Journal of Artificial Organs最新文献

{"title":"Special feature: \"current status and future development of organ preservation technology\" novel techniques for assessing pulmonary function in cellular ex vivo lung perfusion: a republication of the review published in Japanese Journal of Artificial Organs.","authors":"Ryo Kosaka, Daisuke Sakota, Hiromichi Niikawa, Yoshinori Okada, Tetsuhito Kigata, Katsuhiro Ohuchi, Eiki Nagaoka, Tomoyuki Fujita, Ichiro Sakanoue, Toshihiro Okamoto","doi":"10.1007/s10047-026-01557-8","DOIUrl":"https://doi.org/10.1007/s10047-026-01557-8","url":null,"abstract":"<p><p>Lung transplantation is the definitive therapy for end-stage respiratory diseases. To expand the donor lung pool, ex vivo lung perfusion (EVLP) has been developed for the assessment of marginal donor lungs. However, current evaluation methods remain limited. This study aimed to develop non-invasive imaging and monitoring techniques for the quantitative and early assessment of pulmonary function during EVLP. Three novel approaches were established: (1) lung thermography during the initial reperfusion period to assess pulmonary function, (2) optical oxygen saturation (SaO₂) imaging to assess pulmonary oxygenation, and (3) real-time lung weight measurement as an early indicator of transplant suitability. Lung thermography revealed that lung surface temperature at 8 min after shunt closure was significantly lower in non-suitable cases than in suitable cases (25.1 ± 0.6 °C vs. 27.8 ± 1.2 °C, P < 0.01). Optical SaO₂ imaging demonstrated a strong correlation between lower lobe SaO₂ calculated from SaO₂ imaging and PaO₂/FiO₂ (P/F) ratio in the lower pulmonary vein (R = 0.855, P < 0.01), with SaO₂ being significantly lower in non-suitable cases. Real-time lung weight measurement showed that lung weight gain increased significantly after 40 min in non-suitable cases compared with suitable cases (51.6 ± 46.0 g vs. -8.8 ± 25.7 g, P < 0.01). These three approaches proved effective for the quantitative and early assessment of pulmonary function during EVLP. This review was created based on a translation of the Japanese review written in the Japanese Journal of Artificial Organs in 2024 (Vol. 53, No. 3, pp. 216-220).</p>","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygenator salvage with low-dose thrombolysis. Case report.","authors":"Rodrigo Díaz, Dafna García, Catalina Alvarado-Neves, Carmen Gloria Karlezi, Javier Gárate","doi":"10.1007/s10047-026-01559-6","DOIUrl":"https://doi.org/10.1007/s10047-026-01559-6","url":null,"abstract":"<p><p>Membrane oxygenator exchange can be a frequent requirement during extracorporeal membrane oxygenation (ECMO). In low-income health systems, the scarcity and cost of disposables pose significant challenges to timely exchanges. We describe a 48-year-old woman placed on veno-venous ECMO for refractory hypoxemic respiratory failure secondary to pneumonia. Within 30 min, the oxygenator developed thrombosis, characterized by a transmembrane pressure gradient of 229 mmHg. A total of 10 mg of recombinant tissue plasminogen activator (rt-PA) was administered through the premembrane port. Sixty minutes after infusion, the gradient decreased to 116 mmHg, with subsequent improvement in oxygenation. No bleeding occurred. The patient was successfully weaned from ECMO and discharged from the ICU without complications. Low-dose rtPA instillation into a failing oxygenator can postpone exchange and represents a viable salvage strategy for resource-limited ECMO programs.</p>","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulation optimization and clinical impact of post-transplant deep vein thrombosis: clinical impact and a VV-ECMO subgroup analysis.","authors":"Chitaru Kurihara, Yudai Miyashita, Taisuke Kaiho, Dai Yamanouchi","doi":"10.1007/s10047-026-01554-x","DOIUrl":"https://doi.org/10.1007/s10047-026-01554-x","url":null,"abstract":"<p><p>Post-transplant deep vein thrombosis (DVT) is common after lung transplantation and may contribute to pulmonary embolism and other complications. Whether DVT adversely affects contemporary outcomes and how venovenous ECMO (VV-ECMO) bridging influences early DVT patterns remain unclear. We performed a retrospective single-center study of adult lung transplant recipients (2018-2025). DVT and clinical outcomes were ascertained. Primary analyses compared outcomes and overall survival between recipients with and without DVT in the overall cohort. Secondary analyses assessed DVT-free survival and early anatomic distribution among recipients bridged with preoperative VV-ECMO. Comparisons used Fisher's exact/Mann-Whitney U tests; survival used Kaplan-Meier/log-rank tests. Among 502 recipients, 240 developed DVT. Compared with those without DVT, recipients with DVT had higher rates of pulmonary embolism (22.5% vs. 5.0%, p < 0.0001), acute kidney injury (52.9% vs. 41.2%, p = 0.009), PGD grade 3 (18.3% vs. 10.7%, p = 0.016), longer hospitalization (21 vs. 14 days, p < 0.001), and worse overall survival (HR 2.19, 95% CI 1.49-3.23; log-rank p < 0.001). Of 240 DVT cases, 31 (12.9%) were bridged with VV-ECMO. Within 14 days, upper-extremity DVT was more frequent with VV-ECMO (53.3% vs. 23.5%, p = 0.03), whereas lower-extremity and neck distributions were similar. In multivariable models, operative time was independently associated with DVT (OR 1.18 per hour, 95% CI 1.07-1.31, p < 0.001). Post-transplant DVT is frequent and portends worse outcomes. VV-ECMO bridging is associated with an upper-extremity-predominant DVT pattern but is not an independent DVT predictor after adjustment. Vigilant surveillance is warranted in this high-risk population.</p>","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology, diagnosis, and management of hemolysis in patients with prosthetic valve related paravalvular leaks.","authors":"Macit Kalçık, Emrah Bayam, Ahmet Güner, Mehmet Özkan","doi":"10.1007/s10047-026-01556-9","DOIUrl":"https://doi.org/10.1007/s10047-026-01556-9","url":null,"abstract":"","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical circulatory support as a bridge to cancer therapy in patients with end stage heart failure: a single center experience.","authors":"Nandini Nair, Cameron Burmeister, Patricia Louis, Anne Dimmock, Thomas Scanlon, Tyler Thomas, Jordan Shouey, Behzad Soleimani, Balakrishnan Mahesh","doi":"10.1007/s10047-026-01553-y","DOIUrl":"https://doi.org/10.1007/s10047-026-01553-y","url":null,"abstract":"","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytochrome P450-derived metabolites of docosahexaenoic acid or arachidonic acid enhance contractility of cultured rat cardiomyocytes: a pilot study.","authors":"Hikari Kawakami, Daisuke Sato, Masaki Sazuka, Saki Tsuchida, Atsuyoshi Nishina, Takao Nakamura, Masataka Kusunoki, Kazuhiko Tsutsumi, Zhonggang Feng","doi":"10.1007/s10047-026-01552-z","DOIUrl":"10.1007/s10047-026-01552-z","url":null,"abstract":"","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical challenges and prospects for ex vivo heart perfusion: a republication of the review published in Japanese journal of artificial organs.","authors":"Daisuke Sakota, Ryo Kosaka, Eiki Nagaoka, Tomoki Tahara, Katsuhiro Ohuchi, Tetsuhito Kigata, Ichiro Sakanoue, Tomoyuki Fujita, Toshihiro Okamoto","doi":"10.1007/s10047-026-01550-1","DOIUrl":"10.1007/s10047-026-01550-1","url":null,"abstract":"","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart transplantation following a successful bridge-to-bridge strategy in acute type A aortic dissection with left main coronary malperfusion.","authors":"Tomoki Ushijima, Tobuhiro Nita, Takeo Fujino, Hiromichi Sonoda, Satoshi Kimura, Tatsushi Onzuka, Kunihiko Joo, Yusuke Ando, Shogo Matsunaga, Sho Matsuyama, Hirofumi Onitsuka, Kohtaro Abe, Akira Shiose","doi":"10.1007/s10047-026-01548-9","DOIUrl":"https://doi.org/10.1007/s10047-026-01548-9","url":null,"abstract":"<p><p>A 55-year-old woman developed Stanford type A acute aortic dissection complicated by occlusion of the left main coronary artery. The patient underwent an emergency ascending aortic replacement with concomitant coronary artery bypass grafting to the left anterior descending artery. Owing to extensive myocardial ischemia and the resultant severe cardiopulmonary impairment, the patient could not be weaned from the cardiopulmonary bypass. Therefore, central veno-arterial extracorporeal membrane oxygenation was initiated, with aortic perfusion via a branch of the ascending aortic graft and right atrial drainage. The central veno-arterial extracorporeal membrane oxygenation system was subsequently converted to a paracorporeal left ventricular assist device with an oxygenator, following which respiratory support was no longer required. The patient was listed for heart transplantation and underwent an elective conversion to a durable left ventricular assist device as a bridge-to-bridge strategy. During this operation, relocation of the outflow graft was necessary, and aortic valvuloplasty was performed simultaneously to address the mild residual post-dissection aortic insufficiency. Ultimately, the patient underwent heart transplantation more than 4 years after the bridge-to-bridge operation. An effective sequential mechanical circulatory support strategy, combined with meticulous technical management during bridge-to-bridge surgery, can successfully facilitate bridging to heart transplantation.</p>","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) and mechanical prosthetic valve thrombosis.","authors":"Fidel Manuel Caceres-Loriga, Humberto Morais","doi":"10.1007/s10047-026-01551-0","DOIUrl":"https://doi.org/10.1007/s10047-026-01551-0","url":null,"abstract":"","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic analysis of the aortic root based on differences in outflow graft angle in patients with implantable left ventricular assist devices.","authors":"Hiroaki Yamamoto, Hiroki Kohno, Hiroki Ikeuchi, Tomoyoshi Kanda, Michiko Watanabe, Tomohiko Inui, Kaoru Matsuura, Goro Matsumiya","doi":"10.1007/s10047-026-01547-w","DOIUrl":"10.1007/s10047-026-01547-w","url":null,"abstract":"<p><p>Aortic insufficiency (AI) that develops during long-term support with continuous-flow left ventricular assist devices (LVADs) remains a significant clinical problem. Abnormal flow patterns and altered wall shear stress (WSS) on the aortic valve are believed to contribute to leaflet remodeling, yet the hemodynamic influence of outflow graft orientation in patient-specific anatomies is not fully understood. This study investigated how different outflow graft angles affect aortic valve WSS and coronary perfusion using computational fluid dynamics (CFD). Three LVAD recipients who underwent preoperative ECG-gated coronary CT were retrospectively analyzed. Patient-specific geometries of the ascending aorta, aortic root, and coronary arteries were reconstructed. A cylindrical outflow graft was virtually anastomosed 25 mm above the sino-tubular junction, and three inclination angles (30°, 60°, 90°) were modeled with a fixed azimuthal angle of 90°. CFD simulations were performed under constant LVAD inflow (5.0 L/min) and uniform outlet pressure conditions. WSS on the aortic valve cusps and coronary flow rates were evaluated after achieving quasi-steady flow. Increasing outflow graft angle resulted in higher WSS on the ascending aortic wall opposite the anastomosis and consistently elevated WSS on the left coronary cusp. In some cases, the non-coronary cusp also showed localized WSS increases. Coronary flow decreased with shallower graft angles, with left coronary artery flow approximately halved at 30° compared with 90°, while right coronary flow exhibited a smaller reduction. Outflow graft angle substantially affects aortic valve WSS distribution and coronary perfusion. Steeper angles increase leaflet WSS, whereas shallower angles reduce coronary flow. Patient-specific CFD simulations may aid in optimizing graft positioning and reducing the risk of AI progression in LVAD patients.</p>","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}