用电化学激活的市售丝网印刷碳电极伏安法检测尿液样本中的多巴胺

I. S. Muratova, K. Mikhelson
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引用次数: 5

摘要

多巴胺(DA)是人类和动物体内负责神经信号传递的神经递质(神经介质)的代表。1-5人体内多巴胺的水平对学习和记忆、心血管和肾脏系统以及人类行为至关重要。1 - 3,6 - 8偏离正常水平的多巴胺会导致精神分裂症、帕金森病和许多其他健康问题,包括吸毒成瘾。血液中多巴胺浓度随年龄变化的正常水平为0.1 ~ 0.4 nM,尿液中多巴胺浓度变化范围更广:0.1 ~ 2 μM。13,14因此,在实际样品中,多巴胺必须在相当低的浓度下测量,并且存在各种干扰,特别是抗坏血酸(AA)和尿酸(UA)。液相色谱法是临床上测量多巴胺和其他儿茶酚胺的首选方法然而,电化学控制多巴胺的方法越来越受到人们的关注,因为电化学传感具有快速、灵敏、选择性和低成本的检测各种生物分子分析物的前景。在多巴胺传感的电化学方法中,有报道称电位测定法的电极可以选择多巴胺,16,17或参与多巴胺氧化过程的离子,如IO4 - .18由于选择性和灵敏度不足,这些测量只适用于控制药物制剂,而不适用于体液。利用金纳米线阵列,证明了一种测量多巴胺抵抗的可能性在各种测量多巴胺20 - 23的技术综述中提出的数据表明伏安法是电化学测量该分析物的主要方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Voltammetric sensing of dopamine in urine samples with electrochemically activated commercially available screen-printed carbon electrodes
Dopamine (DA) is a representative of neurotransmitters (neuromediators) responsible for the transfer of neural signals in human and animal bodies.1–5 The level of dopamine in the human body is crucial for learning and memory, for cardiovascular and renal systems, and for human behavior.1–3,6–8 Deviations from normal levels of dopamine cause schizophrenia, Parkinson’s disease, and a number of other health problems, including drug addiction.9–12 Normal levels of dopamine concentration, dependent on the age, are from 0.1 to 0.4 nM in the blood, variation in urine is wider: from 0.1 to 2 μM.13,14 Thus, in real samples, dopamine must be measured at rather low concentrations and in the presence of various interferences, in particular ascorbic acid (AA) and uric acid (UA). Liquid chromatography is the method of choice for measurements of dopamine and other catecholamine’s in clinics.15 However, electrochemical methods of the dopamine control attract increasing attention because electrochemical sensing is promising in view of a rapid, sensitive, selective, and low-cost detection of various biomolecular analytes. Among electrochemical methods of dopamine sensing, it was reported on potentiometry with electrodes selective either to dopamine,16,17 or to ions involved in the dopamine oxidation process, e.g IO4 −.18 Due to insufficient selectivity and sensitivity, these measurements are only suitable to control pharmaceutical formulations, but not for body fluids. A possibility was demonstrated of sensing dopamine resist metrically, with arrays of gold nanowires.19 The data presented in reviews on various techniques of measurements of dopamine20–23 indicate voltammetry as the predominating approach to measure this analyte electrochemically.
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