Optimizing vancomycin release from novel carbon fiber-reinforced polymer implants with small holes: periprosthetic joint infection treatment.

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Journal of Artificial Organs Pub Date : 2024-09-01 Epub Date: 2023-06-02 DOI:10.1007/s10047-023-01407-x
Satoshi Kamihata, Wataru Ando, Ichiro Nakahara, Hideaki Enami, Kazuma Takashima, Keisuke Uemura, Hidetoshi Hamada, Nobuhiko Sugano
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引用次数: 0

Abstract

Periprosthetic joint infection (PJI) is a catastrophic complication after total hip arthroplasty. A new drug-loaded carbon fiber-reinforced polymer (CFRP) prosthesis with a sustained drug-release mechanism is being developed for one-stage surgery. We aimed to examine the diffusion dynamics of vancomycin from vancomycin paste-loaded CFRP implants. The differences in the in vitro diffusion dynamics of vancomycin paste were investigated using the elution test by varying parameters. These included the mixing ratio of vancomycin and distilled water (1:0.8, 1:1.2, and 1:1.4) for vancomycin paste, and hole diameter (1 mm and 2 mm) on the container. The in vivo diffusion dynamics were investigated using a rabbit model with vancomycin-loaded CFRP implants placed subcutaneously. The in vitro experiments showed that the diffusion effect of vancomycin was highest in the parameters of vancomycin paste with distilled water mixed in a ratio of 1:1.4, and with a 2 mm hole diameter. The in vivo experiments revealed diffusion dynamics similar to those observed in the in vitro study. The drug diffusion effect tended to be high for vancomycin paste with a large water ratio, and a large diameter of holes. These results indicate that the drug diffusion dynamics from a CFRP implant with holes can be adjusted by varying the water ratio of the vancomycin paste, and the hole size on the CFRP implant.

Abstract Image

优化带有小孔的新型碳纤维增强聚合物植入物的万古霉素释放:假体周围关节感染治疗。
假体周围关节感染(PJI)是全髋关节置换术后的一种灾难性并发症。目前正在开发一种具有持续药物释放机制的新型药物负载碳纤维增强聚合物(CFRP)假体,用于一步手术。我们的目的是研究万古霉素从万古霉素膏负载的 CFRP 假体中的扩散动力学。我们使用洗脱试验,通过改变参数来研究万古霉素膏体外扩散动力学的差异。这些参数包括万古霉素膏与蒸馏水的混合比例(1:0.8、1:1.2 和 1:1.4)以及容器上的孔径(1 毫米和 2 毫米)。研究人员用一只皮下植入了万古霉素的 CFRP 植入物的兔子模型对体内扩散动力学进行了研究。体外实验表明,万古霉素膏与蒸馏水的混合比例为 1:1.4,孔径为 2 毫米时,万古霉素的扩散效果最好。体内实验显示的扩散动态与体外研究中观察到的扩散动态相似。水比大、孔径大的万古霉素糊的药物扩散效果往往较高。这些结果表明,可以通过改变万古霉素膏的水比率和 CFRP 植入体上的孔径来调节带孔 CFRP 植入体的药物扩散动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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