Journal of Biomaterials Applications最新文献

{"title":"Multifunctional biopolymer-hydroxyapatite composite scaffolds for antibiotic delivery in osteomyelitis treatment and bone regeneration.","authors":"Tehseen Riaz, Anila Asif, Rabia Zeeshan, Tanya J Levingstone, Faiza Sharif, Nicholas Dunne","doi":"10.1177/08853282251383102","DOIUrl":"https://doi.org/10.1177/08853282251383102","url":null,"abstract":"<p><p>High bone-localized concentrations of antimicrobial agents are necessary for the long-term effective treatment of chronic osteomyelitis, particularly in cases of severe infection and bone loss. This study addressed infection control and bone regeneration simultaneously using hydroxyapatite and natural biopolymers. Moxifloxacin hydrochloride was delivered via composite scaffolds produced from polyvinyl alcohol/gelatin and hydroxyapatite with potential applications in osteomyelitis treatment and bone tissue engineering. The composite scaffolds exhibited a well-defined porous architecture, characterised by macropores (≥100 µm) and micropores (≤20 µm), facilitating cellular infiltration and drug loading. Biomineralization and cell culture assays were used to evaluate the scaffold's bioactivity and biocompatibility. Analyses of mineralized scaffolds using Fourier-transform infrared spectroscopy and scanning electron microscopy revealed HA nucleation on the scaffold's surface after immersion in simulated bodily fluid for varied time points. Protein adsorption and haemolysis tests were conducted to confirm the blood compatibility of scaffolds. Cell culture studies using human mesenchymal stem cells indicated non-cytotoxicity and robust cell adhesion. These findings suggest the potential suitability of these scaffolds for future clinical applications in the treatment of chronic osteomyelitis and bone regeneration.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251383102"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant and antibacterial alginate/lignin composite hydrogels loaded with vancomycin for wound dressing applications.","authors":"Faeze Shojaeinia, Masoumeh Haghbin Nazarpak, Akbar Karkhaneh","doi":"10.1177/08853282251347768","DOIUrl":"10.1177/08853282251347768","url":null,"abstract":"<p><p>Hydrogels are advantageous for wound healing as they provide mechanical support and maintain a moist environment, essential for tissue repair. Although conventional alginate-based hydrogels are commonly used in wound care, they often lack essential properties like antibacterial and antioxidant functionality. To address this limitation, this research focused on synthesizing composite hydrogels combining alginate with lignin and loading them with Vancomycin. The incorporation of lignin and Vancomycin imparted antibacterial and antioxidant properties to the hydrogels, enhancing their therapeutic potential. The hydrogels are dual crosslinked (physically and chemically), where lignin counteracts high levels of reactive oxygen species and reduces excessive inflammation at the wound site. Furthermore, the hydrogels had pores ranging from 100 to 135 μm, which is beneficial to gas and nutrient exchange and wound fluid absorption. Results showed that lignin improved the hydrogels' stability in physiological conditions by 50%. Additionally, the incorporation of lignin led to a 30% increase in antioxidant activity and a 50% boost in antibacterial activity. Vancomycin release from the hydrogels was measured, which showed alginate-only hydrogels releasing 50% and lignin-reinforced hydrogels releasing 35% over the first 24 hours. The MTT test confirmed approximately 90% cell viability across all samples, suggesting that the designed hydrogels are promising candidates for wound dressing applications.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"473-486"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oyster shell powder reinforced chitosan-poly(vinyl alcohol) freeze-dried composite sponge for on-site hemorrhage control.","authors":"Pranabesh Kumar Sasmal, Sujankrishna Samanta, Shalini Dasgupta, Samit Kumar Nandi, Abhijit Chanda, Pallab Datta","doi":"10.1177/08853282251347348","DOIUrl":"10.1177/08853282251347348","url":null,"abstract":"<p><p>A composite hemostatic sponge consisting of chitosan (CS) with oyster shell powder (OSP) has been developed as a potentially sustainable composite material for controlling hemorrhage at the injury site. The system is designed assuming that Ca⁺ released by OSP will accelerate the effect of chitosan at damage sites, enhancing the overall hemostatic efficacy. The sponge was thoroughly characterized using FTIR, SEM, and EDX analysis. In vitro, blood clotting assays such as clotting time (CT) [188 ± 4 s], prothrombin time (PT) [36 ± 1 s], activated partial thromboplastin time (aPTT) [51 ± 2 s], and plasma recalcification time (PRT) [58 ± 3 s] demonstrated that the inclusion of CaCO₃ significantly improved clot formation, with the CS-OSP sponge outperforming control sponges without OSP. RT-PCR analysis of vascular endothelial growth factor A (VEGF-A), platelet-derived growth factor (PDGF), and interleukin growth factor 1 (IGF-1) on fibroblast cell lines evidenced the wound healing-promoting activity of OSP-reinforced CS sponges. This was further supported by in vivo studies using a rabbit femoral artery injury model, where the CaCO₃-enhanced sponge achieved superior hemostasis and reduced blood loss more effectively than the control sponges without CaCO₃. These findings suggest that the oyster shell-derived CaCO₃ enhances the hemostatic activity of chitosan-based sponges, providing a promising candidate for rapid hemorrhage control in clinical settings, particularly in scenarios involving both oozing and pressurized bleeding.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"487-499"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical study on the application of biodegradable pure magnesium mesh in abdominal wall defect repair: Material characterization, biocompatibility, and regenerative mechanisms.","authors":"Qi Zheng, Zequn Zhuang, Yonglin Li, Rongwei Wei, Jing Wang, Xiaojing Lu, Chengyu Wu, Ziliang Zong, Haidong Xu, Chenguang Wei, Hui Shen, Jun Yan, Xiaonong Zhang, Yigang Chen","doi":"10.1177/08853282251383875","DOIUrl":"https://doi.org/10.1177/08853282251383875","url":null,"abstract":"<p><p>This study evaluates a novel biodegradable magnesium (Mg) mesh for abdominal wall repair. Current synthetic meshes present clinical limitations, while Mg alloys offer favorable mechanical properties and biodegradability that remain underexplored. The Mg mesh was characterized through tensile/burst testing and finite element analysis, demonstrating sufficient strength (initial: 167.2 ± 5.9 N/cm; 1 month: 55.9 ± 1.6 N/cm) to withstand tensile breaking strength of abdominal wall (16 N/cm). Degradation studies revealed faster rates in simulated body fluid (2.62 mm/year) versus Hanks' solution (1.14 mm/year), with 60% structural integrity maintained after 8 weeks in vivo. Biocompatibility assessment using human skin fibroblasts showed >60% viability (Grade 0-1 cytotoxicity) across extract concentrations, with 60% concentration enhancing proliferation. In rat abdominal wall defect models, the Mg mesh exhibited superior performance to polypropylene meshes, demonstrating reduced foreign body reaction and upregulated collagen III/V expression. Proteomic analysis (TMT), PCR, and Western blot confirmed enhanced wound healing mechanisms. The mesh maintained tight tissue integration throughout degradation while providing mechanical support matching physiological demands. These findings collectively indicate that the biodegradable Mg mesh combines: (1) appropriate time-dependent mechanical properties, (2) controlled degradation matching tissue regeneration timelines, (3) excellent cytocompatibility with pro-proliferative effects, and (4) improved healing outcomes compared to standard polypropylene meshes. The results support its potential as a next-generation material for abdominal wall reconstruction, addressing key limitations of permanent synthetic meshes through its optimal balance of biomechanical performance and bioresorbability. Further clinical studies are warranted to validate these promising preclinical outcomes.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251383875"},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional CuHP/Mg-CaP/PLLA nanofibrous scaffold for photothermal anti-infection therapy and enhanced bone regeneration.","authors":"Jian Gu, Shuangjian He, Peng Zhang, Long Zhou","doi":"10.1177/08853282251384021","DOIUrl":"https://doi.org/10.1177/08853282251384021","url":null,"abstract":"<p><p>Infected bone defects are characterised by inadequate local blood supply and the formation of bacterial biofilms, which impede bone tissue regeneration and repair, presenting a significant clinical challenge. In this study, we developed a bifunctional scaffold combining near-infrared (NIR)-responsive antibacterial activity with osteogenic properties by co-electrospinning photothermally active copper hydroxyphosphate (Cu₂(OH)PO₄, CuHP) and osteogenic magnesium-calcium phosphate (Mg-CaP) into poly (L-lactic acid) (PLLA) membranes. Near-infrared (NIR) irradiation activates the photothermal response of CuHP in nanofiber membrane scaffolds, effectively killing bacteria through photothermal therapy (PTT), while the released Mg-CaP synergistically promotes osteogenesis. Animal studies have revealed that the scaffold effectively inhibit infections while accelerating bone healing, offering a promising strategy for infected bone defects.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251384021"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc doped silica nanoparticles gelatin methacrylate hydrogel on BMSCs cell viability and differentiation: Potential for rat mandibular bone defect repair.","authors":"Hai Liu, Yuteng Chen, Yifan Ma, Yuanyuan Zhu, Shiyu Qiang, Songlin Zhou, Chao Deng, Donglin Zhang","doi":"10.1177/08853282251383321","DOIUrl":"https://doi.org/10.1177/08853282251383321","url":null,"abstract":"<p><p>The various maxillofacial bone defect caused by fractures, tumors, and inflammationsis challenging to repair clinically. Therefore, developing a functional material with bone tissue regeneration capabilities has significant practical importance. In this study, Zn doped silica nanoparticles were produced by microemulsion assisted sol-gel method and then different concentrations of nanoparticles was added to the gelatin methacrylated hydrogel to form the composite materials for potential rat mandibular bone defect repair. First, the elements of Zn, O, and Si were effectively integrated into nanoparticles. SEM analysis revealed the presence of Zn doped silica nanoparticles on the hydrogel's surface. Second, the 0.2 ZnSNPs/GelMA had good biocompatibility, and the ability to effectively induce osteogenic differentiation in Bone marrow mesenchymal stem cells (BMSCs). Finally, in vivo 4 mm diameter circular bone defect repair experiments indicated that the 0.2 ZnSNPs/GelMA promoted new bone regeneration in vivo. Overall, we believe that composite material with good biocompatibility and excellent osteoinductive property will provide new ideas for enhancing the efficacy of hard tissue repair.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251383321"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside II-loaded neutrophil nanocarrier drug delivery system for liver cancer treatment.","authors":"Guangyi Gao, Xuan Jiang, Jun Ma, Zeai Wang","doi":"10.1177/08853282251381435","DOIUrl":"https://doi.org/10.1177/08853282251381435","url":null,"abstract":"<p><p><b>Background:</b> Liver cancer is one of the most lethal cancers globally, with current treatments offering limited efficacy and significant side effects. Astragaloside II (ASII), a compound derived from traditional Chinese medicine, shows promise in reducing adverse effects, improving patient constitution, and prolonging survival. However, its clinical application is hindered by poor solubility and distribution. This study aims to develop a neutrophil-based nanocarrier system to enhance the tumor-targeting capability and therapeutic efficacy of ASII. <b>Methods:</b> We encapsulated ASII within PEG-PLGA nanomicelles and loaded them into neutrophils to create a neutrophil nanocarrier system (PG@AS-Neu). The physical properties of PG@AS-Neu were characterized using dynamic light scattering (DLS) and transmission electron microscopy. The encapsulation efficiency and release profile of ASII were investigated using high-performance liquid chromatography. The inhibitory effects of ASII and PG@AS-Neu on liver cancer cells were evaluated through cell viability, apoptosis, scratch wound, Transwell, and hemolysis assays to assess the nanocarrier's biosafety. <b>Results:</b> The neutrophil nanocarrier system demonstrated excellent stability and intact cellular morphology. Hemolysis assays confirmed the nanocarrier's blood compatibility. Cell viability, apoptosis, and invasion and migration assays revealed that both ASII and PG@AS-Neu significantly inhibited liver cancer cells. The preparation process of PG@AS-Neu did not compromise the anticancer activity of ASII, showing similar efficacy to free ASII. <b>Conclusion:</b> PG@AS-Neu exhibits potent anticancer effects and holds significant potential for liver cancer treatment.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251381435"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-responsive dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy.","authors":"Yang Yang, Hua Xie, Bi Zhou, Yuling Liu, Jiqing Hao","doi":"10.1177/08853282251381646","DOIUrl":"https://doi.org/10.1177/08853282251381646","url":null,"abstract":"<p><p>A single drug therapeutic approach fails to sufficiently eliminate tumors in clinics, owing to the tumoral complexity and heterogeneity. The integration of chemotherapy with novel treatment modalities offers a promising synergistic strategy for enhancing therapeutic outcomes. Herein, we successfully develop pH-triggered dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy, which are prepared through incorporation of Cu_2-xSe nanoparticles (NPs) and lipophilic mixture (OPC) including orthoester compound, polycaprolactone and carboplatin into imine-crosslinked polysaccharide-based hydrogels. The dynamic imine linkages endow the hydrogels with favorable injectability and self-adaptability as well as tumoral extracellular pH-triggered degradation. OPC can enhance drug escape from hydrogels, tumor penetration and pH-responsive prolonged and sustained release of the drug. Cu_2-xSe NPs endow the hydrogels with photothermal therapy (PTT), photodynamic therapy (PDT) and chemo-dynamic therapy (CDT). These superior physicochemical properties result in significant tumor growth inhibition while decreasing side effect on normal tissues. Therefore, the pH-responsive dynamic organic nanocomposite hydrogels have great potential for local tumor therapy in clinics.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251381646"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and <i>in-vitro</i> and <i>in-vivo</i> evaluation of polyacrylonitrile and polyethylene oxide nanofibers loaded with resveratrol and silver nanoparticles for skin wound healing application.","authors":"Niloofar Seyedi, Somayeh Taymouri, Alireza Allafchian, Mohsen Minaiyan, Elham Omidi, Jaleh Varshosaz","doi":"10.1177/08853282251383323","DOIUrl":"https://doi.org/10.1177/08853282251383323","url":null,"abstract":"<p><p>This study developed hybrid nanofiber scaffolds composed of polyacrylonitrile (PAN) and polyethylene oxide (PEO), loaded with resveratrol (RSV) and silver nanoparticles (Ag NPs), aiming to enhance wound healing and provide antimicrobial protection. Using electrospinning combined with a full factorial design, we optimized formulation parameters including total polymer concentration, drug/polymer ratio, and PEO/polymer ratio. We found that increasing the drug/polymer ratio resulted in an increase in fiber diameter, whereas raising the PEO concentration decreased fiber diameter. Additionally, elevating the total polymer and PEO content significantly increased the encapsulation efficiency (EE) % of RSV in the nanofibers. Moreover, higher levels of PEO positively influenced the swelling % and release efficiency (RE) %. The optimized RSV-loaded PAN/PEO nanofibers exhibited a smooth, cylindrical, and bead-free morphology with an average diameter of 217.36 ± 37.20 nm, an EE of 83.71 ± 2.28%, drug loading of 14.47 ± 1.09%, RE over 30 h of 60.95 ± 2.36%, swelling of 1111.67 ± 122.58%, ultimate tensile strength of 2.84 ± 0.34 MPa, and Young's modulus of 26.06 ± 5.58 MPa. The incorporation of Ag NPs resulted in bead-free fibers with a slightly reduced diameter and a swelling of 1032.5 ± 106.45%.X-ray diffraction analysis confirmed the crystalline presence of both RSV and Ag NPs within the fibers. The Ag NPs imparted strong antibacterial activity, producing inhibition zones against <i>Escherichia coli</i> (31.66 ± 2.51 mm) and <i>Staphylococcus aureus</i> (18.33 ± 3.51 mm), whereas RSV alone showed no antibacterial effect. <i>In vivo</i> wound healing studies demonstrated a significantly faster wound healing rate for Ag NPs-RSV- nanofiber compared to other groups, with complete wound closure, full re-epithelialization, enhanced collagen deposition, and the formation of skin appendages by day 15. These findings suggest that RSV-loaded PAN/PEO nanofibers offer a promising medicated wound dressing capable of promoting tissue regeneration and preventing infection.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251383323"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired 3D-printing strategies for skeletal tissue regeneration: From natural architectures to clinical applications.","authors":"Sahar Jelodari, Payam Baei, Majid Halvaei, Niloofar Hosseinpour, Mohsen Sheykhhasan, Samaneh Hosseini","doi":"10.1177/08853282251382716","DOIUrl":"https://doi.org/10.1177/08853282251382716","url":null,"abstract":"<p><p>Skeletal tissues possess complicated structures and thereby their regeneration confronts considerable challenges. The final objective of skeletal tissue engineering is the development of efficient engineered substitutes in order to promote tissue regeneration. Numerous efforts have been made to develop functional biomimetic constructs with superior functions and characteristics to create advanced biomaterials for skeletal regeneration. One of the efficient approaches for designing bioinspired materials is mimicking the microstructure and architecture of natural living organisms and applying them in developing biomaterials with relevant functionality. Moreover, bioinspired complex structures which are developed by mimicking natural or synthetic architectures provide a crucial role in tissue engineering. Since the traditional approaches can not fulfill the demands to design intricate biomimetic materials, employing novel technologies may be satisfying. 3D bioprinting is a rapidly evolving technology which offers accurate multi-material and multi-scale manufacturing of biomimetic constructs for the patient-specific tissue regeneration. Numerous attempts such as mimicking the hierarchical structure and function of bone tissue, resembling the zonal architecture of cartilage tissue and imitating the microstructure and mechanical characteristics of natural osteochondral tissue, can suggest clinically desirable candidates for skeletal reconstruction. Here, 3D bioprinting technology for creating bioinspired constructs for use in skeletal tissue regeneration is discussed. We review various types of bioinspired constructs developed by mimicking the endogenous structure and function of skeletal tissues. Next, biomimetic constructs that are designed by imitating other natural and synthetic structures are discussed. Clinical trials utilizing 3D-printed constructs for skeletal tissue regeneration is discussed as the final part of the story. Different strategies such as mimicking strong adhesion to different surfaces, imitating the morphology of different architectures and resembling the hierarchical structure of natural and synthetic structures can expand the opportunity to develop realistic and effective constructs for clinical regeneration of skeletal tissue.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251382716"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}