Journal of Artificial Organs最新文献_第5页

Durable left ventricular assist devices in pediatrics: impact of body size on outcomes and size limitations. 儿科耐用左心室辅助装置：体型对疗效和尺寸限制的影响。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2024-09-06 DOI: 10.1007/s10047-024-01467-7

Mimi Xiaoming Deng, Nao Yoshida, Christoph Haller, Aamir Jeewa, Shi-Joon Yoo, Osami Honjo

{"title":"Durable left ventricular assist devices in pediatrics: impact of body size on outcomes and size limitations.","authors":"Mimi Xiaoming Deng, Nao Yoshida, Christoph Haller, Aamir Jeewa, Shi-Joon Yoo, Osami Honjo","doi":"10.1007/s10047-024-01467-7","DOIUrl":"10.1007/s10047-024-01467-7","url":null,"abstract":"Despite the range of body sizes in children, few ventricular assist devices (VAD) exist to support pediatric patients with end-stage heart failure. Large registry data identified weight < 20 kg to be associated with higher rates of VAD-related stroke, compared to > 40 kg. Moreover, patients < 1 years of age experience the highest post-implant mortality, with 1-year survival improving in an age-dependent manner. Within different VAD types, intracorporeal continuous (IC) devices confer the greatest clinical benefit and quality of life compared to paracorporeal alternatives. The major limitation of IC VADs is the technical challenge of implantation into patients of small body size, thus the majority of patients with IC devices are pre-adolescents or older. However, since 2021, the use of HeartMate 3™ (HM3) has expanded to patients as small as 17.7 kg. Although HM3 offers equally favorable survival outcomes irrespective of body size, patients of low body surface area are more likely to experience non-device-related major infections and renal dysfunction, with suggestion for elevated risk of major bleeding and stroke. Innovative imaging strategies have emerged to assess the feasibility of HM3 implantation and facilitate preoperative planning in small children. Moreover, the unmet need for an IC device in the infant population has revived interest in the axial pump, with a pivotal clinical trial currently underway. VAD outcomes in the pediatric population are not equivalent across all ages and body sizes, thus size-stratified analyses and device development to serve the full spectrum of body habitus are key considerations as this field rapidly evolves.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"171-176"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amiodarone extraction by continuous renal replacement therapy: results from an ex vivo study. 持续肾脏替代疗法提取胺碘酮：体内外研究结果。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2025-06-01 Epub Date: 2024-10-14 DOI: 10.1007/s10047-024-01475-7

Danielle J Green, Autumn M McKnite, J Porter Hunt, Carina E Imburgia, Walter Kelley, Kevin M Watt

{"title":"Amiodarone extraction by continuous renal replacement therapy: results from an ex vivo study.","authors":"Danielle J Green, Autumn M McKnite, J Porter Hunt, Carina E Imburgia, Walter Kelley, Kevin M Watt","doi":"10.1007/s10047-024-01475-7","DOIUrl":"10.1007/s10047-024-01475-7","url":null,"abstract":"Continuous renal replacement therapy (CRRT) is a lifesaving therapy for critically ill patients with acute renal failure. Some patients supported with CRRT suffer from cardiac arrhythmias, which are often treated with amiodarone. While amiodarone is a very effective antiarrhythmic, it has a relatively narrow therapeutic window and a long half-life, making it challenging to dose safely. This is especially true in patients supported with CRRT, where drug pharmacokinetics are likely altered. This ex vivo study measured the extent of amiodarone extraction by the CRRT circuit. Amiodarone was administered to a closed-loop CRRT circuit. Drug was dosed to achieve therapeutic concentrations. Circuits were primed with a human blood-plasma mixture and maintained at physiologic temperature and pH. Serial blood samples were collected over time and drug concentrations were quantified. Amiodarone was heavily extracted by the ex vivo CRRT circuit with only 23% amiodarone remaining in the plasma at 6 h. The relative concentration was significantly greater in the controls than in the CRRT circuits within 2 h (n = 3; p = 0.0059). Amiodarone is heavily adsorbed by CRRT circuit components, suggesting that clinical dosing adjustments are likely required to achieve therapeutic targets.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"275-279"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status and challenges of DCD heart transplantation in the Asia-Pacific region. 亚太地区DCD心脏移植现状与挑战

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-05-27 DOI: 10.1007/s10047-025-01514-x

Yorihiko Matsumoto

{"title":"Current status and challenges of DCD heart transplantation in the Asia-Pacific region.","authors":"Yorihiko Matsumoto","doi":"10.1007/s10047-025-01514-x","DOIUrl":"https://doi.org/10.1007/s10047-025-01514-x","url":null,"abstract":"Heart transplantation remains the definitive treatment for end-stage heart failure, but donor shortages persist globally. This review aims to evaluate the current status, enabling technologies, ethical considerations, and future prospects of donation after circulatory death (DCD) heart transplantation in the Asia-Pacific region. A comprehensive narrative review was conducted using published literature and country-specific reports to assess global and regional trends in DCD heart transplantation. Particular focus was given to enabling technologies (e.g., thoracoabdominal normothermic regional perfusion [taNRP] and ex situ machine perfusion), legal and ethical frameworks, and implementation barriers across countries in the Asia-Pacific. While countries such as the UK, US, and Australia have achieved comparable survival outcomes between DCD and donation after brain death (DBD) heart transplantation, most Asia-Pacific countries remain in early stages. Australia leads the region with over 70 successful DCD heart transplants using the Organ Care System. Japan lacks legal clarity and clinical protocols for withdrawal of life-sustaining therapy, restricting DCD to kidney transplants. China employs a hybrid DBCD model but faces logistical and ethical constraints. In South Korea, India, and others, DCD heart programs are not yet established. High cost and limited availability of enabling technologies, alongside ethical controversy surrounding taNRP, are key barriers. Broader adoption of DCD heart transplantation in Asia-Pacific countries requires legal reform, ethical consensus, cost-effective perfusion strategies, and public engagement. Coordinated efforts across technological, societal, and regulatory domains are essential to expand access to this life-saving modality.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Smoker's paradox" in in-hospital outcomes of left ventricular assist device implantation: a population-based analysis of National Inpatient Sample from 2015-2021. “吸烟者悖论”在左心室辅助装置植入的住院结果：2015-2021年全国住院患者样本的基于人群的分析

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-05-26 DOI: 10.1007/s10047-025-01515-w

Renxi Li, Deyanira J Prastein, Steven W Boyce

{"title":"\"Smoker's paradox\" in in-hospital outcomes of left ventricular assist device implantation: a population-based analysis of National Inpatient Sample from 2015-2021.","authors":"Renxi Li, Deyanira J Prastein, Steven W Boyce","doi":"10.1007/s10047-025-01515-w","DOIUrl":"https://doi.org/10.1007/s10047-025-01515-w","url":null,"abstract":"Left ventricular assist device (LVAD) implantation is a treatment option for advanced heart failure. The relationship between smoking and perioperative outcomes in LVAD implantation remains inconclusive, as evidence has been limited to single-center studies. This study aimed to examine the association between smoking and in-hospital outcomes of LVAD implantation in a large-scale population-based analysis. Patients who underwent LVAD implantation were selected from National Inpatient Sample from Q4 2015-2021. Multivariable logistic regression was used to compare in-hospital outcomes between smokers and non-smokers, where demographics, socioeconomic status, primary payer status, hospital characteristics, comorbidities, and transfer/admission status were adjusted. There were 1346 (26.5%) smokers and 3737 (73.5%) non-smokers who underwent LVAD implantation. Smokers presented with a higher burden of comorbidities. After multivariable adjustment, smokers had lower in-hospital mortality (aOR 0.68, 95 CI 0.52-0.889, p < 0.01), MACE (aOR 0.74, 95 CI 0.554-0.987, p = 0.04), neurological complications (aOR 0.555, 95 CI 0.367-0.839, p = 0.01), stroke (aOR 0.508, 95 CI 0.311-0.832, p = 0.01), pericardial complications (aOR 0.705, 95 CI 0.545-0.913, p = 0.01), renal complications (aOR 0.691, 95 CI 0.595-0.801, p < 0.01), venous thromboembolism (aOR 0.523, 95 C = 0.295-0.929, p = 0.03), hemorrhage/hematoma (aOR 0.746, 95 CI 0.641-0.869, p < 0.01), and superficial wound complication (aOR 0.458, 95 CI 0.286-0.733, p < 0.01). Moreover, smokers had a shorter time from admission to operation (p = 0.02), shorter length of stay (p < 0.01), lower transfer out rate (p < 0.01), and lower hospital charge (p < 0.01). This study uncovered a \"smoker's paradox\" in LVAD implantation. These findings added to the long-standing observation of a \"smoker's paradox\" in cardiac surgery. However, the underlying reasons require further investigation.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial pancreas: the past and the future. 人工胰腺：过去与未来。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-05-25 DOI: 10.1007/s10047-025-01510-1

Hiroyuki Kitagawa, Masaya Munekage, Satoru Seo, Kazuhiro Hanazaki

引用次数: 0

Survival and hospitalization in home versus Institutional hemodialysis-nine years of follow up. 生存和住院在家与机构血液透析- 9年随访。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-05-18 DOI: 10.1007/s10047-025-01511-0

Verica Todorov Sakic, Petar Djuric, Ana Bulatovic, Jelena Bjedov, Aleksandar Jankovic, Snezana Pesic, Zivka Djuric, Radomir Naumovic

{"title":"Survival and hospitalization in home versus Institutional hemodialysis-nine years of follow up.","authors":"Verica Todorov Sakic, Petar Djuric, Ana Bulatovic, Jelena Bjedov, Aleksandar Jankovic, Snezana Pesic, Zivka Djuric, Radomir Naumovic","doi":"10.1007/s10047-025-01511-0","DOIUrl":"https://doi.org/10.1007/s10047-025-01511-0","url":null,"abstract":"Increasing interest in home dialysis treatments are driven by better outcomes, less complications, patients desire and economic reasons. We compared 26 prevalent home hemodialysis (HHD) patients with 52 matched institutional hemodialysis patients (IHD) in survival and morbidity. Median age for HHD and IHD patients was 55,7 and 56 years respectively, and 77% were men. HHD patients had significantly better anemia control (Hgb level 12.2 ± 1.7 vs. 10.8 ± 1.3gr/dl; p = 0,001 respectively), and significantly higher albumin and cholesterol levels than IHD (42.5 ± 2 vs. 39 ± 3 g/l, p = 0.001; 5.1 ± 1 vs.4.7 ± 0.8 mmol/l, p = 0.05, respectively). During the nine years of follow up, there was no difference between groups in overall number of hospitalization (3.7 ± 3.3 vs. 3.9 ± 2.8; p = 0.47), nor in annual admission rate for everyone cause (0.5 ± 0.4 vs. 0.6 ± 0.4, p = 0.28), but IHD patients stayed longer in hospital (7.4 ± 9.8 days vs. 9.3 ± 8.7 days; p = 0.05). Cause-specific morbidity showed that IHD patients had more frequent annual admission rate for cardiovascular diseases (CVD) than HHD (0.4 ± 0.3 vs. 0.2 ± 0.1 respectively, p = 0.05), while there were no differences for infections (0.3 ± 0.3 vs. 0.3 ± 0.2 respectively, p = 0.9) nor vascular access (VA) dysfunction (0.4 ± 0.3 vs. 0.3 ± 0.3 respectively, p = 0.3). Also annual in-hospital stay for CVD (3.0 ± 3.1 vs. 4.0 ± 4.5 days; p = 0.5), infection (6,4 ± 7,5 vs. 5,7 ± 7,6 days; p = 0,6) and VA dysfunction (6.0 ± 7.0 vs. 7.7 ± 7.8 days; p = 0,5) did not differ between HHD and IHD group. As revealed by Kaplan Meier curve, survival in HHD and IHD patients were 92.3% vs. 90.4% at 3 years, 84.6% vs. 70.2% at 5 years, and 55.7% vs. 50% at 9 years (log-rank test p = 0,5). HHD provides better anemia and nutrition control; shorter hospitalizations and less frequent hospitalizations for CVD.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of fatal acute saddle embolism of the terminal aorta after long-term support using Impella CP. 长期使用Impella CP后致死性急性主动脉鞍状栓塞1例。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-12 DOI: 10.1007/s10047-025-01499-7

Satoru Kishimoto, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka

{"title":"A case of fatal acute saddle embolism of the terminal aorta after long-term support using Impella CP.","authors":"Satoru Kishimoto, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka","doi":"10.1007/s10047-025-01499-7","DOIUrl":"https://doi.org/10.1007/s10047-025-01499-7","url":null,"abstract":"A 69-year-old male diagnosed with subacute myocardial infarction was subsequently transferred to our institution. Upon admission, echocardiography revealed ventricular septal rupture (VSR). The patient was promptly supported via venoarterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella CP before surgical VSR repair on the 12th day of admission. Following surgery, the patient decided to be transferred to the intensive care unit under new VA-ECMO assistance. Subsequently, Impella CP removal and arterial cannula reinsertion were performed at the ipsilateral site, with no pulsatile bleeding observed from the arterial cannulation site. Emergency aortography revealed a contrast defect at the terminal aorta. Owing to the possibility of acute thrombotic occlusion, the Fogarty procedure was performed through the bilateral common femoral artery (CFA); however, no thrombus retrieved. Contrast-enhanced computed tomography revealed complete occlusion of the bilateral common iliac arteries, extending to the abdominal aorta. The uncontrollable, rapid progression of acidemia resulted in sudden cardiac arrest. Acute arterial occlusion leading to fatal outcomes can occur because of thrombosis following long-term Impella CP use. Impella-associated thrombi can form around the shaft of a mixed area of blood flow caused by the interaction between Impella and ECMO and often develop distal to the aortic arch, which is often overlooked during routine examinations. Therefore, planning for long-term Impella with ECMO support must utilize various imaging modalities to search for thrombi and prepare several means of revascularization during Impella removal.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impella support for refractory cardiogenic shock accompanied by diabetic ketoacidosis: a case report. Impella支持治疗伴有糖尿病酮症酸中毒的难治性心源性休克：病例报告。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-05-26 DOI: 10.1007/s10047-024-01450-2

Masaki Nakagaito, Makiko Nakamura, Teruhiko Imamura, Hiroshi Ueno, Koichiro Kinugawa

{"title":"Impella support for refractory cardiogenic shock accompanied by diabetic ketoacidosis: a case report.","authors":"Masaki Nakagaito, Makiko Nakamura, Teruhiko Imamura, Hiroshi Ueno, Koichiro Kinugawa","doi":"10.1007/s10047-024-01450-2","DOIUrl":"10.1007/s10047-024-01450-2","url":null,"abstract":"Sodium-glucose cotransporter 2 (SGLT2) inhibitors are strongly recommended in patients with heart failure, regardless of the presence of diabetes mellitus. A 74 year-old woman with a reduced left ventricular ejection fraction and diabetes mellitus (the types were unknown), receiving insulin and SGLT2 inhibitor, was hospitalized for altered consciousness with systemic hypotension. Upon admission, she was diagnosed with cardiogenic shock due to diabetic ketoacidosis. Intensive fluid resuscitation under Impella CP support successively improved her metabolic acidosis, preventing worsening pulmonary congestion by mechanically unloading the heart. After hemodynamic stabilization, she was diagnosed with type 1 diabetes mellitus for the first time. She was discharged on day 54 and was followed for 6 months without any recurrences. We must remain vigilant regarding the risk of diabetic ketoacidosis in patients using SGLT2 inhibitors, particularly those on insulin therapy or with diabetes mellitus of unknown types. Impella device shows promise as a circulatory support system in alleviating the left ventricle's workload and averting exacerbated pulmonary congestion, especially in cases where patients necessitate aggressive fluid replacement therapy, such as in the treatment of diabetic ketoacidosis concurrent with compromised cardiac function.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"78-82"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of truncus arteriosus with severe heart failure and pulmonary stenosis: bridge to transplant candidacy with surgical correction and a ventricular-assist device. 一例动脉导管未闭并伴有严重心衰和肺动脉狭窄的病例：通过手术矫正和心室辅助装置为移植候选者搭建桥梁。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-07-15 DOI: 10.1007/s10047-024-01456-w

Kazuki Tanimoto, Takashi Kido, Masaki Taira, Takuji Watanabe, Jun Narita, Hidekazu Ishida, Ryo Ishii, Takayoshi Ueno, Shigeru Miyagawa

{"title":"A case of truncus arteriosus with severe heart failure and pulmonary stenosis: bridge to transplant candidacy with surgical correction and a ventricular-assist device.","authors":"Kazuki Tanimoto, Takashi Kido, Masaki Taira, Takuji Watanabe, Jun Narita, Hidekazu Ishida, Ryo Ishii, Takayoshi Ueno, Shigeru Miyagawa","doi":"10.1007/s10047-024-01456-w","DOIUrl":"10.1007/s10047-024-01456-w","url":null,"abstract":"Ventricular-assist device therapy for small patients with congenital heart disease is challenging due to its complex anatomy and hemodynamics. We describe a 3-year-old patient with heart failure with truncus arteriosus in the palliative stage. The patient underwent palliative right ventricular outflow tract reconstruction following bilateral pulmonary artery banding. At 6 months of age, the patient developed severe truncal valve regurgitation and left ventricular dysfunction. Emergent truncal valve replacement with a mechanical valve was performed, but left ventricular dysfunction persisted. At 3 years of age, the patient developed acute progression of heart failure triggered by influenza infection. The patient was intubated and transferred to our center to determine the indication for heart transplantation. On the second day after admission, signs of multiorgan failure appeared. Emergent ventricular-assist device implantation for both ventricles was performed with truncal valve closure, ventricular septal defect closure, atrial septal defect closure, and re-right ventricular outflow tract reconstruction. The right ventricular-assist device was successfully removed on the seventh postoperative day. Due to the small pulmonary arteries, severe pulmonary stenosis persisted after ventricular-assist device implantation, but it gradually improved with multiple pulmonary angioplasties. The patient was registered in the Japanese organ transplant network and is awaiting a donor organ in a stable condition.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"90-94"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of destination therapy for post-fulminant myocarditis with myelodysplastic syndrome. 骨髓增生异常综合征后急性心肌炎的终点治疗病例。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-06-11 DOI: 10.1007/s10047-024-01455-x

Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Toshihide Izumida, Masaki Nakagaito, Saori Nagura, Toshio Doi, Kazuaki Fukahara, Koichiro Kinugawa

{"title":"A case of destination therapy for post-fulminant myocarditis with myelodysplastic syndrome.","authors":"Makiko Nakamura, Teruhiko Imamura, Yuki Hida, Toshihide Izumida, Masaki Nakagaito, Saori Nagura, Toshio Doi, Kazuaki Fukahara, Koichiro Kinugawa","doi":"10.1007/s10047-024-01455-x","DOIUrl":"10.1007/s10047-024-01455-x","url":null,"abstract":"We encountered a 64-year-old woman who experienced fulminant myocarditis and underwent treatment with veno-arterial extracorporeal membrane oxygenation and Impella CP support. Subsequently, she underwent a device upgrade to Impella 5.5 and received continuous hemodiafiltration for 3 months. During mechanical circulatory support, she developed refractory anemia and thrombocytopenia, leading to a diagnosis of myelodysplastic syndrome. Following the removal of the devices, she no longer required blood transfusions. She received HeartMate 3 left ventricular assist device implantation as a destination therapy indication despite the presence of myelodysplastic syndrome. She was successfully managed by aspirin-free antithrombotic therapy without any hemocompatibility-related adverse events for 4 months after index discharge on foot. We present a patient with a unique and rare presentation, wherein HeartMate 3 was implanted and successfully managed without aspirin to prevent bleeding complications associated with myelodysplastic syndrome.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"30-35"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0