ChemPlusChem最新文献_第3页

Cover Feature: Effect of UV Light Exposure Duration on the Removal of Exfoliation Agent Residues in Two-Dimensional Perovskite Nanosheets: An AFM Study (ChemPlusChem 3/2025)

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-17 DOI: 10.1002/cplu.202580303

Fatma Pinar Gordesli-Duatepe, Begümnur Küçükcan, Özge Sağlam

引用次数: 0

High-Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-17 DOI: 10.1002/cplu.202500164

R Graham Cooks, Jyotirmoy Ghosh, Nicolás M Morato, Yunfei Feng

{"title":"High-Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry.","authors":"R Graham Cooks, Jyotirmoy Ghosh, Nicolás M Morato, Yunfei Feng","doi":"10.1002/cplu.202500164","DOIUrl":"https://doi.org/10.1002/cplu.202500164","url":null,"abstract":"Adapting high-throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should expedite drug discovery. Here, we demonstrate the applicability of HT desorption electrospray ionization mass spectrometry (DESI MS) to achieve late-stage functionalization (LSF) and so to rapidly generate a modified opioid library. Specifically, aza-Michael addition and sulfur (VI) fluoride exchange (SuFEx) reactions were used for functionalization. The modified drugs are both synthesized and characterized using an automated HT-DESI MS platform, with the reaction occurring during the droplet flight. Analysis by MS characterizes reaction products at a throughput of ˃ 1 reaction per second. With this platform, multiple nor-opioid scaffolds and functionalization reagents were screened and a selection of the hits obtained was subjected to HT label-free bioassays using the same DESI-MS platform. This combination of accelerated LSF reactions to rapidly create a diverse library of functionalized drugs with direct bioassays of the crude reaction mixtures for SAR evaluation, both using the same platform, is anticipated to help expedite the early drug discovery process.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500164"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Preparation and Catalytic Properties of Gold Single-Atom and Cluster Catalysts Utilizing Nanoparticulate Mg-Al Layered Double Hydroxides (ChemPlusChem 3/2025)

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-17 DOI: 10.1002/cplu.202580301

Akihiro Nakayama, Ayano Yoshida, Chika Aono, Tetsuo Honma, Norihito Sakaguchi, Ayako Taketoshi, Takashi Fujita, Toru Murayama, Tetsuya Shimada, Shinsuke Takagi, Tamao Ishida

引用次数: 0

Synthesis, Spectroscopic and Electrochemical Characterization of Carbazole and Triphenylamine BOPHY Derivatives. Electrochemical Generation of an Optoelectronic Polymeric Film.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-14 DOI: 10.1002/cplu.202500051

Melisa Renfige, Jhair C Leon Jaramillo, Andres Calosso, Claudia Solis, Javier Durantini, Luis A Otero, Silvestre Bongiovanni Abel, Yohana B Palacios, Edwin J Gonzalez Lopez, Edgardo N Durantini, Daniel A Heredia, Miguel A Gervaldo

{"title":"Synthesis, Spectroscopic and Electrochemical Characterization of Carbazole and Triphenylamine BOPHY Derivatives. Electrochemical Generation of an Optoelectronic Polymeric Film.","authors":"Melisa Renfige, Jhair C Leon Jaramillo, Andres Calosso, Claudia Solis, Javier Durantini, Luis A Otero, Silvestre Bongiovanni Abel, Yohana B Palacios, Edwin J Gonzalez Lopez, Edgardo N Durantini, Daniel A Heredia, Miguel A Gervaldo","doi":"10.1002/cplu.202500051","DOIUrl":"10.1002/cplu.202500051","url":null,"abstract":"In this study, two new BOPHY-based derivatives were efficiently synthesized with high yields and characterized by using spectroscopic, electrochemical, and spectroelectrochemical techniques. The introduction of non-conjugated (carbazole (CBZ)) and conjugated (triphenylamine (TPA)) donor groups into the BOPHY macrocycle imparted different electrochemical and spectroscopic properties. Oxidation of BP-2CBZ led to the formation of unstable CBZ radical cations, which further reacted to generate dicarbazole (DCBZ) units, allowing the formation of a polymeric film during anodic cycling. In contrast, BP-2TPA exhibited a reversible oxidation process, generating stable BOPHY and TPA radical cations which inhibited the polymerization process. Spectroscopic differences were also observed, with BP-2CBZ displaying a high fluorescence quantum yield (Φf), while BP-2TPA emission was nearly quenched, exhibiting solvent-dependent fluorescence with a large Stokes shift (~160 nm). BP-2TPA also demonstrated aggregation-induced emission (AIE) properties, showing an increase in fluorescence intensity of around 12 times when the water content changes from 0 to 90 %. These experimental findings were further corroborated by DFT and TDDFT calculations. The BP-2CBZ polymer presented electrochromic properties, showing color changes upon oxidation. This work represents the first report of a BOPHY-based polymer synthesized through electrochemical methods.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500051"},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How an external electric field makes N2O a potent oxidizing agent.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-13 DOI: 10.1002/cplu.202500029

Pradeep Kumar, Vishva Jeet Anand

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Single-Atom Catalysts Boosted Electrochemiluminescence.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-12 DOI: 10.1002/cplu.202400767

Dan-Ling Wang, Wei Zhao

{"title":"Single-Atom Catalysts Boosted Electrochemiluminescence.","authors":"Dan-Ling Wang, Wei Zhao","doi":"10.1002/cplu.202400767","DOIUrl":"10.1002/cplu.202400767","url":null,"abstract":"Electrochemiluminescence (ECL) combines electrochemical redox processes with photochemical light emission, offering exceptional sensitivity, spatial control, and stability. Widely applied in biosensing, medical diagnostics, and environmental monitoring, its efficiency often depends on advanced catalytic materials. Single-atom catalysts (SACs), featuring isolated metal atoms dispersed on a support, have emerged as promising candidates due to their unique electronic structures, high atom utilization, and tunable catalytic properties. These features enable SACs to improve reaction kinetics, enhance light-emitting efficiency, and provide precise control over the generation of excited-state species essential for ECL. This review highlights recent advancements in SACs-boosted ECL systems, with a focus on their reaction mechanisms, design strategies, and roles in improving electrocatalytic and luminescent performance. Additionally, it summarizes the applications of SACs-boosted ECL in bioanalysis, environmental monitoring, and single-particle imaging. By highlighting the synergies between single-atom catalysis and ECL, this work aims to provide a comprehensive overview of the field and a roadmap for future research, paving the way for innovative applications in analytical and sensing technologies.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202400767"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organocatalyzed Diels-Alder Reactions: Unexplored Hydrogen Bond Donor Catalysts.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-12 DOI: 10.1002/cplu.202500081

Eveline H Tiekink, Ron Verdijk, Trevor A Hamlin, F Matthias Bickelhaupt

引用次数: 0

Investigating the Degradation of Historical Man-Made Cellulose-Derived Textiles via Accelerated Ageing.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-12 DOI: 10.1002/cplu.202500025

Louise Giselle Garner, Simoní Da Ros, Katherine Curran

引用次数: 0

Extensive Fragmentation, Atom Transfer, H loss and Cross-linking Induced by Single Collisions between Carbon Ions and Protonated Antibiotics in the Gas Phase.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-12 DOI: 10.1002/cplu.202500008

Min Liu, Alain Méry, Violaine Vizcaino, Jimmy Rangama, Thomas Schlathölter, Jean-Christophe Poully

{"title":"Extensive Fragmentation, Atom Transfer, H loss and Cross-linking Induced by Single Collisions between Carbon Ions and Protonated Antibiotics in the Gas Phase.","authors":"Min Liu, Alain Méry, Violaine Vizcaino, Jimmy Rangama, Thomas Schlathölter, Jean-Christophe Poully","doi":"10.1002/cplu.202500008","DOIUrl":"10.1002/cplu.202500008","url":null,"abstract":"The direct effects of ionizing radiation on antibiotics are largely unknown. Here, we report mass spectra of the cationic products of the irradiation of three antibiotics by carbon ions at 10.4 MeV kinetic energy. Carbon ion beams used in cancer treatments have this energy when they deliver the maximum dose to malignant cells. We find that upon single carbon ion collision, extensive fragmentation of antibiotics occurs, predominantly through channels similar to those observed in soft X-ray photoabsorption. However, new product ions are also detected and attributed to the ability of MeV carbon ions to eject electrons from the molecular target in an unspecific manner. Proton transfer appears to play a key role in the dissociation dynamics of rifamycin and actinomycin, and it is complemented by sodium transfer in sodiated rifamycin and its dimer. Importantly, we report the first evidence for abundant loss of H from precursor ions, as well as for intramolecular cross-linking triggered by carbon ion collision. All these processes most probably take place in the vibrationally hot electronic ground state of the molecular system.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500008"},"PeriodicalIF":3.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction.

IF 3 4区化学

ChemPlusChem Pub Date : 2025-03-11 DOI: 10.1002/cplu.202500084

Samar K Das, Debu Jana, Hema Kumari Kolli, M Praveen Kumar

{"title":"Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction.","authors":"Samar K Das, Debu Jana, Hema Kumari Kolli, M Praveen Kumar","doi":"10.1002/cplu.202500084","DOIUrl":"https://doi.org/10.1002/cplu.202500084","url":null,"abstract":"Polyoxometalate (POM) gel is well-known but mostly with organic molecules. Pure inorganic POM gel, i.e., a combination of a 'POM anion and a metal cation', is hardly known and unexplored area of materials research. When an aqueous solution of sodium tungstate is mixed with an aqueous solution of ferric chloride, the resulting suspension forms a straw-color hydrogel. The behavior of this hydrogel {W72Fe30}HG has been studied by performing rheology studies. Dehydration of hydrogel at room temperature brings about the corresponding xerogel, characterization of which confirms that the xerogel is a {W72Fe30} type giant Keplerate-based POM compound [Fe(H2O)6]14[W72Fe30O252(H2O)72(OH)60]·166H2O ({W72Fe30}XG) and the basic building unit of the gel is {W72Fe30} cluster. The xerogel is macroporous material characterized with 60 hydroxyl groups per formula unit and these hydroxyl groups are acidic in nature. Interestingly, the title xerogel {W72Fe30}XG, which is nothing but an inorganic acid and an inexpensive metal-oxide-based material, exhibits proton conduction in its solid state. The xerogel material shows super proton conductivity of 1.71×10-2 S cm-1 at 80 ⁰C and 98% relative humidity with an activation energy (Ea) of 0.18 eV.","PeriodicalId":148,"journal":{"name":"ChemPlusChem","volume":" ","pages":"e202500084"},"PeriodicalIF":3.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0