Journal of Biomaterials Applications最新文献

{"title":"Promotion of infected wound healing by black phosphorus-strontium via photothermal therapy.","authors":"Gyeonghwi Yu, Sen Zhang, Jingyi Chen, Guixue Lian, Junhao Zhong, Yongzhe Liu, Xin Xu","doi":"10.1177/08853282251376879","DOIUrl":"https://doi.org/10.1177/08853282251376879","url":null,"abstract":"<p><p>Bacterial infection, as one of the most common inflammatory complications of skin wounds, presents a critical challenge in clinical treatment: how to effectively control infection while preventing the emergence of drug-resistant strains. In this study, black phosphorus (BP) nanosheets were prepared using the liquid-phase exfoliation method. Strontium ions (Sr²⁺) were then loaded onto the BP surface via electrostatic self-assembly technology, forming a composite nanomaterial named Black Phosphorus Strontium (BP-Sr) that exhibits both antibacterial properties and the ability to promote soft tissue growth. Utilizing photothermal therapy (PTT), BP-Sr effectively kills bacteria, reduces inflammatory responses, and promotes soft tissue regeneration. This research provides a novel approach for anti-infection treatment and pro-healing strategies for infected wounds.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251376879"},"PeriodicalIF":2.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in polymeric ultrafine fibrous scaffolds for enabling cell infiltration in tissue engineering.","authors":"S M Kamrul Hasan, Prosenjit Sen, Habibur Rahman Anik, Md Redwanul Islam, Mowshumi Roy, Toufique Ahmed, Abu Naser Md Ahsanul Haque","doi":"10.1177/08853282251380622","DOIUrl":"10.1177/08853282251380622","url":null,"abstract":"<p><p>The structural features of polymer-based tissue engineering scaffolds engineered to support cell adhesion, proliferation, and differentiation have been consistently and assiduously studied over the past few decades. It is now well known that scaffolds composed of polymers with ultrafine fibrous morphologies produced via electrospinning and integrated porosity, can positively influence cell response. The primary objective of most studies in tissue engineering scaffold development is to create a scaffold that emulates the native in vivo-like environment of extracellular matrices (ECMs). Achieving an even distribution of cells throughout the scaffold is critical for exactly mimicking the native extracellular matrix environment. However, inadequate cell infiltration towards the center of the scaffolds has been a common issue in many studies. Only a limited subset of researchers has successfully identified the structural features of scaffolds that facilitate cell penetration and has consequently introduced innovative scaffolds. This study aims to identify the critical structural features of polymeric scaffolds that facilitate cell infiltration and presents novel ultrafine fibrous scaffolds engineered to enhance uniform cellular penetration.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251380622"},"PeriodicalIF":2.5,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fabrication method using unconventional pattern designs to enhance the mechanical strength of 3D bio-printed PCL scaffolds.","authors":"Yating Wang, Minglei Bi, Mai Xu","doi":"10.1177/08853282251374420","DOIUrl":"https://doi.org/10.1177/08853282251374420","url":null,"abstract":"<p><p><b>Purpose:</b> Cartilage tissue has a very limited self-repairing capacity due to its aneural and avascular nature, and current clinical strategies fail to consistently regenerate normal hyaline cartilage for effective chondrogenic repair. This study aims to explore the potential of 3D bioprinting, particularly through hybrid constructs of cell-embedded soft and synthetic materials, as a solution for enhancing the mechanical and biological properties of tissue-engineered scaffolds. <b>Methods:</b> We developed and implemented optimization protocols for melt-extrusion bioprinting to fine-tune mechanical properties by adjusting strand distance and pattern shapes. Gelatin methacryloyl (GelMA) and polycaprolactone (PCL) hybrid constructs were fabricated to investigate the synergy between materials in achieving improved mechanical strength while preserving biological compatibility. <b>Results:</b> The optimized printing parameters yielded scaffolds with compressive modulus values aligning closely with the target, demonstrating the clinical applicability of the method. The hybrid GelMA-PCL constructs exhibited enhanced mechanical properties and retained a high biological fraction, validating their potential for chondrogenic applications. <b>Conclusion:</b> This study presents an innovative approach to improving the mechanical strength of tissue-engineered constructs through architectural optimization. These findings represent a significant step toward advancing tissue-engineered cartilaginous products from laboratory research to clinical applications, addressing a critical challenge in cartilage repair.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251374420"},"PeriodicalIF":2.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable hydrogels loaded with EGCG /KGN for the treatment of osteoarthritis.","authors":"Jie Zhou, Jiao Liang, Kun Yang, Guangyu Zhang","doi":"10.1177/08853282251379151","DOIUrl":"https://doi.org/10.1177/08853282251379151","url":null,"abstract":"<p><p>Osteoarthritis is confronted with a multifaceted pathological microenvironment, and the implementation of palliative pharmacological strategies facilitates the continued progression of osteoarthritis. In this study, a dynamic hydrogel composed of oxidized hyaluronic acid and gelatin was devised for encapsulating and dispensing EGCG to combat inflammation and oxidative stress in the initial phase, stimulating the differentiation of BMSCs to preserve the metabolic equilibrium of the extracellular matrix through the gradual release of KGN-loaded PLGA microspheres. Subsequently, accomplished adhesion and in-situ delivery were achieved through minimally invasive injection into the joint cavity. These hydrogels possess excellent shear-thinning properties and biocompatibility. The design of double-loaded hydrogel is capable of eradicating intracellular reactive oxygen species while fostering cartilage differentiation via controlled release of EGCG and KGN. A double-loaded injectable hydrogel may provide a new idea for early minimally invasive treatment of osteoarthritis.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251379151"},"PeriodicalIF":2.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of a PDMS-based substrate with a stiffness gradient for modeling the mechanical microenvironment in single and collective cell studies.","authors":"Minoo Alavi, Mohammad Tabatabaei, Mohammad Tafazzoli-Shadpour, Mohamad Sadegh Aghajanzadeh","doi":"10.1177/08853282251375172","DOIUrl":"https://doi.org/10.1177/08853282251375172","url":null,"abstract":"<p><p>Mechanotransduction plays a pivotal role in shaping cellular behavior including migration, differentiation, and proliferation. To investigate this mechanism more accurately further, this study came up with a novel elastomeric substrate with a stiffness gradient using a sugar-based replica molding technique combined with a two-layer PDMS system. The efficient water solubility of candy allows easy release, creating a smooth substrate. By adjusting the substrate's thickness, the optimal effective gradient length for the study is achievable. Additionally, adjusting substrate thickness precisely controls stiffness, from very soft to hard-tissue-like rigidity. Atomic force microscopy characterization confirmed a continuous stiffness gradient on three commonly used PDMS mixtures, 1:30, 1:50, and 1:75, demonstrating the versatility of this method for fabricating and tuning substrates to mimic various tissue environments. In cellular experiments, 3T3 fibroblast cells exhibited a significant migratory response toward the 1:50/1:75 two-layer stiffness gradient, with cells migrating preferably in stiffer directions. Its cost-effectiveness, smooth surface, and ability to regulate gradient substrates with varied stiffness via different PDMS combinations are key advantages. By precisely replicating physiologically relevant mechanical microenvironments, this method advances mechanobiology research and facilitates modeling of stiffness-guided cellular behaviors, paving the way for reliable tissue engineering and regenerative medicine studies.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251375172"},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel dual-targeted modified polyester albumin nano-carriers enhance the efficacy of hepatocellular carcinoma outcomes after encapsulating lenvatinib.","authors":"Yong Jiang, Le Fan, Yunxia Chai, Feng Xiao, Nan Zhu, Bin Yi","doi":"10.1177/08853282251374426","DOIUrl":"10.1177/08853282251374426","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Lenvatinib (LEN) is a potentially effective HCC-targeted drug, but poor water solubility, rapid metabolism, drug resistance, and clinical side effects hinder its satisfactory efficacy. In this study, we proposed to prepare a novel epithelial cell adhesion molecule (EpCAM)/Vimentin dual-targeting modified polyester albumin nanocarriers to load LEN (EpCAM/Vimentin-LEN-ANs) to improve the therapeutic efficacy of the drug for HCC. The results showed that the EpCAM/Vimentin-LEN-ANs had a particle size of (236.08 ± 6.39) nm, a potential of (38.93 ± 7.15) mv, and were characterized by nanovesicles, with an encapsulation rate of (97.57 ± 2.43) % and a drug loading capacity of (11.16 ± 1.75) %. EpCAM/Vimentin-LEN-ANs can specifically target HCC cells and slowly release LEN drugs, thus effectively inhibiting the growth of HCC cells; in addition, they have good anti-tumor effects and biosafety in vivo. In this study, EpCAM/Vimentin-LEN-ANs were successfully prepared, which can carry LEN and then target into HCC cells to achieve precise delivery and release of drugs, improve anti-tumor efficacy and alleviate the toxic side effects of anti-tumor drugs on the organism, which has a better potential for application and clinical translation in the treatment of HCC.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"8853282251374426"},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-adherence capacity of phytosphingosine on titanium surfaces.","authors":"Enni Liinoja, Nagat Areid, Elisa Närvä, Floris J Bikker, Vuokko Loimaranta, Timo O Närhi","doi":"10.1177/08853282251334902","DOIUrl":"10.1177/08853282251334902","url":null,"abstract":"<p><p>Firm soft tissue attachment on oral implant components together with good bacterial control are important prerequisites for uneventful implant healing. TiO₂ coatings have been shown to enhance human gingival fibroblast attachment, but the coating does not have antimicrobial properties. Phytosphingosine (PHS) is known to have antifouling properties against the cariogenic bacterium <i>Streptococcus mutans (S. mutans)</i> which is also among the first colonizers on implant surfaces. This makes PHS an interesting agent to prevent microbial adhesion on dental implant surfaces. The aim of this study was to examine the impact of PHS on <i>S. mutans</i> and human gingival fibroblast adhesion on titanium surfaces with or without TiO₂ -coating. Titanium discs (<i>n</i> = 99, diameter 14 mm, thickness 1 mm) were fabricated for the study. The discs were divided into four groups: (1) non-coated discs (NC), (2) titanium discs with hydrothermally induced TiO₂ coatings (HT), (3) NC discs treated with PHS solution and (4) HT discs treated with PHS solution. Hydrophilicity of the discs was evaluated by water contact angle measurement. <i>S. mutans</i> was added on HT and NC discs with or without PHS treatment for 30 minutes and the number of attached bacteria was estimated by plate counting method. For fibroblast experiment, the cells were plated on the discs and the number of adhered fibroblasts was determined at three time points (1, 3, 6 h). Additionally, confocal microscope images were obtained to examine fibroblast and <i>S.</i> <i>mutans</i> adhesion and to evaluate cell spreading. PHS treatment significantly decreased the hydrophilicity of HT and NC titanium surfaces (<i>p</i> < .001). <i>S. mutans</i> adhesion was significantly reduced after PHS treatment on both NC (<i>p</i> < .001) and HT surfaces (<i>p</i> < .001). Fibroblast adhesion was significantly reduced in HT group at 1 and 3h time points (<i>p</i> < .001), situation leveling out by the 6th hour. PHS reduced the number of adhered fibroblasts to the surface at incubation times of 1 hours (<i>p</i> = .0011) and 3 hours (<i>p</i> = .0194). At the 6 hour time point the number of adhered cells was no longer reduced, but still a reduction in cell spreading on the surface was observed (<i>p</i> < .05). The adhesion differences were present only in HT group. The PHS treatment reduced adherence <i>of S. mutans</i> and fibroblasts on TiO₂ coated titanium, which may result from reduced hydrophilicity of the surfaces. The dual approach of PHS treatment and TiO₂ coating could provide microbial antifouling properties of dental implants but may also affect fibroblast adhesion.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"419-427"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of fused deposition modeling (FDM) printing parameters on quality aspects of polycaprolactone (PCL) for coronary stent applications: A review.","authors":"Kuang Yee Ng, Noorhafiza Muhammad, Siti Noor Fazliah Mohd Noor, Shayfull Zamree Abd Rahim, Mohd Shuhidan Saleh, Nur Amalina Muhammad, Asnul Hadi Ahmad, Kamalakanta Muduli","doi":"10.1177/08853282251334880","DOIUrl":"10.1177/08853282251334880","url":null,"abstract":"<p><p>Fused deposition modeling (FDM) is emerging as a promising technique for manufacturing bioresorbable stents (BRS), particularly for coronary artery disease treatment. Polycaprolactone (PCL) has emerged as a favored material due to its biocompatibility, controlled degradation rate and mechanical properties. This review provides a comprehensive analysis of the effects of key FDM printing parameters on the quality aspects of PCL-based BRS, focusing on morphological, mechanical and biological characteristics. This review also highlights inconsistencies in previous studies, particularly in the impact of these parameters on stent dimensions and mechanical properties, emphasizing the need for standardization in experimental methodologies. Additionally, the current gaps in research related to the mechanical and biological performances of PCL-based BRS are discussed, with a call for further studies on long-term effects. This review aims to guide future research by offering insights into optimizing FDM parameters for improving the overall performance and clinical outcomes of PCL-based BRS.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"327-344"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and evaluation of sodium alginate-based hydrogel containing green tea for the treatment of diabetic ulcers in rat model.","authors":"Pirasteh Norouzi, Nariman Rezaei Kolarijani, Naimeh Mahheidari, Arian Ehterami, Arindam Bit, Anneh Mohammad Gharravi, Seyed Meysam Yekesadat, Seyedeh Nazanin Aghayan, Saeed Haghi-Daredeh, Majid Salehi","doi":"10.1177/08853282251345004","DOIUrl":"10.1177/08853282251345004","url":null,"abstract":"<p><p>A functional and biocompatible biomaterial is essential for accelerating the regeneration of skin tissue at the wound site. Hydrogel scaffolds in three dimensions show promising candidates for this purpose. This study was conducted to design a novel porous cross-linked alginate (Alg) hydrogel containing green tea (GT) and assess its morphology, swelling, weight loss, hemocompatibility, and cytocompatibility. Ultimately, the created hydrogel's therapeutic effectiveness was examined in a complete dermal diabetes wound model. The findings indicated that the hydrogel prepared had significant porosity, with interconnected pores around 75.821 µm in size. The weight loss evaluation indicated that the created hydrogel can be degraded naturally, with a weight loss ratio of about 74% for Alg/GT 80 mg after being incubated for 24 hours. Additionally, the study indicated that hydrogel dressings exhibited greater wound closure compared to gauze-treated wounds, which served as the control. The group with GT at a concentration of 80 mg showed the highest percentage of wound closure. The histopathological studies and IHC evaluation for TGF-β1 confirmed the in vivo finding. This study proposes utilizing 3D Alg hydrogels with GT as a wound dressing, but further studies are needed.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"359-373"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D printed biomimetic composite scaffold based on graphene/gelatin/sodium alginate bioink: Cell proliferation effects and toxicity assessments.","authors":"Zhenyu Wang, Jiayi Yang, Jun Peng, Jingjing Zhu, Xiangqin Li, Jiang Du, Yuen Yee Cheng, Jie Xu, Fei Song, Zhilin Jia, Kedong Song","doi":"10.1177/08853282251341091","DOIUrl":"10.1177/08853282251341091","url":null,"abstract":"<p><p>Peripheral nerve injuries are a major global health issue, with current treatments showing significant limitations. Neural tissue engineering provides a promising solution by creating supportive environments for nerve regeneration. This study used advanced 3D bioprinting to produce biomimetic scaffolds from graphene-enhanced bio-inks, integrating cells, scaffold materials, and growth signals. Compared to traditional methods, 3D printing ensures precise material distribution, improving cell density. The bio-ink, made of graphene (Gr), gelatin (Gel), and sodium alginate (SA), was tested at concentrations of 0.02%, 0.08%, and 0.2% to find the best formula for neural repair. Among four scaffold groups (Gel/SA, 0.02% Gr/Gel/SA, 0.08% Gr/Gel/SA, 0.2% Gr/Gel/SA), the 0.08% Gr scaffold showed the best mechanical strength, structural integrity, and biocompatibility. Graphene improved the scaffolds' compressive strength and degradation balance but reduced water absorption, porosity and increased the contact angle at higher concentrations. PC12 cells on the scaffolds showed excellent proliferation and minimal toxicity at lower graphene levels. The 0.08% Gr scaffold was most effective in nerve regeneration, highlighting the potential of graphene-enhanced 3D-printed scaffolds for neural tissue engineering. This research underscores the importance of 3D bioprinting in advancing nerve repair treatments.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"389-401"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}