Journal of Biosensors and Bioelectronics最新文献

{"title":"Voltammetric sensing of dopamine in urine samples with electrochemically activated commercially available screen-printed carbon electrodes","authors":"I. S. Muratova, K. Mikhelson","doi":"10.15406/IJBSBE.2018.04.00120","DOIUrl":"https://doi.org/10.15406/IJBSBE.2018.04.00120","url":null,"abstract":"Dopamine (DA) is a representative of neurotransmitters (neuromediators) responsible for the transfer of neural signals in human and animal bodies.1–5 The level of dopamine in the human body is crucial for learning and memory, for cardiovascular and renal systems, and for human behavior.1–3,6–8 Deviations from normal levels of dopamine cause schizophrenia, Parkinson’s disease, and a number of other health problems, including drug addiction.9–12 Normal levels of dopamine concentration, dependent on the age, are from 0.1 to 0.4 nM in the blood, variation in urine is wider: from 0.1 to 2 μM.13,14 Thus, in real samples, dopamine must be measured at rather low concentrations and in the presence of various interferences, in particular ascorbic acid (AA) and uric acid (UA). Liquid chromatography is the method of choice for measurements of dopamine and other catecholamine’s in clinics.15 However, electrochemical methods of the dopamine control attract increasing attention because electrochemical sensing is promising in view of a rapid, sensitive, selective, and low-cost detection of various biomolecular analytes. Among electrochemical methods of dopamine sensing, it was reported on potentiometry with electrodes selective either to dopamine,16,17 or to ions involved in the dopamine oxidation process, e.g IO4 −.18 Due to insufficient selectivity and sensitivity, these measurements are only suitable to control pharmaceutical formulations, but not for body fluids. A possibility was demonstrated of sensing dopamine resist metrically, with arrays of gold nanowires.19 The data presented in reviews on various techniques of measurements of dopamine20–23 indicate voltammetry as the predominating approach to measure this analyte electrochemically.","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83866682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folding nano-scale paper cranes–the power of origami and kirigami in metamaterials","authors":"Anna Lappala, N. Macauley","doi":"10.15406/IJBSBE.2018.04.00119","DOIUrl":"https://doi.org/10.15406/IJBSBE.2018.04.00119","url":null,"abstract":"Folding, the mechanism of self-assembly into a compact state is universally observed on different scales in a wide range of materials. In this review, we discuss folding and compaction on molecular scales. Generally, folding can be classified into two groups – specific, whereby the number of folding pathways is limited, or non-specific where associations between all functional units are equiprobable, yet directed by a number of physical principles such as coil-globule transition and nucleation processes, regulating the kinetics of collapse as well as the morphology of the final folded state. Complex events such as aggregation, gelation and molecular folding often incorporate both non-specific and specific collapse pathways, linking the two together in a non-trivial manner. Here, we focus on specific ‘designer’ folding pathways of origami and kirigami (a variation of origami that involves cuts) on a molecular scale. These particular folds are a result of highly selective interactions that allow one to robustly produce a large number of stable interaction-dependent collapsed morphologies. Even though the folding of origami relies on trivial operations from a mechanistic perspective, the physics of origami folds is intriguing: origami folds can 1) undergo large reversible deformations 2) show nonlinear auxetic behavior– a property of a material with a negative Poisson’s ratio (i.e. the material expands when tension is applied) 3) bistability (the origami fold has two stable states – expanded and compressed) and 4) topological locking – an increase in resisting force upon folding.1 All the physical properties of origami can be tuned by the geometry of the fold (Figure 1). Like origami, kirigami structures provide multifunctional shape-changing capabilities. Due to an increased number of structural degrees of freedom originating from incisions, kirigami-based 3D nanostructures allow for a larger variety of morphologies as well as load bearing capabilities that are not accessible using traditional origami techniques.2,3","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85760380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terahertz multispectral imaging for the analysis of gold nanoparticles’ size and the number of unit cells in comparison with other techniques","authors":"A. Rahman, Aunik K. Rahman, William Ghann, Hyeonggon Kang, J. Uddin","doi":"10.15406/ijbsbe.2018.04.00118","DOIUrl":"https://doi.org/10.15406/ijbsbe.2018.04.00118","url":null,"abstract":"Advances in the controlled assembly of nanoscale building blocks, such as gold and silver nanoscale spheres, and quantum dots (QDs) have resulted in functional devices, such as nano-optoelectronic components, bio-photonics, nanosensors, and novel contrast probes for molecular imaging.1,2 In the assembled structures, the photophysical properties of nanomaterials are a function of the number and the size of the nanomaterials and the distances among them. For instance, the fluorescence lifetime of a quantum dot cluster depends on the number of the QDs, due to the energy transfer between them.3 The surface enhanced Raman spectroscopy (SERS) signal in noble metal nanoparticle arrays depends not only on the properties of the building blocks, but also on the geometric characteristics of the whole array, such as array size. The absorption band of gold nanoparticles is a function of the size and the different fractal structures of the gold nanoparticles and depends on electron-photon relaxation rate.4 Therefore, accurate determination of the size parameter of the nanomaterials is important in order to control the photophysical properties of these nanomaterials. Techniques currently deployed in the determination of particle size include Dynamic Light Scattering,5 Transmission Electron microscope,3 Scanning Electron Microscope7 and Atomic Force Microscope.8 The measured diameter of nanoparticles usually varies depending on the type of instrumentation used for respective measurements. For TEM and SEM, the samples must be small and must remain in high vacuum. Also, for TEM, the samples must be thin enough for electron transparency; as such the sample preparation involves tedious and time consuming steps. AFM imaging is also conducted only on small samples and is strictly a surface imaging technique. In this research, we utilized the terahertz technique as a nondestructive tool capable of non-contact probing and measuring both the size and size distribution of the nanoparticles. Especially, the technique gives one beneficial advantage compared to the AFM, SEM and TEM. It allows us not only to measure the photophysical properties of materials but also to determine the size dimension of some materials9,10 as well as spectroscopic analysis leading to unique identification capabilities.","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85869991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a mobile multimodal biosignal instrument for simultaneous measurement and analysis of four clinically relevant biosignals, obtained from both normal and pathological subjects","authors":"A. S. Ajani, O. M. Alade, S. Oluwatayo, ra Ajani, Oladosu Jamiu Alabi","doi":"10.15406/ijbsbe.2018.04.00117","DOIUrl":"https://doi.org/10.15406/ijbsbe.2018.04.00117","url":null,"abstract":"Biomedical electronic applications, derived from biosignals, such as cortical mapping, seizure detection, conduction defects, diagnosis of ischemia, arrhythmia, neuromuscular problems, prosthesis and sleep studies, have received attention recently in clinical health practices. However, biosignals are of low frequencies and small amplitudes, with interference from environmental sources as a major challenge. Instrumentations for measurement and monitoring of these biosignals are in very limited supply, if not mostly unavailable, even in hospitals designed for modern health care in Nigeria. The existing ones in most clinical laboratories can only measure parameters for one type of biosignals; and they are quite expensive, due to the cost of construction and maintenance of the laboratories as well as payment of laboratory personnel. Another limitation is non-availability of wireless transmission of biosignal data from the laboratories directly to the medical experts expected to make medical decisions and diagnoses based on the outcome of the tests carried out. World Health Organization confirmed that each year a figure which represents 30 percent of the global cause of death, approximately estimated as 18 million people around the world died of cardiovascular and other related diseases in year 2017.1 Therefore, an instrument that accommodates multimodal signal evaluation and operates with sensor network wirelessly needs to be designed and made readily available to hospitals. Patients’ health can then be monitored outside clinical environment such as offices and homes, if individuals or organizations have access to biosignal device that allows self monitoring. The wireless transmission will be expedient in the biosignal facility to enhance patient’s mobility and transfer of real time clinical data, thus limiting patients’ wheeling to and from the laboratories and related testing locations. Methodology","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91169412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Himalayan lapsi, Choerospondias axillaris (Roxb.) enhances concentration of vitamin C in tissues of rohu (Labeo rohita H) cultured at Chitwan (Nepal)","authors":"S. Shakya, S. N. Labh","doi":"10.15406/ijbsbe.2018.04.00116","DOIUrl":"https://doi.org/10.15406/ijbsbe.2018.04.00116","url":null,"abstract":"Himalayan lapsi, Choerospondias axillaris (Roxb.) is native to Nepal and is also reported from south-east Asian countries.1 Its fruits containing vitamin C,2 Phenol and flavonoid compounds3,4 are consumed to enhance the immunity5 and neutralize free radicals formed in the body. Vitamin C is required to form collagen, growth, reproduction, resist diseases and for immunity in many fishes.6 Oxygen present in air, high temperature, enzymes and multivalent cations destroy it. In the manufacturing process and storage of diet Vitamin C supplemented in it is lost.7 Many structural and functional abnormalities result in fishes due to insufficient supply of vitamin C.8 Teleost fishes like rohu lacking GLO enzyme9 needs supply of vitamin C along with the diet.10 Many researches on the effect of vitamin C on growth, its concentration in different tissues and stress overcome in fishes are available.11 But the work on the effect of lapsi extract on growth and its concentration in brain, liver and blood in L. rohita is not available.","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80439332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of biomechanical parameters of walking in the exoskeleton in patients with complete lower palsy","authors":"Pismennaya Ev, Petrushanskaya Ka, Shapkova Ev","doi":"10.15406/ijbsbe.2018.04.00115","DOIUrl":"https://doi.org/10.15406/ijbsbe.2018.04.00115","url":null,"abstract":"Development of exoskeleton as assistive and rehabilitation equipment for people with the locomotor disturbances has become a world tendency.1,2–8 Application of exoskeletons in patients with locomotor disturbances demands instrumental estimation of walking parameters. A number of the necessary primary parameters of walking and corresponding methods of investigations have been formed in the world biomechanics, namely, biomechanical, energetic and electromyographic. The following methods belong to the biomechanical ones: podometry, goniometry, and dynamometry, which record correspondingly the temporal, kinematic and dynamic parameters of walking. Investigation of the energetic parameters of walking supposes estimation of the energy expenditures by means of a method of mathematic modeling. At last, investigation of the electromyographic parameters supposes recording the electrical activity of muscles during the locomotor cycle, so called EMGpattern of muscles. 9","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84892808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbonaceous nanomaterials: production and application. R&D of gas institute of NAS of Ukraine","authors":"A. Khovavko, Strativnov Ev, Kozhan Ap, Moraru Vn, Sviatenko Am, A. A. Nebesny, D. Filonenko, Sidorenko Sv","doi":"10.15406/IJBSBE.2018.04.00113","DOIUrl":"https://doi.org/10.15406/IJBSBE.2018.04.00113","url":null,"abstract":"Gas Institute of NAS of Ukraine made a series of important new researches to create technology and equipment for nanomaterials and nanofluids that can effectively be used in the newest and traditional energetics. Scientists of the Institute carried out thermodynamic study and created a pilot unit of electro thermal fluidized bed (ETFB). ETFB – a bed of electrically conductive particles in a fluidized state heated by electric current passing through its volume. It is possible to realize various processes at extremely high level of temperature (up to 2000 °C). For the benefit of micro plasma charges in the created aggregate (one of the biggest in the Western Europe) it was implemented a continuous coating of pure quartz particles by lustrous nanopyrocarbon.1 The layer of pyrographite that capsulated quarts can be obtained in different thickness range by pyrolysis of hydrocarbons. Carbothermic reduction of silicon from quartz sand coated by pyrolytic carbon was accomplished in plasma arc discharge in the environment of vacuum with atomic hydrogen. So, we suggested to obtain pure silicon suitable for use in photovoltaic bypassing the expensive and dangerous “Siemens” chloride method (Figure 1).","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76226016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of human biosignal information with developed application software for ECG, EMG, EEG and speech signals","authors":"Ajani Adegbenro Sunday, Olusoji Amos Ogunbode, S. Oluwatayo, ra Ajani, O. M. Alade, Oladosu Jamiu Alabi","doi":"10.15406/ijbsbe.2018.04.00112","DOIUrl":"https://doi.org/10.15406/ijbsbe.2018.04.00112","url":null,"abstract":"Biosignals are biomedical signals which represent collective electrical and mechanical signals obtained from organs in human body to represent different physical variables of interest. The signals exist as time functions and are describable in terms of their amplitudes, frequencies and phases. These complex biosignals are generally controlled by the nervous system which is responsible for the transfer, sending and reception of generated microinformation or less from different body parts to the brain for processing.1,2 Few organs among many that generate biomedical signals include the following;","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76537168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advance and challenge of disease-related detection based immunosensor by using antibodies","authors":"O. M. Saka","doi":"10.15406/IJBSBE.2018.04.00111","DOIUrl":"https://doi.org/10.15406/IJBSBE.2018.04.00111","url":null,"abstract":"A sensor is a device used to gather information recorded by chemical, physical or biological changes, and then convert the collected information into a qualitative or quantitative signal. Biological sensors (biosensors) consist of a biological sensing element and an electrochemical transducer. Target analyte reacts selectively with recognition elements such as antibodies, enzymes, nucleic acids, and then an electrical signal is produced by transducer. After separation and amplification processes, electrical signal converted into a measurable value. Electrochemical biosensors have been widely developed in last decades. Biomarkers are rationally used as a characteristic indicator of some pathogenic and pharmacological response to therapeutic intervention. One important class of biomarkers includes proteinic molecules that, when present at elevated or depressed concentrations in serum, tissue, or saliva, can be indicative of disease states. Various forms of voltammetry (linear sweep, differential pulse, square-wave,stripping) and amperometry are the most widely used electrochemical methods for detection of disease-related biomarkers. Although some of them are produced commercially and routinely used in clinical, environmental, and industrial analysis. But sometimes, enzyme of the substation or analyte in living organisms couldn’t be available to detect, or electrochemical biosystem is too expensive to use.1 So that affinity sensors were developed as an acceptable alternative. Affinity biosensors are based on selective interaction between the targeted analyte and biological component such as an antibody (immunosensor) or nucleic acids,1 DNA/microRNA (electrochemical DNA hybridization biosensor).2","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"94 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73976706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic system based on PSoC technology and implemented in android platform for the electrochemical characterization of materials through the cyclic voltammetry technique","authors":"A. Arrieta, Oscar Fuentes, K. Navas, Katerine Ballesteros","doi":"10.15406/IJBSBE.2018.04.00110","DOIUrl":"https://doi.org/10.15406/IJBSBE.2018.04.00110","url":null,"abstract":"In the industry, many methods to obtain electrochemical information about materials are used. The aim is to characterize electrochemical materials to evaluate their utility in some applications. Nowadays, there are different techniques of electrochemical analysis, which are capable to classify physical chemistry parameters. An usual technique is called cyclic voltammetry, this technique is responsible to set a potential ramp to a sample and to register the current flowing through the material during the electrochemical reaction, the results from this process is a Current vs Voltage graphic called Voltammogram.1 The potentiostat is the electrochemical device responsible to apply the cyclic voltammetry technique, through three electrodes, reference electrode, counter electrode and working electrode. The basic circuit of a potentiostat is based on operational amplifier and microprocessors capable to communicate the electrochemical signals to the computer equipment. However there are some sectors where a potentiostat is not sufficient since the physical chemistry analysis is required in situ, thus, was developed a portable electrochemical device based on PSoC and Android technology capable to apply the cyclic voltammetry technique in situ.","PeriodicalId":15247,"journal":{"name":"Journal of Biosensors and Bioelectronics","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77215006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}