Association of urinary 8-hydroxydeoxyguanosine level with arteriosclerosis-related factors in healthy, urban residents aged ≥50 years in Japan.

Abstract

Previous studies have suggested a relationship between the urinary 8-hydroxydeoxyguanosine level and hypertension, but an association between the urinary 8-hydroxydeoxyguanosine level and systolic blood pressure has not been reported. The aim of this cross-sectional study was to examine the association between the 8-hydroxydeoxyguanosine level, a marker of DNA oxidative damage, and arteriosclerosis-related factors in healthy, urban residents aged ≥50 years who participated in annual health promotion activities in Mitaka City, Tokyo from 2008 to 2018. Arteriosclerosis-related factors were used as independent variables and the urinary 8-hydroxydeoxyguanosine creatinine concentration-corrected level (urinary 8-hydroxydeoxyguanosine/creatinine) as the dependent variable in multiple logistic regression. Two hundred and forty-eight participants were divided into two groups using a cutoff point of 6.2/6.3 ‍ng/mg creatinine, which corresponds to the urinary 8-hydroxydeoxyguanosine/creatinine levels in approximately 80% of the participants. A high urinary 8-hydroxydeoxyguanosine/creatinine level was significantly associated with a body mass index ≥25, obesity, and systolic blood pressure ≥140. Our findings suggest that in healthy individuals aged ≥50 years, arteriosclerosis-related factors such as inappropriate weight management and poor systolic blood pressure control may be associated with the urinary 8-hydroxydeoxyguanosine level.