Journal of Artificial Organs最新文献_第2页

Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review. 心血管研究中使用的大型动物物种凝血系统的差异：系统综述。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-05-20 DOI: 10.1007/s10047-024-01446-y

Louis Staelens, Tom Langenaeken, Filip Rega, Bart Meuris

{"title":"Difference in coagulation systems of large animal species used in cardiovascular research: a systematic review.","authors":"Louis Staelens, Tom Langenaeken, Filip Rega, Bart Meuris","doi":"10.1007/s10047-024-01446-y","DOIUrl":"10.1007/s10047-024-01446-y","url":null,"abstract":"Preclinical testing using animal models is indispensable in cardiovascular research. However, the translation to clinical practice of these animal models is questionable since it is not always clear how representative they are. This systematic review intends to summarize the interspecies differences in the coagulation profile of animal models used in cardiovascular research. It aims to guide future research in choosing the optimal animal species. A literature search of PubMed, Embase, Web of Science (Core Collection) and Cochrane Library was performed using a search string that was well defined and not modified during the study. An overview of the search terms used in each database can be found in the appendix. Articles describing coagulation systems in large animals were included. We identified 30 eligible studies of which 15 were included. Compared to humans, sheep demonstrated a less active external pathway of coagulation. Sheep had a higher platelet count but the platelet activatability and response to biomaterials were lower. Both sheep and pigs displayed no big differences in the internal coagulation system compared to humans. Pigs showed results very similar to those of humans, with the exception of a higher platelet count and stronger platelet aggregation in pigs. Coagulation profiles of different species used for preclinical testing show strong variation. Adequate knowledge of these differences is key in the selection of the appropriate species for preclinical cardiovascular research. Future thrombogenicity research should compare sheep to pig in an identical experimental setup.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"1-14"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical hematological parameters in bleeding during extracorporeal membrane oxygenation support. 体外膜氧合支持期间出血的关键血液学参数。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-08-12 DOI: 10.1007/s10047-024-01466-8

Ngan Hoang Kim Trieu, Tuan Anh Mai, Huy Minh Pham

引用次数: 0

Introduction of ex vivo perfusion of extended-criteria donor hearts in a single center in Asia. 在亚洲的一个中心引入扩展标准供体心脏体外灌注。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-05-23 DOI: 10.1007/s10047-024-01447-x

Oswald Joseph On Jing Lee, Inderjeet Bhatia, Sylvia Ho Yan Wan, Katherine Yue Yan Fan, Michael Ka Lam Wong, Timmy Wing Kuk Au, Cally Ka Lai Ho

{"title":"Introduction of ex vivo perfusion of extended-criteria donor hearts in a single center in Asia.","authors":"Oswald Joseph On Jing Lee, Inderjeet Bhatia, Sylvia Ho Yan Wan, Katherine Yue Yan Fan, Michael Ka Lam Wong, Timmy Wing Kuk Au, Cally Ka Lai Ho","doi":"10.1007/s10047-024-01447-x","DOIUrl":"10.1007/s10047-024-01447-x","url":null,"abstract":"The shortage of organs for heart transplantation has created a need to explore the use of extended-criteria organs. We report the preliminary use of normothermic TransMedics Organ Care System-an ex vivo approach to preserve extended-criteria brain-dead donor hearts. This System maintains a normal temperature, provides continuous perfusion and oxygenation, reduces ischemic time, and enables additional viability assessment options. In a retrospective single-centre study conducted from April 2020 to March 2023, four extended criteria brain-dead donor hearts were perfused and monitored using the Organ Care System. Suitability for transplantation was assessed based on stable or decreasing lactate levels, along with appropriate perfusion parameters. The Organ Care for use of the Organ Care System were coronary artery disease, left ventricular hypertrophy, high-dose inotrope use in the donor, a downtime exceeding 20 min, and a left ventricular ejection fraction of 40-50%. Three out of the four donor hearts were transplanted, while one was discarded due to rising lactate concentration. The three recipients had a higher surgical risk profile for heart transplant. All showed normal cardiac function and no primary graft dysfunction postoperatively. At 2-3 years post-transplant, all recipients have a ventricular function of > 60%, with only one showing evidence of mild rejection. The Organ Care System enables the successful transplantation of marginal donor organs in high-risk recipients, showcasing the feasibility of recruiting donors with extended criteria. This technique is safe and promising, expanding the donor pool and addressing the organ shortage in heart transplantation in Hong Kong.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"69-77"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of anisotropic pore structure and dense selective layer of capillary membranes for long-term ECMO by cross-sectional ion-milling method. 利用横截面离子研磨法表征用于长期 ECMO 的毛细管膜的各向异性孔隙结构和致密选择层。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-08-20 DOI: 10.1007/s10047-024-01461-z

Makoto Fukuda, Kazunori Sadano, Tomoki Maeda, Eri Murata, Naoyuki Miyashita, Tsutomu Tanaka, Tomohiro Mori, Akane Saito, Kiyotaka Sakai

{"title":"Characterization of anisotropic pore structure and dense selective layer of capillary membranes for long-term ECMO by cross-sectional ion-milling method.","authors":"Makoto Fukuda, Kazunori Sadano, Tomoki Maeda, Eri Murata, Naoyuki Miyashita, Tsutomu Tanaka, Tomohiro Mori, Akane Saito, Kiyotaka Sakai","doi":"10.1007/s10047-024-01461-z","DOIUrl":"10.1007/s10047-024-01461-z","url":null,"abstract":"Since the COVID-19 pandemic of 2020-2023, extracorporeal membrane oxygenator (ECMO) has attracted considerable attention worldwide. It is expected that ECMO with long-term durability is put into practical use in order to prepare for next emerging infectious diseases and to facilitate manufacturing for novel medical devices. Polypropylene (PP) and polymethylpentene (PMP) capillary membranes are currently the mainstream for gas exchange membrane for ECMO. ECMO support days for COVID-19-related acute hypoxemic respiratory failure have been reported to be on average for 14 or 24 days. It is necessary to improve opposing functions such that promoting the permeation of oxygen and carbon dioxide and inhibiting the permeation of water vapor or plasma to develop sufficient durability for long-term use. For this purpose, accurately controlling the anisotropy of the pore structure of the entire cross section and functions of capillary membrane is significant. In this study, we focused on the cross-sectional ion-milling (CSIM) method, to precisely clarify the pore structure of the entire cross section of capillary membrane for ECMO, because there is less physical stress on the porous structure applied during the preparation of cross-sectional samples of porous capillary membranes. We attempted to observe the cross sections of commercially available PMP membranes using the CSIM method. As a result, we succeeded in fabricating fine-scale flat cross-sectional samples of PMP capillary membranes. The pore structures and the degree of anisotropy of the cross sections are quantitatively clarified. The achievements and the approaches of this study are being applied to the development of next-generation gas exchange membranes.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"50-60"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationships among hemolysis indicators and neuron-specific-enolase in patients undergoing veno-arterial extracorporeal membrane oxygenation. 静脉-动脉体外膜氧合患者溶血指标与神经元特异性烯醇化酶之间的关系。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-03-01 Epub Date: 2024-07-10 DOI: 10.1007/s10047-024-01454-y

Ryo Okubo, Tomonori Shirasaka, Ryohei Ushioda, Masahiko Narita, Shingo Kunioka, Yuta Kikuchi, Masahiro Tsutsui, Nobuya Motoyoshi, Hiroyuki Kamiya

{"title":"Relationships among hemolysis indicators and neuron-specific-enolase in patients undergoing veno-arterial extracorporeal membrane oxygenation.","authors":"Ryo Okubo, Tomonori Shirasaka, Ryohei Ushioda, Masahiko Narita, Shingo Kunioka, Yuta Kikuchi, Masahiro Tsutsui, Nobuya Motoyoshi, Hiroyuki Kamiya","doi":"10.1007/s10047-024-01454-y","DOIUrl":"10.1007/s10047-024-01454-y","url":null,"abstract":"Neuron-specific-enolase is used as a marker of neurological prognosis after cardiopulmonary resuscitation. It is also present in red blood cells and platelets. It is not known whether hemolysis increases the values of neuron-specific-enolase enough to clinically affect its interpretation in critically ill patients who are to be introduced to veno-arterial extracorporeal oxygenation. In this study, we examined the relationships among neuron-specific-enolase and hemolysis indicators such as free hemoglobin and lactate dehydrogenase after the introduction of veno-arterial extracorporeal oxygenation. Of the 91 patients who underwent veno-arterial extracorporeal membrane oxygenation in our hospital from January 1, 2018, to February 24, 2021, 68 patients survived for more than 24 h. Of these, 14 patients who were categorized into the better cerebral performance categories (1-3) and 19 patients who were categorized into the poor neurological prognosis category (4) were included. After the introduction of veno-arterial extracorporeal membrane oxygenation, neuron-specific-enolase was markedly higher in the poor neurological prognosis group than in the good neurological prognosis group (41.6 vs. 92.0, p = 0.04). A significant positive correlation was revealed between neuron-specific-enolase and free hemoglobin in the good neurological prognosis group (rs = 0.643, p = 0.0131). A similar relationship was observed for lactate dehydrogenase and neuron-specific-enolase in both the conscious (rs = 0.737, p = 0.00263) and non-conscious groups (rs = 0.544, p = 0.0176). When neuron-specific-enolase is used as a marker for neuroprognostic evaluation, an abnormally high value is likely to indicate the lack of consciousness, whereas a lower elevation should be interpreted with caution, taking into account the effects of hemolysis.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":"43-49"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk-elastin sponge is effective for burn therapy after surgical debridement. 丝弹性蛋白海绵是外科清创后烧伤的有效治疗方法。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-02-28 DOI: 10.1007/s10047-025-01496-w

Yoshitaka Matsuura, Katsuya Kawai, Shingo Kawabata, Kazuo Noda, Eiichi Sawaragi, Naoki Morimoto

{"title":"Silk-elastin sponge is effective for burn therapy after surgical debridement.","authors":"Yoshitaka Matsuura, Katsuya Kawai, Shingo Kawabata, Kazuo Noda, Eiichi Sawaragi, Naoki Morimoto","doi":"10.1007/s10047-025-01496-w","DOIUrl":"https://doi.org/10.1007/s10047-025-01496-w","url":null,"abstract":"Silk-elastin is an artificial protein that helps promote wound healing. The present study was performed to examine the effect of silk-elastin on burns using an animal model. Partial- and full-thickness burns were applied to the back of rats using a metal device. And the necrotic tissue was excised via surgical debridement and dressing materials were applied. Two groups, namely, the silk-elastin sponge and control groups, were established in the case of deep partial-thickness burns and full-thickness burns, respectively. Tissue samples from the partial-thickness burn model obtained at the 5th day and the 7th day after debridement were analyzed. The length of epithelization in the tissue sample and wound healing rate were evaluated on macro-photographs. And tissue samples from the full-thickness burn model obtained at the 7th day and 14th day after debridement were analyzed. The area of granulation, length of epithelization, and number of vessels in the tissue sample and wound healing rate were evaluated on macro-photographs. The silk-elastin group showed a better wound healing rate and superior epithelization and granulation and angiogenesis in comparison to control group. And our findings on day 14 in full-thickness burn suggest a potential difference in the quality of scars. Silk-elastin sponge can help promote burn wound healing after debridement. This new material can accelerate epithelization, granulation, and neoangiogenesis at the early stage after application with less dressing change. We believe that silk-elastin is a good material for use in topical burn therapy. And the new material may reduce scar forming after healed.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptation of the hemodialysis self-management scale into Turkish culture: a psychometric study. 根据土耳其文化改编血液透析自我管理量表：心理测量学研究。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-02-28 DOI: 10.1007/s10047-025-01498-8

Özge Coşkun, Hatice Karabuğa Yakar

引用次数: 0

Fouling process of hemodiafiltration membranes by hemodialysis and hemodiafiltration therapy. 血液透析及血液滤过治疗对血液滤过膜的污染过程。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-02-27 DOI: 10.1007/s10047-025-01497-9

Yoshihiro Tange, Masashi Kawakami, Shingo Takesawa

{"title":"Fouling process of hemodiafiltration membranes by hemodialysis and hemodiafiltration therapy.","authors":"Yoshihiro Tange, Masashi Kawakami, Shingo Takesawa","doi":"10.1007/s10047-025-01497-9","DOIUrl":"https://doi.org/10.1007/s10047-025-01497-9","url":null,"abstract":"During hemodialysis, proteins, such as albumin and globulin, are deposited on the dialysis membrane surface, causing fouling that affects solute removal and biocompatibility. This study aimed to measure the filtration coefficient as an index of dialysis membrane conditions in hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration modes using two different hemodiafiltration membranes ex vivo. The filtration coefficients of hemodiafiltration membranes in hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration modes were continuously measured for 123 min using 2 L bovine blood, which was adjusted with 32% hematocrit and 6.5 g/dL of total proteins. Polysulfone and cellulose triacetate were used as test membrane materials, and both membrane structures were asymmetric. The first fouling step was observed 20 s after filtration of both polysulfone and cellulose triacetate membranes in each mode. Thereafter, the filtration coefficient recovered in the pre-dilution online hemodiafiltration mode. However, it plateaued in the cellulose triacetate membrane and decreased in the polysulfone membrane. A flushing effect of the intermittent infusion hemodiafiltration mode was observed in both the cellulose triacetate and polysulfone membranes. The differences in fouling steps in each of the three modes-hemodialysis, pre-dilution online hemodiafiltration, and intermittent infusion hemodiafiltration-can be identified by continuously measuring filtration coefficient values.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central vein stenosis- prevalence, clinical characteristics, outcome and its impact on dialysis access. 中央静脉狭窄-患病率，临床特征，结果及其对透析通路的影响。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-02-21 DOI: 10.1007/s10047-025-01495-x

K Sai Sindhu Singh, Yerramachu Dharanidhar Reddy, Manoj Kumar, Lakshmi Aishwarya Pavuluri, Elayaperumal Indhumathi

{"title":"Central vein stenosis- prevalence, clinical characteristics, outcome and its impact on dialysis access.","authors":"K Sai Sindhu Singh, Yerramachu Dharanidhar Reddy, Manoj Kumar, Lakshmi Aishwarya Pavuluri, Elayaperumal Indhumathi","doi":"10.1007/s10047-025-01495-x","DOIUrl":"https://doi.org/10.1007/s10047-025-01495-x","url":null,"abstract":"Central vein stenosis (CVS) is a complication primarily affecting chronic hemodialysis patients, frequently resulting in vascular access dysfunction and decreased dialysis efficacy. While CVS has a variable mortality rate, its impact on dialysis access is profound, including arm edema, facial swelling, and venous hypertension. We describe the prevalence, clinical presentation, and treatment outcomes of CVS for vascular access in hemodialysis patients. We conducted a prospective observational study from July 2023 to June 2024, on patients undergoing maintenance hemodialysis (MHD) at a tertiary care center in South India who had CVS detected by CT Venography. Demographic information, comorbidity, access type, stenosis location, clinical presentation, treatment, and outcome data were collected and analyzed. Of the 152 patients on MHD, 20 (13.1%) had CVS. Of them, 7 patients were on tunneled catheter and 13 were on AVF. Arm edema (47%) was the most common symptom, followed by face swelling (29%) and prolonged bleeding (11%) from arteriovenous fistula post dialysis. The brachiocephalic vein (BCV) was the most common site of stenosis in 65% of patients. Angioplasty was performed in (N = 9) nine patients with a primary success rate of 66% and a six-month patency of 44.4%. In the remaining eleven (N = 11) four patients (20%) transitioned to CAPD, three (15%) had new access of which two had femoral catheter inserted and other one had new AVF creation done and two (10%) continued dialysis via same access. Mortality occurred in two patients (10%) due to pulmonary edema. The Prevalence of CVS in our study population was 13.1%. Six-month primary patency rate among those who underwent intervention was 44.4%. Vascular access had to be terminated in 55%.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first case of central Y-Y extra-corporeal membrane oxygenation system in a pediatric patient. 第一例中央Y-Y体外膜氧合系统在儿科患者。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2025-02-16 DOI: 10.1007/s10047-024-01490-8

Kazuki Tanimoto, Shigemitsu Iwai, Motoki Komori, Naoki Tadokoro, Satsuki Fukushima, Hajime Ichikawa

{"title":"The first case of central Y-Y extra-corporeal membrane oxygenation system in a pediatric patient.","authors":"Kazuki Tanimoto, Shigemitsu Iwai, Motoki Komori, Naoki Tadokoro, Satsuki Fukushima, Hajime Ichikawa","doi":"10.1007/s10047-024-01490-8","DOIUrl":"https://doi.org/10.1007/s10047-024-01490-8","url":null,"abstract":"The mechanical circulatory support (MCS) for pediatric patients with severe acute heart failure and poor pulmonary conditions is challenging. Herein, we report the first pediatric case of successfully treated by central Y-Y extra-corporeal membrane oxygenation (ECMO). A 10-year-old boy weighing 35 kg with a body surface area of 1.11 m2 was transferred to our institution in cardiac arrest with ongoing cardiopulmonary resuscitation using intra-aortic balloon pump and peripheral ECMO inserted at the previous hospital. Then, MCS system was converted to central ECMO with left heart drainage due to severe pulmonary congestion and the anticipation of long-term MCS. After 3 days, we converted it to central Y-Y ECMO because of concern about intracavitary thrombus formation due to poor pulmonary conditions. After four more days, the pulmonary conditions were improved, and we converted the MCS system into left ventricular assist device (LVAD) system. He is awaiting the heart transplantation eligibility review in a stable condition. Central Y-Y ECMO system can be used as a bridge to decision also for a pediatric patient with acute severe heart failure and poor pulmonary conditions.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0