pH-responsive dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy.

IF 2.5 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2025-09-25 DOI:10.1177/08853282251381646

Yang Yang, Hua Xie, Bi Zhou, Yuling Liu, Jiqing Hao

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引用次数: 0

Abstract

A single drug therapeutic approach fails to sufficiently eliminate tumors in clinics, owing to the tumoral complexity and heterogeneity. The integration of chemotherapy with novel treatment modalities offers a promising synergistic strategy for enhancing therapeutic outcomes. Herein, we successfully develop pH-triggered dynamic organic nanocomposite hydrogels for enhanced local tumor combination therapy, which are prepared through incorporation of Cu_2-xSe nanoparticles (NPs) and lipophilic mixture (OPC) including orthoester compound, polycaprolactone and carboplatin into imine-crosslinked polysaccharide-based hydrogels. The dynamic imine linkages endow the hydrogels with favorable injectability and self-adaptability as well as tumoral extracellular pH-triggered degradation. OPC can enhance drug escape from hydrogels, tumor penetration and pH-responsive prolonged and sustained release of the drug. Cu_2-xSe NPs endow the hydrogels with photothermal therapy (PTT), photodynamic therapy (PDT) and chemo-dynamic therapy (CDT). These superior physicochemical properties result in significant tumor growth inhibition while decreasing side effect on normal tissues. Therefore, the pH-responsive dynamic organic nanocomposite hydrogels have great potential for local tumor therapy in clinics.

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ph响应动态有机纳米复合水凝胶增强局部肿瘤联合治疗。

由于肿瘤的复杂性和异质性，单一的药物治疗方法无法在临床中充分消除肿瘤。化疗与新型治疗方式的整合为提高治疗效果提供了一个有希望的协同策略。本研究通过将Cu2-xSe纳米颗粒（NPs）和亲脂性混合物（OPC）（包括正酯化合物、聚己内酯和卡铂）加入亚胺交联多糖基水凝胶中，成功开发了ph触发的有机纳米复合水凝胶，用于增强局部肿瘤联合治疗。动态亚胺键使水凝胶具有良好的可注射性和自适应性，以及肿瘤细胞外ph触发的降解。OPC可促进药物从水凝胶中逃逸、穿透肿瘤和ph响应性延长和持续释放药物。Cu2-xSe NPs赋予水凝胶光热治疗（PTT），光动力治疗（PDT）和化学动力治疗（CDT）。这些优越的物理化学性质导致了显著的肿瘤生长抑制，同时减少了对正常组织的副作用。因此，ph响应动态有机纳米复合水凝胶在临床上具有很大的局部肿瘤治疗潜力。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.