe, Yuriko Yasuda, Nobuhiro Fukuta, Naoyuki Sakamoto, Kazuhiko Uchiyama, Akihiro Obora, Yoshiki Murakami, Takao Kojima, Yuji Naito, Yoshito Itoh, Nobuaki Yagi","doi":"10.3164/jcbn.24-64","DOIUrl":"10.3164/jcbn.24-64","url":null,"abstract":"Zinc is an essential element and important for inflammatory bowel disease patients. Herein, we aimed to elucidate the correlation between serum zinc concentration and various parameters, especially the disease activity index and endoscopic scores, in these patients. We measured serum zinc concentrations in 37 patients with Crohn's disease and 64 with ulcerative colitis and retrospectively analyzed patient characteristics, blood test values, disease activity, and endoscopic scores. Hypozincemia (<80 ‍μg/dl) was observed in 45.9% and 29.7% of patients with Crohn's disease and ulcerative colitis, respectively. Serum zinc concentration showed a weak negative correlation with Crohn's Disease Activity Index and C-reactive protein levels in Crohn's disease patients, and a weak negative correlation with white blood cell count in ulcerative colitis patients. The zinc concentrations in ulcerative colitis patients were significantly lower in Mayo endoscopic sub-score grade 2 than in grades 0 and 1. The simple endoscopic score for Crohn's disease moderately correlated with zinc concentration. In addition, serum zinc concentration showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index in both Crohn's disease and ulcerative colitis patients. Serum zinc concentration clearly correlated with inflammatory bowel disease activity, endoscopy scores, and immunonutritional parameters, suggesting the importance of monitoring zinc levels.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"50-58"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in healthy, urban residents aged ≥50 years in Japan.

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI: 10.3164/jcbn.24-96

Hiroteru Okamoto, Koji Teruya

{"title":"Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in healthy, urban residents aged ≥50 years in Japan.","authors":"Hiroteru Okamoto, Koji Teruya","doi":"10.3164/jcbn.24-96","DOIUrl":"10.3164/jcbn.24-96","url":null,"abstract":"Previous studies have suggested a relationship between the urinary 8-hydroxydeoxyguanosine level and hypertension, but an association between the urinary 8-hydroxydeoxyguanosine level and systolic blood pressure has not been reported. The aim of this cross-sectional study was to examine the association between the 8-hydroxydeoxyguanosine level, a marker of DNA oxidative damage, and arteriosclerosis-related factors in healthy, urban residents aged ≥50 years who participated in annual health promotion activities in Mitaka City, Tokyo from 2008 to 2018. Arteriosclerosis-related factors were used as independent variables and the urinary 8-hydroxydeoxyguanosine creatinine concentration-corrected level (urinary 8-hydroxydeoxyguanosine/creatinine) as the dependent variable in multiple logistic regression. Two hundred and forty-eight participants were divided into two groups using a cutoff point of 6.2/6.3 ‍ng/mg creatinine, which corresponds to the urinary 8-hydroxydeoxyguanosine/creatinine levels in approximately 80% of the participants. A high urinary 8-hydroxydeoxyguanosine/creatinine level was significantly associated with a body mass index ≥25, obesity, and systolic blood pressure ≥140. Our findings suggest that in healthy individuals aged ≥50 years, arteriosclerosis-related factors such as inappropriate weight management and poor systolic blood pressure control may be associated with the urinary 8-hydroxydeoxyguanosine level.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"90-95"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans.

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.3164/jcbn.24-69

Mahendra P Kapoor, Aya Abe, So Morishima, Atsushi Nakajima, Makoto Ozeki, Norio Sato

{"title":"Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans.","authors":"Mahendra P Kapoor, Aya Abe, So Morishima, Atsushi Nakajima, Makoto Ozeki, Norio Sato","doi":"10.3164/jcbn.24-69","DOIUrl":"10.3164/jcbn.24-69","url":null,"abstract":"Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 ‍g PHGG dietary fiber (n = 35) or a 5 ‍g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"96-115"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori infection and oxidative stress. 幽门螺杆菌感染和氧化应激。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.3164/jcbn.24-109

Hidekazu Suzuki, Miwa Hirai

引用次数: 0

Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study. 1 型糖尿病患者中乳糜泻的患病率：一项单中心横断面队列研究。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-06-14 DOI: 10.3164/jcbn.24-39

Yuki Nishimoto, Naoko Hashimoto, Nozomi Kido, Aya Irahara, Takehito Takeuchi, Michinori Takabe, Shunji Ishihara, Yoshikazu Kinoshita, Takeshi Ohara

{"title":"Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study.","authors":"Yuki Nishimoto, Naoko Hashimoto, Nozomi Kido, Aya Irahara, Takehito Takeuchi, Michinori Takabe, Shunji Ishihara, Yoshikazu Kinoshita, Takeshi Ohara","doi":"10.3164/jcbn.24-39","DOIUrl":"10.3164/jcbn.24-39","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) may be associated with other autoimmune diseases. Celiac disease (CD), another autoimmune disorder that mainly affects the small intestine, is caused by intolerance to gluten ingestion. CD has a higher prevalence in patients with T1DM than in the general population. However, the prevalence of CD in patients with T1DM in Japan is unknown. This study investigated the prevalence of CD in Japanese patients with T1DM. We included 115 patients with T1DM treated at Hyogo Brain and Heart Center from December 2020 to April 2021. A questionnaire survey about dietary habits and abdominal symptoms was administered, and serum anti-tissue transglutaminase (TTG) antibody titers were determined for all participants. A CD (CD-seropositive) diagnosis was based on TTG levels >10 U/ml. Fifty-eight patients (50.4%) had some abdominal symptoms (such as constipation, diarrhea, and abdominal pain). The average TTG-IgA antibody titer was 0.75 ± 0.49 U/ml and negative (<10 U/ml) in all patients. In conclusion, the prevalence of CD among patients with T1DM at our hospital was 0%. Thus, the prevalence of CD in Japan is low compared to that in other countries, even among patients with T1DM, who are considered to have high comorbidity rates.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"213-216"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation. 冷大气压等离子体射流辐照脂质体的脂质过氧化机理。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.3164/jcbn.24-72

Tokuko Takajo, Koichi Saito, Kazunori Tsuchida, Shunji Kato, Kiyotaka Nakagawa, Akitoshi Okino, Kazunori Anzai

{"title":"Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation.","authors":"Tokuko Takajo, Koichi Saito, Kazunori Tsuchida, Shunji Kato, Kiyotaka Nakagawa, Akitoshi Okino, Kazunori Anzai","doi":"10.3164/jcbn.24-72","DOIUrl":"10.3164/jcbn.24-72","url":null,"abstract":"Liposome lipid peroxidation induced by cold atmospheric pressure plasma jet (CAPPJ) irradiation was investigated. The formation of thiobarbituric acid reactive substances (TBARS), an indicator of lipid peroxidation final products, as a function of irradiation was observed. Lipid radicals, peroxidation reaction intermediates generated by CAPPJ irradiation, were confirmed by increased NBD-pen fluorescence intensity. Additionally, lipid peroxidation products, liposomal phosphatidylcholine (PC) isomers, were analyzed by LC-MS/MS. Products specific to singlet oxygen (1O2) oxidation, 16:0/10-hydroperoxy-8E,12Z-octadecanoic acid (10-8E,12Z-HpODE) PC and 16:0/12-9E,13E-HpODE PC, were not detected, but radical oxidation specific products 16:0/13-9E,11E-HpODE PC and 16:0/9-10E,12E-HpODE PC were. This suggests that during CAPPJ irradiation, radicals, rather than 1O2, are the primary reactive species of lipid peroxidation. This is also supported by the β-carotene quenching of 1O2 not suppressing TBARS and lipid radical generation. Also, neither TBARS formation nor lipid radical generation were suppressed by SOD, indicating that the superoxide radical (O2 •-) is not responsible for the lipid peroxidation reaction. As the CAPPJ irradiation of water produces large quantities of hydroxyl radical (•OH) and •OH scavengers decreased the amount of TBARS produced by CAPPJ irradiation, it is highly plausible that •OH is the primary species involved in CAPPJ-induced liposome lipid peroxidation.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"183-189"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 mg/dl during annual or biannual medical checkups: a case-control study in Japan. 日本一项病例对照研究：年度或半年度体检中首次被诊断为高血糖超过 126 毫克/分升的受试者的特征因素。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.3164/jcbn.24-98

Miwako Minami, Tomohiro Imamura, Ayako Takamori, Hiromu Minagawa, Rina Matsuo, Junko Miyakawa, Kenichi Izumi, Shoichiro Ohta, Kohei Yamanouchi, Nobuya Souta, Kyosuke Yamamoto, Sadatosi Tsuji, Tsukuru Umemura, Keizo Anzai, Yuji Hirai, Kazuma Fujimoto, Takuya Kishi

{"title":"Characterized factors of subjects who were first time diagnosed as hyperglycemia more than 126 mg/dl during annual or biannual medical checkups: a case-control study in Japan.","authors":"Miwako Minami, Tomohiro Imamura, Ayako Takamori, Hiromu Minagawa, Rina Matsuo, Junko Miyakawa, Kenichi Izumi, Shoichiro Ohta, Kohei Yamanouchi, Nobuya Souta, Kyosuke Yamamoto, Sadatosi Tsuji, Tsukuru Umemura, Keizo Anzai, Yuji Hirai, Kazuma Fujimoto, Takuya Kishi","doi":"10.3164/jcbn.24-98","DOIUrl":"10.3164/jcbn.24-98","url":null,"abstract":"The present study examined factors in subjects diagnosed with hyperglycemia during periodic medical checkups. In total, 9,324 subjects (males: 4,532, females: 4,792) visited the Takagi Hospital for medical checkups in 2019. Eighty-two subjects (59 males) whose fasting blood glucose exceeded 126 mg/dl for the first time during the annual or biannual follow-up were included. Sex- and age-matched controls were used. Data from cases with hyperglycemia were compared to data from themselves one or two years before hyperglycemia. Body mass index (BMI), waist circumference, fatty liver, and blood pressure were higher in cases than in controls. Fasting blood glucose and hemoglobin A1c were higher in cases. Blood test results indicated that triglyceride, low-density lipoprotein (LDL) cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (γ-GTP), were significantly enhanced in cases. Multiple logistic regression analysis revealed that BMI, waist circumference, blood pressure, triglyceride, ALT, and γ-GTP were significant independent risk factors for cases with hyperglycemia. These risk factors were already enhanced in the cases of themselves in one or two years before hyperglycemia. In conclusion, BMI, waist circumference, blood pressure, and fatty liver indicated by ALT and γ-GTP were exacerbated concomitant with hyperglycemia, and increases in these factors preceded hyperglycemia.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"217-221"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cerium oxide on iron metabolism in mice. 氧化铈对小鼠铁代谢的影响

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.3164/jcbn.24-38

Yuki Kanome, Shunki Ohtomo, Masaharu Nakatsu, Masahiro Kohno, Koji Fukui

{"title":"Effect of cerium oxide on iron metabolism in mice.","authors":"Yuki Kanome, Shunki Ohtomo, Masaharu Nakatsu, Masahiro Kohno, Koji Fukui","doi":"10.3164/jcbn.24-38","DOIUrl":"10.3164/jcbn.24-38","url":null,"abstract":"The use of metal nanoparticles such as cerium oxide nanoparticles (nanoceria) in living organisms is attracting increasing attention. We administered nanoceria to chronic kidney disease model rats, including a 5/6 nephrectomy model and adenine administration model rats, and reported high phosphorus adsorption capacity and renal function improvement effects of nanoceria. However, the iron ion concentration in the serum fluctuated significantly after administration. Therefore, we investigated changes in proteins related to iron metabolism following administration of nanoceria to normal mice without chronic kidney disease over different periods of time. Nanoceria were administered to 10-week-old C57BL/6 mice for 4 or 12 weeks. Another group was administrated lanthanum carbonate, which is currently used as a phosphorus adsorbent. The amount of iron in the serum and the concentration of transferrin in the liver were significantly increased following nanoceria administration, and the amount of iron in the liver was significantly decreased. There were no changes in serum hepcidin, ferroportin, cholesterol, or low-density lipoprotein levels. These results indicate that nanoceria administration can affect iron metabolism in mice. Although the detailed mechanism remains unknown, caution is warranted when considering biological utilization in the future.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"190-196"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0