Journal of Clinical Biochemistry and Nutrition最新文献_第3页

Identification and validation of lactylation-related diagnostic biomarkers for type 2 diabetes by WGCNA. WGCNA对2型糖尿病乳酸化相关诊断生物标志物的鉴定和验证

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-03-06 DOI: 10.3164/jcbn.25-245

Najun Zhu, Suping Gu, Ying Shen, Lvxia Zhou, Weiping Tu

{"title":"Identification and validation of lactylation-related diagnostic biomarkers for type 2 diabetes by WGCNA.","authors":"Najun Zhu, Suping Gu, Ying Shen, Lvxia Zhou, Weiping Tu","doi":"10.3164/jcbn.25-245","DOIUrl":"10.3164/jcbn.25-245","url":null,"abstract":"Lactylation, a novel post-translational histone modification, has emerged as a critical regulatory mechanism in various metabolic disorders. However, its role in the pathogenesis of type 2 diabetes (T2D) remains poorly understood. This study aims to investigate the potential of lactylation-related genes as diagnostic biomarkers for T2D. Differential analysis and weighted gene co-expression network analysis (WGCNA) were performed on the GSE164416 dataset. Genes obtained from these analyses were intersected with the lactylation-related genes to screen candidate genes. The LASSO, SVM-RFE and random forest algorithms were applied to screen the characteristic genes, and their diagnostic efficacy was verified in the independent cohort. The functions and immune associations were analyzed by GSVA, ssGSEA, and TF-miRNA regulatory network analysis, and qRT-PCR, Western blot and CCK-8 experiments were conducted in the T2D cell model for verification. Lactylation-related IKZF1, S100A4, and VIM were identified as potential diagnostic markers for T2D. These three genes were significantly upregulated in T2D samples and exhibited excellent diagnostic performance (AUC >0.80) in both the training set and validation set. The GSVA analysis revealed that these three genes were involved in key biological processes such as immune regulation, transcriptional modification, metabolic homeostasis and cytoskeleton remodeling. Cell experiments demonstrated that the three genes were upregulated in T2D cell models and knockdown of their expression could promote cell viability. This study identified and validated three potential diagnostic markers related to lactylation for T2D, providing new molecular evidence for the early diagnosis and mechanism research of this disease.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"238-250"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI. 血清维生素（维生素D、维生素B12）和微量元素（铁、锌、铜）水平对行原发性PCI的STEMI患者主要不良心血管事件和不良预后的影响

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2025-12-27 DOI: 10.3164/jcbn.25-166

ChunYan Wang, Dong Liu, MinJie Tang, JinDa Liu, YiJia Ma

{"title":"Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.","authors":"ChunYan Wang, Dong Liu, MinJie Tang, JinDa Liu, YiJia Ma","doi":"10.3164/jcbn.25-166","DOIUrl":"10.3164/jcbn.25-166","url":null,"abstract":"To investigate the impact of serum vitamin {25-hydroxyvitamin D3 [25(OH)D3] and vitamin B12} and trace element [iron (Fe), zinc (Zn), and copper (Cu)] levels on major adverse cardiovascular events (MACE) and prognosis in patients with first-onset ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). A total of 202 first-onset STEMI patients undergoing emergency PCI were prospectively enrolled and divided into MACE (n = 72) and non-MACE (n = 130) groups according to 12-month postoperative MACE occurrence. Baseline characteristics, cardiac function parameters, and serum levels of 25(OH)D3, vitamin B12, Fe, Zn, and Cu were measured. Multivariate logistic regression was performed to identify independent influencing factors. Receiver operating characteristic curves were used to evaluate predictive value for MACE. Kaplan-Meier analysis was conducted to assess associations with rehospitalization rates and quality of life (SF-36 scale). The MACE group exhibited significantly lower serum 25(OH)D3, vitamin B12, and Zn levels but higher Fe and Cu levels compared with the non-MACE group. Multivariate analysis identified 25(OH)D3, vitamin B12, and Zn were independently associated with a lower risk of MACE, while Fe and Cu were independently associated with a higher risk of MACE. The combined predictive AUC of 25(OH)D3 and vitamin B12 for MACE was 0.79, which was superior to individual indicators. Moreover, abnormal levels were associated with higher 12-month rehospitalization rates and lower SF-36 scores. Decreased serum 25(OH)D3, vitamin B12, and Zn levels and elevated Fe/Cu levels are significantly associated with MACE occurrence and poor prognosis in first-onset STEMI patients post-PCI.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"189-196"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rank-based robust change-point regression approach in human intervention studies of functional foods. 基于秩的稳健变点回归方法在功能性食品人为干预研究中的应用。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-02-13 DOI: 10.3164/jcbn.25-264

Kohsuke Hayamizu

{"title":"A rank-based robust change-point regression approach in human intervention studies of functional foods.","authors":"Kohsuke Hayamizu","doi":"10.3164/jcbn.25-264","DOIUrl":"10.3164/jcbn.25-264","url":null,"abstract":"Heterogeneity of treatment effects is common in functional-food studies, particularly when baseline characteristics influence the magnitude of response. Change-point regression models (CPRM) are useful for identifying the baseline level at which an intervention effect begins to appear. However, conventional CPRM relies on ordinary least squares (OLS-CPRM) and is sensitive to outliers, which can lead to unstable estimation of the change point (τ). To address this issue, I developed a rank-based robust CPRM (RR-CPRM) and evaluated its utility using two clinical datasets. RR-CPRM produced estimates of τ consistent with those of the conventional model while providing narrower bootstrap confidence intervals, indicating improved stability and reduced sensitivity to outliers. In datasets with little to no influence from outliers, RR-CPRM yielded results comparable to OLS-CPRM, demonstrating that robustness is achieved without loss of performance. These findings suggest that RR-CPRM offers a reliable and flexible framework for evaluating baseline-dependent intervention effects in human functional-food trials and may contribute to more accurate interpretation of clinical outcomes.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"231-237"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle-based antioxidants suppress angioplasty-induced neointimal hyperplasia in rat carotid arteries. 纳米颗粒抗氧化剂抑制大鼠颈动脉血管成形术诱导的新生内膜增生。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-28 DOI: 10.3164/jcbn.25-231

Daisuke Watanabe, Aiki Marushima, Yukio Nagasaki, Eiichi Ishikawa, Yuji Matsumaru

{"title":"Nanoparticle-based antioxidants suppress angioplasty-induced neointimal hyperplasia in rat carotid arteries.","authors":"Daisuke Watanabe, Aiki Marushima, Yukio Nagasaki, Eiichi Ishikawa, Yuji Matsumaru","doi":"10.3164/jcbn.25-231","DOIUrl":"10.3164/jcbn.25-231","url":null,"abstract":"Oxidative stress and vascular inflammation predominantly influence restenosis following angioplasty, causing neointimal hyperplasia. Conventional antioxidants are rapidly eliminated and inadequately localized to injured vessels. We evaluated nitroxide radical-containing nanoparticles (RNPs), polymeric micelles covalently conjugated with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, in a rat carotid artery balloon injury model. Rhodamine-labeled RNPs selectively accumulated at the injured endothelium and penetrated into the neointima and media. RNPs significantly reduced intimal area, intima-to-media ratio, and preserved lumen patency compared with saline and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL). Mechanistic analyses revealed suppression of reactive oxygen species and oxidized low-density lipoprotein accumulation, LOX-1 expression attenuation, E-selectin-positive endothelial cell reduction, and decreased proinflammatory M1 macrophage infiltration. These findings demonstrate that RNPs effectively suppress angioplasty-induced neointimal hyperplasia through selective vascular accumulation and sustained radical scavenging. Therefore, antioxidant nanomedicine represents a promising therapeutic approach distinct from conventional antioxidants or drug-eluting stents, with translational potential for restenosis prevention.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"205-213"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of chronic kidney disease caused by dietary risks in China from 1990 to 2021: a systematic analysis and comparison with global levels. 1990 - 2021年中国膳食风险引起的慢性肾脏疾病负担：与全球水平的系统分析与比较

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-14 DOI: 10.3164/jcbn.25-143

Lyuxia Zhou, Xiaoni Cai, Shaoqing Qian, Dongyao Guan, Heping Lyu

{"title":"Burden of chronic kidney disease caused by dietary risks in China from 1990 to 2021: a systematic analysis and comparison with global levels.","authors":"Lyuxia Zhou, Xiaoni Cai, Shaoqing Qian, Dongyao Guan, Heping Lyu","doi":"10.3164/jcbn.25-143","DOIUrl":"10.3164/jcbn.25-143","url":null,"abstract":"Diet is a modifiable risk factor for chronic kidney disease (CKD). However, in China, the trend of changes in CKD burden caused by dietary risk has not been fully elucidated. The CKD burden in China and globally from 1990 to 2021 was analyzed, with the time-dependent trend in CKD burden detected through Joinpoint regression analysis. We also analyzed the trend of CKD burden with age and the contribution of specific dietary risk behaviors to the burden of CKD. From 1990 to 2021, the ASR of deaths and disability-adjusted life years (DALYs) caused by dietary risk factors showed a downward trend in China, decreasing by 31.82% and 33.38%, respectively, while exhibiting an upward trend at the global level, increasing by 18.44% and 11.18%, respectively. The analysis of specific dietary risk behaviors demonstrated that highly sweetened beverages had the largest contribution to the increase in age standardized mortality rate (ASMR) and age standardized DALY rate (ASDR) for CKD at both the Chinese and global levels. Our study revealed that the burden of CKD caused by dietary risk factors is decreasing in China, while it is increasing globally. This result provides a scientific reference for developing targeted dietary and public health strategies.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"181-188"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of serum vitamin D and serum vitamin C with the risk of melanoma among adults in the United States: a cross-sectional analysis of 2003-2006 and 2017-2018 NHANES data. 美国成年人血清维生素D和血清维生素C与黑色素瘤风险的关系：2003-2006年和2017-2018年NHANES数据的横断面分析

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-02-14 DOI: 10.3164/jcbn.25-280

Yimei Han, Yan Liang, Jinming Wang, Dongfeng Zheng, Fenghua Sun, Rongyao Zhou, Jinde Lin

{"title":"Association of serum vitamin D and serum vitamin C with the risk of melanoma among adults in the United States: a cross-sectional analysis of 2003-2006 and 2017-2018 NHANES data.","authors":"Yimei Han, Yan Liang, Jinming Wang, Dongfeng Zheng, Fenghua Sun, Rongyao Zhou, Jinde Lin","doi":"10.3164/jcbn.25-280","DOIUrl":"10.3164/jcbn.25-280","url":null,"abstract":"To analyze the relationship between serum Vitamin D (VD) and Vitamin C (VC) levels and melanoma risk in American adults using NHANES data. The exposure variables were serum VD and VC. The outcome variable was melanoma presence. Covariates included sex, age, race, BMI, poverty-income ratio, alcohol consumption, smoking, diabetes, hypertension, sunscreen use, and sunburn history. We use weighted logistic regression and restricted cubic spline (RCS) analyses to evaluate the relationship and receiver operating characteristic (ROC) curve to assess the prediction performance. Data from 12,743 (VD) and 12,615 (VC) participants were included. Higher serum VD levels (≥75 nmol/L) and the highest VC quartile levels (OR = 1.91, 95% CI: 1.24-2.97) were associated with an increased melanoma risk. The ROC analysis indicated that the combination of VC or VD with covariates exhibited excellent predictive efficacy (VD and VC model 3: AUC = 0.863). RCS analysis revealed a non-linear correlation between VD and melanoma, and a significant non-linear dose-response relationship between serum VC levels and melanoma. Stratified analysis indicated the adverse effect of higher VD on melanoma was more pronounced in men (OR = 3.55, 95% CI: 1.99-6.33; p<0.001), non-Hispanic white individuals (95% CI: 1.19-2.95; p = 0.009), and diabetic patients (OR = 18.81, 95% CI: 3.44-102.79; p = 0.002). Sensitivity analysis confirmed results stability. High serum VD and VC levels are associated with increased melanoma risk. Personalized prevention considering ultraviolet exposure and genetic factors are recommended to avoid excessive supplementation.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"219-230"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-thermal plasma-activated methionine-containing Ringer's solution enhances cytotoxicity by increasing oxidative stress. 非热等离子体激活的含有蛋氨酸的林格氏溶液通过增加氧化应激增强细胞毒性。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-02-27 DOI: 10.3164/jcbn.25-241

Kosei Fujisawa, Sakura Tanahashi, Kyoka Katagiri, Soo Takasu, Tomohiro Otsuka, Tetsuro Kamiya, Kenji Ishikawa, Yukihiro Esaka, Hirokazu Hara

{"title":"Non-thermal plasma-activated methionine-containing Ringer's solution enhances cytotoxicity by increasing oxidative stress.","authors":"Kosei Fujisawa, Sakura Tanahashi, Kyoka Katagiri, Soo Takasu, Tomohiro Otsuka, Tetsuro Kamiya, Kenji Ishikawa, Yukihiro Esaka, Hirokazu Hara","doi":"10.3164/jcbn.25-241","DOIUrl":"10.3164/jcbn.25-241","url":null,"abstract":"Non-thermal plasma (NTP) is an ionized gas composed of electrons, ions, radicals, and UV. NTP-irradiated solutions induce reactive oxygen species (ROS)-dependent cell death. NTP irradiation of solutions containing methionine (Met) has been reported to enhance the cytotoxic effects of NTP; however, the exact mechanism by which NTP-irradiated Met solutions exhibit cytotoxicity is not fully understood. In this study, we aimed to elucidate the mechanism using the human breast cancer cell line MDA-MB-231 cells. NTP-irradiated Met-containing acetate Ringer's solution (Met/PAA) potently induced cytotoxicity compared with NTP-irradiated acetate Ringer's solution (PAA). Catalase-treated Met/PAA induced cytotoxicity to the same extent, suggesting that NTP irradiation might generate a novel cytotoxic substance distinct from ROS. Catalase-treated Met/PAA decreased intracellular glutathione (GSH) levels, increased ROS production, and caused mitochondrial dysfunction. When catalase-treated Met/PAA was pretreated with antioxidants, GSH and N-acetylcysteine, its cytotoxicity was suppressed. These phenomena indicate that oxidative stress is involved in cell death induced by catalase-treated Met/PAA. Dehydromethionine and methionine sulfoxide were identified as oxidation products of Met in the Met/PAA solution, but neither of the products exhibited cytotoxicity. Taken together, the irradiation of Met-containing solutions likely generates unidentified Met oxidation products other than ROS, resulting in cell death through oxidative stress-induced energy production failure.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"251-258"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of lignan metabolites with prevalent stroke and mortality in stroke patients: results from NHANES. 木脂素代谢物与卒中患者流行卒中和死亡率的关系：来自NHANES的结果。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-03-14 DOI: 10.3164/jcbn.25-271

Wan Zhang, Dan Yu, Jingna Liu, Chunxia Yang, Mei Zhang

{"title":"Association of lignan metabolites with prevalent stroke and mortality in stroke patients: results from NHANES.","authors":"Wan Zhang, Dan Yu, Jingna Liu, Chunxia Yang, Mei Zhang","doi":"10.3164/jcbn.25-271","DOIUrl":"10.3164/jcbn.25-271","url":null,"abstract":"This study explores the association between urinary lignan metabolites (enterolactone and enterodiol) and prevalent stroke (self-reported history of stroke), as well as the long-term likelihood of all-cause mortality (ACM) in patients with a history of stroke. This study employed a mixed-methods design integrating cross-sectional and retrospective cohort analyses, leveraging data from the National Health and Nutrition Examination Survey (NHANES) spanning the period 1999-2010. Eligible participants were those with complete data on urinary lignan metabolites (enterolactone and enterodiol), stroke status assessment, and long-term survival outcomes. Weighted logistic regression models were utilized to elucidate the association between enterolactone, enterodiol, and the likelihood of prevalent stroke, with subgroup analyses stratified by age and gender; effect sizes were quantified as odds ratios (ORs) with corresponding 95% confidence intervals (CIs). The study included 9,752 participants, among whom 194 were dead patients. Follow-up was conducted through December 2019, with a total duration of 164.97 ± 0.87 months. The analysis revealed no statistical association between enterodiol and prevalent stroke or ACM in patients with a history of stroke. Using the first quartile of enterolactone as a reference, the fourth quartile group of enterolactone was significantly associated with a lower likelihood of prevalent stroke [OR: 0.64 (0.42-0.98)], particularly in males [OR: 0.43 (0.20-0.91)] and those under the age of 65 years [OR: 0.43 (0.19-0.97)]. Higher urinary enterolactone levels were associated with a lower likelihood of prevalent stroke and reduced ACM likelihood in patients with a history of stroke.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"268-276"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling systemic disease from the gut: intestinal ROS as an upstream driver of systemic inflammation. 从肠道控制全身性疾病：肠道ROS作为全身性炎症的上游驱动因素。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.3164/jcbn.26-13

Yukio Nagasaki

{"title":"Controlling systemic disease from the gut: intestinal ROS as an upstream driver of systemic inflammation.","authors":"Yukio Nagasaki","doi":"10.3164/jcbn.26-13","DOIUrl":"10.3164/jcbn.26-13","url":null,"abstract":"Oxidative stress has long been implicated in the pathogenesis of a wide range of chronic diseases; however, systemic antioxidant therapies have yielded limited clinical benefits, partly due to their non-selective distribution and interference with physiological redox signaling. Increasing evidence suggests that the intestine plays a central role in amplifying systemic inflammation, yet the causal contribution of intestinal reactive oxygen species (ROS) has remained unclear. In this review, we summarize a series of studies demonstrating that selective scavenging of intestinal ROS, achieved by orally administered, non-absorbable antioxidant nanoparticles, exerts profound effects on whole-body pathophysiology without systemic drug exposure. These gut-localized antioxidants remain confined to the intestinal lumen, effectively suppressing oxidative damage to the intestinal barrier while avoiding adverse effects associated with intracellular or mitochondrial ROS depletion. Experimental evidence across multiple disease models shows that attenuation of intestinal oxidative stress prevents systemic inflammation, reduces circulating pro-inflammatory cytokines such as interleukin-6, and improves diverse pathological outcomes, including exercise-induced organ damage, depression-like behaviors via the gut-brain axis, and muscle wasting in cancer cachexia. Collectively, these findings establish intestinal oxidative stress as an upstream driver of systemic disease progression and highlight gut-confined antioxidant intervention as a safe and mechanistically distinct therapeutic strategy. This concept provides a new framework for re-evaluating oral antioxidant therapy from the perspective of intestinal redox control and its clinical implications.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"169-180"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between dietary fiber intake and mortality in populations with accelerated biological aging: a study based on NHANES 1999-2018 data. 在加速生物衰老的人群中，膳食纤维摄入量与死亡率之间的关系：基于NHANES 1999-2018年数据的研究。

IF 1.9 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2026-05-01 Epub Date: 2026-01-27 DOI: 10.3164/jcbn.25-196

Wei Wang

{"title":"Association between dietary fiber intake and mortality in populations with accelerated biological aging: a study based on NHANES 1999-2018 data.","authors":"Wei Wang","doi":"10.3164/jcbn.25-196","DOIUrl":"10.3164/jcbn.25-196","url":null,"abstract":"To investigate associations of total dietary fiber intake (DFI) and fiber sources with all-cause and cardiovascular mortality in individuals with accelerated biological aging, and to assess inflammation's mediating role. This study included 9,322 adults with accelerated aging from National Health and Nutrition Examination Survey (NHANES) 1999-2018. Weighted Cox models examined associations between DFI and mortality. Restricted cubic spline, subgroup, and mediation analyses were applied. Compared to the lowest quartile, the highest DFI quartile had 35% lower all-cause mortality risk [hazard ratio (HR) = 0.65, 95% confidence interval (CI): 0.45-0.92] and 49% lower cardiovascular mortality risk (HR = 0.51, 95% CI: 0.30-0.87). Each 9.74 ‍g/day increase in DFI was associated with an 18% (HR = 0.82, 95% CI: 0.71-0.94) and 24% (HR = 0.76, 95% CI: 0.63-0.93) reduction in all-cause and cardiovascular mortality risk, respectively. Only grain-based fiber showed a significant inverse association with both outcomes. Mediation analysis indicated inflammation partially mediated the association, with the monocyte-to-lymphocyte ratio having the strongest effect. In adults with accelerated aging, higher DFI, particularly from grains, is inversely associated with all-cause and cardiovascular mortality, partly by attenuating systemic inflammation, suggesting a potential nutritional intervention to improve prognosis.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"78 3","pages":"197-204"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13193796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0