Journal of Clinical and Experimental Dentistry最新文献

{"title":"Effect of Brazilian red propolis on microtensile bond strength and sealing ability of the methacrylate-based bonding agents.","authors":"Gustavo César Feitosa Vidal, Edson Philippe Bezerra Balbino, José Marcos Dos Santos Oliveira, Natanael Barbosa Dos Santos, Teresa de Lisieux Guedes Ferreira Lôbo, Ticiano Gomes do Nascimento, Johnnatan Duarte de Freitas, Jeniffer Mclaine Duarte de Freitas, Isabel Cristina Celerino de Moraes Porto","doi":"10.4317/jced.62587","DOIUrl":"10.4317/jced.62587","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to analyze the sealing ability and microtensile bond strength of a dental adhesive with propolis.</p><p><strong>Material and methods: </strong>Red propolis extract was added to an experimental methacrylate-based adhesive (EA) at following concentrations: 100 (EA PV100), 250 (EA PV250) e 500 μg/mL (EA PV500). Single Bond Universal adhesive (SB) and EA without propolis were used as controls. The effectiveness of the dentin sealing was evaluated at nanoscale (silver uptake) and microscale (dye microleakage). Microtensile bond strength (µTBS) was measured 24 hours after the bonding process. Data were analyzed by one-way ANOVA and Tukey's test (α=0.05).</p><p><strong>Results: </strong>EA PV500 showed the best coronal sealing, with better performance than the control and the commercial adhesive. Immediate µTBS values ranged from 28.94 + 9.25 MPa (EA PV100) to 39.09 + 9.60 MPa (SB). Comparing SB and EA with propolis, a significant decrease in µTBS was noted (<i>p</i><0.05). The EA without propolis had similar performance to SB (<i>p</i>=1.000).</p><p><strong>Conclusions: </strong>Nanoleakage and microleakage were not eliminated in any of the groups, but EA PV500 µg/mL exhibited the best sealing ability, with superior performance compared to the control and commercial adhesive. A decrease in μTBS of AE with propolis was observed. <b>Key words:</b>Dentin-bonding agents, Propolis, Dental materials, Dental marginal adaptation.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e665-e674"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Hydroxyapatite-Coated Titania Nanotubes for Dental Implant Surface Enhancement.","authors":"Parkavi Arumugam, Bianca Princeton, Pradeep Kumar Yadalam, Carlos M Ardila","doi":"10.4317/jced.62626","DOIUrl":"10.4317/jced.62626","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to develop novel hydroxyapatite-coated titanium dioxide or titania nanotubes (TNTs) as a surface modification on titanium dental implants and analyze their surface, chemical properties, biocompatibility, and corrosion resistance.</p><p><strong>Material and methods: </strong>The titanium implant surface was treated with 1 ml of Kroll's reagent, 5 ml of nitric acid, 1.5 ml of sulfuric acid, and water for 10 seconds to allow etching of the surface. The etched surface was then anodized to create a layer of titanium dioxide, which, on treatment with 1wt% of hydrofluoric acid in water under the anodization process with 100 volts for 1 hour at room temperature, led to the formation of TNTs. The nanotube surface was then dipped in Hank's solution, allowing hydroxyapatite deposition on the surface. After 7 days, the hydroxyapatite-coated TNTs (GROUP A) as a surface coating on titanium implants was characterized and compared with bare titanium implants (Group B).</p><p><strong>Results: </strong>The material characterization showed successful development of hydroxyapatite-coated TNT formation on titanium implant surface, which supported cell adhesion, proliferation, and migration, similar to uncoated titanium surfaces. No statistically significant difference in the percentage of cell viability was noted between Groups A and B at any time point, with the highest percentage of cell viability with a mean of 93.20 +/- 4.324 for Group A and 94.00 +/- 6.205 for Group B noted at 72 hours, with a p-value of 0.21. Corrosion testing showed the coating's higher corrosion potential and reduced corrosion density compared to uncoated titanium surfaces with the bode phase angle approaching 1, suggesting its potential for better clinical outcomes.</p><p><strong>Conclusions: </strong>The hydroxyapatite-coated TNTs have good surface, chemical corrosion-resistant properties, and optimal biocompatibility. Further in vivo studies are warranted to assess the osteogenic and antimicrobial properties, as well as the clinical efficacy, of this coating. <b>Key words:</b>Dental implant, hydroxyapatite, titania nanotubes, biocompatibility, corrosion, osseointegration.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e695-e704"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of early arthrocentesis in temporomandibular joint closed lock by disc displacement without reduction. A case review.","authors":"Jordi Borrás-Ferreres, Cosme Gay-Escoda","doi":"10.4317/jced.62767","DOIUrl":"10.4317/jced.62767","url":null,"abstract":"<p><p>Arthrocentesis (joint lysis and lavage) and hydraulic distension with manipulation of the temporomandibular joint have been described as effective options for reducing joint pain and improving function in patients with limited mouth opening (closed lock) due to disc displacement without reduction, fundamentally in the acute phase of the disorder. However, the efficacy and scientific basis of such treatment have not been validated to date. As a result, the most frequent management strategies tend to be more conservative and mainly focus on the use of nonsteroidal antiinflammatory drugs and/or muscle relaxants, occlusal splints and physiotherapy. The present study was carried out to assess the efficacy of early arthrocentesis in improving mouth opening and reducing joint pain in a woman with a 10-day history of acute closed lock due to left temporomandibular joint disc displacement without reduction. <b>Key words:</b>Arthrocentesis, early use, closed lock, disc displacement without reduction, limited mouth opening, temporomandibular joint.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e746-e751"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligneous periodontitis: A molecularly confirmed case of type I plasminogen deficiency.","authors":"Atanur Sarioglu, Kubra Ugurlu, Meltem Karaman, Taner Karakaya, Tugrul Kirtiloglu, Ayse Zeynep Zengin","doi":"10.4317/jced.62773","DOIUrl":"10.4317/jced.62773","url":null,"abstract":"<p><p>Congenital plasminogen (PLG) deficiency is an exceptionally uncommon hereditary disease associated with biallelic pathogenic / likely pathogenic variants in the PLG gene. Ligneous periodontitis (LP) is a rare disorder that can occur as a result of a lack of plasminogen. It is defined by the presence of lobulated, membranous, and ulcerated masses in the gums, as well as significant damage to the surrounding bone. This case report presents the diagnosis, treatment, and follow-up outcomes of a 23-year-old male patient who referred to our clinic with a complaint of widespread gingival enlargement. We identified a novel c.2087G>C (p.Arg696Pro) variant with a known variant detected in a compound heterozygous state in PLG confirming the molecular etiology. This case report emphasizes the importance of dentists identifying oral manifestations of various systemic diseases. Careful examination of such findings and the timely referral of patients to appropriate specialists for diagnosis and treatment are of critical significance. <b>Key words:</b>Ligneous periodontitis, plasminogen deficiency, genetic confirmation, histopathological diagnosis.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e752-e755"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual dentin thickness in maxillary first premolars with palatal groove after endodontic and restorative procedures: An e-Vol DX analysis.","authors":"Gilberto Siebert Filho, Helder Fernandes de Oliveira, Alline Soares Vaz, Karolina Kellen Matias, Orlando Aguirre Guedes, Jesus Djalma Pécora, Álvaro Henrique Borges, Rafael Ratto de Moraes","doi":"10.4317/jced.62794","DOIUrl":"10.4317/jced.62794","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to measure residual dentin thickness in maxillary first premolars with a palatal groove after root canal instrumentation, filling material removal, and post space preparation using e-Vol DX, an advanced CBCT imaging analysis software.</p><p><strong>Material and methods: </strong>Fourteen extracted maxillary first premolars with a palatal groove on the buccal root were selected. Dentin thickness was measured at 4 stages: initial (M1), after instrumentation (M2), after filling material removal (M3), and after post space preparation (M4). Measurements were taken in 3 root regions: cervical (1 mm coronal to the groove), middle (at the groove's deepest point), and apical (2 mm apical to the groove). Data were analyzed using ANOVA and Tukey's post hoc test (α = 5%).</p><p><strong>Results: </strong>Significant reductions in dentin thickness were found in all walls across treatment phases. In the palatal wall, dentin thickness dropped below 1 mm after instrumentation, retreatment, and post space preparation. In the buccal and mesial walls, thickness fell below 1 mm after retreatment and/or post space preparation. The distal wall was less affected. The average groove depth was 0.66 ± 0.20 mm, and average groove length was 5.72 ± 1.65 mm.</p><p><strong>Conclusions: </strong>Post space preparation in maxillary first premolars with palatal groove on the buccal root significantly reduces dentin thickness, especially in the palatal wall, increasing the risk of root weakening. Clinicians should carefully assess the indication of intraradicular posts in such cases to avoid potential complications. <b>Key words:</b>Cone-beam computed tomography, e-vol DX software, Maxillary first premolar, residual dentin thickness, root thickness.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e705-e712"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XXIX Sespo congress, Santiago de Compostela, Spain, October 25-26, 2024.","authors":"","doi":"10.4317/jced.1122335667804","DOIUrl":"https://doi.org/10.4317/jced.1122335667804","url":null,"abstract":"","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 Suppl 1","pages":"S1-S21"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gelatin methacryloyl advances in regenerative dentistry: A global bibliometric analysis.","authors":"Adriana Poli Castilho Dugaich, Andressa da Silva Barboza, Christiane Cabral Leite, Aurélio de Oliveira Rocha, Lucas Menezes Dos Anjos, Alexandre Henrique Dos Reis-Prado, Marco Cícero Bottino, Juliana Silva Ribeiro de Andrade","doi":"10.4317/jced.62741","DOIUrl":"10.4317/jced.62741","url":null,"abstract":"<p><strong>Background: </strong>This study aims to comprehensively appraise the bibliometric features of articles evaluating the utilization of gelatin methacryloyl (GelMA) in dentistry by conducting a bibliographic search on the Web of Science databases until January 2025.</p><p><strong>Material and methods: </strong>The following data were gathered: number and density of citations; authors; year, journal of publication and impact factor; study design and theme; keywords; institution and country of origin. The collaborative network was identified with the VOSviewer software and used to generate collaborative network maps for authors and keywords.</p><p><strong>Results: </strong>A total of 133 articles reporting the use of GelMA in dentistry were included. The articles were published between 2014 and 2025, and the most prevalent journals were Dental Materials (10,17% and 276 citations) and Acta Biomaterialia (10,1% and 208 citations) The most frequent study designs and themes were laboratory-based in vitro studies (58,6%) and endodontics (37,6%), respectively. Bottino MC (9%; 464 citations) and Dubey N (4,5%; 345 citations) were the most prominent authors in the list. Most articles originated from China (52,6%) and the United States (29,3%). University of Michigan (12,8%) and Sichuan University (6,7%), located in the USA and China, respectively, were the institutions with the most articles. There was a strong negative correlation between the number of citations and the year of publication, with the most recent articles being the most cited.</p><p><strong>Conclusions: </strong>Global articles related to the use of GelMA in dentistry were published mainly in China, with laboratory-based studies conducted in vitro addressing topics related to the use of GelMA in endodontics. <b>Key words:</b>Gelatin Methacryloyl, Dental Materials, Bibliometric Analysis.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e732-e741"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stafne Bone Cavity: A systematic review.","authors":"Paolo Boffano, Muhammad Ruslin","doi":"10.4317/jced.62755","DOIUrl":"10.4317/jced.62755","url":null,"abstract":"<p><strong>Background: </strong>The typical imaging aspect of Stafne Bone Cavities is that of a radiolucent ovoid or round shape image in the posterior mandible below the nerve canal. Anyway, bilobate and bilateral lesions have been reported too, as well as lesions above the inferior alveolar canal. The etiology and pathogenesis are still unknown. The aim of the present article is to review the literature about the current knowledge of this peculiar anatomical condition.</p><p><strong>Material and methods: </strong>The current study was a comprehensive systematic review that was conducted by using databases on the following online sites: PubMed, Embase, SCOPUS, Wiley Online Library, and Ovid MEDLINE.</p><p><strong>Results: </strong>Before applying the filters, 238 publications were identified at first in the considered databases. After the application of the filters, the removal of the duplicates, and the screening process, we ended up with 39 articles that were used in our review. The prevalence of Stafne Bone Cavities oscillates between 0,03% and 3,55%. Mean age ranges between 45,4 and 60,8 years. Males outnumber females, with male:female ratios ranging between 9:4 and 11:0. The most common sites of SBC are observed in the posterior mandible, with body and/or angle regions being the most frequent localization in all studies.</p><p><strong>Discussion: </strong>A wait-and-see approach in terms of a periodic radiograph is recommended in view of the features of this entity, as in exceptional cases tumors seem to have developed in the invaginated salivary gland tissue. <b>Key words:</b>Stafne Bone Cavities, Stafne bone cyst, diagnosis; anatomy, epidemiology.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e725-e731"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation between cheiloscopic patterns and canine relationship in permanent dentition.","authors":"Elanthendral Saravanan, Vignesh Ravindran, Abirami Arthanari","doi":"10.4317/jced.62752","DOIUrl":"10.4317/jced.62752","url":null,"abstract":"<p><strong>Background: </strong>The precise determination of occlusal relationships, particularly the alignment of maxillary and mandibular canines, is fundamental to orthodontic diagnosis and treatment planning. Cheiloscopy, the study of lip print patterns, has gained prominence in forensic odontology and is hypothesized to have potential relevance in orthodontics. This study aims to evaluate the relationship between cheiloscopic patterns and canine relationships in permanent dentition to assess its diagnostic significance.</p><p><strong>Material and methods: </strong>A cross-sectional observational study was conducted on 300 adolescents (aged 14-16 years) from Chennai. Canine relationships were classified as Class I, Class II, or Class III based on standard intraoral examination protocols. Lip prints were collected using the lipstick-cellophane transfer technique and analyzed based on the Suzuki and Tsuchihashi classification system. Statistical analysis, including the Chi-Square test and Fisher's Exact Test, was performed using SPSS software (version 22.0), with a significance threshold of <i>p</i> < 0.05.</p><p><strong>Results: </strong>Type II (branched) lip prints were the most prevalent across all canine relationships (71.3%), followed by Type IV (reticular) (17.7%). A significant gender-based difference was observed in Class III canine relationships (p = 0.003), where males predominantly exhibited Type II patterns (86.7%), while females showed a higher frequency of Type IV patterns (36.4%). No significant gender differences were noted in Class I and Class II relationships.</p><p><strong>Conclusions: </strong>Cheiloscopic patterns demonstrate notable variations across different canine relationships, with significant gender-based differences in Class III relationships. These findings suggest that cheiloscopy may serve as a non-invasive adjunct in orthodontic diagnosis and forensic odontology. <b>Key words:</b>Cheiloscopy, canine relationships, orthodontic diagnosis, lip print patterns, forensic odontology.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e718-e724"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of Chemically Cured Conventional Glass Ionomer after Light Emitting Diode Radiant Heat Enhancement: A Randomized Controlled Clinical Trial.","authors":"Eman Awad Ebrahim, Basma Hosny Mohamed, Ola Mohamed Ibrahim Fahmy, Rehab Khalil Safy","doi":"10.4317/jced.62440","DOIUrl":"10.4317/jced.62440","url":null,"abstract":"<p><strong>Background: </strong>Assessing the clinical efficiency of chemically cured conventional glass ionomer after light-emitting diode radiant heat enhancement using Federation Dentaire International (FDI) criteria for assessment of dental restorations, regarding both functional and biological properties immediately, after 6 months and 12 months.</p><p><strong>Material and methods: </strong>Twenty-two healthy patients were selected where each patient had two oclusso- mesial cavities in upper or lower second permanent molar. Standardized oclusso- mesial cavities were prepared for all the selected teeth, for each patient the first tooth was restored with chemically cured conventional glass ionomer cements (GICs) without any enhancement (M1 group). Meanwhile, the second tooth was restored by the same material enhanced with radiant heat light emitting diode (LED) (M2 group). Functional and biological criteria of each restoration was clinically evaluated immediately after restoration (T0), six months later (T1), and after 12 months (T2) using Federation Dentaire International (FDI) criteria for assessment of dental restorations.</p><p><strong>Results: </strong>Chi-squared and Wilcoxon's signed rank test revealed that there was no statistically significant difference between both groups for the tested properties at baseline and 6 months follow-up time. At 12 months of follow-up time, 55% of M1 group and 95% of M2 group were clinically successful with significant difference between them.</p><p><strong>Conclusions: </strong>Chemically cured conventional GIC enhanced with LED radiant heat exhibited better clinical performance than the same material without enhancement at 12 months of follow-up time. <b>Key words:</b>Chemically cured glass ionomer cements (GICs), Radiant heat enhancement, Light emitting diode (LED), Randomized controlled clinical trial (RCT), Federation Dentaire International criteria for assessment of dental restorations (FDI criteria).</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 6","pages":"e635-e641"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}