Journal of Artificial Organs最新文献_第3页

Hepatitis A vaccination during ventricular assist device support in heart transplant candidates: immunogenicity and safety in a single-center cohort. 在心脏移植候选人心室辅助装置支持期间接种甲型肝炎疫苗：单中心队列的免疫原性和安全性

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-08-07 DOI: 10.1007/s10047-026-01579-2

Masahiro Arima, Shinya Yamamoto, Maho Adachi-Katayama, Koh Okamoto, Masahiko Ando, Shu Okugawa, Minoru Ono, Takeya Tsutsumi

{"title":"Hepatitis A vaccination during ventricular assist device support in heart transplant candidates: immunogenicity and safety in a single-center cohort.","authors":"Masahiro Arima, Shinya Yamamoto, Maho Adachi-Katayama, Koh Okamoto, Masahiko Ando, Shu Okugawa, Minoru Ono, Takeya Tsutsumi","doi":"10.1007/s10047-026-01579-2","DOIUrl":"10.1007/s10047-026-01579-2","url":null,"abstract":"Vaccination is among the cornerstones of infectious disease prevention in heart transplant candidates and recipients. Guidelines recommend an inactivated hepatitis A virus vaccine for heart transplant candidates, many of whom are on ventricular assist devices and at risk of hepatitis A virus exposure. However, data on the immunogenicity and safety of hepatitis A virus vaccines in these patients are lacking.This retrospective, observational, single-center study was conducted at our outpatient clinic between December 2019 and December 2025. The study participants were heart transplant candidates with ventricular assist devices aged ≥16 years who tested negative for anti-hepatitis A virus immunoglobulin G at baseline and completed the inactivated hepatitis A virus vaccination series. Anti-hepatitis A virus immunoglobulin G titers were measured after vaccination using a chemiluminescent immunoassay. Thirty-five individuals were included in the study. Immunosuppressive agents were used in four patients (11.4%). All participants achieved seroconversion at a median of 1 month after vaccination. The reverse cumulative distribution of the Anti-hepatitis A virus immunoglobulin G sample/cutoff values indicated that an adequate antibody response was achieved in individuals with ventricular assist devices. Adverse events of the vaccine were minor; two patients (6%) experienced local pain, and two (6%) subcutaneous hemorrhage. Seroconversion in patients with ventricular assist devices was high. hepatitis A virus vaccination should be completed before transplantation in heart transplant candidates, if indicated.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From guidance to reliable practice: an auditable hemocompatibility cockpit for outpatient HeartMate 3 care. 从指导到可靠的实践：门诊HeartMate 3护理的可审计血液相容性座舱。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-08-07 DOI: 10.1007/s10047-026-01580-9

Arif Albulushi, Gamal Aly, Hatem Farhan

引用次数: 0

Centrifugation-based plasma exchange overcomes blood flow restriction to rescue hyperviscosity syndrome in IgM-κ multiple myeloma: a case report. 以离心为基础的血浆交换克服血流限制以挽救IgM-κ多发性骨髓瘤的高粘度综合征：1例报告

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-08-01 DOI: 10.1007/s10047-026-01578-3

Hiroto Osakabe, Shinkuro Yamamoto, Ryu Shigehisa, Yuki Osakabe, Tatsuki Matsumoto, Rie Yoshimura, Satoshi Fukata, Keiji Inoue

{"title":"Centrifugation-based plasma exchange overcomes blood flow restriction to rescue hyperviscosity syndrome in IgM-κ multiple myeloma: a case report.","authors":"Hiroto Osakabe, Shinkuro Yamamoto, Ryu Shigehisa, Yuki Osakabe, Tatsuki Matsumoto, Rie Yoshimura, Satoshi Fukata, Keiji Inoue","doi":"10.1007/s10047-026-01578-3","DOIUrl":"10.1007/s10047-026-01578-3","url":null,"abstract":"When blood flow cannot be raised to the 150-200 mL/min threshold required for membrane-based therapeutic plasma exchange, centrifugation-based therapeutic plasma exchange represents the only mechanistically viable option-yet this specific clinical scenario has not been reported. We describe an 86-year-old man with IgM-κ multiple myeloma who developed hyperviscosity syndrome. Sequential membrane-based approaches failed owing to blood flow restriction: double-filtration plasmapheresis was discontinued when secondary membrane pressure reached 277 mmHg, and membrane-based therapeutic plasma exchange achieved only a 20.1% IgM level reduction at a subtherapeutic flow of 45-60 mL/min. Centrifugation-based therapeutic plasma exchange, operable at 10-150 mL/min, was performed in two sessions via bilateral peripheral antecubital venous access using fresh frozen plasma, achieving IgM level reductions of 67.3 and 66.2% with prompt symptomatic relief and no serious adverse events. Diagnosis of IgM-κ multiple myeloma was established by absence of the MyD88 L265P mutation and presence of t(11;14) on bone marrow cytogenetics. The patient was discharged on lenalidomide plus dexamethasone, with no hyperviscosity syndrome recurrence at follow-up. To our knowledge, this is the first reported case in which centrifugation-based therapeutic plasma exchange served as rescue therapy in a patient for whom blood flow restriction rendered membrane-based modalities non-functional-a clinical niche not addressed in prior comparative studies.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful destination therapy after stepwise mechanical circulatory support in a patient with cardiogenic shock following mechanical aortic valve replacement. 机械主动脉瓣置换术后心源性休克患者逐步机械循环支持后的成功终点治疗。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-31 DOI: 10.1007/s10047-026-01573-8

Rina Ebe, Tatsuki Fujiwara, Eiki Nagaoka, Takuya Kawabata, Hironobu Sakurai, Junya Nabeshima, Takuro Takashima, Taishi Yonetsu, Makoto Araki, Yoshitaka Isotani, Tetsuo Sasano, Tomoyuki Fujita

{"title":"Successful destination therapy after stepwise mechanical circulatory support in a patient with cardiogenic shock following mechanical aortic valve replacement.","authors":"Rina Ebe, Tatsuki Fujiwara, Eiki Nagaoka, Takuya Kawabata, Hironobu Sakurai, Junya Nabeshima, Takuro Takashima, Taishi Yonetsu, Makoto Araki, Yoshitaka Isotani, Tetsuo Sasano, Tomoyuki Fujita","doi":"10.1007/s10047-026-01573-8","DOIUrl":"10.1007/s10047-026-01573-8","url":null,"abstract":"Patients with mechanical aortic valve replacement and end-stage heart failure present major challenges when mechanical circulatory support is required, as transvalvular devices such as the Impella 5.5 are contraindicated. We report a 57-year-old man with idiopathic dilated cardiomyopathy who developed cardiogenic shock after prior mechanical aortic valve replacement. Despite cardiac resynchronization therapy defibrillator support and intra-aortic balloon pumping, he became dialysis dependent. The patient's condition progressively deteriorated, necessitating more robust mechanical circulatory support. Although durable left ventricular assist device implantation was considered, transvalvular Impella 5.5 support was precluded by the mechanical aortic valve, and simultaneous durable left ventricular assist device implantation with redo aortic valve replacement was considered high risk because of poor surgical tolerance and end-organ dysfunction. Therefore, we planned a staged surgical strategy. Reoperative aortic valve replacement with a bioprosthetic valve was therefore performed to enable Impella 5.5 implantation. Impella support resulted in hemodynamic stabilization, end-organ recovery, and improvement in risk stratification. Subsequently, a HeartMate 3 was successfully implanted as destination therapy. The patient recovered progressively and was discharged. This case demonstrates that intentional conversion to a bioprosthetic valve may be a viable strategy to enable advanced mechanical circulatory support.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13427982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between real sieving coefficient determined using novel lab-scale module and pore structure of hemodiafiltration membranes. 用新型实验室规模模块测定的真实筛分系数与血液滤过膜孔结构的相关性。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-30 DOI: 10.1007/s10047-026-01577-4

Mizuki Ichikawa, Makoto Fukuda, Takuma Morikawa, Kousei Takeuchi, Kiyotaka Sakai

{"title":"Correlation between real sieving coefficient determined using novel lab-scale module and pore structure of hemodiafiltration membranes.","authors":"Mizuki Ichikawa, Makoto Fukuda, Takuma Morikawa, Kousei Takeuchi, Kiyotaka Sakai","doi":"10.1007/s10047-026-01577-4","DOIUrl":"10.1007/s10047-026-01577-4","url":null,"abstract":"The novel lab-scale hollow fiber membrane module was fabricated to determine the apparent sieving coefficient ([Formula: see text]) of commercial hemodiafiltration membranes, MFX-SW eco (polyethersulfone, Sample A) and NVF-P (polysulfone, Sample B), using the aqueous solution of dextran with a broader molecular weight distribution. All the molecular weight cut-off curves plotted as [Formula: see text] versus filtration flow rate (QF) exhibited smooth profiles without intersecting each other, showing distinct variations depending on QF across a wide range of molecular weights. Field emission scanning electron microscopy (FE-SEM) observations revealed that the equivalent pore diameters of samples A and B were nearly identical at 23.0 ± 15.5 nm and 23.3 ± 15.5 nm, respectively. Although the surface porosity of sample A (14.5 ± 3.9%) was higher than that of sample B (10.2 ± 3.2%), the difference was not statistically significant. These numerical data were in excellent agreement with the qualitative morphological findings obtained from the FE-SEM images. Furthermore, it is suggested that the subtle structural differences between the two membranes are also reflected in the relationship between the real sieving coefficients ([Formula: see text]) calculated by using [Formula: see text] and the equivalent pore diameters. Since the lab-scale modules are fabricated relatively easily by hand, this methodology is extremely valuable to rigorously define membrane performance.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations and future challenges in managing ECMO for pediatric patients. 儿科患者ECMO管理的考虑和未来的挑战。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-30 DOI: 10.1007/s10047-026-01574-7

Koichi Kashiwa, Kent Doi, Fumiaki Shikata, Minoru Ono

{"title":"Considerations and future challenges in managing ECMO for pediatric patients.","authors":"Koichi Kashiwa, Kent Doi, Fumiaki Shikata, Minoru Ono","doi":"10.1007/s10047-026-01574-7","DOIUrl":"10.1007/s10047-026-01574-7","url":null,"abstract":"In managing ECMO, preventing thrombus formation and hemolysis is crucial. While centrifugal pumps are increasingly used in pediatric ECMO, pumps designed for low flow range are not approved in Japan. Thus, centrifugal pumps for adults are used in pediatric ECMO cases. This increases the risk of thrombus formation in the enlarged flow paths before and after the centrifugal pump. To prevent thrombus formation in the ECMO circuit, it is necessary not only to appropriately optimize the dosage of anticoagulants but also to pay meticulous attention to circuit configuration. Furthermore, using centrifugal pumps at low flow rates increases shear stress on the blood, making hemolysis significantly more likely to occur in pediatric cases compared to adult cases. To reduce the incidence of hemolysis, it is necessary to use centrifugal pumps designed for low flow range. However, given the current situation where such centrifugal pumps are not approved in Japan, we must proceed with the understanding that hemolysis is more likely to occur in pediatric ECMO cases using centrifugal pumps. Moving forward, to reduce complications and improve outcomes in pediatric ECMO, the development of pediatric ECMO systems, including centrifugal pumps optimized for low-flow range, is required.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adsorption characteristics of erythropoietin in two β2-microglobulin absorption systems: a preliminary in vitro study using FILTOR^® and Lixelle^®. 促红细胞生成素在两种β2-微球蛋白吸收系统中的吸附特性：使用FILTOR®和Lixelle®的初步体外研究

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-27 DOI: 10.1007/s10047-026-01576-5

Shoichiro Hara, Masakazu Hirose, Taisuke Goto, Katsuro Imamura

{"title":"Adsorption characteristics of erythropoietin in two β2-microglobulin absorption systems: a preliminary in vitro study using FILTOR® and Lixelle®.","authors":"Shoichiro Hara, Masakazu Hirose, Taisuke Goto, Katsuro Imamura","doi":"10.1007/s10047-026-01576-5","DOIUrl":"10.1007/s10047-026-01576-5","url":null,"abstract":"Purpose: To compare the erythropoietin adsorption characteristics of two adsorption devices, Lixelle® and FILTOR®, used for the treatment of dialysis-related amyloidosis, using bovine serum.Methods: Three recirculating perfusion studies were performed using bovine serum containing recombinant human erythropoietin (epoetin beta; EPO), darbepoetin alfa (DA), or epoetin beta pegol (C.E.R.A.). Because direct quantitative assays for DA and C.E.R.A. were unavailable, and it was difficult to obtain suitable measurement systems for these agents, they were evaluated using an erythropoietin immunoassay based on assay cross-reactivity.Results: In the EPO perfusion test (n = 3), the 4-h EPO removal rate was 18.7 ± 3.2% in the Lixelle® group and 53.0 ± 3.1% in the FILTOR® group (p < 0.05). In the DA perfusion test (n = 3), the 4-h removal rate based on erythropoietin immunoassay measurements was 3.3 ± 1.5% in the Lixelle® group and 31.0 ± 6.1% in the FILTOR® group (p < 0.05). In the C.E.R.A. perfusion test (n = 3), the corresponding removal rates were 0.3 ± 0.6% and 1.3 ± 2.3%, respectively, with no significant difference (p = 0.5351).Conclusions: The FILTOR® adsorption device showed greater reductions in erythropoietin concentration than the Lixelle® device in experiments using EPO. A similar trend was observed for DA, whereas no apparent difference was observed for C.E.R.A. Because DA and C.E.R.A. were evaluated using assay cross-reactivity, and quantitative assessment was limited by the sampling strategy, these findings should be interpreted with caution.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal life support for severe heart failure in a diffuse panbronchiolitis patient awaiting lung transplant: a case report. 等待肺移植的弥漫性泛细支气管炎患者重症心力衰竭的体外生命支持一例报告。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-27 DOI: 10.1007/s10047-026-01575-6

Yoshikazu Kimura, Shuji Okahara, Haruki Sunami, Shin Tanaka, Hisao Higo, Satoshi Suzuki, Kazuyoshi Shimizu

{"title":"Extracorporeal life support for severe heart failure in a diffuse panbronchiolitis patient awaiting lung transplant: a case report.","authors":"Yoshikazu Kimura, Shuji Okahara, Haruki Sunami, Shin Tanaka, Hisao Higo, Satoshi Suzuki, Kazuyoshi Shimizu","doi":"10.1007/s10047-026-01575-6","DOIUrl":"10.1007/s10047-026-01575-6","url":null,"abstract":"A 55-year-old woman with chronic respiratory failure due to diffuse panbronchiolitis, on a lung transplant waitlist, developed acute left ventricular failure with an ejection fraction of 18%. Although cardiac reversibility was uncertain, it was considered potentially reversible and transplant eligibility was judged to be maintainable; therefore, veno-arterial extracorporeal membrane oxygenation with Impella was initiated as extracorporeal life support (ECLS), with combined support selected to prevent left ventricular distension and provide circulatory stabilization. Cardiac function improved, and she was successfully weaned from ECLS, subsequently undergoing bilateral lung transplantation. In this case, the decision to initiate ECLS was determined not only by the need for life-saving circulatory support but also by the simultaneous assessment of cardiac reversibility and the feasibility of maintaining transplant eligibility. This case highlights the importance of integrating these considerations in selecting appropriate candidates for ECLS as a bridge-to-decision.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148603390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fracture of the cannula tip during removal of a long-term indwelling Impella 5.5: a case report. 长期内留置Impella 5.5拔除过程中套管尖端骨折1例。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-13 DOI: 10.1007/s10047-026-01571-w

Ryuhei Yamamoto, Yusuke Iguchi, Bryan James Mathis, Hiroaki Sakamoto

引用次数: 0

Investigation of the cleaning effect by the intermittent backfiltration in diafilters with polysulfone and polymethylmethacrylate membranes. 聚砜和聚甲基丙烯酸甲酯膜滤池间歇反滤净化效果的研究。

IF 1.2 4区医学

Journal of Artificial Organs Pub Date : 2026-07-13 DOI: 10.1007/s10047-026-01572-9

Takayoshi Kiguchi, Ayaka Tanuma, Akihiro C Yamashita

{"title":"Investigation of the cleaning effect by the intermittent backfiltration in diafilters with polysulfone and polymethylmethacrylate membranes.","authors":"Takayoshi Kiguchi, Ayaka Tanuma, Akihiro C Yamashita","doi":"10.1007/s10047-026-01572-9","DOIUrl":"10.1007/s10047-026-01572-9","url":null,"abstract":"An intermittent infusion during dialysis therapy across the membrane by backfiltration is expected to have a cleaning effect on the membrane in addition to stabilizing blood pressure. In this study, the effect of backfiltration infusion on the solute removal performance was investigated for both diafilters with polysulfone (PSf) and polymethylmethacrylate (PMMA) membrane in vitro experiment using bovine whole blood. To clarify the infusion method with a high cleaning effect, the infusion was performed under two conditions for dialysate flow: countercurrent and parallel flow to blood flow, aiming to induce backfiltration at different area in a diafilter. A scanning electron microscope (SEM) and a scanning probe microscope (SPM) were used for evaluation of the degree of fouling on the membrane after experiments. Although intermittent backfiltration did not show any effect on the removal efficiency of creatinine and inulin, it was slightly effective in maintaining protein permeability under certain conditions. SEM observations and SPM measurements revealed that protein adsorption to the membrane caused the macropore blocking, and the fouling was partly removed by intermittent infusion primarily in areas where backfiltration mainly occurs. In conclusion, backfiltraion had an effect on resolving fouling and recovering solute removal performance for both membrane materials; however, its effect was limited.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":"29 3","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0