Journal of Artificial Organs最新文献_第10页

Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials. 旋转培养法制备的巨噬细胞聚集体的特征及其对聚合物材料的反应

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-01-09 DOI: 10.1007/s10047-023-01428-6

Shota Toda, Yoshihide Hashimoto, Naoko Nakamura, Masahiro Yamada, Ryusuke Nakaoka, Wataru Nomura, Masaya Yamamoto, Tsuyoshi Kimura, Akio Kishida

{"title":"Characteristics of macrophage aggregates prepared by rotation culture and their response to polymeric materials.","authors":"Shota Toda, Yoshihide Hashimoto, Naoko Nakamura, Masahiro Yamada, Ryusuke Nakaoka, Wataru Nomura, Masaya Yamamoto, Tsuyoshi Kimura, Akio Kishida","doi":"10.1007/s10047-023-01428-6","DOIUrl":"https://doi.org/10.1007/s10047-023-01428-6","url":null,"abstract":"Understanding the interaction between macrophages and biomaterials is important for the creation of new biomaterials and the development of technologies to control macrophage function. Since macrophages are strongly adhesive, caution is required when performing in vitro evaluations. Similarly, when THP-1 cells, macrophage precursor cells, are differentiated into macrophages using phorbol-12-myristate-13-acetate (PMA), it becomes difficult to detach them from the adherent substrate, which has been a problem on investigation of immunological responses to biomaterials. In this study, the interaction of THP-1 cell-differentiated macrophages with biomaterials was analyzed based on a new method of seeding THP-1 cells. THP-1 cells were cultured in static and rotation culture without and with PMA. In undifferentiated THP-1 cells, there was no change in cellular function between static and rotation cultures. In rotation culture with PMA, THP-1 cells differentiated and formed macrophage aggregates. IL-1β and MRC1 expression in macrophage aggregates was examined after differentiation and M1/M2 polarization. Macrophage aggregates in rotation culture tended to be polarized toward M2 macrophages compared with those in static culture. In the evaluation of the responses of macrophage aggregates to several kinds of polymeric materials, macrophage aggregates showed different changes in MRC1 expression over time at 30, 50, and 70 rpm. Rotation speed of 30 rpm was considered most appropriate condition in that it gave stable results with the same trend as obtained with static culture. The use of macrophage aggregates obtained by rotational culture is expected to provide new insights into the evaluation of inflammatory properties of biomaterials.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol. 体外机械循环支持选择标准化方案-左心室挑战方案的成果。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-01-08 DOI: 10.1007/s10047-023-01427-7

Naoki Tadokoro, Tetsuya Koyamoto, Kohei Tonai, Yuki Yoshida, Koudai Hirahsima, Satoshi Kainuma, Naonori Kawamoto, Kimito Minami, Hiroshi Nishioka, Tsukamoto Yasumasa, Tomoyuki Fujita, Satsuki Fukushima

{"title":"The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol.","authors":"Naoki Tadokoro, Tetsuya Koyamoto, Kohei Tonai, Yuki Yoshida, Koudai Hirahsima, Satoshi Kainuma, Naonori Kawamoto, Kimito Minami, Hiroshi Nishioka, Tsukamoto Yasumasa, Tomoyuki Fujita, Satsuki Fukushima","doi":"10.1007/s10047-023-01427-7","DOIUrl":"https://doi.org/10.1007/s10047-023-01427-7","url":null,"abstract":"There are no criteria for surgical mechanical circulatory system (MCS) selection for acute heart failure. Since 2021, we have utilized cardiopulmonary bypass system to assess patients' heart and lung condition to inform surgical MCS selection. we aimed to retrospectively analyze the outcomes of treatments administered using our protocol. We analyzed the data of 19 patients who underwent surgical MCS implantation. We compared patients' characteristics across the biventricular-assist device (BiVAD), central Y-Y extracorporeal membrane oxygenation (ECMO), central ECMO, and left VAD (LVAD) systems. Patients' diagnoses included fulminant myocarditis (47.4%), dilated cardiomyopathy (21.1%), acute myocardial infarction (15.8%), infarction from aortic dissection (5.3%), doxorubicin-related cardiomyopathy (5.3%), and tachycardia-induced myocarditis (5.3%). Eight patients (42.1%) underwent LVAD implantation, 1 (5.2%) underwent central ECMO, 4 (21.1%) underwent BiVAD implantation, and 6 (31.6%) underwent central Y-Y ECMO. 48 h after surgery, both the pulmonary arterial and right atrial pressures were effectively controlled, with median values being 19.0 mmHg and 9.0 mmHg, respectively. No patients transitioned from LVAD to BiVAD in the delayed period. Cerebrovascular events occurred in 21.1%. Successful weaning was achieved in 11 patients (57.9%), and 5 patients (26.3%) were converted to durable LVAD. Two-year cumulative survival was 84.2%. Our protocol showed good results for device selection in patients with heart failure, and device selection according to this protocol enabled good control of the pulmonary and systemic circulations.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical support for bridge to transplant in an infant with post-cardiotomy end-stage heart failure and complete heart block: report of a case 机械支持为心脏切除术后终末期心力衰竭和完全性心脏传导阻滞的婴儿搭建移植桥梁：病例报告

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-29 DOI: 10.1007/s10047-023-01425-9

Haruhiro Nagase, Takaya Hoashi, Koichi Toda, Kentaro Hotoda, Yuji Fuchigami, Yukino Iijima, Takaaki Suzuki

{"title":"Mechanical support for bridge to transplant in an infant with post-cardiotomy end-stage heart failure and complete heart block: report of a case","authors":"Haruhiro Nagase, Takaya Hoashi, Koichi Toda, Kentaro Hotoda, Yuji Fuchigami, Yukino Iijima, Takaaki Suzuki","doi":"10.1007/s10047-023-01425-9","DOIUrl":"https://doi.org/10.1007/s10047-023-01425-9","url":null,"abstract":"The patient was diagnosed with perimembranous ventricular septal defect (VSD). She underwent VSD closure and muscle bundle resection across right ventricular outflow tract at the age of 3 months. Since then, she had suffered from severe heart failure and complete heart block. Permanent pacemaker generator was implanted in the left hypochondrium. She was depended on continuous catecholamine administration, so transferred to our hospital for further management. On arrival, her body weight was 5686 g (− 2.7 SD). She underwent Excor pediatric left ventricular assist device implantation at the age of 9 months. Because the position of the left ventricular assist device cannula interfered with the pacemaker, herein, the pacemaker pocket was newly created in the left thoracic cavity. An 1 mm in thickness of expanded polytetrafluoroethylene sheet was trimmed and sutured under the anterolateral wall of left thoracic cavity as a pacemaker pocket. Bipolar ventricular lead was sutured on left ventricular apex and basal wall to face each other, mimicking cardiac regeneration therapy. Even though she unfortunately required right diaphragmatic plication for iatrogenic phrenic nerve palsy, her respiratory function was well maintained; therefore, secondary right heart failure was not observed. Her cardiopulmonary function was quite stable until post-operative day 275 when the patient was transferred to another hospital for heart transplantation.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVAHEART 2 with double cuff tipless inflow cannula is suitable for long-term support atrial switch operation in transposition of great arteries. EVAHEART 2双袖带无尖端流入套管适用于大动脉转位的长期支持心房开关手术。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2023-01-23 DOI: 10.1007/s10047-023-01380-5

Sawako Furukawa, Osamu Kinoshita, Masahiko Ando, Minoru Ono

引用次数: 0

Removal performance of pre- and post-dilution online hemodiafiltration using identical hemodiafilters in the same patients. 同一患者使用相同的血液滤过器进行稀释前和稀释后在线血液滤过的去除效果。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-12-14 DOI: 10.1007/s10047-022-01379-4

Kazuyoshi Okada, Hiroyuki Michiwaki, Hiroaki Mori, Manabu Tashiro, Tomoko Inoue, Hisato Shima, Koji Ohshima, Jun Minakuchi, Shu Kawashima

{"title":"Removal performance of pre- and post-dilution online hemodiafiltration using identical hemodiafilters in the same patients.","authors":"Kazuyoshi Okada, Hiroyuki Michiwaki, Hiroaki Mori, Manabu Tashiro, Tomoko Inoue, Hisato Shima, Koji Ohshima, Jun Minakuchi, Shu Kawashima","doi":"10.1007/s10047-022-01379-4","DOIUrl":"10.1007/s10047-022-01379-4","url":null,"abstract":"Online hemodiafiltration (OHDF) for renal replacement therapy has two modes: pre- (pre-OHDF) and post-dilution OHDF (post-OHDF). To elucidate the precise differences between the two modes, a clinical study was performed using the same polysulfone hemodiafilters in the same patients. Eight patients were treated with ABH™-22PA for 6 weeks: 3 weeks of pre-OHDF (with substitution volumes of 24, 36, and 48 L) and 3 weeks of post-OHDF (6, 8, and 10 L). The reduction ratios of urea, uric acid (UA), creatinine (CRE), inorganic phosphorus (iP), beta-2-microglobulin (β2-MG), and alpha-1-microglobulin (α1-MG) were evaluated. The removal amounts of β2-MG, α1-MG, and albumin were also evaluated by analyzing the spent dialysis fluids. The types and numbers of adverse events (AEs) and device malfunctions were recorded. The reduction ratios of urea, UA, CRE, iP, and β2-MG were comparable among all conditions, while that of α1-MG tended to be slightly higher in post-OHDF than in pre-OHDF. The removal amounts of α1-MG and albumin in pre-OHDF and post-OHDF were significantly greater with the maximum substitution volume than with the minimum volume. However, the selective removal indices, which were obtained by dividing the amount of α1-MG removed by the albumin level, tended to be slightly higher in pre- than in post-OHDF. No device-related AEs or device malfunctions occurred in either mode. No significant differences in inflammatory responses, evaluated by high-sensitivity C-reactive protein and interleukin-6, were observed. This study provides removal performance and safety data regarding the application of ABH-22PA for pre- and post-OHDF.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10635926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10342996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sustainability of peritoneal dialysis and renal function with proactive combination therapy. 积极联合治疗腹膜透析和肾功能的可持续性。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-12-06 DOI: 10.1007/s10047-022-01375-8

Kei Nagai, Atsushi Ueda

{"title":"Sustainability of peritoneal dialysis and renal function with proactive combination therapy.","authors":"Kei Nagai, Atsushi Ueda","doi":"10.1007/s10047-022-01375-8","DOIUrl":"10.1007/s10047-022-01375-8","url":null,"abstract":"Most combined peritoneal dialysis and hemodialysis therapies are used to compensate for the lack of dialysis volume and efficiency in pre-started peritoneal dialysis patients. The aim was to determine the effects on both peritoneal dialysis and residual renal function when proactively combined therapy is started at dialysis induction. This report was based on observation of 10 patients who initiated dialysis therapy with a combination of peritoneal and hemodialysis at induction, and the control group consisted of 24 patients with peritoneal monotherapy in a single dialysis center. The technical survival of peritoneal dialysis therapy and urinary volume and creatinine clearance as residual renal function were assessed. Technical survival of peritoneal dialysis during the 5-year observation period was much better in patients who started with proactive combination therapy than with peritoneal dialysis monotherapy. Between induction and 24 months later, median urinary volume (interquartile value) changed from 1500 (1100-1583) to 800 (545-1875) mL/day and from 1600 (1300-2150) to 1480 (115-1885) mL/day for peritoneal alone and for combination therapy, respectively. Creatinine clearance values changed from 7.0 (6.0-8.7) to 2.0 (1.0-3.0) mL/min for peritoneal alone and from 6.0 (4.0-7.3) to 3.0 (0.5-4.0) mL/min for combination therapy. Though some possible confounding factors, including selection bias, cannot be ruled out, this investigation suggests the benefit of proactive combination dialysis therapy on the sustainability of peritoneal dialysis and residual renal function.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35258140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In memory of Prof. Takashi Akiba (1950-2022). 纪念秋叶隆教授(1950-2022)。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2023-08-09 DOI: 10.1007/s10047-023-01415-x

Tadao Akizawa

引用次数: 0

Feasibility study of an artificial placenta system consisting of a loop circuit configuration extracorporeal membrane oxygenation with a bridge circuit in the form of the umbilical arterial-venous connection. 人工胎盘系统的可行性研究，该系统由环路配置体外膜氧合和以脐动-静脉连接形式的桥式电路组成。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-10-13 DOI: 10.1007/s10047-022-01370-z

Ayako Inatomi, Tomohiro Nishinaka, Akihide Umeki, Tomonori Tsukiya, Nobumasa Katagiri, Masahiko Fujii, Futoshi Kobayashi, Syusuke Imaoka, Shun Tanaka, Toshihide Mizuno, Takashi Murakami

{"title":"Feasibility study of an artificial placenta system consisting of a loop circuit configuration extracorporeal membrane oxygenation with a bridge circuit in the form of the umbilical arterial-venous connection.","authors":"Ayako Inatomi, Tomohiro Nishinaka, Akihide Umeki, Tomonori Tsukiya, Nobumasa Katagiri, Masahiko Fujii, Futoshi Kobayashi, Syusuke Imaoka, Shun Tanaka, Toshihide Mizuno, Takashi Murakami","doi":"10.1007/s10047-022-01370-z","DOIUrl":"10.1007/s10047-022-01370-z","url":null,"abstract":"We developed a new artificial placenta (AP) system consisting of a loop circuit configuration extracorporeal membrane oxygenation (ECMO) with a bridge circuit designed to be applied to the fetus in the form of an umbilical arterial-venous connection. We aimed to evaluate the feasibility of the AP system by performing a hydrodynamic simulation using a mechanical mock circulation system and fetal animal experiment. The effect of the working condition of the AP system on the fetal hemodynamics was evaluated by hydrodynamic simulation using a mechanical mock circulation system, assuming the weight of the fetus to be 2 kg. The AP system was introduced to two fetal goats at a gestational age of 135 days. The general conditions of the experimental animals were evaluated. The mock simulation showed that in an AP system with ECMO in the form of an umbilical arterial-venous connection in series, it could be difficult to maintain fetal hemodynamics when high ECMO flow was applied. The developed AP system could have high ECMO flow with less umbilical blood flow; however, the possibility of excessive load on the fetal right-sided heart should be noted. In the animal experiment, kid 1 (1.9 kg) was maintained on the AP system for 12 days and allowed to grow to term. In kid 2 (1.6 kg), the AP system could not be established because of the occlusion of the system by a thrombus. The developed AP system was feasible under both in vitro and in vivo conditions. Improvements in the AP system and management of the general fetal conditions are essential.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of time off anticoagulation in patients with continuous-flow left ventricular assist devices. 停用抗凝时间对连续血流左心室辅助装置患者的影响。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-10-08 DOI: 10.1007/s10047-022-01367-8

Christian A Inchaustegui, Ashley Patel, Harveen K Lamba, Andrew Brown, Justin Arunthamakun, Kevin Ting, Subhasis Chatterjee, Ajith P Nair, Joggy K George, Alexis E Shafii, Kenneth K Liao, Andrew B Civitello

{"title":"Impact of time off anticoagulation in patients with continuous-flow left ventricular assist devices.","authors":"Christian A Inchaustegui, Ashley Patel, Harveen K Lamba, Andrew Brown, Justin Arunthamakun, Kevin Ting, Subhasis Chatterjee, Ajith P Nair, Joggy K George, Alexis E Shafii, Kenneth K Liao, Andrew B Civitello","doi":"10.1007/s10047-022-01367-8","DOIUrl":"10.1007/s10047-022-01367-8","url":null,"abstract":"Patients with left ventricular assist devices (LVADs) receive anticoagulation to decrease the risk of thrombosis. Various circumstances require discontinuing anticoagulation in LVAD patients, but the risks entailed are not well defined. In a retrospective review of LVAD implantation procedures, we examined the effect of time off anticoagulation on thrombosis and mortality rates after implantation. An international normalized ratio ≤ 1.5 was used to screen for patients taken off anticoagulation. Patients were divided into three groups by the cumulative number of days off anticoagulation: no discontinuation, short-term discontinuation (< 30 days), and long-term discontinuation (≥ 30 days). Rates of ischemic stroke, pump thrombosis, and mortality were compared among groups. Of 245 patients who underwent LVAD implantation during the study, 70 (28.6%) were off anticoagulation during follow-up: 37 (15.1%) had short-term discontinuation (median, 11 days), and 33 (13.5%) had long-term discontinuation (median, 124 days). Patients with long-term discontinuation had a higher rate of ischemic stroke (adjusted hazard ratio 8.5, p = 0.001) and death (adjusted hazard ratio 3.9, p = 0.001). The three groups did not differ in pump thrombosis rate. We conclude that after LVAD implantation, discontinuing anticoagulation for ≥ 30 days is independently associated with an increased risk of ischemic stroke and death.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33495241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The uric acid-urea distribution volume ratio is a potential marker of hydration status in patients on hemodialysis. 尿酸-尿素分布体积比是血液透析患者水合状态的潜在标志。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2023-12-01 Epub Date: 2022-12-24 DOI: 10.1007/s10047-022-01377-6

Yuki Kawaguchi, Norio Hanafusa, Satoko Sakurai, Mai Miyaji, Naohiro Toda, Kazuhiro Iwadoh, Ken Tsuchiya

{"title":"The uric acid-urea distribution volume ratio is a potential marker of hydration status in patients on hemodialysis.","authors":"Yuki Kawaguchi, Norio Hanafusa, Satoko Sakurai, Mai Miyaji, Naohiro Toda, Kazuhiro Iwadoh, Ken Tsuchiya","doi":"10.1007/s10047-022-01377-6","DOIUrl":"10.1007/s10047-022-01377-6","url":null,"abstract":"The distribution volume of uric acid is affected by the amount of extracellular water (ECW), while urea distribution volume can be considered as total body water (TBW). Thus, the ratio of distribution volumes of uric acid and urea can be paralleled to and be considered as the proxy of ECW/TBW. A total of 108 patients at our facility was included. The uric acid and urea distribution volume ratio (UUVdR) calculated from the single-pool model, which was measured within 1 month of the time when the bioimpedance index was measured. ECW/TBW at the end of the HD session was measured by InBody S10. We investigated the association between the UUVdR and the ECW/TBW values and the factors affecting the residuals of the regression equation. We also evaluated the predictive ability of overhydration or dehydration in randomly selected two groups, i.e., the training group and the validation group. ECW/TBW correlated highly with UUVdR. Multivariate analysis demonstrated that only creatinine and ECW/TBW were significantly associated with regression residuals. The cutoff values of UUVdR for overhydration and dehydration were 0.666 and 0.579, respectively, in the training group. Their AUC were 0.872 and 0.898, respectively. The sensitivity and specificity values in the validation group were 0.571 and 0.868 for overhydration, and 0.444 and 0.953 for dehydration, respectively. UUVdR might be a proxy of hydration status in hemodialysis patients. It may be possible to predict hydration status without dedicated devices in the epidemiological study.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0