Journal of Artificial Organs最新文献_第5页

Severe right heart failure following HeartMate 3 implantation in a small pediatric patient: a case report. 心脏伴侣3植入后严重右心衰1例儿童：1例报告。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-06-13 DOI: 10.1007/s10047-026-01563-w

Ryoichi Kondo, Shogo Shimada, Tetsuri Takei, Kenta Matsui, Toshiaki Mishima, Masaomi Fukuzumi, Tomo Yoshizumi, Yoshimi Tamura, Yuta Murai, Atsushi Otani, Kaho Aoi, Kagami Miyaji

{"title":"Severe right heart failure following HeartMate 3 implantation in a small pediatric patient: a case report.","authors":"Ryoichi Kondo, Shogo Shimada, Tetsuri Takei, Kenta Matsui, Toshiaki Mishima, Masaomi Fukuzumi, Tomo Yoshizumi, Yoshimi Tamura, Yuta Murai, Atsushi Otani, Kaho Aoi, Kagami Miyaji","doi":"10.1007/s10047-026-01563-w","DOIUrl":"10.1007/s10047-026-01563-w","url":null,"abstract":"HeartMate 3 (HM3) has demonstrated excellent outcomes in adults, and its use in pediatric patients has recently increased. In small pediatric patients, previous studies have mainly focused on whether the device can be accommodated within the thoracic cavity. However, the physiological suitability of pump flow relative to body size and the potential mechanical effects of the device have not been well investigated. A 12-year-old girl (height 138 cm, weight 28.9 kg, body surface area 1.07 m2) with dilated cardiomyopathy and complete atrioventricular block developed progressive heart failure and became catecholamine dependent. HM3 implantation with pacemaker placement was performed. Preoperative pulmonary artery pulsatility index (PAPi) was 2.3, with no obvious right heart failure (RHF). Postoperatively, central venous pressure (CVP) remained elevated at 15-18 mmHg and PAPi decreased to 0.2, indicating severe RHF. Massive left pleural effusion and hypoxemia occurred, and extubation was delayed until postoperative day 7. Lymphangiography and treatment for subclavian vein occlusion did not improve the effusion, suggesting RHF as the primary cause. Adjustment of HM3 pump speed and pacemaker settings during cardiac catheterization reduced CVP and rapidly improved the pleural effusion. In small pediatric patients undergoing HM3 implantation, device-related mechanical effects within the limited thoracic cavity and relatively high circulatory support for patient body size may contribute to RHF even when anatomical accommodation is feasible. Careful optimization of pump speed and heart rate may therefore be important in small pediatric patients.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of outflow graft obstruction after EVAHEART2 implantation: role of device log analysis. EVAHEART2植入术后流出部移植物梗阻1例：设备日志分析的作用。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-06-01 DOI: 10.1007/s10047-026-01558-7

Yudai Muratsuji, Ai Kawamura, Daisuke Yoshioka, Takuji Kawamura, Shin Yajima, Yusuke Misumi, Shigetaka Kusumoto, Yusuke Minematsu, Takeshi Matsumoto, Shunsuke Saito, Takayoshi Ueno, Masaki Takashina, Shigeru Miyagawa

引用次数: 0

Ambulatory venoarterial ECMO via right subclavian artery and internal jugular vein cannulation: a novel technical approach to bridge-to-transplant. 通过右锁骨下动脉和颈内静脉插管的动态静脉动脉ECMO：一种新的桥到移植的技术途径。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-05-16 DOI: 10.1007/s10047-026-01555-w

Woo Sung Jang, Kyungsub Song

{"title":"Ambulatory venoarterial ECMO via right subclavian artery and internal jugular vein cannulation: a novel technical approach to bridge-to-transplant.","authors":"Woo Sung Jang, Kyungsub Song","doi":"10.1007/s10047-026-01555-w","DOIUrl":"10.1007/s10047-026-01555-w","url":null,"abstract":"Standard femoral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) severely limits patient mobility. We introduce a novel \"femoral-free\" Ambulatory Subclavian-Jugular V-A ECMO technique to maximize rehabilitation capabilities. We employed a subclavian-right internal jugular configuration. Initially, a vascular graft anastomosis was used for arterial return, but this resulted in upper limb swelling. Subsequently, we modified our approach as a technical refinement: inserting a 17-Fr reinfusion cannula directly into the right subclavian artery with a 6-Fr distal perfusion catheter to prevent arm ischemia. For drainage, a long venous cannula was inserted into the right internal jugular vein and advanced to the inferior vena cava. Furthermore, inserting the drainage cannula via the internal jugular vein in a retrograde fashion, contrary to the conventional approach, provided adequate venous drainage for ECMO support. This optimized configuration maintained stable ECMO flow (3.5-4.0 L/min) and enabled active bedside rehabilitation comparable to that of dual-lumen veno-venous ECMO. Notably, no right arm swelling was observed with the direct cannulation method in our single case, although this observation requires further validation. This \"femoral-free\" approach is a feasible and effective strategy for patients requiring prolonged V-A ECMO support, such as bridge-to-transplant candidates, by facilitating continuous active physical therapy. Direct cannulation may represent a promising technical refinement to minimize local limb complications, though comparative conclusions cannot be drawn from this limited experience.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special feature: "current status and future development of organ preservation technology" novel techniques for assessing pulmonary function in cellular ex vivo lung perfusion: a republication of the review published in Japanese Journal of Artificial Organs. 专题：“器官保存技术的现状和未来发展”细胞离体肺灌注评估肺功能的新技术：发表在日本《人工器官杂志》上的综述再版。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-05-08 DOI: 10.1007/s10047-026-01557-8

Ryo Kosaka, Daisuke Sakota, Hiromichi Niikawa, Yoshinori Okada, Tetsuhito Kigata, Katsuhiro Ohuchi, Eiki Nagaoka, Tomoyuki Fujita, Ichiro Sakanoue, Toshihiro Okamoto

{"title":"Special feature: \"current status and future development of organ preservation technology\" novel techniques for assessing pulmonary function in cellular ex vivo lung perfusion: a republication of the review published in Japanese Journal of Artificial Organs.","authors":"Ryo Kosaka, Daisuke Sakota, Hiromichi Niikawa, Yoshinori Okada, Tetsuhito Kigata, Katsuhiro Ohuchi, Eiki Nagaoka, Tomoyuki Fujita, Ichiro Sakanoue, Toshihiro Okamoto","doi":"10.1007/s10047-026-01557-8","DOIUrl":"10.1007/s10047-026-01557-8","url":null,"abstract":"Lung transplantation is the definitive therapy for end-stage respiratory diseases. To expand the donor lung pool, ex vivo lung perfusion (EVLP) has been developed for the assessment of marginal donor lungs. However, current evaluation methods remain limited. This study aimed to develop non-invasive imaging and monitoring techniques for the quantitative and early assessment of pulmonary function during EVLP. Three novel approaches were established: (1) lung thermography during the initial reperfusion period to assess pulmonary function, (2) optical oxygen saturation (SaO₂) imaging to assess pulmonary oxygenation, and (3) real-time lung weight measurement as an early indicator of transplant suitability. Lung thermography revealed that lung surface temperature at 8 min after shunt closure was significantly lower in non-suitable cases than in suitable cases (25.1 ± 0.6 °C vs. 27.8 ± 1.2 °C, P < 0.01). Optical SaO₂ imaging demonstrated a strong correlation between lower lobe SaO₂ calculated from SaO₂ imaging and PaO2/FiO2 (P/F) ratio in the lower pulmonary vein (R = 0.855, P < 0.01), with SaO₂ being significantly lower in non-suitable cases. Real-time lung weight measurement showed that lung weight gain increased significantly after 40 min in non-suitable cases compared with suitable cases (51.6 ± 46.0 g vs. -8.8 ± 25.7 g, P < 0.01). These three approaches proved effective for the quantitative and early assessment of pulmonary function during EVLP. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2024 (Vol. 53, No. 3, pp. 216-220).","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygenator salvage with low-dose thrombolysis. Case report. 低剂量溶栓修复氧合器。病例报告。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-05-06 DOI: 10.1007/s10047-026-01559-6

Rodrigo Díaz, Dafna García, Catalina Alvarado-Neves, Carmen Gloria Karlezi, Javier Gárate

引用次数: 0

Anticoagulation optimization and clinical impact of post-transplant deep vein thrombosis: clinical impact and a VV-ECMO subgroup analysis. 移植后深静脉血栓的抗凝优化和临床影响：临床影响和VV-ECMO亚组分析。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-05-05 DOI: 10.1007/s10047-026-01554-x

Chitaru Kurihara, Yudai Miyashita, Taisuke Kaiho, Dai Yamanouchi

{"title":"Anticoagulation optimization and clinical impact of post-transplant deep vein thrombosis: clinical impact and a VV-ECMO subgroup analysis.","authors":"Chitaru Kurihara, Yudai Miyashita, Taisuke Kaiho, Dai Yamanouchi","doi":"10.1007/s10047-026-01554-x","DOIUrl":"10.1007/s10047-026-01554-x","url":null,"abstract":"Post-transplant deep vein thrombosis (DVT) is common after lung transplantation and may contribute to pulmonary embolism and other complications. Whether DVT adversely affects contemporary outcomes and how venovenous ECMO (VV-ECMO) bridging influences early DVT patterns remain unclear. We performed a retrospective single-center study of adult lung transplant recipients (2018-2025). DVT and clinical outcomes were ascertained. Primary analyses compared outcomes and overall survival between recipients with and without DVT in the overall cohort. Secondary analyses assessed DVT-free survival and early anatomic distribution among recipients bridged with preoperative VV-ECMO. Comparisons used Fisher's exact/Mann-Whitney U tests; survival used Kaplan-Meier/log-rank tests. Among 502 recipients, 240 developed DVT. Compared with those without DVT, recipients with DVT had higher rates of pulmonary embolism (22.5% vs. 5.0%, p < 0.0001), acute kidney injury (52.9% vs. 41.2%, p = 0.009), PGD grade 3 (18.3% vs. 10.7%, p = 0.016), longer hospitalization (21 vs. 14 days, p < 0.001), and worse overall survival (HR 2.19, 95% CI 1.49-3.23; log-rank p < 0.001). Of 240 DVT cases, 31 (12.9%) were bridged with VV-ECMO. Within 14 days, upper-extremity DVT was more frequent with VV-ECMO (53.3% vs. 23.5%, p = 0.03), whereas lower-extremity and neck distributions were similar. In multivariable models, operative time was independently associated with DVT (OR 1.18 per hour, 95% CI 1.07-1.31, p < 0.001). Post-transplant DVT is frequent and portends worse outcomes. VV-ECMO bridging is associated with an upper-extremity-predominant DVT pattern but is not an independent DVT predictor after adjustment. Vigilant surveillance is warranted in this high-risk population.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology, diagnosis, and management of hemolysis in patients with prosthetic valve related paravalvular leaks. 人工瓣膜相关瓣旁渗漏患者溶血的病理生理、诊断和处理。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-04-28 DOI: 10.1007/s10047-026-01556-9

Macit Kalçık, Emrah Bayam, Ahmet Güner, Mehmet Özkan

{"title":"Pathophysiology, diagnosis, and management of hemolysis in patients with prosthetic valve related paravalvular leaks.","authors":"Macit Kalçık, Emrah Bayam, Ahmet Güner, Mehmet Özkan","doi":"10.1007/s10047-026-01556-9","DOIUrl":"10.1007/s10047-026-01556-9","url":null,"abstract":"Paravalvular leak (PVL) is a recognized complication after prosthetic valve implantation, occurring in up to 17% of cases. While small leaks are often clinically silent, moderate or severe PVLs may result in significant hemolysis or heart failure. Hemolysis is driven by turbulent flow through the defect, leading to red blood cell fragmentation. Laboratory features include anemia, elevated lactate dehydrogenase, low haptoglobin, indirect hyperbilirubinemia, and schistocytes on peripheral smear. Diagnosis relies primarily on echocardiography, with transesophageal imaging providing superior sensitivity. Cardiac computed tomography may be helpful in complex or recurrent cases. Management depends on symptom burden and hemolytic severity. Conservative therapy with transfusions, iron and folate supplementation, or beta-blockade may stabilize mild cases, but persistent hemolysis or heart failure generally requires intervention. Redo surgery offers definitive repair but carries high operative risk, particularly in patients with comorbidities. In recent years, transcatheter PVL closure has emerged as a less invasive alternative, with high procedural success and improvement in hematologic and clinical outcomes, although residual leakage remains a limitation. Long-term prognosis is determined by early recognition and individualized treatment. A multidisciplinary heart team approach is essential, and future research should refine patient selection and improve closure outcomes.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical circulatory support as a bridge to cancer therapy in patients with end stage heart failure: a single center experience. 机械循环支持作为终末期心力衰竭患者癌症治疗的桥梁：单中心经验。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-04-22 DOI: 10.1007/s10047-026-01553-y

Nandini Nair, Cameron Burmeister, Patricia Louis, Anne Dimmock, Thomas Scanlon, Tyler Thomas, Jordan Shouey, Behzad Soleimani, Balakrishnan Mahesh

{"title":"Mechanical circulatory support as a bridge to cancer therapy in patients with end stage heart failure: a single center experience.","authors":"Nandini Nair, Cameron Burmeister, Patricia Louis, Anne Dimmock, Thomas Scanlon, Tyler Thomas, Jordan Shouey, Behzad Soleimani, Balakrishnan Mahesh","doi":"10.1007/s10047-026-01553-y","DOIUrl":"10.1007/s10047-026-01553-y","url":null,"abstract":"Using mechanical circulatory support in end-stage heart failure patients is an important emerging indication for bridging to cancer therapy. This is crucial for survival in end stage heart failure patients with cancer, allowing chemotherapy and surgery. The utility of both temporary and durable mechanical circulatory support is demonstrated in this retrospective analysis of four cases presented here. This approach highlights a multidisciplinary, proactive management strategy for co-existing, life-limiting conditions. Mechanical circulatory support is useful in selected patients who need curative treatments. One of the important messages learnt from these cases is that a multidisciplinary approach improves quality of life as outpatients and reduces the frequency of hospitalization, challenging the notion that active cancer is an absolute contraindication. Contemporary smaller pumps have lower shear stress and reduced damage to blood cell components, but future research is warranted in this area to optimize anticoagulation protocols because cancer patients with end stage heart failure are at high risk for bleeding and thrombosis.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochrome P450-derived metabolites of docosahexaenoic acid or arachidonic acid enhance contractility of cultured rat cardiomyocytes: a pilot study. 二十二碳六烯酸或花生四烯酸的细胞色素p450衍生代谢物增强培养大鼠心肌细胞的收缩性：一项初步研究。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-04-03 DOI: 10.1007/s10047-026-01552-z

Hikari Kawakami, Daisuke Sato, Masaki Sazuka, Saki Tsuchida, Atsuyoshi Nishina, Takao Nakamura, Masataka Kusunoki, Kazuhiko Tsutsumi, Zhonggang Feng

{"title":"Cytochrome P450-derived metabolites of docosahexaenoic acid or arachidonic acid enhance contractility of cultured rat cardiomyocytes: a pilot study.","authors":"Hikari Kawakami, Daisuke Sato, Masaki Sazuka, Saki Tsuchida, Atsuyoshi Nishina, Takao Nakamura, Masataka Kusunoki, Kazuhiko Tsutsumi, Zhonggang Feng","doi":"10.1007/s10047-026-01552-z","DOIUrl":"10.1007/s10047-026-01552-z","url":null,"abstract":"Regenerative medicine is perceived as a new treatment for severe heart disease. However, cell-based regenerative therapy for cardiac tissue primarily contributes through its paracrine effect, with limited direct impact on contractile force. We have previously found that docosahexaenoic (DHA) and arachidonic (AA) acid could improve the contractility of cultured cardiomyocytes. On the other hand, the beneficial effect of their metabolites produced by cytochrome P450 (CYP) has not been clarified yet because CYPs are abundantly expressed in the liver. In the present study, we evaluated the effects of CYP-derived metabolite of DHA or AA on contractility of cultured rat cardiomyocytes. The cardiomyocytes were cultured in the medium which were supplemented each metabolite for 4 days, and then we evaluated contractile fraction, beat rate, and contraction velocity under a microscope. In addition, we fabricated collagen gel-based myocardial tissue, cultured them for 24 h in the metabolites-containing medium, and measured the contractile force generated by the tissue. 19,20-epoxydocosapentaenoic acid (EpDPE) enhanced both contractile fraction and contraction velocity of cardiomyocytes, whereas 22-hydroxydocosahexaenoic and 8,9-eicosatrienoic acids increased contractile fraction only, and 18- and 20-hydroxyeicosatetraenoic acids increased contraction velocity. Furthermore, 19,20-EpDPE tended to increase the contractile force of myocardial tissue, whereas none of the other metabolites produced a comparable effect. These results indicate that some DHA and AA metabolites can improve contractile fraction as well as contraction velocity of cardiomyocytes in culture; however, an appreciable contribution to contractile force within 24 h is not anticipated.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical challenges and prospects for ex vivo heart perfusion: a republication of the review published in Japanese journal of artificial organs. 体外心脏灌注的技术挑战与前景：日本《人工器官》杂志综述再版。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-03-21 DOI: 10.1007/s10047-026-01550-1

Daisuke Sakota, Ryo Kosaka, Eiki Nagaoka, Tomoki Tahara, Katsuhiro Ohuchi, Tetsuhito Kigata, Ichiro Sakanoue, Tomoyuki Fujita, Toshihiro Okamoto

{"title":"Technical challenges and prospects for ex vivo heart perfusion: a republication of the review published in Japanese journal of artificial organs.","authors":"Daisuke Sakota, Ryo Kosaka, Eiki Nagaoka, Tomoki Tahara, Katsuhiro Ohuchi, Tetsuhito Kigata, Ichiro Sakanoue, Tomoyuki Fujita, Toshihiro Okamoto","doi":"10.1007/s10047-026-01550-1","DOIUrl":"10.1007/s10047-026-01550-1","url":null,"abstract":"Ex vivo heart perfusion (EVHP) has been clinically utilized for the preservation and functional assessment of donor hearts before heart transplantation. In the field of EVHP research, perfusion methods are often referred to as “modes”. This manuscript describes the characteristics of the EVHP modes that have been proposed to date. The resting mode (Langendorff mode) involves cannulation of the aorta and exclusive coronary perfusion. It is the simplest EVHP mode, and all currently available clinical EVHP systems employ this perfusion method. In contrast, the working mode allows perfusate inflow from the left atrium, thereby generating preload and enabling cardiac output. In our experimental studies, the working mode demonstrated enhanced myocardial metabolism compared with the resting mode; however, it was also associated with increased energy consumption due to cardiac contraction. To address this issue, we developed a left ventricular assist device (LVAD) mode, in which cardiac contraction is supported by a LVAD pump operating in the working mode. LVAD mode was associated with significantly better cardiac function than the resting and working mode. The preservation of cardiac function during EVHP is considered to be greatly influenced by the perfusion mode. Further development of optimized modes will be essential for the effective preservation and evaluation of donor hearts in the future. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2024 (Vol. 53, No. 3, pp. 210–215).","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0