利用幂律溶血模型中使用的不同系数集和标度剪切应力模型,对 FDA 基准血泵进行计算流体动力学模拟。

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Ahmet Onder, Omer Incebay, Rafet Yapici
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引用次数: 0

摘要

溶血是设计和优化血液接触设备时需要考虑的最重要问题。尽管在溶血预测研究中使用计算流体动力学(CFD)提供了便利并具有广阔的前景,但这是一个极具挑战性的过程。利用 CFD 进行溶血预测取决于网格、实施方法、系数集和标量剪切应力模型。为此,我们尝试找到一种组合,利用通常引用的基于幂律的溶血模型进行溶血预测,从而获得最准确的结果。在使用 CFD 对食品与药物管理局 (FDA) 基准血泵进行溶血预测时,使用了 3 种不同的标量剪切应力模型和 5 种不同的系数集,以及基于幂律的溶血模型。此外,还进行了基于溶血和压头的网格独立性测试。将 CFD 模拟的压头结果与已公布的 FDA 基准血泵的压头结果进行了比较,结果显示两者吻合良好。此外,采用标量-剪切应力模型和系数集组合进行的 CFD 溶血预测结果与三种工作条件下的实验溶血数据进行了比较,如 3500 转/分钟转速下 6-7 升/分钟的流量和 2500 转/分钟转速下 6 升/分钟的流量。结果发现,其中一个标量-剪切应力模型和系数组合在实验测量误差范围之内,而所有其他组合都高估了溶血量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Computational fluid dynamics simulating of the FDA benchmark blood pump with different coefficient sets and scaler shear stress models used in the power-law hemolysis model.

Computational fluid dynamics simulating of the FDA benchmark blood pump with different coefficient sets and scaler shear stress models used in the power-law hemolysis model.

Hemolysis is the most important issue to consider in the design and optimization of blood-contacting devices. Although the use of Computational Fluid Dynamics (CFD) in hemolysis prediction studies provides convenience and has promising potential, it is an extremely challenging process. Hemolysis predictions with CFD depend on the mesh, implementation method, coefficient set, and scalar-shear-stress model. To this end, an attempt was made to find the combination that would provide the most accurate result in hemolysis prediction with the commonly cited power-law based hemolysis model. In the hemolysis predictions conducted using CFD on the Food and Drug Administration (FDA) benchmark blood pump, 3 different scalar-shear-stress models, and 5 different coefficient sets with the power-law based hemolysis model were used. Also, a mesh independence test based on hemolysis and pressure head was performed. The pressure head results of CFD simulations were compared with published pressure head of the FDA benchmark blood pump and a good agreement was observed. In addition, results of CFD-hemolysis predictions which are conducted with scalar-shear-stress model and coefficient set combinations were compared with experimental hemolysis data at three operating conditions such as 6-7 L/min flow rates at 3500 rpm rotational speeds and 6 L/min at 2500 rpm. One of the combinations of the scalar-shear-stress model and the coefficient set was found to be within the error limits of the experimental measurements, while all other combinations overestimated hemolysis.

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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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