Journal of Artificial Organs最新文献_第6页

Successful use of extracorporeal life support and hemadsorption in the context of venlafaxine intoxication requiring cardiopulmonary resuscitation: a case report. 在文拉法辛中毒需要心肺复苏的情况下成功使用体外生命支持和吸血疗法：病例报告。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-04-28 DOI: 10.1007/s10047-023-01399-8

Matthias Hoffmann, Samira Akbas, Rahel Kindler, Dominique Bettex

{"title":"Successful use of extracorporeal life support and hemadsorption in the context of venlafaxine intoxication requiring cardiopulmonary resuscitation: a case report.","authors":"Matthias Hoffmann, Samira Akbas, Rahel Kindler, Dominique Bettex","doi":"10.1007/s10047-023-01399-8","DOIUrl":"10.1007/s10047-023-01399-8","url":null,"abstract":"Venlafaxine is a serotonin and noradrenalin reuptake inhibitor prescribed as an antidepressant. Overdose clinically manifests with neurological, cardiovascular and gastrointestinal abnormalities based on, amongst others, serotonin syndrome and can be life-threatening due to cardiovascular collapse. Besides immediate decontamination via gastric lavage and inhibition of enteral absorption through active charcoal, successful hemadsorption with CytoSorb® has been reported. We present the case of a 17-year-old female who required extracorporeal life support (ECLS) for cardiovascular collapse as a result of life-threatening venlafaxine intoxication. Serial serum blood concentrations of venlafaxine/desmethylvenlafaxine on admission at a tertiary hospital (approx. 24 h after ingestion) and subsequently 6 h and 18 h thereafter, as well as on days 2 and 4, were measured. CytoSorb® was initiated 6 h after admission and changed three times over 72 h. The initial blood concentration of venlafaxine/desmethylvenlafaxine was 53.52 µmol/l. After 6 h, it declined to 30.7 µmol/l and CytoSorb® was initiated at this point. After 12 h of hemadsorption, the blood level decreased to 9.6 µmol/l. On day 2, it was down to 7.17 µmol/l and decreased further to 3.74 µmol/l. Additional continuous renal replacement therapy using CVVHD was implemented on day 5. The combination of hemadsorption, besides traditional decontamination strategies along maximal organ supportive therapy with ECLS, resulted in the intact neurological survival of the highest venlafaxine intoxication reported in the literature to date. Hemadsorption with CytoSorb® might help to reduce blood serum levels of venlafaxine. Swift clearance of toxic blood levels may support cardiovascular recovery after life-threatening intoxications.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11126471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9357849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuron-specific enolase levels immediately following cardiovascular surgery is modulated by hemolysis due to cardiopulmonary bypass, making it unsuitable as a brain damage biomarker. 心血管手术后的神经元特异性烯醇化酶水平会受到心肺旁路溶血的影响，因此不适合作为脑损伤的生物标志物。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-04-29 DOI: 10.1007/s10047-023-01398-9

Nobuya Motoyoshi, Masahiro Tsutsui, Kouji Soman, Tomonori Shirasaka, Takayuki Narita, Shingo Kunioka, Katsuyuki Naya, Daisuke Yamazaki, Masahiko Narita, Hiroyuki Kamiya

{"title":"Neuron-specific enolase levels immediately following cardiovascular surgery is modulated by hemolysis due to cardiopulmonary bypass, making it unsuitable as a brain damage biomarker.","authors":"Nobuya Motoyoshi, Masahiro Tsutsui, Kouji Soman, Tomonori Shirasaka, Takayuki Narita, Shingo Kunioka, Katsuyuki Naya, Daisuke Yamazaki, Masahiko Narita, Hiroyuki Kamiya","doi":"10.1007/s10047-023-01398-9","DOIUrl":"10.1007/s10047-023-01398-9","url":null,"abstract":"Neuron-specific enolase (NSE) is one of the biomarkers used as an indicator of brain disorder, but since it is also found in blood cell components, there is a concern that a spurious increase in NSE may occur after cardiovascular surgery, where cardiopulmonary bypass (CPB) causes hemolysis. In the present study, we investigated the relationship between the degree of hemolysis and NSE after cardiovascular surgery and the usefulness of immediate postoperative NSE values in the diagnosis of brain disorder. A retrospective study of 198 patients who underwent surgery with CPB in the period from May 2019 to May 2021 was conducted. Postoperative NSE levels and Free hemoglobin (F-Hb) levels were compared in both groups. In addition, to verify the relationship between hemolysis and NSE, we examined the correlation between F-Hb levels and NSE levels. We also examined whether different surgical procedures could produce an association between hemolysis and NSE. Among 198 patients, 20 had postoperative stroke (Group S) and 178 had no postoperative stroke (Group U). There was no significant difference in postoperative NSE levels and F-Hb levels between Group S and Group U (p = 0.264, p = 0.064 respectively). F-Hb and NSE were weakly correlated (r = 0.29. p < 0.01). In conclusion, NSE level immediately after cardiac surgery with CPB is modified by hemolysis rather than brain injury, therefore it would be unreliable as a biomarker of brain disorder.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11126439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9370396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Veno-arterial-venous extracorporal membrane oxygenation (V-AV ECMO) in a patient in ARDS and cardiac instability after severe polytrauma. 对一名严重多发性创伤后出现 ARDS 和心脏不稳定的患者进行静脉-动脉-静脉椎体外膜氧合（V-AV ECMO）治疗。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-04-18 DOI: 10.1007/s10047-023-01393-0

Johannes Heymer, Benjamin Fohr, Daniel Raepple

引用次数: 0

Late outflow graft stenosis of left ventricular assist device and endovascular treatment. 左心室辅助装置和血管内治疗的晚期流出导管狭窄。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-05-05 DOI: 10.1007/s10047-023-01400-4

Sedat Karaca, Dilek Erdinli, Umit Kahraman, Celal Çınar, Çağatay Engin, Tahir Yağdı, Mustafa Özbaran

引用次数: 0

Diamond-like carbon coating to inner surface of polyurethane tube reduces Staphylococcus aureus bacterial adhesion and biofilm formation. 聚氨酯管内表面的类金刚石碳涂层可减少金黄色葡萄球菌的细菌粘附和生物膜的形成。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-05-25 DOI: 10.1007/s10047-023-01403-1

Noriaki Kuwada, Yasuhiro Fujii, Tatsuyuki Nakatani, Daiki Ousaka, Tatsunori Tsuji, Yuichi Imai, Yasuyuki Kobayashi, Susumu Oozawa, Shingo Kasahara, Kazuo Tanemoto

{"title":"Diamond-like carbon coating to inner surface of polyurethane tube reduces Staphylococcus aureus bacterial adhesion and biofilm formation.","authors":"Noriaki Kuwada, Yasuhiro Fujii, Tatsuyuki Nakatani, Daiki Ousaka, Tatsunori Tsuji, Yuichi Imai, Yasuyuki Kobayashi, Susumu Oozawa, Shingo Kasahara, Kazuo Tanemoto","doi":"10.1007/s10047-023-01403-1","DOIUrl":"10.1007/s10047-023-01403-1","url":null,"abstract":"Staphylococcus aureus is one of the main causative bacteria for polyurethane catheter and artificial graft infection. Recently, we developed a unique technique for coating diamond-like carbon (DLC) inside the luminal resin structure of polyurethane tubes. This study aimed to elucidate the infection-preventing effects of diamond-like carbon (DLC) coating on a polyurethane surface against S. aureus. We applied DLC to polyurethane tubes and rolled polyurethane sheets with our newly developed DLC coating technique for resin tubes. The DLC-coated and uncoated polyurethane surfaces were tested in smoothness, hydrophilicity, zeta-potential, and anti-bacterial properties against S. aureus (biofilm formation and bacterial attachment) by contact with bacterial fluids under static and flow conditions. The DLC-coated polyurethane surface was significantly smoother, more hydrophilic, and had a more negative zeta-potential than did the uncoated polyurethane surface. Upon exposure to bacterial fluid under both static and flow conditions, DLC-coated polyurethane exhibited significantly less biofilm formation than uncoated polyurethane, based on absorbance measurements. In addition, the adherence of S. aureus was significantly lower for DLC-coated polyurethane than for uncoated polyurethane under both conditions, based on scanning electron microscopy. These results show that applying DLC coating to the luminal resin of polyurethane tubes may impart antimicrobial effects against S. aureus to implantable medical polyurethane devices, such as vascular grafts and central venous catheters.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11126441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9872016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-tailored silicone plug for HeartMate 3™ left ventricular assist device explantation. 为HeartMate 3™左心室辅助装置植入量身定制的硅胶塞。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-04-26 DOI: 10.1007/s10047-023-01397-w

Mohamed Elbayomi, Rene Tandler, Nina Ebel, Dirk W Schubert, Siegfried Werner, Markus Kondruweit, Micheal Weyand, Christian Heim

引用次数: 0

Monocyte to HDL ratio may predict thrombosis in patients with mechanical mitral and aortic valve prosthesis. 单核细胞与高密度脂蛋白的比率可预测二尖瓣和主动脉瓣机械假体患者的血栓形成。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-04-21 DOI: 10.1007/s10047-023-01395-y

Mustafa Ozan Gürsoy, Cemalettin Yılmaz, Emrah Bayam, Ahmet Güner, Sadık Volkan Emren, Semih Kalkan, Yusuf Üzüm, Nurşen Keleş, Ali Karagöz, Mehmet Özkan

{"title":"Monocyte to HDL ratio may predict thrombosis in patients with mechanical mitral and aortic valve prosthesis.","authors":"Mustafa Ozan Gürsoy, Cemalettin Yılmaz, Emrah Bayam, Ahmet Güner, Sadık Volkan Emren, Semih Kalkan, Yusuf Üzüm, Nurşen Keleş, Ali Karagöz, Mehmet Özkan","doi":"10.1007/s10047-023-01395-y","DOIUrl":"10.1007/s10047-023-01395-y","url":null,"abstract":"Increased inflammatory biomarkers have been reported in prosthetic heart valve thrombosis (PHVT). Monocyte to HDL ratio (MHR) and albumin to CRP levels (CAR) are two biomarkers used widely for systemic inflammation but there is a lack of data on prosthetic heart valves. This study aimed to find out the potential predictive value of MHR and CAR for PHVT. Patients who had the diagnosis of mechanical mitral/aortic PHVT and normally functioning prosthesis were retrospectively analyzed. Laboratory data including complete blood count and biochemistry were recorded. Transesophageal echocardiography was performed to diagnose PHVT. The study included 118 patients with mechanical PHVT and 120 patients with normally functioning prosthesis. White blood count, monocyte levels, C-reactive protein, MHR and CAR were significantly higher whereas the lymphocyte, HDL and INR levels on admission were lower in patients with PHVT. Multivariate analysis showed that as well as inadequate anticoagulation, MHR, but not CAR, was found to be an independent predictor of thrombosis in patients with PHVT. Receiver operating characteristic curve analysis was performed to detect the best cut-off value of MHR in the prediction of thrombosis in patients with prosthetic valves. MHR level of > 12.8 measured on admission, yielded an AUC value of 0.791 [(CI 95% 0.733-0.848 p < 0.001) sensitivity 71%, specificity 70%]. Inadequate anticoagulation is the primary cause that leads to thrombosis in mechanical prosthetic valves. Increased MHR, but not CAR, was also shown to be an independent predictor of thrombosis in patients with mechanical mitral and aortic prosthetic valves.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nighttime sleep and daytime sleepiness patterns among left ventricular assist device patients. 左心室辅助装置患者的夜间睡眠和白天嗜睡模式。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-06-30 DOI: 10.1007/s10047-023-01410-2

Umar A Siddiqi, Aashka Patel, Yena Jang, Jennifer Cruz, Pamela Combs, Jesus M Casida

{"title":"Nighttime sleep and daytime sleepiness patterns among left ventricular assist device patients.","authors":"Umar A Siddiqi, Aashka Patel, Yena Jang, Jennifer Cruz, Pamela Combs, Jesus M Casida","doi":"10.1007/s10047-023-01410-2","DOIUrl":"10.1007/s10047-023-01410-2","url":null,"abstract":"Despite the high prevalence of sleep disturbance in the heart failure population, information about its consequence on daytime function in patients with left-ventricular assist devices (LVADs) is limited. This study examined the nighttime and daytime sleep patterns and changes from pre-implant to 6 months post-implant. This study included 32 LVAD patients. Demographics, nighttime and daytime sleep variables were collected pre-implant and at 1, 3, and 6 months post-implant. Wrist actigraphy and self-report questionnaires measured objective and subjective sleep, respectively. Objective nighttime sleep data were sleep efficiency (SE), sleep latency (SL), total sleep time (TST), wake after sleep onset (WASO), and sleep fragmentation (SF). Objective daytime sleep data were nap times. Self-reported Subjective Sleep Quality Scale (SSQS) and Stanford Sleepiness Scale (SSS) were subjective measures. Increased SF and WASO scores and decreased TST and SE scores were found pre-LVAD implant, indicative of poor sleep quality. TST, SE, naptime and SSQS scores were higher at 3 and 6 months post-implant compared to baseline. Decreases in TST and SF scores were observed at 3 and 6 months post-implant along with increases in SSS scores. Increasing SSS scores and decreasing overall scores from pre- and up to 6 months post-implant suggest improvement in daytime function. This study provides information on sleep-daytime function in the LVAD patient population. Improvements in daytime sleepiness do not imply \"good\" sleep quality, consistent with the extant knowledge in LVAD literature. Future investigations should elucidate the mechanism by which sleep-daytime function influences quality of life.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D porous structure imaging of membranes for medical devices using scanning probe microscopy and electron microscopy: from membrane science points of view. 利用扫描探针显微镜和电子显微镜对医疗设备用膜进行三维多孔结构成像：从膜科学的角度。

IF 1.1 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2024-02-05 DOI: 10.1007/s10047-023-01431-x

Makoto Fukuda, Kiyotaka Sakai

{"title":"3D porous structure imaging of membranes for medical devices using scanning probe microscopy and electron microscopy: from membrane science points of view.","authors":"Makoto Fukuda, Kiyotaka Sakai","doi":"10.1007/s10047-023-01431-x","DOIUrl":"10.1007/s10047-023-01431-x","url":null,"abstract":"The evolution of hemodialysis membranes (dialyzer, artificial kidney) was remarkable, since Dow Chemical began manufacturing hollow fiber hemodialyzers in 1968, especially because it involved industrial chemistry, including polymer synthesis and membrane manufacturing process. The development of hemodialysis membranes has brought about the field of medical devices as a major industry. In addition to conventional electron microscopy, scanning probe microscopy (SPM), represented by atomic force microscopy (AFM), has been used in membrane science research on porous membranes for hemodialysis, and membrane science contributes greatly to the hemodialyzer industry. Practical studies of membrane porous structure-function relationship have evolved, and methods for analyzing membrane cross-sectional morphology were developed, such as the ion milling method, which was capable of cutting membrane cross sections on the order of molecular size to obtain smooth surface structures. Recently, following the global pandemic of SARS-CoV-2 infection, many studies on new membranes for extracorporeal membrane oxygenator have been promptly reported, which also utilize membrane science researches. Membrane science is playing a prominent role in membrane-based technologies such as separation and fabrication, for hemodialysis, membrane oxygenator, lithium ion battery separators, lithium recycling, and seawater desalination. These practical studies contribute to the global medical devices industry.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mid-term outcomes and hemodynamic performance of the St Jude Medical Epic aortic bioprosthesis for severe aortic stenosis. St Jude Medical Epic 主动脉生物假体治疗重度主动脉瓣狭窄的中期疗效和血液动力学表现。

IF 1.3 4区医学

Journal of Artificial Organs Pub Date : 2024-06-01 Epub Date: 2023-06-08 DOI: 10.1007/s10047-023-01405-z

Tatsuto Wakami, Naoto Fukunaga, Akio Shimoji, Toshi Maeda, Otohime Mori, Kosuke Yoshizawa, Nobushige Tamura

{"title":"Mid-term outcomes and hemodynamic performance of the St Jude Medical Epic aortic bioprosthesis for severe aortic stenosis.","authors":"Tatsuto Wakami, Naoto Fukunaga, Akio Shimoji, Toshi Maeda, Otohime Mori, Kosuke Yoshizawa, Nobushige Tamura","doi":"10.1007/s10047-023-01405-z","DOIUrl":"10.1007/s10047-023-01405-z","url":null,"abstract":"The St. Jude Medical Epic Supra valve is a porcine bioprosthesis designed for complete supraannular implantation. No report has shown the hemodynamic performance and clinical outcomes of aortic valve replacement with the Epic Supra valve for severe aortic stenosis in a Japanese cohort. We retrospectively evaluated 65 patients who underwent aortic valve replacement using the Epic Supra valve for aortic stenosis at our department between May, 2011 and October, 2016. The mean follow-up period was 68.7 ± 32.7 months, and the follow-up rate was 89.2%. The mean age was 76.8 ± 5.3 years. The 1-, 5-, and 8-year survival rates were 96.9%, 79.4%, and 60.3%, respectively. The rates of freedom from valve-related events were 96.6% and 81.9% at 5 and 8 years, respectively. Four patients were diagnosed with structural valve deterioration (SVD), and reintervention was performed in two patients. The rates of freedom from SVD were 98.2% and 83.3% at 5 and 8 years, respectively, and the mean time to diagnosis of SVD was 72.5 ± 25.3 months. The mean pressure gradient (MPG) was 16.8 ± 6.0 mmHg postoperatively, 17.5 ± 9.4 mmHg at 5 years, and 21.2 ± 12.4 mmHg at 8 years (p = 0.08). The effective orifice area index (EOAI) was 0.95 ± 0.2 cm2/m2 immediately after surgery, 0.96 ± 0.27 cm2/m2 at 5 years, and 0.84 ± 0.2 cm2/m2 at 8 years (p = 0.10). An increase in MPG and decrease in EOAI were also observed, which may be associated with SVD. Follow-up after 5 years is important to determine if there is an increase.","PeriodicalId":15177,"journal":{"name":"Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9598924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0