Journal of Clinical Biochemistry and Nutrition最新文献_第4页

3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes. 3-（4-羟基-3-甲氧基苯基）丙酸通过降低小鼠C2C12骨骼肌管中atroggin -1和MuRF-1的表达来减轻地塞米松诱导的肌肉萎缩。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.3164/jcbn.23-70

Anayt Ulla, Md Mizanur Rahman, Takayuki Uchida, Hiroyuki Kayaki, Yosuke Nishitani, Susumu Yoshino, Hiroshige Kuwahara, Takeshi Nikawa

{"title":"3-(4-Hydroxy-3-methoxyphenyl) propionic acid mitigates dexamethasone-induced muscle atrophy by attenuating Atrogin-1 and MuRF-1 expression in mouse C2C12 skeletal myotubes.","authors":"Anayt Ulla, Md Mizanur Rahman, Takayuki Uchida, Hiroyuki Kayaki, Yosuke Nishitani, Susumu Yoshino, Hiroshige Kuwahara, Takeshi Nikawa","doi":"10.3164/jcbn.23-70","DOIUrl":"10.3164/jcbn.23-70","url":null,"abstract":"3-(4-Hydroxy-3-methoxyphenyl) propionic acid is an in vivo metabolite of 4-hydroxy-3-methoxycinnamic acid which is abundantly found in coffee bean, rice bran, fruits, and vegetables. Previous studies reported that polyphenols and their metabolites exhibit positive effects on muscle health. Thus, the effect of 3-(4-hydroxy-3-methoxyphenyl) propionic acid on muscle atrophy induced by dexamethasone was investigated using mouse C2C12 skeletal myotubes. Dexamethasone treatment (10 ‍μM) reduced the diameter and myosin heavy chain protein expression in C2C12 myotubes; it also increased muscle atrophy-associated ubiquitin ligases, such as muscle atrophy F-box protein 1/Atrogin-1 and muscle ring finger protein-1, along with their upstream regulator Krüppel-like factor 15. Dexamethasone dephosphorylated FoxO3a transcription factor and increased total FoxO3a expression. Interestingly, 10 ‍μM 3-(4-hydroxy-3-methoxyphenyl) propionic acid treatment significantly attenuated dexamethasone-induced reduction in myotube thickness and muscle protein degradation and suppressed muscle atrophy-associated ubiquitin ligases. 3-(4-Hydroxy-3-methoxyphenyl) propionic acid also prevented dexamethasone-induced Krüppel-like factor 15 and FoxO3a expression. In conclusion, these results suggest that in vivo metabolite of polyphenols per se could be the real origin of the anti-muscular atrophy activity, as 3-(4-hydroxy-3-methoxyphenyl) propionic acid ameliorated glucocorticoid-induced muscle atrophy by suppressing Atrogin-1 and MuRF-1.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"16-24"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of circadian rhythm disruption induced by time-restricted feeding and exercise on oxidative stress and immune in mice. 限时喂养和运动引起的昼夜节律紊乱对小鼠氧化应激和免疫的影响。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-08-22 DOI: 10.3164/jcbn.24-126

Yun-Shan Li, Hiroaki Fujihara, Koichi Fujisawa, Kazuaki Kawai

{"title":"Effect of circadian rhythm disruption induced by time-restricted feeding and exercise on oxidative stress and immune in mice.","authors":"Yun-Shan Li, Hiroaki Fujihara, Koichi Fujisawa, Kazuaki Kawai","doi":"10.3164/jcbn.24-126","DOIUrl":"10.3164/jcbn.24-126","url":null,"abstract":"Frequent or long-term circadian disorders can lead to a range of health problems, including chronic insomnia, depression, chronic diseases, and cancer. It has also been shown that altering the feeding time of mice from night to day can result in circadian disorder. Recent studies have revealed complex interactions between circadian rhythm and oxidative stress. However, little is known about the impact of circadian rhythm disorders caused by time-restricted feeding on mental state, immune function, and oxidative DNA damage. In this study, we investigated the effects of circadian rhythm disruption by controlling the timing of feeding and exercise on oxidative DNA damage and immune responses in 8-week-old mice for 14 days. Body weight, daytime running wheel activity, serum interleukin-6 levels, urinary 8-hydroxy-2'-deoxyguanosine levels, and nuclear DNA (liver, lung, testes, and pancreas) were significantly increased in the night-restricted group compared with the control group. Additionally, the mice in the night-restricted group exhibited anxiety-like behavior. These results indicated that the circadian rhythm disruption due to abnormal dietary timing can lead to obesity, mental state dysregulation, immune function changes and oxidative DNA damage in mice. This oxidative DNA damage may contribute to the initiation and increased risk of cancer.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"35-41"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to serial articles: New findings on the relationship between aging and oxidative stress. 系列文章导言：衰老与氧化应激关系的新发现。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.3164/jcbn.24-intro

Koji Fukui

引用次数: 0

Effects of an 8-week intake of lysolecithin on cognitive function and concentrations of blood choline and lysophosphatidylcholine: a randomized, double-blinded, placebo-controlled trial. 8周溶卵磷脂摄入对认知功能和血胆碱和溶血磷脂浓度的影响：一项随机、双盲、安慰剂对照试验

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-08-24 DOI: 10.3164/jcbn.24-105

Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada

{"title":"Effects of an 8-week intake of lysolecithin on cognitive function and concentrations of blood choline and lysophosphatidylcholine: a randomized, double-blinded, placebo-controlled trial.","authors":"Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada","doi":"10.3164/jcbn.24-105","DOIUrl":"10.3164/jcbn.24-105","url":null,"abstract":"Choline is an essential nutrient for normal brain function, but its bioavailability is not as high as choline esters. Among choline esters, lysophosphatidylcholine (LPC) has unexplored potential as a choline source and cognitive enhancer in humans. This placebo-controlled, double-blinded study, involving healthy participants aged 40-74 years, aimed to assess the effects of an 8-week intake of lysolecithin containing 480 ‍mg LPC on cognitive function and plasma levels of choline and LPC. Twenty-three participants were assigned to both the placebo and lysolecithin groups, and memory was assessed as the primary outcome. Additionally, subjective mental function was assessed. Plasma levels of derivatives of reactive oxygen metabolites were also evaluated for a safety assessment. No significant between-group differences were observed in the memory or mental function score, but a post-hoc analysis yielded significant within-group increases from baseline in subjective mental acuity and calmness in the lysolecithin group. Lysolecithin intake slightly increased plasma choline and LPC18:2 concentrations over 8 weeks, but plasma levels of saturated and total LPC concentrations, associated with inflammation, and derivatives of reactive oxygen metabolites remained unchanged. No adverse events were attributed to lysolecithin supplementation. This study demonstrated lysolecithin's good tolerability and potential as a new choline supplement.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"59-63"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prune extract prevents disuse osteoporosis by inhibiting the decrease in osteoblast-related gene expression in sciatic-denervated rats. 梅干提取物通过抑制坐骨神经失神经大鼠成骨细胞相关基因表达的减少来预防废用性骨质疏松症。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI: 10.3164/jcbn.24-139

Fumiaki Hanzawa, Kohei Kiriyama, Ayano Nakashima, Akari Iwami, Hirotaka Yamamoto

{"title":"Prune extract prevents disuse osteoporosis by inhibiting the decrease in osteoblast-related gene expression in sciatic-denervated rats.","authors":"Fumiaki Hanzawa, Kohei Kiriyama, Ayano Nakashima, Akari Iwami, Hirotaka Yamamoto","doi":"10.3164/jcbn.24-139","DOIUrl":"10.3164/jcbn.24-139","url":null,"abstract":"In sedentary modern society, disuse osteoporosis is a health issue. Here, we investigate whether prune extract prevents disuse osteoporosis in rats. After feeding a control diet or 10% (wt/wt) prune extract-containing diet for 14 ‍days, we performed sham operation in the left leg and sciatic denervation in the right leg to induce disuse osteoporosis in rats. The rats were fed the same diet prior to surgery for 7 days. The rats fed a control diet before sham operation on both legs were set as the control group, and those with sciatic denervation in the right leg fed a control diet or prune extract containing diet were set as the denervation with control diet and denervation with prune extract diet groups, respectively. Femoral bone volume/tissue volume, trabecular number, and trabecular thickness were reduced in the right leg of denervation with control diet group; however, this reduction was not observed in the denervation with prune extract diet group. Similar results were obtained for mRNA levels of osteoblast-related genes, such as osteocalcin. Overall, prune extract inhibited bone loss by preventing the decrease in osteoblast-related gene expression in disuse osteoporosis, thus showing to improve the bone metabolism and quality of life.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"42-49"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between serum zinc level and clinical features in patients with inflammatory bowel disease. 炎症性肠病患者血清锌水平与临床特征的关系

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.3164/jcbn.24-64

Tatsushi Omatsu, Tomohisa Takagi, Takeshi Yasuda, Yuki Nakahata, Sadanari Hayashi, Rieko Mukai, Takuya Kurobe, Yuriko Yasuda, Nobuhiro Fukuta, Naoyuki Sakamoto, Kazuhiko Uchiyama, Akihiro Obora, Yoshiki Murakami, Takao Kojima, Yuji Naito, Yoshito Itoh, Nobuaki Yagi

{"title":"The association between serum zinc level and clinical features in patients with inflammatory bowel disease.","authors":"Tatsushi Omatsu, Tomohisa Takagi, Takeshi Yasuda, Yuki Nakahata, Sadanari Hayashi, Rieko Mukai, Takuya Kurobe, Yuriko Yasuda, Nobuhiro Fukuta, Naoyuki Sakamoto, Kazuhiko Uchiyama, Akihiro Obora, Yoshiki Murakami, Takao Kojima, Yuji Naito, Yoshito Itoh, Nobuaki Yagi","doi":"10.3164/jcbn.24-64","DOIUrl":"10.3164/jcbn.24-64","url":null,"abstract":"Zinc is an essential element and important for inflammatory bowel disease patients. Herein, we aimed to elucidate the correlation between serum zinc concentration and various parameters, especially the disease activity index and endoscopic scores, in these patients. We measured serum zinc concentrations in 37 patients with Crohn's disease and 64 with ulcerative colitis and retrospectively analyzed patient characteristics, blood test values, disease activity, and endoscopic scores. Hypozincemia (<80 ‍μg/dl) was observed in 45.9% and 29.7% of patients with Crohn's disease and ulcerative colitis, respectively. Serum zinc concentration showed a weak negative correlation with Crohn's Disease Activity Index and C-reactive protein levels in Crohn's disease patients, and a weak negative correlation with white blood cell count in ulcerative colitis patients. The zinc concentrations in ulcerative colitis patients were significantly lower in Mayo endoscopic sub-score grade 2 than in grades 0 and 1. The simple endoscopic score for Crohn's disease moderately correlated with zinc concentration. In addition, serum zinc concentration showed a moderate correlation with serum albumin and Onodera's prognostic nutritional index in both Crohn's disease and ulcerative colitis patients. Serum zinc concentration clearly correlated with inflammatory bowel disease activity, endoscopy scores, and immunonutritional parameters, suggesting the importance of monitoring zinc levels.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"50-58"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in healthy, urban residents aged ≥50 years in Japan. 日本年龄≥50岁的健康城市居民尿8-羟基脱氧鸟苷水平与动脉硬化相关因素的关系

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI: 10.3164/jcbn.24-96

Hiroteru Okamoto, Koji Teruya

{"title":"Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in healthy, urban residents aged ≥50 years in Japan.","authors":"Hiroteru Okamoto, Koji Teruya","doi":"10.3164/jcbn.24-96","DOIUrl":"10.3164/jcbn.24-96","url":null,"abstract":"Previous studies have suggested a relationship between the urinary 8-hydroxydeoxyguanosine level and hypertension, but an association between the urinary 8-hydroxydeoxyguanosine level and systolic blood pressure has not been reported. The aim of this cross-sectional study was to examine the association between the 8-hydroxydeoxyguanosine level, a marker of DNA oxidative damage, and arteriosclerosis-related factors in healthy, urban residents aged ≥50 years who participated in annual health promotion activities in Mitaka City, Tokyo from 2008 to 2018. Arteriosclerosis-related factors were used as independent variables and the urinary 8-hydroxydeoxyguanosine creatinine concentration-corrected level (urinary 8-hydroxydeoxyguanosine/creatinine) as the dependent variable in multiple logistic regression. Two hundred and forty-eight participants were divided into two groups using a cutoff point of 6.2/6.3 ‍ng/mg creatinine, which corresponds to the urinary 8-hydroxydeoxyguanosine/creatinine levels in approximately 80% of the participants. A high urinary 8-hydroxydeoxyguanosine/creatinine level was significantly associated with a body mass index ≥25, obesity, and systolic blood pressure ≥140. Our findings suggest that in healthy individuals aged ≥50 years, arteriosclerosis-related factors such as inappropriate weight management and poor systolic blood pressure control may be associated with the urinary 8-hydroxydeoxyguanosine level.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"90-95"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans. 饮食干预益生元部分水解瓜尔胶改善皮肤粘弹性，角质层水化，减少表皮水分流失：一项随机，双盲，安慰剂对照的健康人临床研究。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.3164/jcbn.24-69

Mahendra P Kapoor, Aya Abe, So Morishima, Atsushi Nakajima, Makoto Ozeki, Norio Sato

{"title":"Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epidermal water loss: a randomized, double-blind, and placebo-controlled clinical study in healthy humans.","authors":"Mahendra P Kapoor, Aya Abe, So Morishima, Atsushi Nakajima, Makoto Ozeki, Norio Sato","doi":"10.3164/jcbn.24-69","DOIUrl":"10.3164/jcbn.24-69","url":null,"abstract":"Dietary fiber-rich diets are gaining popularity as an alternative therapy for skin health. Plant-based prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber promotes gastrointestinal health, which is imperative for skin health through the gut microbiome. In this randomized, double-blind, and placebo-controlled study, the purpose was to assess the therapeutic effects of PHGG on skin hydration, trans-epidermal water loss (TEWL), and skin viscoelastic properties during the winter season. Healthy male and female subjects (n = 70; 9 male and 61 female; mean age: 45.5 ± 8.1 years) were recruited. They received either the 5 ‍g PHGG dietary fiber (n = 35) or a 5 ‍g placebo (n = 35) for twelve weeks. Skin moisture, TEWL, skin elasticity and skin color parameters, and related features were assessed at baseline, after 6 and 12 weeks, and questionnaires to evaluate the study outcomes. The results confirmed the improvement in skin conditions throughout the winter season by restoring skin hydration, reducing TEWL, and improving skin elasticity parameters. After 6 weeks of PHGG intake, there was a substantial decrease in TEWL and improvement in viscoelasticity metrics when compared to placebo. Subject satisfaction with efficacy reflected these encouraging findings, and PHGG was well tolerated, with no adverse events occurring during the study period.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"76 1","pages":"96-115"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori infection and oxidative stress. 幽门螺杆菌感染和氧化应激。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.3164/jcbn.24-109

Hidekazu Suzuki, Miwa Hirai

引用次数: 0

Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study. 1 型糖尿病患者中乳糜泻的患病率：一项单中心横断面队列研究。

IF 2 4区医学

Journal of Clinical Biochemistry and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-06-14 DOI: 10.3164/jcbn.24-39

Yuki Nishimoto, Naoko Hashimoto, Nozomi Kido, Aya Irahara, Takehito Takeuchi, Michinori Takabe, Shunji Ishihara, Yoshikazu Kinoshita, Takeshi Ohara

{"title":"Prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study.","authors":"Yuki Nishimoto, Naoko Hashimoto, Nozomi Kido, Aya Irahara, Takehito Takeuchi, Michinori Takabe, Shunji Ishihara, Yoshikazu Kinoshita, Takeshi Ohara","doi":"10.3164/jcbn.24-39","DOIUrl":"10.3164/jcbn.24-39","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) may be associated with other autoimmune diseases. Celiac disease (CD), another autoimmune disorder that mainly affects the small intestine, is caused by intolerance to gluten ingestion. CD has a higher prevalence in patients with T1DM than in the general population. However, the prevalence of CD in patients with T1DM in Japan is unknown. This study investigated the prevalence of CD in Japanese patients with T1DM. We included 115 patients with T1DM treated at Hyogo Brain and Heart Center from December 2020 to April 2021. A questionnaire survey about dietary habits and abdominal symptoms was administered, and serum anti-tissue transglutaminase (TTG) antibody titers were determined for all participants. A CD (CD-seropositive) diagnosis was based on TTG levels >10 U/ml. Fifty-eight patients (50.4%) had some abdominal symptoms (such as constipation, diarrhea, and abdominal pain). The average TTG-IgA antibody titer was 0.75 ± 0.49 U/ml and negative (<10 U/ml) in all patients. In conclusion, the prevalence of CD among patients with T1DM at our hospital was 0%. Thus, the prevalence of CD in Japan is low compared to that in other countries, even among patients with T1DM, who are considered to have high comorbidity rates.","PeriodicalId":15429,"journal":{"name":"Journal of Clinical Biochemistry and Nutrition","volume":"75 3","pages":"213-216"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0