{"title":"双功能CuHP/Mg-CaP/PLLA纳米纤维支架光热抗感染治疗和增强骨再生。","authors":"Jian Gu, Shuangjian He, Peng Zhang, Long Zhou","doi":"10.1177/08853282251384021","DOIUrl":null,"url":null,"abstract":"<p><p>Infected bone defects are characterised by inadequate local blood supply and the formation of bacterial biofilms, which impede bone tissue regeneration and repair, presenting a significant clinical challenge. In this study, we developed a bifunctional scaffold combining near-infrared (NIR)-responsive antibacterial activity with osteogenic properties by co-electrospinning photothermally active copper hydroxyphosphate (Cu<sub>2</sub>(OH)PO<sub>4</sub>, CuHP) and osteogenic magnesium-calcium phosphate (Mg-CaP) into poly (L-lactic acid) (PLLA) membranes. Near-infrared (NIR) irradiation activates the photothermal response of CuHP in nanofiber membrane scaffolds, effectively killing bacteria through photothermal therapy (PTT), while the released Mg-CaP synergistically promotes osteogenesis. Animal studies have revealed that the scaffold effectively inhibit infections while accelerating bone healing, offering a promising strategy for infected bone defects.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251384021"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dual-functional CuHP/Mg-CaP/PLLA nanofibrous scaffold for photothermal anti-infection therapy and enhanced bone regeneration.\",\"authors\":\"Jian Gu, Shuangjian He, Peng Zhang, Long Zhou\",\"doi\":\"10.1177/08853282251384021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Infected bone defects are characterised by inadequate local blood supply and the formation of bacterial biofilms, which impede bone tissue regeneration and repair, presenting a significant clinical challenge. In this study, we developed a bifunctional scaffold combining near-infrared (NIR)-responsive antibacterial activity with osteogenic properties by co-electrospinning photothermally active copper hydroxyphosphate (Cu<sub>2</sub>(OH)PO<sub>4</sub>, CuHP) and osteogenic magnesium-calcium phosphate (Mg-CaP) into poly (L-lactic acid) (PLLA) membranes. Near-infrared (NIR) irradiation activates the photothermal response of CuHP in nanofiber membrane scaffolds, effectively killing bacteria through photothermal therapy (PTT), while the released Mg-CaP synergistically promotes osteogenesis. Animal studies have revealed that the scaffold effectively inhibit infections while accelerating bone healing, offering a promising strategy for infected bone defects.</p>\",\"PeriodicalId\":15138,\"journal\":{\"name\":\"Journal of Biomaterials Applications\",\"volume\":\" \",\"pages\":\"8853282251384021\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials Applications\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/08853282251384021\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Applications","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08853282251384021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Dual-functional CuHP/Mg-CaP/PLLA nanofibrous scaffold for photothermal anti-infection therapy and enhanced bone regeneration.
Infected bone defects are characterised by inadequate local blood supply and the formation of bacterial biofilms, which impede bone tissue regeneration and repair, presenting a significant clinical challenge. In this study, we developed a bifunctional scaffold combining near-infrared (NIR)-responsive antibacterial activity with osteogenic properties by co-electrospinning photothermally active copper hydroxyphosphate (Cu2(OH)PO4, CuHP) and osteogenic magnesium-calcium phosphate (Mg-CaP) into poly (L-lactic acid) (PLLA) membranes. Near-infrared (NIR) irradiation activates the photothermal response of CuHP in nanofiber membrane scaffolds, effectively killing bacteria through photothermal therapy (PTT), while the released Mg-CaP synergistically promotes osteogenesis. Animal studies have revealed that the scaffold effectively inhibit infections while accelerating bone healing, offering a promising strategy for infected bone defects.
期刊介绍：
The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials.
Peer-reviewed articles by biomedical specialists from around the world cover:
New developments in biomaterials, R&D, properties and performance, evaluation and applications
Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices
Current findings in biological compatibility/incompatibility of biomaterials
The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use.
The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
