Leandro Araujo Fernandes, Ana Luiza Marques Reis, Marcela de Cassia Dos Reis, Thamires Mazzola, Joao Vitor da Cruz Pegoraro, Sebastiao Orestes Pereira Neto, Daniela Coelho de Lima, Paulo Henrique Perlatti D'Alpino
{"title":"Bioactive silicon-based dental gel associated with a calcium booster for dentin hypersensitivity treatment: A randomized clinical study.","authors":"Leandro Araujo Fernandes, Ana Luiza Marques Reis, Marcela de Cassia Dos Reis, Thamires Mazzola, Joao Vitor da Cruz Pegoraro, Sebastiao Orestes Pereira Neto, Daniela Coelho de Lima, Paulo Henrique Perlatti D'Alpino","doi":"10.4317/jced.62205","DOIUrl":"https://doi.org/10.4317/jced.62205","url":null,"abstract":"<p><strong>Background: </strong>Dentin hypersensitivity affects a significant portion of the world's population, causing pain and negatively impacting oral health and quality of life This clinical study investigated the effectiveness of a desensitizing fluoride silicon-rich dental gel associated with a calcium booster.</p><p><strong>Material and methods: </strong>In this single-blind, randomized, parallel-group clinical trial, forty-eight volunteers diagnosed with dentin hypersensitivity and qualified to participate were randomized into 2 groups: (1) fluoride silicon-rich dental gel (REFX Technology)/calcium booster (Si/Ca protocol); (2) Pumice stone diluted in saline. A draw was carried out between the right and left sides of the patients so that either a prophylaxis with the dental gel associated with calcium or with fine pumice stone diluted in saline was carried out. An evaporative test was used to check for dentin hypersensitivity in the subjects before and immediately after treatment and scored using the Schiff scale, rated 0 to 3. Data were statistically analyzed (ANOVA/Tukey test, α=5%).</p><p><strong>Results: </strong>The treatment with Si/Ca protocol drastically reduced dentin hypersensitivity (from 2.58 to 0.67) immediately after the use. In the control group (Pumice stone), similar results were observed before and after treatment (2.67 and 2.82, respectively).</p><p><strong>Conclusions: </strong>The Si/Ca protocol was fast and effective in reducing pain caused by dentin hypersensitivity. <b>Key words:</b>Clinical trial, dentin hypersensitivity, desensitizing, toothpaste.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1475-e1480"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"External root resorption of second molars due to impacted third molars.","authors":"Shehab Ahmed Hamad","doi":"10.4317/jced.62080","DOIUrl":"https://doi.org/10.4317/jced.62080","url":null,"abstract":"<p><strong>Background: </strong>The current study attempts to assess the impact of third molar impaction on external root resorption (ERR) of the adjacent second molars. We aimed to determine the prevalence, severity, and associated factors with ERR in a sample of panoramic radiographs.</p><p><strong>Material and methods: </strong>A retrospective cross-sectional study was carried out at teaching hospital. We reviewed panoramic radiographs from September 2021 to September 2024, selecting images with second and third molars in patients over 16 years old and impacted third molars. ERR was analyzed with respect to patient age and sex. The presence of symptoms, site and severity of root resorption, relationship to angulation, and depth of impaction were also recorded.</p><p><strong>Results: </strong>A total of 750 panoramic radiographs were examined, and ERR was observed in 32 cases (4.30%). ERR was slightly more common in males (62.5%) than in females (37.5%), but the difference was not statistically significant. The maximum number of ERR cases was found in the age group of 16-25 years (68.7%). Most classification of ERR was mild (71.8%). Mesioangular impacted third molars were associated with 65.6% of resorption cases and position C third molars were associated with 90.6% of resorption cases. The middle third of the root was the most common site of ERR (59.3%).</p><p><strong>Conclusions: </strong>ERR of second molars was relatively more common among patients with impacted third molars. Associations were significant for angulation (mesioangular), depth of impaction, and ERR. Hence, a question arises in assessing the amount of risk associated with its impaction in panoramic radiographic imaging. <b>Key words:</b>Impacted, digital panoramic radiography, external root resorption, second molar, third molar.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1489-e1494"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel José Blanco-Victorio, Roxana Patricia López-Ramos, Johan Daniel Blanco-Rodriguez, Nieves Asteria López-Luján, Gina Fiorella León-Untiveros, Ana Lucy Siccha-Macassi
{"title":"Early childhood caries (ECC) prediction models using Machine Learning.","authors":"Daniel José Blanco-Victorio, Roxana Patricia López-Ramos, Johan Daniel Blanco-Rodriguez, Nieves Asteria López-Luján, Gina Fiorella León-Untiveros, Ana Lucy Siccha-Macassi","doi":"10.4317/jced.61514","DOIUrl":"10.4317/jced.61514","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the performance of different prediction models based on machine learning to predict the presence of early childhood caries.</p><p><strong>Material and methods: </strong>Cross-sectional analytical study. The sociodemographic and clinical data used came from a sample of 186 children aged 3 to 6 years and their respective parents or guardians treated at a Hospital in Ica, Peru. The database with significant variables was loaded into the Orange Data Mining software to be processed with different prediction models based on Machine Learning. To evaluate the performance of the prediction models, the following indicators were used: precision, recall, F1-score and accuracy. The discriminatory power of the model was determined by the value of the ROC curve.</p><p><strong>Results: </strong>76.88% of the children evaluated had cavities. The Support Vector Machine (SVM) and Neural Network (NN) models obtained the best performance values, showing similar values of accuracy, F1-score and recall (0.927, 0.950 and 0.974; respectively). The probability of correctly distinguishing a child with ECC was 90.40% for the SVM model and 86.68% for the NN model.</p><p><strong>Conclusions: </strong>The Machine Learning-based caries prediction models with the best performance were Support Vector Machine (SVM) and Neural Networks (NN). <b>Key words:</b>Early childhood caries, Caries prediction, Machine Learning, Artificial intelligence, caries.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1523-e1529"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayara Larissa Moura de Souza, Danielle Machado Farias, Anne Evelyn de Oliveira Moura, Jurema Freire Lisboa de Castro, Elaine Judite de Amorim Carvalho, Danyel Elias da Cruz Perez
{"title":"A survey of lip lesions diagnosed in a single institution: A clinicopathological study.","authors":"Mayara Larissa Moura de Souza, Danielle Machado Farias, Anne Evelyn de Oliveira Moura, Jurema Freire Lisboa de Castro, Elaine Judite de Amorim Carvalho, Danyel Elias da Cruz Perez","doi":"10.4317/jced.62203","DOIUrl":"10.4317/jced.62203","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the clinicopathological features of lip lesions diagnosed in a single Oral Pathology service in Brazil.</p><p><strong>Material and methods: </strong>It was a cross-sectional study based on secondary data. Between 2000 and 2019, all lip lesions diagnosed in an Oral Pathology service in Brazil were analyzed. Clinical and demographic data, such as patient age and gender, general habits, location, clinical hypotheses of diagnosis, and biopsy type, were collected from patients' clinical records. All cases were microscopically reviewed. Descriptive statistics were obtained for all described variables. Subsequently, associations between variables and identified lesion groups were performed. The KAPPA test was used to assess the agreement between clinical and histopathological diagnoses.</p><p><strong>Results: </strong>A total of 1,284 cases were analyzed, representing 17.8% of oral lesions. The most prevalent lesions were: mucocele (32.9%), fibrous hyperplasia (15.7%), non-specific chronic sialadenitis (11.1%), and actinic cheilitis (9.6%). The demographic distribution included 740 women (61%) and 472 men (39%). The mean age was 37.6 years (ranging from 3 to 97 years). The primary site of presentation was the lower lip, with 980 cases (86.7%). In 783 cases (64.5%), there was concordance between the clinical and histopathological diagnoses.</p><p><strong>Conclusions: </strong>Lip is a significant region for oral diseases, representing approximately 20% of all oral lesions. Importantly, more than 10% of the cases were oral potentially malignant disorders or malignant neoplasms. <b>Key words:</b>Lip, Lip diseases, Epidemiology.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1517-e1522"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anh Ho-Quynh Nguyen, Oanh Ngoc-Hoang Nguyen, Duy Le Nguyen, Tin Si Ho, Khai Dinh-Thien Pham, Khoa Dang Nguyen, Nam Cong-Nhat Huynh, Hung Trong Hoang
{"title":"Digital analysis of the relationship between maximum bite force and 3-dimensional arrangement of mandibular first molars.","authors":"Anh Ho-Quynh Nguyen, Oanh Ngoc-Hoang Nguyen, Duy Le Nguyen, Tin Si Ho, Khai Dinh-Thien Pham, Khoa Dang Nguyen, Nam Cong-Nhat Huynh, Hung Trong Hoang","doi":"10.4317/jced.62037","DOIUrl":"https://doi.org/10.4317/jced.62037","url":null,"abstract":"<p><strong>Background: </strong>Bite force is one of the important factors that determine the chewing efficiency of molars. This study aimed to investigate the relationship of the maximum bite force (MBF) to the 3-dimensional (3D) arrangement of the first mandibular molars in Angle's class I healthy adults using a digital protocol.</p><p><strong>Material and methods: </strong>Subjects were 33 adults (16 males and 17 females) aged 18-25, with Angle's class I occlusions and healthy dentitions. MBF was recorded by a digital occlusal force gauge (BFM 4th generation, Vietnam). 3D models were scanned using TRIOS 3 intra-oral scanner (3Shape, Denmark), and analyzed using Geomagic Design X software (Artec, Luxembourg). The digital measurement included two steps: reorientation and measuring. First, all the virtual upper models were reoriented into the same Oxyz coordinates using 3 landmarks: one at the incisive papilla and two at the intersection of the palatal sulci of the first permanent molars with the gingival margin. Next, 3D position of the first mandibular molars was measured using crown angulation (CA), crown inclination (CI), and depth of curve of Spee (DCOS). t-tests were conducted to compare the mean values between sides and gender. Pearson's correlation coefficient was performed to evaluate the statistical relationships.</p><p><strong>Results: </strong>Mean MBF was 619.66±36.25 N; mean DCOS was 1.73±0.30 mm; mean CA and CI were 2.21±1.70° and -29.65±6.93°, respectively. Male adults showed greater MBF than females significantly. Correlation coefficient between MBF and CA was -0.60, and between MBF and CI was -0.43 significantly. MBF and DCOS were not related.</p><p><strong>Conclusions: </strong>MBF was influenced by gender and the first mandibular molar CA and CI. Hence, it should be considered carefully when the treatment plan includes restoration or any change in the position of the first mandibular molars. <b>Key words:</b>Bite force, curve of Spee, crown angulation, crown inclination, digital dentistry.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1468-e1474"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danilo de Moraes Castanha, Arthur Alves Thomaz de Aquino, Thalles Moreira Suassuna, Eduarda Gomes Onofre de Araújo, Fábio Andrey da Costa Araújo, Emanuel Sávio de Souza Andrade
{"title":"Biomechanical evaluation of different fixation techniques in the rotation of the maxillary occlusal plane after Le Fort I osteotomy.","authors":"Danilo de Moraes Castanha, Arthur Alves Thomaz de Aquino, Thalles Moreira Suassuna, Eduarda Gomes Onofre de Araújo, Fábio Andrey da Costa Araújo, Emanuel Sávio de Souza Andrade","doi":"10.4317/jced.62324","DOIUrl":"https://doi.org/10.4317/jced.62324","url":null,"abstract":"<p><strong>Background: </strong>To analyze the biomechanical and functional characteristics of different maxillary fixation techniques after Le Fort I osteotomy and occlusal plane rotation, using the finite element method to simulate the mechanical behavior of three different osteosynthesis approaches.</p><p><strong>Material and methods: </strong>This is a virtual experimental study carried out using finite element analysis to compare three different osteosynthesis techniques after Le Fort I osteotomy and rotation of the maxillary occlusal plane. Three configurations were tested: four-point fixation with \"L\" plates (C1), two-point fixation with \"L\" plates (C2), and two-point fixation with pre-modeled Lindorf plates (C3).</p><p><strong>Results: </strong>The analysis indicated that set C1 showed maximum displacement in the anterior region, while C2 and C3 showed displacement in the posterior region. The von Mises stresses revealed that C1 exceeded the yield limit of titanium, indicating potential failure. On the other hand, C2 and C3 showed a more balanced distribution of stresses within acceptable limits.</p><p><strong>Conclusions: </strong>The fixation techniques with fewer points (C2 and C3) proved to be as effective, or even superior, to the traditional four-point fixation method (C1), offering better stress distribution and lower mechanical stress. <b>Key words:</b>Le Fort osteotomy, Internal fixation, Finite elements, Biomechanics.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1530-e1537"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Bibiana Moscoso, Fernán Mendoza, Luz Amparo Gómez, Andrea Londoño, Juan Sebastián Marín, Juan Manuel Sarmiento, Fabian Cortes, Paula Katherine Vargas-Sanchez, David Díaz-Báez, Gloria Inés Lafaurie
{"title":"Incidence of bleeding during and after two non-surgical periodontal therapy schemes in patients with recent acute coronary syndrome on dual antiplatelet therapy: A pilot study.","authors":"Sandra Bibiana Moscoso, Fernán Mendoza, Luz Amparo Gómez, Andrea Londoño, Juan Sebastián Marín, Juan Manuel Sarmiento, Fabian Cortes, Paula Katherine Vargas-Sanchez, David Díaz-Báez, Gloria Inés Lafaurie","doi":"10.4317/jced.61758","DOIUrl":"https://doi.org/10.4317/jced.61758","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the incidence of bleeding using two periodontal treatment protocols in patients with recent Acute Coronary Syndrome (ACS).</p><p><strong>Material and methods: </strong>This is an interim analysis of a double-blind controlled clinical trial evaluating two periodontal treatment schemes in patients with recent ACS treated with different dual antiplatelet regimens: Clopidogrel+ASA, Prasugrel+ASA and Ticagrelor+ASA. After randomisation six patients (22 quadrants) were treated with Scheme A (scaling and root planning-SRP) and six patients (21 quadrants) with Scheme B (ultrasonic scaling-US). Periodontal therapy was performed in two appointments using a preventive local protocol to avoid bleeding. The incidence of bleeding was evaluated at 30 minutes and 12 and 24 h later. The clot formation time and perioperative bleeding were also assessed and associated with the regimen using Chi-square/Fisher tests.</p><p><strong>Results: </strong>Profuse bleeding during treatment was significantly higher in patients with SRP 9/22 (40.91%) than in those with US 2/21 (9.52%) (<i>p</i> = 0.018). Intra-operatory bleeding in quadrants was major in SRP treated with Clopidogrel +ASA (<i>p</i> = 0.009). Only 2/12 patients presented with late bleeding after periodontal treatments, representing 16.6% per individual and 11.6% (5/43) per quadrant. However, the incidence of bleeding did not differ significantly between the two protocols.</p><p><strong>Conclusions: </strong>Post-treatment bleeding was moderate and similar in non-invasive and invasive periodontal treatment with different dual antiplatelet therapies. The periodontal treatment in patients with recent ACS treated with dual antiplatelet therapy is safe. The incidence of bleeding is low, and it can be controlled using local methods. <b>Key words:</b>Bleeding, dual platelet anti-aggregation, periodontitis, acute coronary syndrome.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1495-e1502"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of a clinical case of caries lesions by undergraduate dentistry students.","authors":"Sebastiana Arroyo-Bote, Aina Antonelli-Sastre","doi":"10.4317/jced.61889","DOIUrl":"https://doi.org/10.4317/jced.61889","url":null,"abstract":"<p><strong>Background: </strong>Dental caries remains the most prevalent chronic disease worldwide. Hence the importance of detecting and evaluating caries and combining this with additional diagnostic methods to ensure the best treatment. The main objective was to study what is the sensitivity and specificity for detecting initial and cavitated caries lesions by students in third, fourth and fifth year of the Degree in Dentistry at the University of Barcelona, analysing if there is any difference between the diagnoses and treatments among the different years and each student's clinical experience. It was also determined if they apply the techniques based on the concepts of minimal intervention.</p><p><strong>Material and methods: </strong>An observational cross-sectional study using an online survey was performed, based on a real clinical case, aimed at the students in third, fourth and fifth year of the Degree in Dentistry at the University of Barcelona.</p><p><strong>Results: </strong>Most of the respondents (72.13%) observed demineralization or cavities caused by caries in the clinical image and all in the radiographic image (100%). Meanwhile, they showed a more conservative attitude in the treatment of occlusal face, where 23.08% in 4.6 and 46.25% in 4.7 indicate filling of pits and fissures. On the other hand, on the proximal faces, they directly opted for a class II filling (95% in 4.5 distal, 94% in 4.6 mesial and 84% in 4.6 distal). Eighty-five percent of the students considered applying techniques based on the concepts of minimal intervention.</p><p><strong>Conclusions: </strong>The students use similar criteria when diagnosing and treating possible caries lesions regardless of academic year or clinical experience. The personal evaluation of the application of the concepts of minimal intervention does not correlate with the clinical attitude to those cases. <b>Key words:</b>Dental caries, caries diagnosis, caries management, questionnaire.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1433-e1444"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Stella Moreira, Maria Emília Mota, Suely Kunimi Kubo Ariga, Graziella Chagas Jaguar, Márcia Martins Marques
{"title":"Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review.","authors":"Maria Stella Moreira, Maria Emília Mota, Suely Kunimi Kubo Ariga, Graziella Chagas Jaguar, Márcia Martins Marques","doi":"10.4317/jced.62242","DOIUrl":"https://doi.org/10.4317/jced.62242","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is one of the main treatments for head and neck cancer; however, due to its non-selectivity the glandular tissue can be affected. This scoping review aimed to identify the evidence about mesenchymal stem cell therapies for irradiated salivary gland regeneration.</p><p><strong>Material and methods: </strong>Two independent reviewers performed a literature search in MEDLINE/PubMed, Scopus, and Web of Science. The inclusion criteria were: 1) studies evaluation regeneration of irradiated salivary glands by stem cell therapies (cell-based or cell-free), (2) <i>in vivo</i> studies.</p><p><strong>Results: </strong>The search resulted in 13 included studies. In general, both therapies demonstrated increased salivary levels, with mucin and amylase increased and structural protection of acinar cells. The cell-free therapy based on labial glands stem cell extract demonstrated a higher number of parasympathetic nerves.</p><p><strong>Conclusions: </strong>Stem cell therapies (cell-free and cell-based) appear promising strategies for recovering saliva production in patients presenting irradiation-induced hyposalivation, with positive results toward regeneration of the form and function of the glands. However, due to the scarcity and heterogenicity of these pre-clinical studies, it is not possible to indicate which is the more indicated therapy. <b>Key words:</b>Mesenchymal stem cells, extracellular vesicles, exosomes, salivary glands, stem cell biology, hyposalivation, radiotherapy.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1547-e1554"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whitening: is Omnichroma universal composite unchanging? Spectrophotometric evaluation.","authors":"Francesca Zotti, Francesca Ferrari, Luciano Malchiodi, Carlotta Dorigatti, Francesca Pilati, Giorgia Lanzaretti, Nicoletta Zerman","doi":"10.4317/jced.62204","DOIUrl":"https://doi.org/10.4317/jced.62204","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the color stability of Class V anterior restorations with universal composite after professional bleaching using a spectrophotometer.</p><p><strong>Material and methods: </strong>Class V cavities were prepared and restored with universal composite in twenty-eight extracted anterior teeth. One week after restoration, color analysis was performed using the spectrophotometer. In-office bleaching was performed. Color analysis was performed 24 hours, 72 hours and 30 days after bleaching. The parameters evaluated were L* values of each tooth and ΔE values between tooth and restoration at different timepoints. Data were analyzed using a statistical software. A P-value ≤0.05 was used to indicate statistical significance of the results.</p><p><strong>Results: </strong>There was a non-statistically significant but noticeable difference between the L* values in term of tooth bleaching effect. Non-statistically significant differences were found between the L* values and the ΔE values at different timepoints when evaluating the chromatic difference between the tooth surface and the restoration. The ΔE value one week after the restoration is higher than the ΔE values at the following timepoints, therefore the color difference between the restoration and the adjacent tooth decreases with time after bleaching.</p><p><strong>Conclusions: </strong>Universal Composite was found to be able to match the color of the surrounding tooth even after the bleaching procedure. <b>Key words:</b>Omnichroma, composite, color, spectrophotometer, whitening.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"16 12","pages":"e1459-e1467"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}